Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents

Autores
Delgado, Fermin; Nicova, Eva; Agotegaray, Mariela Alejandra; González Pardo, María Verónica; Dorn, Viviana; Burrow, Robert A.; Dennehy, Mariana
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This report describes the synthesis and characterization of two nickel thiosaccharinate complexes, [Ni(tsac)2(PPh3)2] (1) and [Ni(tsac)2(dppe)]·CH3CN (2), where tsac = thiosaccharinate anion, PPh3 = triphenylphosphane and dppe = bis(diphenylphosphanyl)ethane. Elemental analysis, FTIR, 1H, 13C and 31P NMR spectra and single crystal X ray diffraction studies of the complexes are presented. DFT optimizations of the two new compounds were performed in order to verify the FTIR vibrational assignations. The two nickel(II) thiosaccharinate complexes consist of mononuclear units in which the Ni atoms are the centre of square-planar coordination spheres, surrounded by two sulfur thiosaccharinate atoms and two phosphorous atoms from the phosphane ligands. In both complexes, the anions are mono-coordinated to the metal. In the [Ni(tsac)2(PPh3)2] structure, the phosphane moieties are located in trans position. In the [Ni(tsac)2(dppe)] structure, the dppe ligand chelates to the metal centre, as expected. Additionally, the superoxide dismutase (SOD) mimetic activity of the complexes was measured and it is reported herein. The effects of the complexes on cell proliferation were also studied and are described.
Fil: Delgado, Fermin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Nicova, Eva. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: González Pardo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Dorn, Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Burrow, Robert A.. Universidade Federal de Santa Maria; Brasil
Fil: Dennehy, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
CELL PROLIFERATION INHIBITION
CRYSTALLINE STRUCTURE
NICKEL
PHOSPHANE
SUPEROXIDE DISMUTASE MIMETIC ACTIVITY
THIONES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120069
Acceder
id CONICETDig_bedd1154b6ba6a32389496f47e11ea98
oai_identifier_str oai:ri.conicet.gov.ar:11336/120069
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agentsDelgado, FerminNicova, EvaAgotegaray, Mariela AlejandraGonzález Pardo, María VerónicaDorn, VivianaBurrow, Robert A.Dennehy, MarianaCELL PROLIFERATION INHIBITIONCRYSTALLINE STRUCTURENICKELPHOSPHANESUPEROXIDE DISMUTASE MIMETIC ACTIVITYTHIONEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This report describes the synthesis and characterization of two nickel thiosaccharinate complexes, [Ni(tsac)2(PPh3)2] (1) and [Ni(tsac)2(dppe)]·CH3CN (2), where tsac = thiosaccharinate anion, PPh3 = triphenylphosphane and dppe = bis(diphenylphosphanyl)ethane. Elemental analysis, FTIR, 1H, 13C and 31P NMR spectra and single crystal X ray diffraction studies of the complexes are presented. DFT optimizations of the two new compounds were performed in order to verify the FTIR vibrational assignations. The two nickel(II) thiosaccharinate complexes consist of mononuclear units in which the Ni atoms are the centre of square-planar coordination spheres, surrounded by two sulfur thiosaccharinate atoms and two phosphorous atoms from the phosphane ligands. In both complexes, the anions are mono-coordinated to the metal. In the [Ni(tsac)2(PPh3)2] structure, the phosphane moieties are located in trans position. In the [Ni(tsac)2(dppe)] structure, the dppe ligand chelates to the metal centre, as expected. Additionally, the superoxide dismutase (SOD) mimetic activity of the complexes was measured and it is reported herein. The effects of the complexes on cell proliferation were also studied and are described.Fil: Delgado, Fermin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Nicova, Eva. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: González Pardo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Dorn, Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Burrow, Robert A.. Universidade Federal de Santa Maria; BrasilFil: Dennehy, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaElsevier Science SA2019-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120069Delgado, Fermin; Nicova, Eva; Agotegaray, Mariela Alejandra; González Pardo, María Verónica; Dorn, Viviana; et al.; Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents; Elsevier Science SA; Inorganica Chimica Acta; 494; 1-8-2019; 55-640020-1693CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S002016931930341Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ica.2019.04.040info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-06-10T09:49:37Zoai:ri.conicet.gov.ar:11336/120069instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-06-10 09:49:37.328CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents
title Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents
spellingShingle Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents
Delgado, Fermin
CELL PROLIFERATION INHIBITION
CRYSTALLINE STRUCTURE
NICKEL
PHOSPHANE
SUPEROXIDE DISMUTASE MIMETIC ACTIVITY
THIONES
title_short Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents
title_full Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents
title_fullStr Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents
title_full_unstemmed Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents
title_sort Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents
dc.creator.none.fl_str_mv Delgado, Fermin
Nicova, Eva
Agotegaray, Mariela Alejandra
González Pardo, María Verónica
Dorn, Viviana
Burrow, Robert A.
Dennehy, Mariana
author Delgado, Fermin
author_facet Delgado, Fermin
Nicova, Eva
Agotegaray, Mariela Alejandra
González Pardo, María Verónica
Dorn, Viviana
Burrow, Robert A.
Dennehy, Mariana
author_role author
author2 Nicova, Eva
Agotegaray, Mariela Alejandra
González Pardo, María Verónica
Dorn, Viviana
Burrow, Robert A.
Dennehy, Mariana
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CELL PROLIFERATION INHIBITION
CRYSTALLINE STRUCTURE
NICKEL
PHOSPHANE
SUPEROXIDE DISMUTASE MIMETIC ACTIVITY
THIONES
topic CELL PROLIFERATION INHIBITION
CRYSTALLINE STRUCTURE
NICKEL
PHOSPHANE
SUPEROXIDE DISMUTASE MIMETIC ACTIVITY
THIONES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This report describes the synthesis and characterization of two nickel thiosaccharinate complexes, [Ni(tsac)2(PPh3)2] (1) and [Ni(tsac)2(dppe)]·CH3CN (2), where tsac = thiosaccharinate anion, PPh3 = triphenylphosphane and dppe = bis(diphenylphosphanyl)ethane. Elemental analysis, FTIR, 1H, 13C and 31P NMR spectra and single crystal X ray diffraction studies of the complexes are presented. DFT optimizations of the two new compounds were performed in order to verify the FTIR vibrational assignations. The two nickel(II) thiosaccharinate complexes consist of mononuclear units in which the Ni atoms are the centre of square-planar coordination spheres, surrounded by two sulfur thiosaccharinate atoms and two phosphorous atoms from the phosphane ligands. In both complexes, the anions are mono-coordinated to the metal. In the [Ni(tsac)2(PPh3)2] structure, the phosphane moieties are located in trans position. In the [Ni(tsac)2(dppe)] structure, the dppe ligand chelates to the metal centre, as expected. Additionally, the superoxide dismutase (SOD) mimetic activity of the complexes was measured and it is reported herein. The effects of the complexes on cell proliferation were also studied and are described.
Fil: Delgado, Fermin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Nicova, Eva. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: González Pardo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Dorn, Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Burrow, Robert A.. Universidade Federal de Santa Maria; Brasil
Fil: Dennehy, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description This report describes the synthesis and characterization of two nickel thiosaccharinate complexes, [Ni(tsac)2(PPh3)2] (1) and [Ni(tsac)2(dppe)]·CH3CN (2), where tsac = thiosaccharinate anion, PPh3 = triphenylphosphane and dppe = bis(diphenylphosphanyl)ethane. Elemental analysis, FTIR, 1H, 13C and 31P NMR spectra and single crystal X ray diffraction studies of the complexes are presented. DFT optimizations of the two new compounds were performed in order to verify the FTIR vibrational assignations. The two nickel(II) thiosaccharinate complexes consist of mononuclear units in which the Ni atoms are the centre of square-planar coordination spheres, surrounded by two sulfur thiosaccharinate atoms and two phosphorous atoms from the phosphane ligands. In both complexes, the anions are mono-coordinated to the metal. In the [Ni(tsac)2(PPh3)2] structure, the phosphane moieties are located in trans position. In the [Ni(tsac)2(dppe)] structure, the dppe ligand chelates to the metal centre, as expected. Additionally, the superoxide dismutase (SOD) mimetic activity of the complexes was measured and it is reported herein. The effects of the complexes on cell proliferation were also studied and are described.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120069
Delgado, Fermin; Nicova, Eva; Agotegaray, Mariela Alejandra; González Pardo, María Verónica; Dorn, Viviana; et al.; Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents; Elsevier Science SA; Inorganica Chimica Acta; 494; 1-8-2019; 55-64
0020-1693
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120069
identifier_str_mv Delgado, Fermin; Nicova, Eva; Agotegaray, Mariela Alejandra; González Pardo, María Verónica; Dorn, Viviana; et al.; Ni-thiosaccharinate complexes: Synthesis, characterization and DFT studies. Biological properties as superoxide dismutase mimetics and as anti-carcinogenic agents; Elsevier Science SA; Inorganica Chimica Acta; 494; 1-8-2019; 55-64
0020-1693
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S002016931930341X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ica.2019.04.040
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science SA
publisher.none.fl_str_mv Elsevier Science SA
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.98848

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