From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer
- Autores
- Fabris, Victoria Teresa
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cytogenetic studies of breast cancer cells have identified numerous chromosomal imbalances, including gains in human chromosome regions 1q, 4p, 8q, and 20q and losses in regions 1p, 3p, 6q, 11q, 16q, 17p, and 22q. Mouse models have been developed to study the mechanisms of mammary carcinogenesis, and in most cases, the corresponding karyotypes have been reported. Here, I summarize the cytogenetic findings and the candidate genes that are involved in mammary tumorigenesis. The most commonly altered chromosomes in mouse breast cancer models are chromosomes 4 and 11, which are orthologous to human chromosomes that are also affected by chromosomal abnormalities in human breast cancer. The genes that are affected by chromosomal imbalances in mouse models have also been found to participate in human breast cancer. In addition, the amplification and overexpression of several new genes in mouse models have subsequently been confirmed in human breast cancer. In this review, I compile information on the available karyotypes for mouse breast cancer models.
Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina - Materia
-
Breast Cancer
Mouse Model
Cytogenetics
Karyotype - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/6684
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From chromosomal abnormalities to the identification of target genes in mouse models of breast cancerFabris, Victoria TeresaBreast CancerMouse ModelCytogeneticsKaryotypehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cytogenetic studies of breast cancer cells have identified numerous chromosomal imbalances, including gains in human chromosome regions 1q, 4p, 8q, and 20q and losses in regions 1p, 3p, 6q, 11q, 16q, 17p, and 22q. Mouse models have been developed to study the mechanisms of mammary carcinogenesis, and in most cases, the corresponding karyotypes have been reported. Here, I summarize the cytogenetic findings and the candidate genes that are involved in mammary tumorigenesis. The most commonly altered chromosomes in mouse breast cancer models are chromosomes 4 and 11, which are orthologous to human chromosomes that are also affected by chromosomal abnormalities in human breast cancer. The genes that are affected by chromosomal imbalances in mouse models have also been found to participate in human breast cancer. In addition, the amplification and overexpression of several new genes in mouse models have subsequently been confirmed in human breast cancer. In this review, I compile information on the available karyotypes for mouse breast cancer models.Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaElsevier Inc2014-06-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6684Fabris, Victoria Teresa; From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer; Elsevier Inc; Cancer Genetics; 207; 6; 25-6-2014; 233-2462210-7762enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cancergen.2014.06.025info:eu-repo/semantics/altIdentifier/pmid/25176624info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2210776214001392info:eu-repo/semantics/altIdentifier/url/http://www.cancergeneticsjournal.org/article/S2210-7762(14)00139-2/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:33Zoai:ri.conicet.gov.ar:11336/6684instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:33.515CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer |
title |
From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer |
spellingShingle |
From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer Fabris, Victoria Teresa Breast Cancer Mouse Model Cytogenetics Karyotype |
title_short |
From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer |
title_full |
From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer |
title_fullStr |
From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer |
title_full_unstemmed |
From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer |
title_sort |
From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer |
dc.creator.none.fl_str_mv |
Fabris, Victoria Teresa |
author |
Fabris, Victoria Teresa |
author_facet |
Fabris, Victoria Teresa |
author_role |
author |
dc.subject.none.fl_str_mv |
Breast Cancer Mouse Model Cytogenetics Karyotype |
topic |
Breast Cancer Mouse Model Cytogenetics Karyotype |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Cytogenetic studies of breast cancer cells have identified numerous chromosomal imbalances, including gains in human chromosome regions 1q, 4p, 8q, and 20q and losses in regions 1p, 3p, 6q, 11q, 16q, 17p, and 22q. Mouse models have been developed to study the mechanisms of mammary carcinogenesis, and in most cases, the corresponding karyotypes have been reported. Here, I summarize the cytogenetic findings and the candidate genes that are involved in mammary tumorigenesis. The most commonly altered chromosomes in mouse breast cancer models are chromosomes 4 and 11, which are orthologous to human chromosomes that are also affected by chromosomal abnormalities in human breast cancer. The genes that are affected by chromosomal imbalances in mouse models have also been found to participate in human breast cancer. In addition, the amplification and overexpression of several new genes in mouse models have subsequently been confirmed in human breast cancer. In this review, I compile information on the available karyotypes for mouse breast cancer models. Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina |
description |
Cytogenetic studies of breast cancer cells have identified numerous chromosomal imbalances, including gains in human chromosome regions 1q, 4p, 8q, and 20q and losses in regions 1p, 3p, 6q, 11q, 16q, 17p, and 22q. Mouse models have been developed to study the mechanisms of mammary carcinogenesis, and in most cases, the corresponding karyotypes have been reported. Here, I summarize the cytogenetic findings and the candidate genes that are involved in mammary tumorigenesis. The most commonly altered chromosomes in mouse breast cancer models are chromosomes 4 and 11, which are orthologous to human chromosomes that are also affected by chromosomal abnormalities in human breast cancer. The genes that are affected by chromosomal imbalances in mouse models have also been found to participate in human breast cancer. In addition, the amplification and overexpression of several new genes in mouse models have subsequently been confirmed in human breast cancer. In this review, I compile information on the available karyotypes for mouse breast cancer models. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-25 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/6684 Fabris, Victoria Teresa; From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer; Elsevier Inc; Cancer Genetics; 207; 6; 25-6-2014; 233-246 2210-7762 |
url |
http://hdl.handle.net/11336/6684 |
identifier_str_mv |
Fabris, Victoria Teresa; From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer; Elsevier Inc; Cancer Genetics; 207; 6; 25-6-2014; 233-246 2210-7762 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/ info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cancergen.2014.06.025 info:eu-repo/semantics/altIdentifier/pmid/25176624 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2210776214001392 info:eu-repo/semantics/altIdentifier/url/http://www.cancergeneticsjournal.org/article/S2210-7762(14)00139-2/abstract |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Inc |
publisher.none.fl_str_mv |
Elsevier Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |