Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets

Autores
Andelova, Katarina; Benova, Tamara Egan; Bacova, Barbara Szeiffova; Sykora, Matus; Prado, Natalia Jorgelina; Diez, Emiliano Raúl; Hlivak, Peter; Tribulova, Narcis
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal caveolae/rafts compartments. GJCs are fundamental for the direct cardiac cell-to-cell transmission of electrical and molecular signals which ensures synchronous myocardial contraction. The HCs and structurally similar pannexin1 (Panx1) channels are active in stressful conditions. These channels are essential for paracrine and autocrine communication through the release of ions and signaling molecules to the extracellular environment, or for uptake from it. The HCs and Panx1 channel-opening profoundly affects intracellular ionic homeostasis and redox status and facilitates via purinergic signaling pro-inflammatory and pro-fibrotic processes. These conditions promote cardiac arrhythmogenesis due to the impairment of the GJCs and selective ion channel function. Crosstalk between GJCs and HCs/Panx1 channels could be crucial in the development of arrhythmogenic substrates, including fibrosis. Despite the knowledge gap in the regulation of these channels, current evidence indicates that HCs and Panx1 channel activation can enhance the risk of cardiac arrhythmias. It is extremely challenging to target HCs and Panx1 channels by inhibitory agents to hamper development of cardiac rhythm disorders. Progress in this field may contribute to novel therapeutic approaches for patients prone to develop atrial or ventricular fibrillation.
Fil: Andelova, Katarina. Slovak Academy of Sciences. Institute for Heart Research; Eslovaquia
Fil: Benova, Tamara Egan. Slovak Academy of Sciences. Institute for Heart Research; Eslovaquia
Fil: Bacova, Barbara Szeiffova. Slovak Academy of Sciences. Institute for Heart Research; Eslovaquia
Fil: Sykora, Matus. Slovak Academy of Sciences. Institute for Heart Research; Eslovaquia
Fil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Hlivak, Peter. National Institute Of Cardiovascular Diseases; Eslovaquia
Fil: Tribulova, Narcis. Slovak Academy of Sciences. Institute for Heart Research; Eslovaquia
Materia
CARDIAC ARRHYTHMIAS
CARDIO-PROTECTION
CX43 HEMI-CHANNELS
MIMETIC PEPTIDES
PANNEXIN1 CHANNELS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173113
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/173113
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targetsAndelova, KatarinaBenova, Tamara EganBacova, Barbara SzeiffovaSykora, MatusPrado, Natalia JorgelinaDiez, Emiliano RaúlHlivak, PeterTribulova, NarcisCARDIAC ARRHYTHMIASCARDIO-PROTECTIONCX43 HEMI-CHANNELSMIMETIC PEPTIDESPANNEXIN1 CHANNELShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal caveolae/rafts compartments. GJCs are fundamental for the direct cardiac cell-to-cell transmission of electrical and molecular signals which ensures synchronous myocardial contraction. The HCs and structurally similar pannexin1 (Panx1) channels are active in stressful conditions. These channels are essential for paracrine and autocrine communication through the release of ions and signaling molecules to the extracellular environment, or for uptake from it. The HCs and Panx1 channel-opening profoundly affects intracellular ionic homeostasis and redox status and facilitates via purinergic signaling pro-inflammatory and pro-fibrotic processes. These conditions promote cardiac arrhythmogenesis due to the impairment of the GJCs and selective ion channel function. Crosstalk between GJCs and HCs/Panx1 channels could be crucial in the development of arrhythmogenic substrates, including fibrosis. Despite the knowledge gap in the regulation of these channels, current evidence indicates that HCs and Panx1 channel activation can enhance the risk of cardiac arrhythmias. It is extremely challenging to target HCs and Panx1 channels by inhibitory agents to hamper development of cardiac rhythm disorders. Progress in this field may contribute to novel therapeutic approaches for patients prone to develop atrial or ventricular fibrillation.Fil: Andelova, Katarina. Slovak Academy of Sciences. Institute for Heart Research; EslovaquiaFil: Benova, Tamara Egan. Slovak Academy of Sciences. Institute for Heart Research; EslovaquiaFil: Bacova, Barbara Szeiffova. Slovak Academy of Sciences. Institute for Heart Research; EslovaquiaFil: Sykora, Matus. Slovak Academy of Sciences. Institute for Heart Research; EslovaquiaFil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Hlivak, Peter. National Institute Of Cardiovascular Diseases; EslovaquiaFil: Tribulova, Narcis. Slovak Academy of Sciences. Institute for Heart Research; EslovaquiaMultidisciplinary Digital Publishing Institute2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173113Andelova, Katarina; Benova, Tamara Egan; Bacova, Barbara Szeiffova; Sykora, Matus; Prado, Natalia Jorgelina; et al.; Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets; Multidisciplinary Digital Publishing Institute; International Journal of Molecular Sciences; 22; 1; 1-2021; 1-221661-6596CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/22/1/260info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms22010260info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:43Zoai:ri.conicet.gov.ar:11336/173113instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:43.813CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets
title Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets
spellingShingle Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets
Andelova, Katarina
CARDIAC ARRHYTHMIAS
CARDIO-PROTECTION
CX43 HEMI-CHANNELS
MIMETIC PEPTIDES
PANNEXIN1 CHANNELS
title_short Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets
title_full Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets
title_fullStr Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets
title_full_unstemmed Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets
title_sort Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets
dc.creator.none.fl_str_mv Andelova, Katarina
Benova, Tamara Egan
Bacova, Barbara Szeiffova
Sykora, Matus
Prado, Natalia Jorgelina
Diez, Emiliano Raúl
Hlivak, Peter
Tribulova, Narcis
author Andelova, Katarina
author_facet Andelova, Katarina
Benova, Tamara Egan
Bacova, Barbara Szeiffova
Sykora, Matus
Prado, Natalia Jorgelina
Diez, Emiliano Raúl
Hlivak, Peter
Tribulova, Narcis
author_role author
author2 Benova, Tamara Egan
Bacova, Barbara Szeiffova
Sykora, Matus
Prado, Natalia Jorgelina
Diez, Emiliano Raúl
Hlivak, Peter
Tribulova, Narcis
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CARDIAC ARRHYTHMIAS
CARDIO-PROTECTION
CX43 HEMI-CHANNELS
MIMETIC PEPTIDES
PANNEXIN1 CHANNELS
topic CARDIAC ARRHYTHMIAS
CARDIO-PROTECTION
CX43 HEMI-CHANNELS
MIMETIC PEPTIDES
PANNEXIN1 CHANNELS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal caveolae/rafts compartments. GJCs are fundamental for the direct cardiac cell-to-cell transmission of electrical and molecular signals which ensures synchronous myocardial contraction. The HCs and structurally similar pannexin1 (Panx1) channels are active in stressful conditions. These channels are essential for paracrine and autocrine communication through the release of ions and signaling molecules to the extracellular environment, or for uptake from it. The HCs and Panx1 channel-opening profoundly affects intracellular ionic homeostasis and redox status and facilitates via purinergic signaling pro-inflammatory and pro-fibrotic processes. These conditions promote cardiac arrhythmogenesis due to the impairment of the GJCs and selective ion channel function. Crosstalk between GJCs and HCs/Panx1 channels could be crucial in the development of arrhythmogenic substrates, including fibrosis. Despite the knowledge gap in the regulation of these channels, current evidence indicates that HCs and Panx1 channel activation can enhance the risk of cardiac arrhythmias. It is extremely challenging to target HCs and Panx1 channels by inhibitory agents to hamper development of cardiac rhythm disorders. Progress in this field may contribute to novel therapeutic approaches for patients prone to develop atrial or ventricular fibrillation.
Fil: Andelova, Katarina. Slovak Academy of Sciences. Institute for Heart Research; Eslovaquia
Fil: Benova, Tamara Egan. Slovak Academy of Sciences. Institute for Heart Research; Eslovaquia
Fil: Bacova, Barbara Szeiffova. Slovak Academy of Sciences. Institute for Heart Research; Eslovaquia
Fil: Sykora, Matus. Slovak Academy of Sciences. Institute for Heart Research; Eslovaquia
Fil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Hlivak, Peter. National Institute Of Cardiovascular Diseases; Eslovaquia
Fil: Tribulova, Narcis. Slovak Academy of Sciences. Institute for Heart Research; Eslovaquia
description Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal caveolae/rafts compartments. GJCs are fundamental for the direct cardiac cell-to-cell transmission of electrical and molecular signals which ensures synchronous myocardial contraction. The HCs and structurally similar pannexin1 (Panx1) channels are active in stressful conditions. These channels are essential for paracrine and autocrine communication through the release of ions and signaling molecules to the extracellular environment, or for uptake from it. The HCs and Panx1 channel-opening profoundly affects intracellular ionic homeostasis and redox status and facilitates via purinergic signaling pro-inflammatory and pro-fibrotic processes. These conditions promote cardiac arrhythmogenesis due to the impairment of the GJCs and selective ion channel function. Crosstalk between GJCs and HCs/Panx1 channels could be crucial in the development of arrhythmogenic substrates, including fibrosis. Despite the knowledge gap in the regulation of these channels, current evidence indicates that HCs and Panx1 channel activation can enhance the risk of cardiac arrhythmias. It is extremely challenging to target HCs and Panx1 channels by inhibitory agents to hamper development of cardiac rhythm disorders. Progress in this field may contribute to novel therapeutic approaches for patients prone to develop atrial or ventricular fibrillation.
publishDate 2021
dc.date.none.fl_str_mv 2021-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173113
Andelova, Katarina; Benova, Tamara Egan; Bacova, Barbara Szeiffova; Sykora, Matus; Prado, Natalia Jorgelina; et al.; Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets; Multidisciplinary Digital Publishing Institute; International Journal of Molecular Sciences; 22; 1; 1-2021; 1-22
1661-6596
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173113
identifier_str_mv Andelova, Katarina; Benova, Tamara Egan; Bacova, Barbara Szeiffova; Sykora, Matus; Prado, Natalia Jorgelina; et al.; Cardiac connexin-43 hemichannels and pannexin1 channels: Provocative antiarrhythmic targets; Multidisciplinary Digital Publishing Institute; International Journal of Molecular Sciences; 22; 1; 1-2021; 1-22
1661-6596
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/22/1/260
info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms22010260
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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