Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer

Autores
Perez, Luis Orlando; Barbisan, Gisela; DiFranza, L.; Contreras, Anahí; Golijow, Carlos Daniel
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Apoptosis is the major component of programmed cell death, an essential process in embryogenesis, tissue turnover and proper function of the immune system. Lack of appropriate control is thought to play an important role in several pathologies, such as autoimmune diseases, AIDS and cancer. In malignant tumors, cells gradually acquire resistance to apoptosis and, moreover, develop mechanisms that could induce death cell in immune cells. Emerging interest has given to the Fas/Fas Ligand interaction, a system that triggers the extrinsic pathway of the apoptosis process. Polymorphisms on Fas and FasL have been extensively described. Single nucleotide polymorphisms located in the promoter region of these genes have been found to be related to differential levels of expression. This review discusses the information published on Fas/Fas Ligand polymorphisms and its effect on human cancers, and also presents new data regarding the impact of Fas-670A/G and FasL-844T/C polymorphisms in a cervical cancer case control study from women of La Plata, Argentina.
Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Barbisan, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: DiFranza, L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Contreras, Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Golijow, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Materia
Fas/Apo-1
Fas Ligand
Cancer Susceptibility
Cervical Cancer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79001
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancerPerez, Luis OrlandoBarbisan, GiselaDiFranza, L.Contreras, AnahíGolijow, Carlos DanielFas/Apo-1Fas LigandCancer SusceptibilityCervical Cancerhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Apoptosis is the major component of programmed cell death, an essential process in embryogenesis, tissue turnover and proper function of the immune system. Lack of appropriate control is thought to play an important role in several pathologies, such as autoimmune diseases, AIDS and cancer. In malignant tumors, cells gradually acquire resistance to apoptosis and, moreover, develop mechanisms that could induce death cell in immune cells. Emerging interest has given to the Fas/Fas Ligand interaction, a system that triggers the extrinsic pathway of the apoptosis process. Polymorphisms on Fas and FasL have been extensively described. Single nucleotide polymorphisms located in the promoter region of these genes have been found to be related to differential levels of expression. This review discusses the information published on Fas/Fas Ligand polymorphisms and its effect on human cancers, and also presents new data regarding the impact of Fas-670A/G and FasL-844T/C polymorphisms in a cervical cancer case control study from women of La Plata, Argentina.Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Barbisan, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: DiFranza, L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Contreras, Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Golijow, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaResearch Trends2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79001Perez, Luis Orlando; Barbisan, Gisela; DiFranza, L.; Contreras, Anahí; Golijow, Carlos Daniel; Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer; Research Trends; Current Topics in Genetics; 4; 1-2011; 95-1030972-8236CONICET DigitalCONICETenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:39Zoai:ri.conicet.gov.ar:11336/79001instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:39.25CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer
title Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer
spellingShingle Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer
Perez, Luis Orlando
Fas/Apo-1
Fas Ligand
Cancer Susceptibility
Cervical Cancer
title_short Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer
title_full Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer
title_fullStr Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer
title_full_unstemmed Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer
title_sort Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer
dc.creator.none.fl_str_mv Perez, Luis Orlando
Barbisan, Gisela
DiFranza, L.
Contreras, Anahí
Golijow, Carlos Daniel
author Perez, Luis Orlando
author_facet Perez, Luis Orlando
Barbisan, Gisela
DiFranza, L.
Contreras, Anahí
Golijow, Carlos Daniel
author_role author
author2 Barbisan, Gisela
DiFranza, L.
Contreras, Anahí
Golijow, Carlos Daniel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Fas/Apo-1
Fas Ligand
Cancer Susceptibility
Cervical Cancer
topic Fas/Apo-1
Fas Ligand
Cancer Susceptibility
Cervical Cancer
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Apoptosis is the major component of programmed cell death, an essential process in embryogenesis, tissue turnover and proper function of the immune system. Lack of appropriate control is thought to play an important role in several pathologies, such as autoimmune diseases, AIDS and cancer. In malignant tumors, cells gradually acquire resistance to apoptosis and, moreover, develop mechanisms that could induce death cell in immune cells. Emerging interest has given to the Fas/Fas Ligand interaction, a system that triggers the extrinsic pathway of the apoptosis process. Polymorphisms on Fas and FasL have been extensively described. Single nucleotide polymorphisms located in the promoter region of these genes have been found to be related to differential levels of expression. This review discusses the information published on Fas/Fas Ligand polymorphisms and its effect on human cancers, and also presents new data regarding the impact of Fas-670A/G and FasL-844T/C polymorphisms in a cervical cancer case control study from women of La Plata, Argentina.
Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Barbisan, Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: DiFranza, L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Contreras, Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
Fil: Golijow, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
description Apoptosis is the major component of programmed cell death, an essential process in embryogenesis, tissue turnover and proper function of the immune system. Lack of appropriate control is thought to play an important role in several pathologies, such as autoimmune diseases, AIDS and cancer. In malignant tumors, cells gradually acquire resistance to apoptosis and, moreover, develop mechanisms that could induce death cell in immune cells. Emerging interest has given to the Fas/Fas Ligand interaction, a system that triggers the extrinsic pathway of the apoptosis process. Polymorphisms on Fas and FasL have been extensively described. Single nucleotide polymorphisms located in the promoter region of these genes have been found to be related to differential levels of expression. This review discusses the information published on Fas/Fas Ligand polymorphisms and its effect on human cancers, and also presents new data regarding the impact of Fas-670A/G and FasL-844T/C polymorphisms in a cervical cancer case control study from women of La Plata, Argentina.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79001
Perez, Luis Orlando; Barbisan, Gisela; DiFranza, L.; Contreras, Anahí; Golijow, Carlos Daniel; Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer; Research Trends; Current Topics in Genetics; 4; 1-2011; 95-103
0972-8236
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79001
identifier_str_mv Perez, Luis Orlando; Barbisan, Gisela; DiFranza, L.; Contreras, Anahí; Golijow, Carlos Daniel; Fas and Fas Ligand polymorphisms in human cancer: their effect in cervical cancer; Research Trends; Current Topics in Genetics; 4; 1-2011; 95-103
0972-8236
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Research Trends
publisher.none.fl_str_mv Research Trends
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270010868760576
score 13.13397

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