From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer

Autores
Fabris, Victoria Teresa
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cytogenetic studies of breast cancer cells have identified numerous chromosomal imbalances, including gains in human chromosome regions 1q, 4p, 8q, and 20q and losses in regions 1p, 3p, 6q, 11q, 16q, 17p, and 22q. Mouse models have been developed to study the mechanisms of mammary carcinogenesis, and in most cases, the corresponding karyotypes have been reported. Here, I summarize the cytogenetic findings and the candidate genes that are involved in mammary tumorigenesis. The most commonly altered chromosomes in mouse breast cancer models are chromosomes 4 and 11, which are orthologous to human chromosomes that are also affected by chromosomal abnormalities in human breast cancer. The genes that are affected by chromosomal imbalances in mouse models have also been found to participate in human breast cancer. In addition, the amplification and overexpression of several new genes in mouse models have subsequently been confirmed in human breast cancer. In this review, I compile information on the available karyotypes for mouse breast cancer models.
Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Materia
Breast Cancer
Mouse Model
Cytogenetics
Karyotype
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6684
Acceder
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network_name_str CONICET Digital (CONICET)
spelling From chromosomal abnormalities to the identification of target genes in mouse models of breast cancerFabris, Victoria TeresaBreast CancerMouse ModelCytogeneticsKaryotypehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cytogenetic studies of breast cancer cells have identified numerous chromosomal imbalances, including gains in human chromosome regions 1q, 4p, 8q, and 20q and losses in regions 1p, 3p, 6q, 11q, 16q, 17p, and 22q. Mouse models have been developed to study the mechanisms of mammary carcinogenesis, and in most cases, the corresponding karyotypes have been reported. Here, I summarize the cytogenetic findings and the candidate genes that are involved in mammary tumorigenesis. The most commonly altered chromosomes in mouse breast cancer models are chromosomes 4 and 11, which are orthologous to human chromosomes that are also affected by chromosomal abnormalities in human breast cancer. The genes that are affected by chromosomal imbalances in mouse models have also been found to participate in human breast cancer. In addition, the amplification and overexpression of several new genes in mouse models have subsequently been confirmed in human breast cancer. In this review, I compile information on the available karyotypes for mouse breast cancer models.Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaElsevier Inc2014-06-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6684Fabris, Victoria Teresa; From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer; Elsevier Inc; Cancer Genetics; 207; 6; 25-6-2014; 233-2462210-7762enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cancergen.2014.06.025info:eu-repo/semantics/altIdentifier/pmid/25176624info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2210776214001392info:eu-repo/semantics/altIdentifier/url/http://www.cancergeneticsjournal.org/article/S2210-7762(14)00139-2/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:16:24Zoai:ri.conicet.gov.ar:11336/6684instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:16:25.034CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer
title From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer
spellingShingle From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer
Fabris, Victoria Teresa
Breast Cancer
Mouse Model
Cytogenetics
Karyotype
title_short From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer
title_full From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer
title_fullStr From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer
title_full_unstemmed From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer
title_sort From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer
dc.creator.none.fl_str_mv Fabris, Victoria Teresa
author Fabris, Victoria Teresa
author_facet Fabris, Victoria Teresa
author_role author
dc.subject.none.fl_str_mv Breast Cancer
Mouse Model
Cytogenetics
Karyotype
topic Breast Cancer
Mouse Model
Cytogenetics
Karyotype
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cytogenetic studies of breast cancer cells have identified numerous chromosomal imbalances, including gains in human chromosome regions 1q, 4p, 8q, and 20q and losses in regions 1p, 3p, 6q, 11q, 16q, 17p, and 22q. Mouse models have been developed to study the mechanisms of mammary carcinogenesis, and in most cases, the corresponding karyotypes have been reported. Here, I summarize the cytogenetic findings and the candidate genes that are involved in mammary tumorigenesis. The most commonly altered chromosomes in mouse breast cancer models are chromosomes 4 and 11, which are orthologous to human chromosomes that are also affected by chromosomal abnormalities in human breast cancer. The genes that are affected by chromosomal imbalances in mouse models have also been found to participate in human breast cancer. In addition, the amplification and overexpression of several new genes in mouse models have subsequently been confirmed in human breast cancer. In this review, I compile information on the available karyotypes for mouse breast cancer models.
Fil: Fabris, Victoria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
description Cytogenetic studies of breast cancer cells have identified numerous chromosomal imbalances, including gains in human chromosome regions 1q, 4p, 8q, and 20q and losses in regions 1p, 3p, 6q, 11q, 16q, 17p, and 22q. Mouse models have been developed to study the mechanisms of mammary carcinogenesis, and in most cases, the corresponding karyotypes have been reported. Here, I summarize the cytogenetic findings and the candidate genes that are involved in mammary tumorigenesis. The most commonly altered chromosomes in mouse breast cancer models are chromosomes 4 and 11, which are orthologous to human chromosomes that are also affected by chromosomal abnormalities in human breast cancer. The genes that are affected by chromosomal imbalances in mouse models have also been found to participate in human breast cancer. In addition, the amplification and overexpression of several new genes in mouse models have subsequently been confirmed in human breast cancer. In this review, I compile information on the available karyotypes for mouse breast cancer models.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6684
Fabris, Victoria Teresa; From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer; Elsevier Inc; Cancer Genetics; 207; 6; 25-6-2014; 233-246
2210-7762
url http://hdl.handle.net/11336/6684
identifier_str_mv Fabris, Victoria Teresa; From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer; Elsevier Inc; Cancer Genetics; 207; 6; 25-6-2014; 233-246
2210-7762
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cancergen.2014.06.025
info:eu-repo/semantics/altIdentifier/pmid/25176624
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2210776214001392
info:eu-repo/semantics/altIdentifier/url/http://www.cancergeneticsjournal.org/article/S2210-7762(14)00139-2/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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