Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma

Autores
Carpano, Marina; Santa Cruz, Gustavo Alberto; Rodriguez, Carla; Nievas, Susana Isabel; Olivera, María Silvina; Perona, Marina; Boggio, Esteban Fabián; Longhino, Juan Manuel; Pisarev, Mario Alberto; Juvenal, Guillermo Juan; Dagrosa, María Alejandra
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Boron neutron capture therapy (BNCT) is a binary modality based on the nuclear reaction 10B (n, α) lithium-7 (7Li) that has been used to treat a variety of tumors, among these, cutaneous melanoma (CM). In previous boron biodistribution studies in agreement with the personalized oncology, we have demonstrated that boronophenylalanine (BPA) uptake can be correlated with the tumoral temperature and viability. The main aim of these studies was to evaluate the relationship between tumoral temperature and the response to the complete BNCT. Methods: Nude mice were implanted with human melanoma cells (Mel J) and divided into different groups (Control, NCT, BNCT I and BNCT II) and irradiated with the thermal neutron beam from RA-6 (4.96× 108/cm2/sec) during 37 and 55 minutes respectively. Tumor and body temperatures were measured by Static Infrared Imaging (SIRI), and it was performed the following up of the animals. Results: Tumor growth showed a complete growth inhibition during the first 20 days after treatment in both BNCT groups (BNCT I and BNCT II vs. Control P<0.001). Considering the analogy between the Fourier's Law of Heat Conduction and the Ohm's law of Electrical Conduction, the quantity (T_tum-T_ inf)/(T_body-T_tum) was analyzed as a function of Vf/Vi (Final volume/Initial volume) ratio. A tendency to higher values of the temperature's ratios, was observed with respect to the degree of tumor control (BNCT I with a R2 of 0.3527, BNCTII with a R2 of 0.3327) in agreement with previous boron biodistribution studies. The histology and immunohistochemical studies showed larger areas of necrosis and picnotic regions and a significant decrease of the Ki-67 antibody labeling in the BNCT II group evidencing important tumor damage. Conclusions: tumoral characteristics, especially the temperature, could be used to plan a personalized treatment for each patient. As values of correlation between temperature and tumoral response showed to be weak, we considered to explore a new model of three dimension for heat transport process.
Fil: Carpano, Marina. Comisión Nacional de Energía Atómica; Argentina
Fil: Santa Cruz, Gustavo Alberto. Comisión Nacional de Energía Atómica; Argentina
Fil: Rodriguez, Carla. Comisión Nacional de Energía Atómica; Argentina
Fil: Nievas, Susana Isabel. Comisión Nacional de Energía Atómica; Argentina
Fil: Olivera, María Silvina. Comisión Nacional de Energía Atómica; Argentina
Fil: Perona, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Boggio, Esteban Fabián. Comisión Nacional de Energía Atómica; Argentina
Fil: Longhino, Juan Manuel. Comisión Nacional de Energía Atómica; Argentina
Fil: Pisarev, Mario Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Juvenal, Guillermo Juan. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dagrosa, María Alejandra. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
BORON NEUTRON CAPTURE THERAPY (BNCT)
MELANOMA
PERSONALIZED ONCOLOGY
STATIC INFRARED IMAGING (SIRI)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216699
Acceder
id CONICETDig_bc3e28108783e253ee70ae17e853328c
oai_identifier_str oai:ri.conicet.gov.ar:11336/216699
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanomaCarpano, MarinaSanta Cruz, Gustavo AlbertoRodriguez, CarlaNievas, Susana IsabelOlivera, María SilvinaPerona, MarinaBoggio, Esteban FabiánLonghino, Juan ManuelPisarev, Mario AlbertoJuvenal, Guillermo JuanDagrosa, María AlejandraBORON NEUTRON CAPTURE THERAPY (BNCT)MELANOMAPERSONALIZED ONCOLOGYSTATIC INFRARED IMAGING (SIRI)https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Boron neutron capture therapy (BNCT) is a binary modality based on the nuclear reaction 10B (n, α) lithium-7 (7Li) that has been used to treat a variety of tumors, among these, cutaneous melanoma (CM). In previous boron biodistribution studies in agreement with the personalized oncology, we have demonstrated that boronophenylalanine (BPA) uptake can be correlated with the tumoral temperature and viability. The main aim of these studies was to evaluate the relationship between tumoral temperature and the response to the complete BNCT. Methods: Nude mice were implanted with human melanoma cells (Mel J) and divided into different groups (Control, NCT, BNCT I and BNCT II) and irradiated with the thermal neutron beam from RA-6 (4.96× 108/cm2/sec) during 37 and 55 minutes respectively. Tumor and body temperatures were measured by Static Infrared Imaging (SIRI), and it was performed the following up of the animals. Results: Tumor growth showed a complete growth inhibition during the first 20 days after treatment in both BNCT groups (BNCT I and BNCT II vs. Control P<0.001). Considering the analogy between the Fourier's Law of Heat Conduction and the Ohm's law of Electrical Conduction, the quantity (T_tum-T_ inf)/(T_body-T_tum) was analyzed as a function of Vf/Vi (Final volume/Initial volume) ratio. A tendency to higher values of the temperature's ratios, was observed with respect to the degree of tumor control (BNCT I with a R2 of 0.3527, BNCTII with a R2 of 0.3327) in agreement with previous boron biodistribution studies. The histology and immunohistochemical studies showed larger areas of necrosis and picnotic regions and a significant decrease of the Ki-67 antibody labeling in the BNCT II group evidencing important tumor damage. Conclusions: tumoral characteristics, especially the temperature, could be used to plan a personalized treatment for each patient. As values of correlation between temperature and tumoral response showed to be weak, we considered to explore a new model of three dimension for heat transport process.Fil: Carpano, Marina. Comisión Nacional de Energía Atómica; ArgentinaFil: Santa Cruz, Gustavo Alberto. Comisión Nacional de Energía Atómica; ArgentinaFil: Rodriguez, Carla. Comisión Nacional de Energía Atómica; ArgentinaFil: Nievas, Susana Isabel. Comisión Nacional de Energía Atómica; ArgentinaFil: Olivera, María Silvina. Comisión Nacional de Energía Atómica; ArgentinaFil: Perona, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Boggio, Esteban Fabián. Comisión Nacional de Energía Atómica; ArgentinaFil: Longhino, Juan Manuel. Comisión Nacional de Energía Atómica; ArgentinaFil: Pisarev, Mario Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Juvenal, Guillermo Juan. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dagrosa, María Alejandra. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAME Publishing Company2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216699Carpano, Marina; Santa Cruz, Gustavo Alberto; Rodriguez, Carla; Nievas, Susana Isabel; Olivera, María Silvina; et al.; Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma; AME Publishing Company; Therapeutic Radiology and Oncology; 5; 6-2021; 1-112616-2768CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://tro.amegroups.com/article/view/6840info:eu-repo/semantics/altIdentifier/doi/10.21037/tro-20-61info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:47Zoai:ri.conicet.gov.ar:11336/216699instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:47.345CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma
title Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma
spellingShingle Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma
Carpano, Marina
BORON NEUTRON CAPTURE THERAPY (BNCT)
MELANOMA
PERSONALIZED ONCOLOGY
STATIC INFRARED IMAGING (SIRI)
title_short Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma
title_full Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma
title_fullStr Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma
title_full_unstemmed Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma
title_sort Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma
dc.creator.none.fl_str_mv Carpano, Marina
Santa Cruz, Gustavo Alberto
Rodriguez, Carla
Nievas, Susana Isabel
Olivera, María Silvina
Perona, Marina
Boggio, Esteban Fabián
Longhino, Juan Manuel
Pisarev, Mario Alberto
Juvenal, Guillermo Juan
Dagrosa, María Alejandra
author Carpano, Marina
author_facet Carpano, Marina
Santa Cruz, Gustavo Alberto
Rodriguez, Carla
Nievas, Susana Isabel
Olivera, María Silvina
Perona, Marina
Boggio, Esteban Fabián
Longhino, Juan Manuel
Pisarev, Mario Alberto
Juvenal, Guillermo Juan
Dagrosa, María Alejandra
author_role author
author2 Santa Cruz, Gustavo Alberto
Rodriguez, Carla
Nievas, Susana Isabel
Olivera, María Silvina
Perona, Marina
Boggio, Esteban Fabián
Longhino, Juan Manuel
Pisarev, Mario Alberto
Juvenal, Guillermo Juan
Dagrosa, María Alejandra
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BORON NEUTRON CAPTURE THERAPY (BNCT)
MELANOMA
PERSONALIZED ONCOLOGY
STATIC INFRARED IMAGING (SIRI)
topic BORON NEUTRON CAPTURE THERAPY (BNCT)
MELANOMA
PERSONALIZED ONCOLOGY
STATIC INFRARED IMAGING (SIRI)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Boron neutron capture therapy (BNCT) is a binary modality based on the nuclear reaction 10B (n, α) lithium-7 (7Li) that has been used to treat a variety of tumors, among these, cutaneous melanoma (CM). In previous boron biodistribution studies in agreement with the personalized oncology, we have demonstrated that boronophenylalanine (BPA) uptake can be correlated with the tumoral temperature and viability. The main aim of these studies was to evaluate the relationship between tumoral temperature and the response to the complete BNCT. Methods: Nude mice were implanted with human melanoma cells (Mel J) and divided into different groups (Control, NCT, BNCT I and BNCT II) and irradiated with the thermal neutron beam from RA-6 (4.96× 108/cm2/sec) during 37 and 55 minutes respectively. Tumor and body temperatures were measured by Static Infrared Imaging (SIRI), and it was performed the following up of the animals. Results: Tumor growth showed a complete growth inhibition during the first 20 days after treatment in both BNCT groups (BNCT I and BNCT II vs. Control P<0.001). Considering the analogy between the Fourier's Law of Heat Conduction and the Ohm's law of Electrical Conduction, the quantity (T_tum-T_ inf)/(T_body-T_tum) was analyzed as a function of Vf/Vi (Final volume/Initial volume) ratio. A tendency to higher values of the temperature's ratios, was observed with respect to the degree of tumor control (BNCT I with a R2 of 0.3527, BNCTII with a R2 of 0.3327) in agreement with previous boron biodistribution studies. The histology and immunohistochemical studies showed larger areas of necrosis and picnotic regions and a significant decrease of the Ki-67 antibody labeling in the BNCT II group evidencing important tumor damage. Conclusions: tumoral characteristics, especially the temperature, could be used to plan a personalized treatment for each patient. As values of correlation between temperature and tumoral response showed to be weak, we considered to explore a new model of three dimension for heat transport process.
Fil: Carpano, Marina. Comisión Nacional de Energía Atómica; Argentina
Fil: Santa Cruz, Gustavo Alberto. Comisión Nacional de Energía Atómica; Argentina
Fil: Rodriguez, Carla. Comisión Nacional de Energía Atómica; Argentina
Fil: Nievas, Susana Isabel. Comisión Nacional de Energía Atómica; Argentina
Fil: Olivera, María Silvina. Comisión Nacional de Energía Atómica; Argentina
Fil: Perona, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Boggio, Esteban Fabián. Comisión Nacional de Energía Atómica; Argentina
Fil: Longhino, Juan Manuel. Comisión Nacional de Energía Atómica; Argentina
Fil: Pisarev, Mario Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Juvenal, Guillermo Juan. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dagrosa, María Alejandra. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: Boron neutron capture therapy (BNCT) is a binary modality based on the nuclear reaction 10B (n, α) lithium-7 (7Li) that has been used to treat a variety of tumors, among these, cutaneous melanoma (CM). In previous boron biodistribution studies in agreement with the personalized oncology, we have demonstrated that boronophenylalanine (BPA) uptake can be correlated with the tumoral temperature and viability. The main aim of these studies was to evaluate the relationship between tumoral temperature and the response to the complete BNCT. Methods: Nude mice were implanted with human melanoma cells (Mel J) and divided into different groups (Control, NCT, BNCT I and BNCT II) and irradiated with the thermal neutron beam from RA-6 (4.96× 108/cm2/sec) during 37 and 55 minutes respectively. Tumor and body temperatures were measured by Static Infrared Imaging (SIRI), and it was performed the following up of the animals. Results: Tumor growth showed a complete growth inhibition during the first 20 days after treatment in both BNCT groups (BNCT I and BNCT II vs. Control P<0.001). Considering the analogy between the Fourier's Law of Heat Conduction and the Ohm's law of Electrical Conduction, the quantity (T_tum-T_ inf)/(T_body-T_tum) was analyzed as a function of Vf/Vi (Final volume/Initial volume) ratio. A tendency to higher values of the temperature's ratios, was observed with respect to the degree of tumor control (BNCT I with a R2 of 0.3527, BNCTII with a R2 of 0.3327) in agreement with previous boron biodistribution studies. The histology and immunohistochemical studies showed larger areas of necrosis and picnotic regions and a significant decrease of the Ki-67 antibody labeling in the BNCT II group evidencing important tumor damage. Conclusions: tumoral characteristics, especially the temperature, could be used to plan a personalized treatment for each patient. As values of correlation between temperature and tumoral response showed to be weak, we considered to explore a new model of three dimension for heat transport process.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216699
Carpano, Marina; Santa Cruz, Gustavo Alberto; Rodriguez, Carla; Nievas, Susana Isabel; Olivera, María Silvina; et al.; Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma; AME Publishing Company; Therapeutic Radiology and Oncology; 5; 6-2021; 1-11
2616-2768
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216699
identifier_str_mv Carpano, Marina; Santa Cruz, Gustavo Alberto; Rodriguez, Carla; Nievas, Susana Isabel; Olivera, María Silvina; et al.; Experimental studies for the personalized application of boron neutron capture therapy to the treatment of cutaneous melanoma; AME Publishing Company; Therapeutic Radiology and Oncology; 5; 6-2021; 1-11
2616-2768
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://tro.amegroups.com/article/view/6840
info:eu-repo/semantics/altIdentifier/doi/10.21037/tro-20-61
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv AME Publishing Company
publisher.none.fl_str_mv AME Publishing Company
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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