Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor
- Autores
- Valles, Ana Sofia; Garbus, Ingrid; Barrantes, Francisco Jose
- Año de publicación
- 2007
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor.
Fil: Valles, Ana Sofia. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Garbus, Ingrid. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Barrantes, Francisco Jose. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina - Materia
-
Antiepileptic Drug
Cholinergic Receptor
Single-Channel - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/29430
Ver los metadatos del registro completo
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Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptorValles, Ana SofiaGarbus, IngridBarrantes, Francisco JoseAntiepileptic DrugCholinergic ReceptorSingle-Channelhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor.Fil: Valles, Ana Sofia. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Garbus, Ingrid. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Barrantes, Francisco Jose. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaLippincott Williams2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29430Valles, Ana Sofia; Garbus, Ingrid; Barrantes, Francisco Jose; Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor; Lippincott Williams; Neuroreport; 18; 1; 12-2007; 45-500959-4965CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/neuroreport/pages/articleviewer.aspx?year=2007&issue=01080&article=00009&type=abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1097/01.wnr.0000246323.66438.94info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:37:43Zoai:ri.conicet.gov.ar:11336/29430instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:37:43.347CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
| title |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
| spellingShingle |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor Valles, Ana Sofia Antiepileptic Drug Cholinergic Receptor Single-Channel |
| title_short |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
| title_full |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
| title_fullStr |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
| title_full_unstemmed |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
| title_sort |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
| dc.creator.none.fl_str_mv |
Valles, Ana Sofia Garbus, Ingrid Barrantes, Francisco Jose |
| author |
Valles, Ana Sofia |
| author_facet |
Valles, Ana Sofia Garbus, Ingrid Barrantes, Francisco Jose |
| author_role |
author |
| author2 |
Garbus, Ingrid Barrantes, Francisco Jose |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
Antiepileptic Drug Cholinergic Receptor Single-Channel |
| topic |
Antiepileptic Drug Cholinergic Receptor Single-Channel |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor. Fil: Valles, Ana Sofia. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Garbus, Ingrid. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Barrantes, Francisco Jose. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina |
| description |
Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor. |
| publishDate |
2007 |
| dc.date.none.fl_str_mv |
2007-12 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/29430 Valles, Ana Sofia; Garbus, Ingrid; Barrantes, Francisco Jose; Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor; Lippincott Williams; Neuroreport; 18; 1; 12-2007; 45-50 0959-4965 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/29430 |
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Valles, Ana Sofia; Garbus, Ingrid; Barrantes, Francisco Jose; Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor; Lippincott Williams; Neuroreport; 18; 1; 12-2007; 45-50 0959-4965 CONICET Digital CONICET |
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eng |
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eng |
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