Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells

Autores
Rela, Lorena; Piantanida, Ana Paula; Bordey, Angelique; Greer, Charles A.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The olfactory nerve is permissive for axon growth throughout life. This has been attributed in part to the olfactory ensheathing glial cells that encompass the olfactory sensory neuron fascicles. Olfactory ensheathing cells (OECs) also promote axon growth in vitro and when transplanted in vivo to sites of injury. The mechanisms involved remain largely unidentified owing in part to the limited knowledge of the physiological properties of ensheathing cells. Glial cells rely for many functions on the properties of the potassium channels expressed; however, those expressed in ensheathing cells are unknown. Here we show that OECs express voltage‐dependent potassium currents compatible with inward rectifier (Kir) and delayed rectifier (KDR) channels. Together with gap junction coupling, these contribute to the heterogeneity of membrane properties observed in OECs. The relevance of K+ currents expressed by ensheathing cells is discussed in relation to plasticity of the olfactory nerve.
Fil: Rela, Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. University of Yale. School of Medicine; Estados Unidos
Fil: Piantanida, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Bordey, Angelique. University of Yale. School of Medicine; Estados Unidos
Fil: Greer, Charles A.. University of Yale. School of Medicine; Estados Unidos
Materia
ENSHEATHING GLIA
POTASSIUM CONDUCTANCE
GAP JUNCTIONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94777
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cellsRela, LorenaPiantanida, Ana PaulaBordey, AngeliqueGreer, Charles A.ENSHEATHING GLIAPOTASSIUM CONDUCTANCEGAP JUNCTIONShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The olfactory nerve is permissive for axon growth throughout life. This has been attributed in part to the olfactory ensheathing glial cells that encompass the olfactory sensory neuron fascicles. Olfactory ensheathing cells (OECs) also promote axon growth in vitro and when transplanted in vivo to sites of injury. The mechanisms involved remain largely unidentified owing in part to the limited knowledge of the physiological properties of ensheathing cells. Glial cells rely for many functions on the properties of the potassium channels expressed; however, those expressed in ensheathing cells are unknown. Here we show that OECs express voltage‐dependent potassium currents compatible with inward rectifier (Kir) and delayed rectifier (KDR) channels. Together with gap junction coupling, these contribute to the heterogeneity of membrane properties observed in OECs. The relevance of K+ currents expressed by ensheathing cells is discussed in relation to plasticity of the olfactory nerve.Fil: Rela, Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. University of Yale. School of Medicine; Estados UnidosFil: Piantanida, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Bordey, Angelique. University of Yale. School of Medicine; Estados UnidosFil: Greer, Charles A.. University of Yale. School of Medicine; Estados UnidosWiley-liss, Div John Wiley & Sons Inc2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94777Rela, Lorena; Piantanida, Ana Paula; Bordey, Angelique; Greer, Charles A.; Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells; Wiley-liss, Div John Wiley & Sons Inc; Glia; 63; 9; 9-2015; 1646-16590894-1491CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.22834info:eu-repo/semantics/altIdentifier/doi/10.1002/glia.22834info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506201/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:31Zoai:ri.conicet.gov.ar:11336/94777instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:31.586CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells
title Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells
spellingShingle Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells
Rela, Lorena
ENSHEATHING GLIA
POTASSIUM CONDUCTANCE
GAP JUNCTIONS
title_short Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells
title_full Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells
title_fullStr Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells
title_full_unstemmed Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells
title_sort Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells
dc.creator.none.fl_str_mv Rela, Lorena
Piantanida, Ana Paula
Bordey, Angelique
Greer, Charles A.
author Rela, Lorena
author_facet Rela, Lorena
Piantanida, Ana Paula
Bordey, Angelique
Greer, Charles A.
author_role author
author2 Piantanida, Ana Paula
Bordey, Angelique
Greer, Charles A.
author2_role author
author
author
dc.subject.none.fl_str_mv ENSHEATHING GLIA
POTASSIUM CONDUCTANCE
GAP JUNCTIONS
topic ENSHEATHING GLIA
POTASSIUM CONDUCTANCE
GAP JUNCTIONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The olfactory nerve is permissive for axon growth throughout life. This has been attributed in part to the olfactory ensheathing glial cells that encompass the olfactory sensory neuron fascicles. Olfactory ensheathing cells (OECs) also promote axon growth in vitro and when transplanted in vivo to sites of injury. The mechanisms involved remain largely unidentified owing in part to the limited knowledge of the physiological properties of ensheathing cells. Glial cells rely for many functions on the properties of the potassium channels expressed; however, those expressed in ensheathing cells are unknown. Here we show that OECs express voltage‐dependent potassium currents compatible with inward rectifier (Kir) and delayed rectifier (KDR) channels. Together with gap junction coupling, these contribute to the heterogeneity of membrane properties observed in OECs. The relevance of K+ currents expressed by ensheathing cells is discussed in relation to plasticity of the olfactory nerve.
Fil: Rela, Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. University of Yale. School of Medicine; Estados Unidos
Fil: Piantanida, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Bordey, Angelique. University of Yale. School of Medicine; Estados Unidos
Fil: Greer, Charles A.. University of Yale. School of Medicine; Estados Unidos
description The olfactory nerve is permissive for axon growth throughout life. This has been attributed in part to the olfactory ensheathing glial cells that encompass the olfactory sensory neuron fascicles. Olfactory ensheathing cells (OECs) also promote axon growth in vitro and when transplanted in vivo to sites of injury. The mechanisms involved remain largely unidentified owing in part to the limited knowledge of the physiological properties of ensheathing cells. Glial cells rely for many functions on the properties of the potassium channels expressed; however, those expressed in ensheathing cells are unknown. Here we show that OECs express voltage‐dependent potassium currents compatible with inward rectifier (Kir) and delayed rectifier (KDR) channels. Together with gap junction coupling, these contribute to the heterogeneity of membrane properties observed in OECs. The relevance of K+ currents expressed by ensheathing cells is discussed in relation to plasticity of the olfactory nerve.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94777
Rela, Lorena; Piantanida, Ana Paula; Bordey, Angelique; Greer, Charles A.; Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells; Wiley-liss, Div John Wiley & Sons Inc; Glia; 63; 9; 9-2015; 1646-1659
0894-1491
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94777
identifier_str_mv Rela, Lorena; Piantanida, Ana Paula; Bordey, Angelique; Greer, Charles A.; Voltage‐dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells; Wiley-liss, Div John Wiley & Sons Inc; Glia; 63; 9; 9-2015; 1646-1659
0894-1491
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.22834
info:eu-repo/semantics/altIdentifier/doi/10.1002/glia.22834
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506201/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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