Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release

Autores
Rey, Rodolfo Alberto
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The mammalian testis is formed by 2 morphologically and functionally distinct compartments: the seminiferous tubules and the interstitial tissue. The seminiferous tubules contain the germ cell population, originating the male gametes in the adult, and the somatic Sertoli cell lineage. In the interstitial tissue lies the Leydig cell population, responsible for androgen secretion, amid connective tissue with blood vessels and nerves. The structure and function of the testes show remarkable changes during postnatal life, especially during pubertal maturation, driven by androgens. One notorious transformation occurs within the seminiferous tubules: prepubertal spermatogenesis, limited to spermatogonial mitoses, switches to adult spermatogenesis, where spermatogonial proliferation is followed by 2 successive meiotic divisions and spermatid maturation leading to the production and release of spermatozoa. This gonad-specific biologic process depends essentially on the support given by mature Sertoli cells. While molecules coming from the blood vessels present in the interstitial tissue have free access to spermatogonia, meiotic and postmeiotic germ cells are completely isolated from blood-borne substances. This is mainly due to the development of the blood-testis barrier (BTB) during pubertal maturation.
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Materia
ACTIN
APICAL ECTOPLASMIC SPECIALIZATIONS
ARP3
EPS8
MTORC1
MTORC2
ROR2
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/168050
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/168050
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm releaseRey, Rodolfo AlbertoACTINAPICAL ECTOPLASMIC SPECIALIZATIONSARP3EPS8MTORC1MTORC2ROR2https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The mammalian testis is formed by 2 morphologically and functionally distinct compartments: the seminiferous tubules and the interstitial tissue. The seminiferous tubules contain the germ cell population, originating the male gametes in the adult, and the somatic Sertoli cell lineage. In the interstitial tissue lies the Leydig cell population, responsible for androgen secretion, amid connective tissue with blood vessels and nerves. The structure and function of the testes show remarkable changes during postnatal life, especially during pubertal maturation, driven by androgens. One notorious transformation occurs within the seminiferous tubules: prepubertal spermatogenesis, limited to spermatogonial mitoses, switches to adult spermatogenesis, where spermatogonial proliferation is followed by 2 successive meiotic divisions and spermatid maturation leading to the production and release of spermatozoa. This gonad-specific biologic process depends essentially on the support given by mature Sertoli cells. While molecules coming from the blood vessels present in the interstitial tissue have free access to spermatogonia, meiotic and postmeiotic germ cells are completely isolated from blood-borne substances. This is mainly due to the development of the blood-testis barrier (BTB) during pubertal maturation.Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaEndocrine Society2021-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/168050Rey, Rodolfo Alberto; Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release; Endocrine Society; Endocrinology; 162; 10; 10-2021; 1-20013-7227CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/doi/10.1210/endocr/bqab159/6342110info:eu-repo/semantics/altIdentifier/doi/10.1210/endocr/bqab159info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:54Zoai:ri.conicet.gov.ar:11336/168050instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:54.629CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release
title Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release
spellingShingle Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release
Rey, Rodolfo Alberto
ACTIN
APICAL ECTOPLASMIC SPECIALIZATIONS
ARP3
EPS8
MTORC1
MTORC2
ROR2
title_short Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release
title_full Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release
title_fullStr Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release
title_full_unstemmed Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release
title_sort Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release
dc.creator.none.fl_str_mv Rey, Rodolfo Alberto
author Rey, Rodolfo Alberto
author_facet Rey, Rodolfo Alberto
author_role author
dc.subject.none.fl_str_mv ACTIN
APICAL ECTOPLASMIC SPECIALIZATIONS
ARP3
EPS8
MTORC1
MTORC2
ROR2
topic ACTIN
APICAL ECTOPLASMIC SPECIALIZATIONS
ARP3
EPS8
MTORC1
MTORC2
ROR2
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The mammalian testis is formed by 2 morphologically and functionally distinct compartments: the seminiferous tubules and the interstitial tissue. The seminiferous tubules contain the germ cell population, originating the male gametes in the adult, and the somatic Sertoli cell lineage. In the interstitial tissue lies the Leydig cell population, responsible for androgen secretion, amid connective tissue with blood vessels and nerves. The structure and function of the testes show remarkable changes during postnatal life, especially during pubertal maturation, driven by androgens. One notorious transformation occurs within the seminiferous tubules: prepubertal spermatogenesis, limited to spermatogonial mitoses, switches to adult spermatogenesis, where spermatogonial proliferation is followed by 2 successive meiotic divisions and spermatid maturation leading to the production and release of spermatozoa. This gonad-specific biologic process depends essentially on the support given by mature Sertoli cells. While molecules coming from the blood vessels present in the interstitial tissue have free access to spermatogonia, meiotic and postmeiotic germ cells are completely isolated from blood-borne substances. This is mainly due to the development of the blood-testis barrier (BTB) during pubertal maturation.
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
description The mammalian testis is formed by 2 morphologically and functionally distinct compartments: the seminiferous tubules and the interstitial tissue. The seminiferous tubules contain the germ cell population, originating the male gametes in the adult, and the somatic Sertoli cell lineage. In the interstitial tissue lies the Leydig cell population, responsible for androgen secretion, amid connective tissue with blood vessels and nerves. The structure and function of the testes show remarkable changes during postnatal life, especially during pubertal maturation, driven by androgens. One notorious transformation occurs within the seminiferous tubules: prepubertal spermatogenesis, limited to spermatogonial mitoses, switches to adult spermatogenesis, where spermatogonial proliferation is followed by 2 successive meiotic divisions and spermatid maturation leading to the production and release of spermatozoa. This gonad-specific biologic process depends essentially on the support given by mature Sertoli cells. While molecules coming from the blood vessels present in the interstitial tissue have free access to spermatogonia, meiotic and postmeiotic germ cells are completely isolated from blood-borne substances. This is mainly due to the development of the blood-testis barrier (BTB) during pubertal maturation.
publishDate 2021
dc.date.none.fl_str_mv 2021-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/168050
Rey, Rodolfo Alberto; Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release; Endocrine Society; Endocrinology; 162; 10; 10-2021; 1-2
0013-7227
CONICET Digital
CONICET
url http://hdl.handle.net/11336/168050
identifier_str_mv Rey, Rodolfo Alberto; Noncanonical wnt signaling in the integrity of the blood-testis barrier and sperm release; Endocrine Society; Endocrinology; 162; 10; 10-2021; 1-2
0013-7227
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/doi/10.1210/endocr/bqab159/6342110
info:eu-repo/semantics/altIdentifier/doi/10.1210/endocr/bqab159
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Endocrine Society
publisher.none.fl_str_mv Endocrine Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613351026458624
score 13.070432

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