Rekindling action language: A neuromodulatory study on parkinson’s disease patients

Autores
Suárez García, Diana; Birba, Agustina; Zimerman, Maximo; Diazgranados, Jesús A.; Lopes Da Cunha, Pamela Johanna; Ibañez, Agustin Mariano; Grisales Cárdenas, Johan; Cardona, Juan Felipe; García, Adolfo Martín
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Impairments of action semantics (a cognitive domain that critically engages motor brain networks) are pervasive in early Parkinson’s disease (PD). However, no study has examined whether action semantic skills in persons with this disease can be influenced by non-invasive neuromodulation. Here, we recruited 22 PD patients and performed a five-day randomized, blinded, sham-controlled study to assess whether anodal transcranial direct current stimulation (atDCS) over the primary motor cortex, combined with cognitive training, can boost action-concept processing. On day 1, participants completed a picture-word association (PWA) task involving action-verb and object-noun conditions. They were then randomly assigned to either an atDCS (n = 11, 2 mA for 20 m) or a sham tDCS (n = 11, 2 mA for 30 s) group and performed an online PWA practice over three days. On day 5, they repeated the initial protocol. Relative to sham tDCS, the atDCS group exhibited faster reaction times for action (as opposed to object) concepts in the post-stimulation test. This result was exclusive to the atDCS group and held irrespective of the subjects’ cognitive, executive, and motor skills, further attesting to its specificity. Our findings suggest that action-concept deficits in PD are distinctively grounded in motor networks and might be countered by direct neuromodulation of such circuits. Moreover, they provide new evidence for neurosemantic models and inform a thriving agenda in the embodied cognition framework.
Fil: Suárez García, Diana. Universidad del Valle; Colombia
Fil: Birba, Agustina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zimerman, Maximo. Universidad de San Andrés; Argentina
Fil: Diazgranados, Jesús A.. No especifíca;
Fil: Lopes Da Cunha, Pamela Johanna. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Educación, Cultura, Ciencia y Tecnología. Secretaria de Gobierno de Ciencia Tecnología e Innovación Productiva. Agencia Nacional de Promoción Científica y Tecnológica. Fondo Argentino Sectorial; Argentina
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile
Fil: Grisales Cárdenas, Johan. Universidad del Valle; Colombia
Fil: Cardona, Juan Felipe. Universidad del Valle; Colombia
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Universidad de San Andrés; Argentina. Universidad de Santiago de Chile; Chile
Materia
ACTION-VERB PROCESSING
EMBODIED COGNITION
MOTOR CIRCUITS
PARKINSON’S DISEASE
TRANSCRANIAL DIRECT CURRENT STIMULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/165531
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/165531
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Rekindling action language: A neuromodulatory study on parkinson’s disease patientsSuárez García, DianaBirba, AgustinaZimerman, MaximoDiazgranados, Jesús A.Lopes Da Cunha, Pamela JohannaIbañez, Agustin MarianoGrisales Cárdenas, JohanCardona, Juan FelipeGarcía, Adolfo MartínACTION-VERB PROCESSINGEMBODIED COGNITIONMOTOR CIRCUITSPARKINSON’S DISEASETRANSCRANIAL DIRECT CURRENT STIMULATIONhttps://purl.org/becyt/ford/6.2https://purl.org/becyt/ford/6https://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Impairments of action semantics (a cognitive domain that critically engages motor brain networks) are pervasive in early Parkinson’s disease (PD). However, no study has examined whether action semantic skills in persons with this disease can be influenced by non-invasive neuromodulation. Here, we recruited 22 PD patients and performed a five-day randomized, blinded, sham-controlled study to assess whether anodal transcranial direct current stimulation (atDCS) over the primary motor cortex, combined with cognitive training, can boost action-concept processing. On day 1, participants completed a picture-word association (PWA) task involving action-verb and object-noun conditions. They were then randomly assigned to either an atDCS (n = 11, 2 mA for 20 m) or a sham tDCS (n = 11, 2 mA for 30 s) group and performed an online PWA practice over three days. On day 5, they repeated the initial protocol. Relative to sham tDCS, the atDCS group exhibited faster reaction times for action (as opposed to object) concepts in the post-stimulation test. This result was exclusive to the atDCS group and held irrespective of the subjects’ cognitive, executive, and motor skills, further attesting to its specificity. Our findings suggest that action-concept deficits in PD are distinctively grounded in motor networks and might be countered by direct neuromodulation of such circuits. Moreover, they provide new evidence for neurosemantic models and inform a thriving agenda in the embodied cognition framework.Fil: Suárez García, Diana. Universidad del Valle; ColombiaFil: Birba, Agustina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zimerman, Maximo. Universidad de San Andrés; ArgentinaFil: Diazgranados, Jesús A.. No especifíca;Fil: Lopes Da Cunha, Pamela Johanna. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Educación, Cultura, Ciencia y Tecnología. Secretaria de Gobierno de Ciencia Tecnología e Innovación Productiva. Agencia Nacional de Promoción Científica y Tecnológica. Fondo Argentino Sectorial; ArgentinaFil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; ChileFil: Grisales Cárdenas, Johan. Universidad del Valle; ColombiaFil: Cardona, Juan Felipe. Universidad del Valle; ColombiaFil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Universidad de San Andrés; Argentina. Universidad de Santiago de Chile; ChileMDPI2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/165531Suárez García, Diana; Birba, Agustina; Zimerman, Maximo; Diazgranados, Jesús A.; Lopes Da Cunha, Pamela Johanna; et al.; Rekindling action language: A neuromodulatory study on parkinson’s disease patients; MDPI; Brain Sciences; 11; 7; 7-2021; 1-162076-3425CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-3425/11/7/887info:eu-repo/semantics/altIdentifier/doi/10.3390/brainsci11070887info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:44Zoai:ri.conicet.gov.ar:11336/165531instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:45.201CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Rekindling action language: A neuromodulatory study on parkinson’s disease patients
title Rekindling action language: A neuromodulatory study on parkinson’s disease patients
spellingShingle Rekindling action language: A neuromodulatory study on parkinson’s disease patients
Suárez García, Diana
ACTION-VERB PROCESSING
EMBODIED COGNITION
MOTOR CIRCUITS
PARKINSON’S DISEASE
TRANSCRANIAL DIRECT CURRENT STIMULATION
title_short Rekindling action language: A neuromodulatory study on parkinson’s disease patients
title_full Rekindling action language: A neuromodulatory study on parkinson’s disease patients
title_fullStr Rekindling action language: A neuromodulatory study on parkinson’s disease patients
title_full_unstemmed Rekindling action language: A neuromodulatory study on parkinson’s disease patients
title_sort Rekindling action language: A neuromodulatory study on parkinson’s disease patients
dc.creator.none.fl_str_mv Suárez García, Diana
Birba, Agustina
Zimerman, Maximo
Diazgranados, Jesús A.
Lopes Da Cunha, Pamela Johanna
Ibañez, Agustin Mariano
Grisales Cárdenas, Johan
Cardona, Juan Felipe
García, Adolfo Martín
author Suárez García, Diana
author_facet Suárez García, Diana
Birba, Agustina
Zimerman, Maximo
Diazgranados, Jesús A.
Lopes Da Cunha, Pamela Johanna
Ibañez, Agustin Mariano
Grisales Cárdenas, Johan
Cardona, Juan Felipe
García, Adolfo Martín
author_role author
author2 Birba, Agustina
Zimerman, Maximo
Diazgranados, Jesús A.
Lopes Da Cunha, Pamela Johanna
Ibañez, Agustin Mariano
Grisales Cárdenas, Johan
Cardona, Juan Felipe
García, Adolfo Martín
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACTION-VERB PROCESSING
EMBODIED COGNITION
MOTOR CIRCUITS
PARKINSON’S DISEASE
TRANSCRANIAL DIRECT CURRENT STIMULATION
topic ACTION-VERB PROCESSING
EMBODIED COGNITION
MOTOR CIRCUITS
PARKINSON’S DISEASE
TRANSCRANIAL DIRECT CURRENT STIMULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/6.2
https://purl.org/becyt/ford/6
https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Impairments of action semantics (a cognitive domain that critically engages motor brain networks) are pervasive in early Parkinson’s disease (PD). However, no study has examined whether action semantic skills in persons with this disease can be influenced by non-invasive neuromodulation. Here, we recruited 22 PD patients and performed a five-day randomized, blinded, sham-controlled study to assess whether anodal transcranial direct current stimulation (atDCS) over the primary motor cortex, combined with cognitive training, can boost action-concept processing. On day 1, participants completed a picture-word association (PWA) task involving action-verb and object-noun conditions. They were then randomly assigned to either an atDCS (n = 11, 2 mA for 20 m) or a sham tDCS (n = 11, 2 mA for 30 s) group and performed an online PWA practice over three days. On day 5, they repeated the initial protocol. Relative to sham tDCS, the atDCS group exhibited faster reaction times for action (as opposed to object) concepts in the post-stimulation test. This result was exclusive to the atDCS group and held irrespective of the subjects’ cognitive, executive, and motor skills, further attesting to its specificity. Our findings suggest that action-concept deficits in PD are distinctively grounded in motor networks and might be countered by direct neuromodulation of such circuits. Moreover, they provide new evidence for neurosemantic models and inform a thriving agenda in the embodied cognition framework.
Fil: Suárez García, Diana. Universidad del Valle; Colombia
Fil: Birba, Agustina. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zimerman, Maximo. Universidad de San Andrés; Argentina
Fil: Diazgranados, Jesús A.. No especifíca;
Fil: Lopes Da Cunha, Pamela Johanna. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Ministerio de Educación, Cultura, Ciencia y Tecnología. Secretaria de Gobierno de Ciencia Tecnología e Innovación Productiva. Agencia Nacional de Promoción Científica y Tecnológica. Fondo Argentino Sectorial; Argentina
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile
Fil: Grisales Cárdenas, Johan. Universidad del Valle; Colombia
Fil: Cardona, Juan Felipe. Universidad del Valle; Colombia
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; Argentina. Universidad de San Andrés; Argentina. Universidad de Santiago de Chile; Chile
description Impairments of action semantics (a cognitive domain that critically engages motor brain networks) are pervasive in early Parkinson’s disease (PD). However, no study has examined whether action semantic skills in persons with this disease can be influenced by non-invasive neuromodulation. Here, we recruited 22 PD patients and performed a five-day randomized, blinded, sham-controlled study to assess whether anodal transcranial direct current stimulation (atDCS) over the primary motor cortex, combined with cognitive training, can boost action-concept processing. On day 1, participants completed a picture-word association (PWA) task involving action-verb and object-noun conditions. They were then randomly assigned to either an atDCS (n = 11, 2 mA for 20 m) or a sham tDCS (n = 11, 2 mA for 30 s) group and performed an online PWA practice over three days. On day 5, they repeated the initial protocol. Relative to sham tDCS, the atDCS group exhibited faster reaction times for action (as opposed to object) concepts in the post-stimulation test. This result was exclusive to the atDCS group and held irrespective of the subjects’ cognitive, executive, and motor skills, further attesting to its specificity. Our findings suggest that action-concept deficits in PD are distinctively grounded in motor networks and might be countered by direct neuromodulation of such circuits. Moreover, they provide new evidence for neurosemantic models and inform a thriving agenda in the embodied cognition framework.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/165531
Suárez García, Diana; Birba, Agustina; Zimerman, Maximo; Diazgranados, Jesús A.; Lopes Da Cunha, Pamela Johanna; et al.; Rekindling action language: A neuromodulatory study on parkinson’s disease patients; MDPI; Brain Sciences; 11; 7; 7-2021; 1-16
2076-3425
CONICET Digital
CONICET
url http://hdl.handle.net/11336/165531
identifier_str_mv Suárez García, Diana; Birba, Agustina; Zimerman, Maximo; Diazgranados, Jesús A.; Lopes Da Cunha, Pamela Johanna; et al.; Rekindling action language: A neuromodulatory study on parkinson’s disease patients; MDPI; Brain Sciences; 11; 7; 7-2021; 1-16
2076-3425
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-3425/11/7/887
info:eu-repo/semantics/altIdentifier/doi/10.3390/brainsci11070887
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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