MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses

• Autores: Devine, Jay; Vidal García, Marta; Liu, Wei; Neves, Amanda; Lo Vercio, Lucas D.; Green, Rebecca M.; Richbourg, Heather A.; Marchini, Marta; Unger, Colton M.; Nickle, Audrey C.; Radford, Bethany; Young, Nathan M.; Gonzalez, Paula Natalia; Schuler, Robert E.; Bugacov, Alejandro; Rolian, Campbell; Percival, Christopher J.; Williams, Trevor; Niswander, Lee; Calof, Anne L.; Lander, Arthur D.; Visel, Axel; Jirik, Frank R.; Cheverud, James M.; Klein, Ophir D.; Birnbaum, Ramon Y.; Merrill, Amy E.; Ackermann, Rebecca R.; Graf, Daniel; Hemberger, Myriam; Dean, Wendy; Forkert, Nils D.; Murray, Stephen A.; Westerberg, Henrik; Marcucio, Ralph S.; Hallgrimsson, Benedikt
• Año de publicación: 2022
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: FACEBASE; MICROCT; MUS MUSCULUS
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Complex morphological traits are the product of many genes with transient or lasting developmental effects that interact in anatomical context. Mouse models are a key resource for disentangling such effects, because they offer myriad tools for manipulating the genome in a controlled environment. Unfortunately, phenotypic data are often obtained using laboratory-specific protocols, resulting in self-contained datasets that are difficult to relate to one another for larger scale analyses. To enable meta-analyses of morphological variation, particularly in the craniofacial complex and brain, we created MusMorph, a database of standardized mouse morphology data spanning numerous genotypes and developmental stages, including E10.5, E11.5, E14.5, E15.5, E18.5, and adulthood. To standardize data collection, we implemented an atlas-based phenotyping pipeline that combines techniques from image registration, deep learning, and morphometrics. Alongside stage-specific atlases, we provide aligned micro-computed tomography images, dense anatomical landmarks, and segmentations (if available) for each specimen (N = 10,056). Our workflow is open-source to encourage transparency and reproducible data collection.
Fil: Devine, Jay. Mccaig Institute For Bone And Joint Health; Canadá. Cumming School Of Medicine; Canadá. Alberta Childrens Hospital Research Institute; Canadá
Fil: Vidal García, Marta. Alberta Childrens Hospital Research Institute; Canadá. Cumming School Of Medicine; Canadá. Mccaig Institute For Bone And Joint Health; Canadá
Fil: Liu, Wei. Mccaig Institute For Bone And Joint Health; Canadá. Alberta Childrens Hospital Research Institute; Canadá. Cumming School Of Medicine; Canadá
Fil: Neves, Amanda. Mcmaster University; Canadá
Fil: Lo Vercio, Lucas D.. Cumming School Of Medicine; Canadá. Alberta Childrens Hospital Research Institute; Canadá. Mccaig Institute For Bone And Joint Health; Canadá
Fil: Green, Rebecca M.. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados Unidos
Fil: Richbourg, Heather A.. University of California; Estados Unidos
Fil: Marchini, Marta. Cumming School Of Medicine; Canadá. Mccaig Institute For Bone And Joint Health; Canadá. Alberta Childrens Hospital Research Institute; Canadá
Fil: Unger, Colton M.. Mccaig Institute For Bone And Joint Health; Canadá. University of Calgary; Canadá
Fil: Nickle, Audrey C.. No especifíca;
Fil: Radford, Bethany. Cumming School Of Medicine; Canadá. Alberta Childrens Hospital Research Institute; Canadá
Fil: Young, Nathan M.. University of California; Estados Unidos
Fil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Schuler, Robert E.. No especifíca;
Fil: Bugacov, Alejandro. No especifíca;
Fil: Rolian, Campbell. University of Calgary; Canadá
Fil: Percival, Christopher J.. No especifíca;
Fil: Williams, Trevor. University of Colorado; Estados Unidos
Fil: Niswander, Lee. State University of Colorado at Boulder; Estados Unidos
Fil: Calof, Anne L.. University of California at Irvine; Estados Unidos
Fil: Lander, Arthur D.. University of California at Irvine; Estados Unidos
Fil: Visel, Axel. Lawrence Berkeley National Laboratory; Estados Unidos
Fil: Jirik, Frank R.. Alberta Childrens Hospital Research Institute; Canadá. Mccaig Institute For Bone And Joint Health; Canadá. Cumming School Of Medicine; Canadá
Fil: Cheverud, James M.. Loyola University Maryland (lum);
Fil: Klein, Ophir D.. Cedars Sinai Medical Center; Estados Unidos
Fil: Birnbaum, Ramon Y.. Ben Gurion University of the Negev; Israel
Fil: Merrill, Amy E.. No especifíca;
Fil: Ackermann, Rebecca R.. University of Cape Town; Sudáfrica
Fil: Graf, Daniel. University of Alberta; Canadá
Fil: Hemberger, Myriam. Cumming School Of Medicine; Canadá. Alberta Childrens Hospital Research Institute; Canadá
Fil: Dean, Wendy. Cumming School Of Medicine; Canadá. Alberta Childrens Hospital Research Institute; Canadá
Fil: Forkert, Nils D.. Cumming School Of Medicine; Canadá. Alberta Childrens Hospital Research Institute; Canadá
Fil: Murray, Stephen A.. No especifíca;
Fil: Westerberg, Henrik. No especifíca;
Fil: Marcucio, Ralph S.. University of California; Estados Unidos
Fil: Hallgrimsson, Benedikt. Alberta Childrens Hospital Research Institute; Canadá. Cumming School Of Medicine; Canadá. Mccaig Institute For Bone And Joint Health; Canadá