Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity

Autores
Cian, Raúl Esteban; Salgado, Pablo Rodrigo; Mauri, Adriana Noemi; Drago, Silvina Rosa
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effects of wall hydrocolloids on delivery and bioaccessibility of encapsulated brewers’ spent grain ACE‐I inhibitory peptides after simulated gastrointestinal digestion were assessed. Microencapsulation of peptides was carried out by spray drying using locust bean gum, P. columbina phycocolloids, or its mixtures as wall materials. Microcapsules presented round external surfaces with some concavities, negative surface charge and encapsulation efficiencies higher than 90%. The incorporation of phycocolloids to formulations increased the encapsulation efficiency, negative surface charge and resistance against digestive enzymes of microcapsules. Encapsulated peptides with P. columbina phycocolloids showed lower IC50 value of ACE‐I inhibition than un‐encapsulated peptides (2.4 ± 0.2 vs. 7.2 ± 0.3 mg mL−1 protein), but higher than that obtained for hydrolysate (1.5 ± 0.2 mg mL−1 protein), indicating a 75% protection of bioactivity. Electrostatic and hydrophobic interactions between P. columbina phycocolloids and brewers’ spent grain peptides could be implicated in the protection of peptides during gastrointestinal digestion.
Fil: Cian, Raúl Esteban. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salgado, Pablo Rodrigo. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina
Fil: Mauri, Adriana Noemi. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina
Fil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Brewers spent grain ACE-I inhibitory peptides
Spray-drying microencapsulation
In vitro gastrointestinal digestion
Phycocolloids
Locust bean gum
Red sea-weeds
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117610
Acceder
id CONICETDig_c3f3d2d45e75f2d0b9904d29596f623e
oai_identifier_str oai:ri.conicet.gov.ar:11336/117610
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activityCian, Raúl EstebanSalgado, Pablo RodrigoMauri, Adriana NoemiDrago, Silvina RosaBrewers spent grain ACE-I inhibitory peptidesSpray-drying microencapsulationIn vitro gastrointestinal digestionPhycocolloidsLocust bean gumRed sea-weedshttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2The effects of wall hydrocolloids on delivery and bioaccessibility of encapsulated brewers’ spent grain ACE‐I inhibitory peptides after simulated gastrointestinal digestion were assessed. Microencapsulation of peptides was carried out by spray drying using locust bean gum, P. columbina phycocolloids, or its mixtures as wall materials. Microcapsules presented round external surfaces with some concavities, negative surface charge and encapsulation efficiencies higher than 90%. The incorporation of phycocolloids to formulations increased the encapsulation efficiency, negative surface charge and resistance against digestive enzymes of microcapsules. Encapsulated peptides with P. columbina phycocolloids showed lower IC50 value of ACE‐I inhibition than un‐encapsulated peptides (2.4 ± 0.2 vs. 7.2 ± 0.3 mg mL−1 protein), but higher than that obtained for hydrolysate (1.5 ± 0.2 mg mL−1 protein), indicating a 75% protection of bioactivity. Electrostatic and hydrophobic interactions between P. columbina phycocolloids and brewers’ spent grain peptides could be implicated in the protection of peptides during gastrointestinal digestion.Fil: Cian, Raúl Esteban. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salgado, Pablo Rodrigo. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; ArgentinaFil: Mauri, Adriana Noemi. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; ArgentinaFil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley Blackwell Publishing, Inc2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117610Cian, Raúl Esteban; Salgado, Pablo Rodrigo; Mauri, Adriana Noemi; Drago, Silvina Rosa; Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity; Wiley Blackwell Publishing, Inc; International Journal of Food Science and Technology; 55; 3; 3-2020; 1311-13170950-54231365-2621CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/ijfs.14397info:eu-repo/semantics/altIdentifier/url/https://ifst.onlinelibrary.wiley.com/doi/10.1111/ijfs.14397info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:32Zoai:ri.conicet.gov.ar:11336/117610instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:32.213CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity
title Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity
spellingShingle Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity
Cian, Raúl Esteban
Brewers spent grain ACE-I inhibitory peptides
Spray-drying microencapsulation
In vitro gastrointestinal digestion
Phycocolloids
Locust bean gum
Red sea-weeds
title_short Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity
title_full Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity
title_fullStr Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity
title_full_unstemmed Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity
title_sort Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity
dc.creator.none.fl_str_mv Cian, Raúl Esteban
Salgado, Pablo Rodrigo
Mauri, Adriana Noemi
Drago, Silvina Rosa
author Cian, Raúl Esteban
author_facet Cian, Raúl Esteban
Salgado, Pablo Rodrigo
Mauri, Adriana Noemi
Drago, Silvina Rosa
author_role author
author2 Salgado, Pablo Rodrigo
Mauri, Adriana Noemi
Drago, Silvina Rosa
author2_role author
author
author
dc.subject.none.fl_str_mv Brewers spent grain ACE-I inhibitory peptides
Spray-drying microencapsulation
In vitro gastrointestinal digestion
Phycocolloids
Locust bean gum
Red sea-weeds
topic Brewers spent grain ACE-I inhibitory peptides
Spray-drying microencapsulation
In vitro gastrointestinal digestion
Phycocolloids
Locust bean gum
Red sea-weeds
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The effects of wall hydrocolloids on delivery and bioaccessibility of encapsulated brewers’ spent grain ACE‐I inhibitory peptides after simulated gastrointestinal digestion were assessed. Microencapsulation of peptides was carried out by spray drying using locust bean gum, P. columbina phycocolloids, or its mixtures as wall materials. Microcapsules presented round external surfaces with some concavities, negative surface charge and encapsulation efficiencies higher than 90%. The incorporation of phycocolloids to formulations increased the encapsulation efficiency, negative surface charge and resistance against digestive enzymes of microcapsules. Encapsulated peptides with P. columbina phycocolloids showed lower IC50 value of ACE‐I inhibition than un‐encapsulated peptides (2.4 ± 0.2 vs. 7.2 ± 0.3 mg mL−1 protein), but higher than that obtained for hydrolysate (1.5 ± 0.2 mg mL−1 protein), indicating a 75% protection of bioactivity. Electrostatic and hydrophobic interactions between P. columbina phycocolloids and brewers’ spent grain peptides could be implicated in the protection of peptides during gastrointestinal digestion.
Fil: Cian, Raúl Esteban. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salgado, Pablo Rodrigo. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina
Fil: Mauri, Adriana Noemi. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina
Fil: Drago, Silvina Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The effects of wall hydrocolloids on delivery and bioaccessibility of encapsulated brewers’ spent grain ACE‐I inhibitory peptides after simulated gastrointestinal digestion were assessed. Microencapsulation of peptides was carried out by spray drying using locust bean gum, P. columbina phycocolloids, or its mixtures as wall materials. Microcapsules presented round external surfaces with some concavities, negative surface charge and encapsulation efficiencies higher than 90%. The incorporation of phycocolloids to formulations increased the encapsulation efficiency, negative surface charge and resistance against digestive enzymes of microcapsules. Encapsulated peptides with P. columbina phycocolloids showed lower IC50 value of ACE‐I inhibition than un‐encapsulated peptides (2.4 ± 0.2 vs. 7.2 ± 0.3 mg mL−1 protein), but higher than that obtained for hydrolysate (1.5 ± 0.2 mg mL−1 protein), indicating a 75% protection of bioactivity. Electrostatic and hydrophobic interactions between P. columbina phycocolloids and brewers’ spent grain peptides could be implicated in the protection of peptides during gastrointestinal digestion.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117610
Cian, Raúl Esteban; Salgado, Pablo Rodrigo; Mauri, Adriana Noemi; Drago, Silvina Rosa; Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity; Wiley Blackwell Publishing, Inc; International Journal of Food Science and Technology; 55; 3; 3-2020; 1311-1317
0950-5423
1365-2621
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117610
identifier_str_mv Cian, Raúl Esteban; Salgado, Pablo Rodrigo; Mauri, Adriana Noemi; Drago, Silvina Rosa; Pyropia columbina phycocolloids as microencapsulating material improve bioaccessibility of brewers’ spent grain peptides with ACE-I inhibitory activity; Wiley Blackwell Publishing, Inc; International Journal of Food Science and Technology; 55; 3; 3-2020; 1311-1317
0950-5423
1365-2621
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/ijfs.14397
info:eu-repo/semantics/altIdentifier/url/https://ifst.onlinelibrary.wiley.com/doi/10.1111/ijfs.14397
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269165106233344
score 13.13397

Publicaciones similares