Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice

Autores
Von Müller, Axel Ricardo; López, Cristina; Eynard, Aldo Renato; Guzman, Carlos Alberto
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Brea gum is a phloematic exudate from Parkinsonia praecox, an autoctonous tree that  grows in the arid areas of Argentina. In this work, we propose its potentiality as a food additive. However, as no toxicological safety evaluation of brea gum has yet been reported, this preliminary study was conducted to evaluate its long term toxicity over a 120 day period in  BALB/c mice fed with brea gum at various levels in the diet. The results showed that animals  on diets containing up to 5% brea gum were healthy exhibiting growth curves similar to controls  for both males (p=0.9138) and females (p=0.9459), thereby indicating that feed intake and   utilization was not affected. A histopathological examination and weight recording of liver,  kidneys and intestine did not reveal any microscopic abnormalities or adverse toxicological  effect (weights respect to control p>0.1). Moreover, haematological parameters and enzyme  activities were within the normal values previously reported for mice. Our findings suggest that feeding brea gum at levels up to 5% by BALB/c mice do not exert any toxicological effects,  pointing out as a potential useful food additive for human consumption. 
Fil: Von Müller, Axel Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: López, Cristina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Guzman, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina
Materia
Plant gums
Tree exudates
Safety evaluation
Food additive
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/146944
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c miceVon Müller, Axel RicardoLópez, CristinaEynard, Aldo RenatoGuzman, Carlos AlbertoPlant gumsTree exudatesSafety evaluationFood additivehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Brea gum is a phloematic exudate from Parkinsonia praecox, an autoctonous tree that  grows in the arid areas of Argentina. In this work, we propose its potentiality as a food additive. However, as no toxicological safety evaluation of brea gum has yet been reported, this preliminary study was conducted to evaluate its long term toxicity over a 120 day period in  BALB/c mice fed with brea gum at various levels in the diet. The results showed that animals  on diets containing up to 5% brea gum were healthy exhibiting growth curves similar to controls  for both males (p=0.9138) and females (p=0.9459), thereby indicating that feed intake and   utilization was not affected. A histopathological examination and weight recording of liver,  kidneys and intestine did not reveal any microscopic abnormalities or adverse toxicological  effect (weights respect to control p>0.1). Moreover, haematological parameters and enzyme  activities were within the normal values previously reported for mice. Our findings suggest that feeding brea gum at levels up to 5% by BALB/c mice do not exert any toxicological effects,  pointing out as a potential useful food additive for human consumption. Fil: Von Müller, Axel Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: López, Cristina. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Guzman, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; ArgentinaTaylor & Francis2009-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146944Von Müller, Axel Ricardo; López, Cristina; Eynard, Aldo Renato; Guzman, Carlos Alberto; Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice; Taylor & Francis; Drug And Chemical Toxicology; 32; 4; 9-2009; 307-3110148-05451525-6014CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/01480540902976903info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/01480540902976903info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:59Zoai:ri.conicet.gov.ar:11336/146944instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:59.61CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice
title Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice
spellingShingle Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice
Von Müller, Axel Ricardo
Plant gums
Tree exudates
Safety evaluation
Food additive
title_short Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice
title_full Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice
title_fullStr Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice
title_full_unstemmed Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice
title_sort Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice
dc.creator.none.fl_str_mv Von Müller, Axel Ricardo
López, Cristina
Eynard, Aldo Renato
Guzman, Carlos Alberto
author Von Müller, Axel Ricardo
author_facet Von Müller, Axel Ricardo
López, Cristina
Eynard, Aldo Renato
Guzman, Carlos Alberto
author_role author
author2 López, Cristina
Eynard, Aldo Renato
Guzman, Carlos Alberto
author2_role author
author
author
dc.subject.none.fl_str_mv Plant gums
Tree exudates
Safety evaluation
Food additive
topic Plant gums
Tree exudates
Safety evaluation
Food additive
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Brea gum is a phloematic exudate from Parkinsonia praecox, an autoctonous tree that  grows in the arid areas of Argentina. In this work, we propose its potentiality as a food additive. However, as no toxicological safety evaluation of brea gum has yet been reported, this preliminary study was conducted to evaluate its long term toxicity over a 120 day period in  BALB/c mice fed with brea gum at various levels in the diet. The results showed that animals  on diets containing up to 5% brea gum were healthy exhibiting growth curves similar to controls  for both males (p=0.9138) and females (p=0.9459), thereby indicating that feed intake and   utilization was not affected. A histopathological examination and weight recording of liver,  kidneys and intestine did not reveal any microscopic abnormalities or adverse toxicological  effect (weights respect to control p>0.1). Moreover, haematological parameters and enzyme  activities were within the normal values previously reported for mice. Our findings suggest that feeding brea gum at levels up to 5% by BALB/c mice do not exert any toxicological effects,  pointing out as a potential useful food additive for human consumption. 
Fil: Von Müller, Axel Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: López, Cristina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Guzman, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina
description Brea gum is a phloematic exudate from Parkinsonia praecox, an autoctonous tree that  grows in the arid areas of Argentina. In this work, we propose its potentiality as a food additive. However, as no toxicological safety evaluation of brea gum has yet been reported, this preliminary study was conducted to evaluate its long term toxicity over a 120 day period in  BALB/c mice fed with brea gum at various levels in the diet. The results showed that animals  on diets containing up to 5% brea gum were healthy exhibiting growth curves similar to controls  for both males (p=0.9138) and females (p=0.9459), thereby indicating that feed intake and   utilization was not affected. A histopathological examination and weight recording of liver,  kidneys and intestine did not reveal any microscopic abnormalities or adverse toxicological  effect (weights respect to control p>0.1). Moreover, haematological parameters and enzyme  activities were within the normal values previously reported for mice. Our findings suggest that feeding brea gum at levels up to 5% by BALB/c mice do not exert any toxicological effects,  pointing out as a potential useful food additive for human consumption. 
publishDate 2009
dc.date.none.fl_str_mv 2009-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/146944
Von Müller, Axel Ricardo; López, Cristina; Eynard, Aldo Renato; Guzman, Carlos Alberto; Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice; Taylor & Francis; Drug And Chemical Toxicology; 32; 4; 9-2009; 307-311
0148-0545
1525-6014
CONICET Digital
CONICET
url http://hdl.handle.net/11336/146944
identifier_str_mv Von Müller, Axel Ricardo; López, Cristina; Eynard, Aldo Renato; Guzman, Carlos Alberto; Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice; Taylor & Francis; Drug And Chemical Toxicology; 32; 4; 9-2009; 307-311
0148-0545
1525-6014
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/01480540902976903
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/01480540902976903
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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