Population pharmacokinetics of amikacin in neonatal intensive care unit patients

Autores
Caceres Guido, Paulo Arturo; Travaglianti, Mónica; Castro, Graciela; Licciardone, Nieves; Ferreyra, Oscar; Bramuglia, Guillermo Federico; García Bournissen, Facundo; Schaiquevich, Paula Susana
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background Amikacin treatment requires close monitoring of blood concentrations to increase the probability that levels achieved are both effective and safe. Aims We described population pharmacokinetics parameters of amikacin in newborns from a Neonatal Intensive Care Unit with suspected or documented sepsis. Methods A nonlinear mixed-effect model approach was used to analyse the data. Results Twenty seven neonates were enrolled. Final parameter estimates were: Ke(h-1)=0.232x(CR) Exp-0.85; V(mL/kg)=497. Conclusion Weight and serum creatinine are associated with neonatal amikacin volume of distribution and elimination constant rate, respectively. The presence of sepsis may decrease amikacin elimination, although this observation should be further explored. These results could help to individualize amikacin dosage for neonates.
Fil: Caceres Guido, Paulo Arturo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Travaglianti, Mónica. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Castro, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Licciardone, Nieves. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Ferreyra, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Bramuglia, Guillermo Federico. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: García Bournissen, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
Fil: Schaiquevich, Paula Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Materia
AMIKACIN
NEONATES
POPULATION PHARMACOKINETICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/78246
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/78246
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Population pharmacokinetics of amikacin in neonatal intensive care unit patientsCaceres Guido, Paulo ArturoTravaglianti, MónicaCastro, GracielaLicciardone, NievesFerreyra, OscarBramuglia, Guillermo FedericoGarcía Bournissen, FacundoSchaiquevich, Paula SusanaAMIKACINNEONATESPOPULATION PHARMACOKINETICShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background Amikacin treatment requires close monitoring of blood concentrations to increase the probability that levels achieved are both effective and safe. Aims We described population pharmacokinetics parameters of amikacin in newborns from a Neonatal Intensive Care Unit with suspected or documented sepsis. Methods A nonlinear mixed-effect model approach was used to analyse the data. Results Twenty seven neonates were enrolled. Final parameter estimates were: Ke(h-1)=0.232x(CR) Exp-0.85; V(mL/kg)=497. Conclusion Weight and serum creatinine are associated with neonatal amikacin volume of distribution and elimination constant rate, respectively. The presence of sepsis may decrease amikacin elimination, although this observation should be further explored. These results could help to individualize amikacin dosage for neonates.Fil: Caceres Guido, Paulo Arturo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Travaglianti, Mónica. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Castro, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Licciardone, Nieves. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Ferreyra, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Bramuglia, Guillermo Federico. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; ArgentinaFil: García Bournissen, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Schaiquevich, Paula Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaAustralasian Medical Journal Pty Ltd2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78246Caceres Guido, Paulo Arturo; Travaglianti, Mónica; Castro, Graciela; Licciardone, Nieves; Ferreyra, Oscar; et al.; Population pharmacokinetics of amikacin in neonatal intensive care unit patients; Australasian Medical Journal Pty Ltd; Australasian Medical Journal; 10; 2; 3-2017; 140-1441836-1935CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.21767/AMJ.2017.2833info:eu-repo/semantics/altIdentifier/url/http://amj.net.au/index.php/AMJ/article/view/2833info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:44Zoai:ri.conicet.gov.ar:11336/78246instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:44.713CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Population pharmacokinetics of amikacin in neonatal intensive care unit patients
title Population pharmacokinetics of amikacin in neonatal intensive care unit patients
spellingShingle Population pharmacokinetics of amikacin in neonatal intensive care unit patients
Caceres Guido, Paulo Arturo
AMIKACIN
NEONATES
POPULATION PHARMACOKINETICS
title_short Population pharmacokinetics of amikacin in neonatal intensive care unit patients
title_full Population pharmacokinetics of amikacin in neonatal intensive care unit patients
title_fullStr Population pharmacokinetics of amikacin in neonatal intensive care unit patients
title_full_unstemmed Population pharmacokinetics of amikacin in neonatal intensive care unit patients
title_sort Population pharmacokinetics of amikacin in neonatal intensive care unit patients
dc.creator.none.fl_str_mv Caceres Guido, Paulo Arturo
Travaglianti, Mónica
Castro, Graciela
Licciardone, Nieves
Ferreyra, Oscar
Bramuglia, Guillermo Federico
García Bournissen, Facundo
Schaiquevich, Paula Susana
author Caceres Guido, Paulo Arturo
author_facet Caceres Guido, Paulo Arturo
Travaglianti, Mónica
Castro, Graciela
Licciardone, Nieves
Ferreyra, Oscar
Bramuglia, Guillermo Federico
García Bournissen, Facundo
Schaiquevich, Paula Susana
author_role author
author2 Travaglianti, Mónica
Castro, Graciela
Licciardone, Nieves
Ferreyra, Oscar
Bramuglia, Guillermo Federico
García Bournissen, Facundo
Schaiquevich, Paula Susana
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AMIKACIN
NEONATES
POPULATION PHARMACOKINETICS
topic AMIKACIN
NEONATES
POPULATION PHARMACOKINETICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background Amikacin treatment requires close monitoring of blood concentrations to increase the probability that levels achieved are both effective and safe. Aims We described population pharmacokinetics parameters of amikacin in newborns from a Neonatal Intensive Care Unit with suspected or documented sepsis. Methods A nonlinear mixed-effect model approach was used to analyse the data. Results Twenty seven neonates were enrolled. Final parameter estimates were: Ke(h-1)=0.232x(CR) Exp-0.85; V(mL/kg)=497. Conclusion Weight and serum creatinine are associated with neonatal amikacin volume of distribution and elimination constant rate, respectively. The presence of sepsis may decrease amikacin elimination, although this observation should be further explored. These results could help to individualize amikacin dosage for neonates.
Fil: Caceres Guido, Paulo Arturo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Travaglianti, Mónica. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Castro, Graciela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Licciardone, Nieves. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Ferreyra, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Bramuglia, Guillermo Federico. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
Fil: García Bournissen, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
Fil: Schaiquevich, Paula Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
description Background Amikacin treatment requires close monitoring of blood concentrations to increase the probability that levels achieved are both effective and safe. Aims We described population pharmacokinetics parameters of amikacin in newborns from a Neonatal Intensive Care Unit with suspected or documented sepsis. Methods A nonlinear mixed-effect model approach was used to analyse the data. Results Twenty seven neonates were enrolled. Final parameter estimates were: Ke(h-1)=0.232x(CR) Exp-0.85; V(mL/kg)=497. Conclusion Weight and serum creatinine are associated with neonatal amikacin volume of distribution and elimination constant rate, respectively. The presence of sepsis may decrease amikacin elimination, although this observation should be further explored. These results could help to individualize amikacin dosage for neonates.
publishDate 2017
dc.date.none.fl_str_mv 2017-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/78246
Caceres Guido, Paulo Arturo; Travaglianti, Mónica; Castro, Graciela; Licciardone, Nieves; Ferreyra, Oscar; et al.; Population pharmacokinetics of amikacin in neonatal intensive care unit patients; Australasian Medical Journal Pty Ltd; Australasian Medical Journal; 10; 2; 3-2017; 140-144
1836-1935
CONICET Digital
CONICET
url http://hdl.handle.net/11336/78246
identifier_str_mv Caceres Guido, Paulo Arturo; Travaglianti, Mónica; Castro, Graciela; Licciardone, Nieves; Ferreyra, Oscar; et al.; Population pharmacokinetics of amikacin in neonatal intensive care unit patients; Australasian Medical Journal Pty Ltd; Australasian Medical Journal; 10; 2; 3-2017; 140-144
1836-1935
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.21767/AMJ.2017.2833
info:eu-repo/semantics/altIdentifier/url/http://amj.net.au/index.php/AMJ/article/view/2833
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Australasian Medical Journal Pty Ltd
publisher.none.fl_str_mv Australasian Medical Journal Pty Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268937158393856
score 13.13397

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