An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum

Autores
Seimandi, Gisela Marisol; Alvarez, Norma Hortensia; Stegmayer, María Inés; Fernandez, Laura Noemí; Ruiz, Verónica Eugenia; Favaro, María Alejandra; Derita, Marcos Gabriel
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The discovery of new pharmaceutical identities, particularly anti-infective agents, rep-resents an urgent need due to the increase in immunocompromised patients and the ineffective-ness/toxicity of the drugs currently used. The scientific community has recognized in the last decades the importance of the plant kingdom as a huge source of novel molecules which could act against different type of infections or illness. However, the great diversity of plant species makes it difficult to select them with probabilities of success, adding to the fact that existing information is difficult to find, it is atomized or disordered. Persicaria and Polygonum constitute two of the main representatives of the Polygonaceae family, which have been extensively used in traditional medicine worldwide. Important and structurally diverse bioactive compounds have been isolated from these genera of wild plants; among them, sesquiterpenes and flavonoids should be remarked. In this article, we firstly mention all the species reported with pharmacological use and their geographical distribution. Moreover, a number of tables which summarize an update detailing the type of natural product (extract or isolated compound), applied doses, displayed bioassays and the results obtained for the main bioactivities of these genera cited in the literature during the past 40 years. Antimicrobial, antioxidant, analgesic and anti-inflammatory, antinociceptive, anticancer, antiviral, antiparasitic, anti-diabetic, antipyretic, hepatoprotective, diuretic, gastroprotective and neuropharmacological activities were explored and reviewed in this work, concluding that both genera could be the source for upcoming molecules to treat different human diseases.
Fil: Seimandi, Gisela Marisol. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Alvarez, Norma Hortensia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Stegmayer, María Inés. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Fernandez, Laura Noemí. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Ruiz, Verónica Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Favaro, María Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Derita, Marcos Gabriel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
Materia
BIOACTIVE COMPOUNDS
INFECTIOUS DISEASES
NATURAL PRODUCTS
PERSICARIA
PHARMACOLOGICAL ACTIVITIES
POLYGONUM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/171016
Acceder
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network_name_str CONICET Digital (CONICET)
spelling An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and PolygonumSeimandi, Gisela MarisolAlvarez, Norma HortensiaStegmayer, María InésFernandez, Laura NoemíRuiz, Verónica EugeniaFavaro, María AlejandraDerita, Marcos GabrielBIOACTIVE COMPOUNDSINFECTIOUS DISEASESNATURAL PRODUCTSPERSICARIAPHARMACOLOGICAL ACTIVITIESPOLYGONUMhttps://purl.org/becyt/ford/4.1https://purl.org/becyt/ford/4The discovery of new pharmaceutical identities, particularly anti-infective agents, rep-resents an urgent need due to the increase in immunocompromised patients and the ineffective-ness/toxicity of the drugs currently used. The scientific community has recognized in the last decades the importance of the plant kingdom as a huge source of novel molecules which could act against different type of infections or illness. However, the great diversity of plant species makes it difficult to select them with probabilities of success, adding to the fact that existing information is difficult to find, it is atomized or disordered. Persicaria and Polygonum constitute two of the main representatives of the Polygonaceae family, which have been extensively used in traditional medicine worldwide. Important and structurally diverse bioactive compounds have been isolated from these genera of wild plants; among them, sesquiterpenes and flavonoids should be remarked. In this article, we firstly mention all the species reported with pharmacological use and their geographical distribution. Moreover, a number of tables which summarize an update detailing the type of natural product (extract or isolated compound), applied doses, displayed bioassays and the results obtained for the main bioactivities of these genera cited in the literature during the past 40 years. Antimicrobial, antioxidant, analgesic and anti-inflammatory, antinociceptive, anticancer, antiviral, antiparasitic, anti-diabetic, antipyretic, hepatoprotective, diuretic, gastroprotective and neuropharmacological activities were explored and reviewed in this work, concluding that both genera could be the source for upcoming molecules to treat different human diseases.Fil: Seimandi, Gisela Marisol. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; ArgentinaFil: Alvarez, Norma Hortensia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; ArgentinaFil: Stegmayer, María Inés. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; ArgentinaFil: Fernandez, Laura Noemí. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; ArgentinaFil: Ruiz, Verónica Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; ArgentinaFil: Favaro, María Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; ArgentinaFil: Derita, Marcos Gabriel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaMolecular Diversity Preservation International2021-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/171016Seimandi, Gisela Marisol; Alvarez, Norma Hortensia; Stegmayer, María Inés; Fernandez, Laura Noemí; Ruiz, Verónica Eugenia; et al.; An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum; Molecular Diversity Preservation International; Molecules; 26; 19; 10-2021; 1-371420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/molecules26195956info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/26/19/5956info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:46:33Zoai:ri.conicet.gov.ar:11336/171016instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:46:33.536CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum
title An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum
spellingShingle An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum
Seimandi, Gisela Marisol
BIOACTIVE COMPOUNDS
INFECTIOUS DISEASES
NATURAL PRODUCTS
PERSICARIA
PHARMACOLOGICAL ACTIVITIES
POLYGONUM
title_short An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum
title_full An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum
title_fullStr An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum
title_full_unstemmed An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum
title_sort An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum
dc.creator.none.fl_str_mv Seimandi, Gisela Marisol
Alvarez, Norma Hortensia
Stegmayer, María Inés
Fernandez, Laura Noemí
Ruiz, Verónica Eugenia
Favaro, María Alejandra
Derita, Marcos Gabriel
author Seimandi, Gisela Marisol
author_facet Seimandi, Gisela Marisol
Alvarez, Norma Hortensia
Stegmayer, María Inés
Fernandez, Laura Noemí
Ruiz, Verónica Eugenia
Favaro, María Alejandra
Derita, Marcos Gabriel
author_role author
author2 Alvarez, Norma Hortensia
Stegmayer, María Inés
Fernandez, Laura Noemí
Ruiz, Verónica Eugenia
Favaro, María Alejandra
Derita, Marcos Gabriel
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOACTIVE COMPOUNDS
INFECTIOUS DISEASES
NATURAL PRODUCTS
PERSICARIA
PHARMACOLOGICAL ACTIVITIES
POLYGONUM
topic BIOACTIVE COMPOUNDS
INFECTIOUS DISEASES
NATURAL PRODUCTS
PERSICARIA
PHARMACOLOGICAL ACTIVITIES
POLYGONUM
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.1
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The discovery of new pharmaceutical identities, particularly anti-infective agents, rep-resents an urgent need due to the increase in immunocompromised patients and the ineffective-ness/toxicity of the drugs currently used. The scientific community has recognized in the last decades the importance of the plant kingdom as a huge source of novel molecules which could act against different type of infections or illness. However, the great diversity of plant species makes it difficult to select them with probabilities of success, adding to the fact that existing information is difficult to find, it is atomized or disordered. Persicaria and Polygonum constitute two of the main representatives of the Polygonaceae family, which have been extensively used in traditional medicine worldwide. Important and structurally diverse bioactive compounds have been isolated from these genera of wild plants; among them, sesquiterpenes and flavonoids should be remarked. In this article, we firstly mention all the species reported with pharmacological use and their geographical distribution. Moreover, a number of tables which summarize an update detailing the type of natural product (extract or isolated compound), applied doses, displayed bioassays and the results obtained for the main bioactivities of these genera cited in the literature during the past 40 years. Antimicrobial, antioxidant, analgesic and anti-inflammatory, antinociceptive, anticancer, antiviral, antiparasitic, anti-diabetic, antipyretic, hepatoprotective, diuretic, gastroprotective and neuropharmacological activities were explored and reviewed in this work, concluding that both genera could be the source for upcoming molecules to treat different human diseases.
Fil: Seimandi, Gisela Marisol. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Alvarez, Norma Hortensia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Stegmayer, María Inés. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Fernandez, Laura Noemí. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Ruiz, Verónica Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Favaro, María Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina
Fil: Derita, Marcos Gabriel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Ciencias Agropecuarias del Litoral. - Universidad Nacional del Litoral. Instituto de Ciencias Agropecuarias del Litoral.; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina
description The discovery of new pharmaceutical identities, particularly anti-infective agents, rep-resents an urgent need due to the increase in immunocompromised patients and the ineffective-ness/toxicity of the drugs currently used. The scientific community has recognized in the last decades the importance of the plant kingdom as a huge source of novel molecules which could act against different type of infections or illness. However, the great diversity of plant species makes it difficult to select them with probabilities of success, adding to the fact that existing information is difficult to find, it is atomized or disordered. Persicaria and Polygonum constitute two of the main representatives of the Polygonaceae family, which have been extensively used in traditional medicine worldwide. Important and structurally diverse bioactive compounds have been isolated from these genera of wild plants; among them, sesquiterpenes and flavonoids should be remarked. In this article, we firstly mention all the species reported with pharmacological use and their geographical distribution. Moreover, a number of tables which summarize an update detailing the type of natural product (extract or isolated compound), applied doses, displayed bioassays and the results obtained for the main bioactivities of these genera cited in the literature during the past 40 years. Antimicrobial, antioxidant, analgesic and anti-inflammatory, antinociceptive, anticancer, antiviral, antiparasitic, anti-diabetic, antipyretic, hepatoprotective, diuretic, gastroprotective and neuropharmacological activities were explored and reviewed in this work, concluding that both genera could be the source for upcoming molecules to treat different human diseases.
publishDate 2021
dc.date.none.fl_str_mv 2021-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/171016
Seimandi, Gisela Marisol; Alvarez, Norma Hortensia; Stegmayer, María Inés; Fernandez, Laura Noemí; Ruiz, Verónica Eugenia; et al.; An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum; Molecular Diversity Preservation International; Molecules; 26; 19; 10-2021; 1-37
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/171016
identifier_str_mv Seimandi, Gisela Marisol; Alvarez, Norma Hortensia; Stegmayer, María Inés; Fernandez, Laura Noemí; Ruiz, Verónica Eugenia; et al.; An Update on Phytochemicals and Pharmacological Activities of the Genus Persicaria and Polygonum; Molecular Diversity Preservation International; Molecules; 26; 19; 10-2021; 1-37
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules26195956
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/26/19/5956
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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