Heparan sulphates, amyloidosis and neurodegeneration

Authors
Vera, Cecilia; Alvarez Orozco, J. A.; Maiza, A.; Chantepie, S.; Chehin, Rosana Nieves; Ouidja, M. Q.; Garcia Orozco Ep Papy, Dulce Maria
Publication Year
2017
Language
Spanish
Format
article
Status
Published version
Description
INTRODUCTION: A number of neurodegenerative disorders have been linked directly to the accumulation of amyloid fibres. These fibres are made up of proteins or peptides with altered structures and which join together in vivo in association with heparan sulphate-type polysaccharides. AIMS: To examine the most recent concepts in the biology of heparan sulphates and their role in the aggregation of the peptide Abeta, of tau protein, of alpha-synuclein and of prions. The study also seeks to analyse their implications in neurodegenerative disorders such as Alzheimer's and Parkinson's disease and prion diseases. DEVELOPMENT: In vitro, heparan sulphates have played an important role in the process of oligomerisation and fibrillation of amyloidogenic proteins or peptides, in the stabilisation of these bodies and their resistance to proteolysis, thereby participating in the formation of a wide range of amyloid fibres. Heparan sulphates have also been related to the internalisation of pro-amyloid fibres during the process of intercellular propagation (spreading), which is considered to be crucial in the development of proteinopathies, the best example of which is Alzheimer's disease. CONCLUSION: This study suggests that the fine structures of heparan sulphates, their localisation in cells and tissues, together with their local concentration, may regulate the amyloidosis processes. The advances made in the understanding of this area of glyconeurobiology will make it possible to improve the understanding of the cell and molecular mechanisms underlying the neurodegenerative process.
Fil: Vera, Cecilia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; Argentina. Université Paris-Est-Créteil-Val-de-Marne; Francia
Fil: Alvarez Orozco, J. A.. Universidad del Valle de Mexico; México
Fil: Maiza, A.. Université Paris-Est-Créteil-Val-de-Marne; Francia
Fil: Chantepie, S.. Université Paris-Est-Créteil-Val-de-Marne; Francia
Fil: Chehin, Rosana Nieves. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Ouidja, M. Q.. Université Paris-Est-Créteil-Val-de-Marne; Francia
Fil: Garcia Orozco Ep Papy, Dulce Maria. Université Paris-Est-Créteil-Val-de-Marne; Francia
Subject
Neurodegeneration
Protein aggregation
Salud Ocupacional
Ciencias de la Salud
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/56586