Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model

Autores
Ross, Gloria Romina; Fabersani Marrades, Mario Emanuel; Russo, Matias Irineo; Gómez, Alba; Japaze, Hugo; Gonzalez, Silvia Nelina; Gauffin Cano, María Paola
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Iodine is an important micronutrient required for nutrition. Excess iodine has adverse effects on thyroid, but there is not enough information regarding its effect on salivary glands. In addition to food and iodized salt, skin disinfectants and maternal nutritional supplements contain iodide, so its intake could be excessive during pregnancy, lactation, and infancy. The aim of this work was to evaluate the effect of excess iodide ingestion on salivary glands during mating, gestation, lactation, and postweaning period in mouse. During assay, mice were allocated into groups: control and treatment groups (received distilled water with NaI 1 mg/mL). Water intake, glandular weight, and histology were analyzed. Treatment groups showed an increase in glandular weight and a significantly (p < 0.05) higher water intake than control groups. Lymphocyte infiltration was observed in animals of treatment groups, while there was no infiltration in glandular sections of control groups. Results demonstrated that a negative relationship could exist between iodide excess and salivary glands. This work is novel evidence that high levels of iodide intake could induce mononuclear infiltration in salivary glands. These results should be considered, especially in pregnant/lactating women, to whom a higher iodine intake is usually recommended.
Fil: Ross, Gloria Romina. Universidad del Norte Santo Tomás de Aquino. Facultad de Ciencias de la Salud; Argentina. Universidad Nacional de Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria.; Argentina
Fil: Fabersani Marrades, Mario Emanuel. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Russo, Matias Irineo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Gómez, Alba. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Japaze, Hugo. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Gonzalez, Silvia Nelina. Universidad Nacional de Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria.; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Gauffin Cano, María Paola. Universidad del Norte Santo Tomás de Aquino. Facultad de Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Materia
IODINE
NUTRITION
SALIVARY GLANDS
PREGNANT/LACTATING WOMEN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64034
Acceder
id CONICETDig_c573df19bf386eb1d49d70c342a0d216
oai_identifier_str oai:ri.conicet.gov.ar:11336/64034
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice ModelRoss, Gloria RominaFabersani Marrades, Mario EmanuelRusso, Matias IrineoGómez, AlbaJapaze, HugoGonzalez, Silvia NelinaGauffin Cano, María PaolaIODINENUTRITIONSALIVARY GLANDSPREGNANT/LACTATING WOMENhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Iodine is an important micronutrient required for nutrition. Excess iodine has adverse effects on thyroid, but there is not enough information regarding its effect on salivary glands. In addition to food and iodized salt, skin disinfectants and maternal nutritional supplements contain iodide, so its intake could be excessive during pregnancy, lactation, and infancy. The aim of this work was to evaluate the effect of excess iodide ingestion on salivary glands during mating, gestation, lactation, and postweaning period in mouse. During assay, mice were allocated into groups: control and treatment groups (received distilled water with NaI 1 mg/mL). Water intake, glandular weight, and histology were analyzed. Treatment groups showed an increase in glandular weight and a significantly (p < 0.05) higher water intake than control groups. Lymphocyte infiltration was observed in animals of treatment groups, while there was no infiltration in glandular sections of control groups. Results demonstrated that a negative relationship could exist between iodide excess and salivary glands. This work is novel evidence that high levels of iodide intake could induce mononuclear infiltration in salivary glands. These results should be considered, especially in pregnant/lactating women, to whom a higher iodine intake is usually recommended.Fil: Ross, Gloria Romina. Universidad del Norte Santo Tomás de Aquino. Facultad de Ciencias de la Salud; Argentina. Universidad Nacional de Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria.; ArgentinaFil: Fabersani Marrades, Mario Emanuel. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Russo, Matias Irineo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Gómez, Alba. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Japaze, Hugo. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Gonzalez, Silvia Nelina. Universidad Nacional de Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria.; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Gauffin Cano, María Paola. Universidad del Norte Santo Tomás de Aquino. Facultad de Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaHindawi Publishing Corporation2017-11-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64034Ross, Gloria Romina; Fabersani Marrades, Mario Emanuel; Russo, Matias Irineo; Gómez, Alba; Japaze, Hugo; et al.; Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model; Hindawi Publishing Corporation; BioMed Research International; 2017; 8-11-2017; 1-62314-61332314-6141CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1155/2017/6302869info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2017/6302869/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T11:52:10Zoai:ri.conicet.gov.ar:11336/64034instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 11:52:10.974CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model
title Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model
spellingShingle Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model
Ross, Gloria Romina
IODINE
NUTRITION
SALIVARY GLANDS
PREGNANT/LACTATING WOMEN
title_short Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model
title_full Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model
title_fullStr Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model
title_full_unstemmed Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model
title_sort Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model
dc.creator.none.fl_str_mv Ross, Gloria Romina
Fabersani Marrades, Mario Emanuel
Russo, Matias Irineo
Gómez, Alba
Japaze, Hugo
Gonzalez, Silvia Nelina
Gauffin Cano, María Paola
author Ross, Gloria Romina
author_facet Ross, Gloria Romina
Fabersani Marrades, Mario Emanuel
Russo, Matias Irineo
Gómez, Alba
Japaze, Hugo
Gonzalez, Silvia Nelina
Gauffin Cano, María Paola
author_role author
author2 Fabersani Marrades, Mario Emanuel
Russo, Matias Irineo
Gómez, Alba
Japaze, Hugo
Gonzalez, Silvia Nelina
Gauffin Cano, María Paola
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv IODINE
NUTRITION
SALIVARY GLANDS
PREGNANT/LACTATING WOMEN
topic IODINE
NUTRITION
SALIVARY GLANDS
PREGNANT/LACTATING WOMEN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Iodine is an important micronutrient required for nutrition. Excess iodine has adverse effects on thyroid, but there is not enough information regarding its effect on salivary glands. In addition to food and iodized salt, skin disinfectants and maternal nutritional supplements contain iodide, so its intake could be excessive during pregnancy, lactation, and infancy. The aim of this work was to evaluate the effect of excess iodide ingestion on salivary glands during mating, gestation, lactation, and postweaning period in mouse. During assay, mice were allocated into groups: control and treatment groups (received distilled water with NaI 1 mg/mL). Water intake, glandular weight, and histology were analyzed. Treatment groups showed an increase in glandular weight and a significantly (p < 0.05) higher water intake than control groups. Lymphocyte infiltration was observed in animals of treatment groups, while there was no infiltration in glandular sections of control groups. Results demonstrated that a negative relationship could exist between iodide excess and salivary glands. This work is novel evidence that high levels of iodide intake could induce mononuclear infiltration in salivary glands. These results should be considered, especially in pregnant/lactating women, to whom a higher iodine intake is usually recommended.
Fil: Ross, Gloria Romina. Universidad del Norte Santo Tomás de Aquino. Facultad de Ciencias de la Salud; Argentina. Universidad Nacional de Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria.; Argentina
Fil: Fabersani Marrades, Mario Emanuel. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Russo, Matias Irineo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Gómez, Alba. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Japaze, Hugo. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Gonzalez, Silvia Nelina. Universidad Nacional de Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Biotecnología Farmaceutica y Alimentaria.; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Gauffin Cano, María Paola. Universidad del Norte Santo Tomás de Aquino. Facultad de Ciencias de la Salud; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
description Iodine is an important micronutrient required for nutrition. Excess iodine has adverse effects on thyroid, but there is not enough information regarding its effect on salivary glands. In addition to food and iodized salt, skin disinfectants and maternal nutritional supplements contain iodide, so its intake could be excessive during pregnancy, lactation, and infancy. The aim of this work was to evaluate the effect of excess iodide ingestion on salivary glands during mating, gestation, lactation, and postweaning period in mouse. During assay, mice were allocated into groups: control and treatment groups (received distilled water with NaI 1 mg/mL). Water intake, glandular weight, and histology were analyzed. Treatment groups showed an increase in glandular weight and a significantly (p < 0.05) higher water intake than control groups. Lymphocyte infiltration was observed in animals of treatment groups, while there was no infiltration in glandular sections of control groups. Results demonstrated that a negative relationship could exist between iodide excess and salivary glands. This work is novel evidence that high levels of iodide intake could induce mononuclear infiltration in salivary glands. These results should be considered, especially in pregnant/lactating women, to whom a higher iodine intake is usually recommended.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64034
Ross, Gloria Romina; Fabersani Marrades, Mario Emanuel; Russo, Matias Irineo; Gómez, Alba; Japaze, Hugo; et al.; Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model; Hindawi Publishing Corporation; BioMed Research International; 2017; 8-11-2017; 1-6
2314-6133
2314-6141
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64034
identifier_str_mv Ross, Gloria Romina; Fabersani Marrades, Mario Emanuel; Russo, Matias Irineo; Gómez, Alba; Japaze, Hugo; et al.; Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model; Hindawi Publishing Corporation; BioMed Research International; 2017; 8-11-2017; 1-6
2314-6133
2314-6141
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1155/2017/6302869
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2017/6302869/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847426597009752064
score 13.10058

Publicaciones similares