Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor
- Autores
- Valles, Ana Sofia; Garbus, Ingrid; Barrantes, Francisco Jose
- Año de publicación
- 2007
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor.
Fil: Valles, Ana Sofia. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Garbus, Ingrid. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Barrantes, Francisco Jose. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina - Materia
-
Antiepileptic Drug
Cholinergic Receptor
Single-Channel - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/29430
Ver los metadatos del registro completo
id |
CONICETDig_c4e461a21043936569cc6c099b66f476 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/29430 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptorValles, Ana SofiaGarbus, IngridBarrantes, Francisco JoseAntiepileptic DrugCholinergic ReceptorSingle-Channelhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor.Fil: Valles, Ana Sofia. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Garbus, Ingrid. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Barrantes, Francisco Jose. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaLippincott Williams2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29430Valles, Ana Sofia; Garbus, Ingrid; Barrantes, Francisco Jose; Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor; Lippincott Williams; Neuroreport; 18; 1; 12-2007; 45-500959-4965CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/neuroreport/pages/articleviewer.aspx?year=2007&issue=01080&article=00009&type=abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1097/01.wnr.0000246323.66438.94info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:43Zoai:ri.conicet.gov.ar:11336/29430instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:43.703CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
title |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
spellingShingle |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor Valles, Ana Sofia Antiepileptic Drug Cholinergic Receptor Single-Channel |
title_short |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
title_full |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
title_fullStr |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
title_full_unstemmed |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
title_sort |
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor |
dc.creator.none.fl_str_mv |
Valles, Ana Sofia Garbus, Ingrid Barrantes, Francisco Jose |
author |
Valles, Ana Sofia |
author_facet |
Valles, Ana Sofia Garbus, Ingrid Barrantes, Francisco Jose |
author_role |
author |
author2 |
Garbus, Ingrid Barrantes, Francisco Jose |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Antiepileptic Drug Cholinergic Receptor Single-Channel |
topic |
Antiepileptic Drug Cholinergic Receptor Single-Channel |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor. Fil: Valles, Ana Sofia. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Garbus, Ingrid. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina Fil: Barrantes, Francisco Jose. Unesco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina |
description |
Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/29430 Valles, Ana Sofia; Garbus, Ingrid; Barrantes, Francisco Jose; Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor; Lippincott Williams; Neuroreport; 18; 1; 12-2007; 45-50 0959-4965 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/29430 |
identifier_str_mv |
Valles, Ana Sofia; Garbus, Ingrid; Barrantes, Francisco Jose; Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor; Lippincott Williams; Neuroreport; 18; 1; 12-2007; 45-50 0959-4965 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/neuroreport/pages/articleviewer.aspx?year=2007&issue=01080&article=00009&type=abstract info:eu-repo/semantics/altIdentifier/doi/10.1097/01.wnr.0000246323.66438.94 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Lippincott Williams |
publisher.none.fl_str_mv |
Lippincott Williams |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613940878770176 |
score |
13.070432 |