The role of process variables in the design of multiproduct batch protein production plants

Autores
Montagna, Jorge Marcelo; Vecchietti, Aldo; Iribarren, Oscar Alberto; Pinto, José M.; Asenjo, Juan A.
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work reports findings about the role of process variables in the design of multiproduct batch plants. Unlike continuous processes, batch processes are subject to size and time constraints which depend on the structure of the plant: the number of units at each stage and the provision of intermediate storage. We used simple process performance models (yet involving all the process variables with significant economic impact) to get explicit expressions for these size and time factors. The traditional approach uses fixed size and time factors. So the addition of those expressions to the original fixed factors model, permitted to simultaneously optimize the plant structure and process variables, and study the role of the latter in the design. We found that if the plant structure constraints are disregarded (with a Free Unlimited Storage operating policy), process variables behave just alike in continuous processes. They trade off cost components with the Total Annual Cost being quite insensitive to them in the neighborhood of the optimal solution. As setting the process variables sets the size and time factors, this means that near the optimal set of process variables, cycle times and size factors can be accommodated to the plant structure, with little effect on the cost of equipment.
Fil: Montagna, Jorge Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentina
Fil: Vecchietti, Aldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentina
Fil: Iribarren, Oscar Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentina
Fil: Pinto, José M.. Universidade de Sao Paulo; Brasil
Fil: Asenjo, Juan A.. Universidad de Chile; Chile
Materia
BATCH PROTEIN
PLANTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/189387
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The role of process variables in the design of multiproduct batch protein production plantsMontagna, Jorge MarceloVecchietti, AldoIribarren, Oscar AlbertoPinto, José M.Asenjo, Juan A.BATCH PROTEINPLANTShttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2This work reports findings about the role of process variables in the design of multiproduct batch plants. Unlike continuous processes, batch processes are subject to size and time constraints which depend on the structure of the plant: the number of units at each stage and the provision of intermediate storage. We used simple process performance models (yet involving all the process variables with significant economic impact) to get explicit expressions for these size and time factors. The traditional approach uses fixed size and time factors. So the addition of those expressions to the original fixed factors model, permitted to simultaneously optimize the plant structure and process variables, and study the role of the latter in the design. We found that if the plant structure constraints are disregarded (with a Free Unlimited Storage operating policy), process variables behave just alike in continuous processes. They trade off cost components with the Total Annual Cost being quite insensitive to them in the neighborhood of the optimal solution. As setting the process variables sets the size and time factors, this means that near the optimal set of process variables, cycle times and size factors can be accommodated to the plant structure, with little effect on the cost of equipment.Fil: Montagna, Jorge Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; ArgentinaFil: Vecchietti, Aldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; ArgentinaFil: Iribarren, Oscar Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; ArgentinaFil: Pinto, José M.. Universidade de Sao Paulo; BrasilFil: Asenjo, Juan A.. Universidad de Chile; ChilePlanta Piloto de Ingeniería Química2001-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/189387Montagna, Jorge Marcelo; Vecchietti, Aldo; Iribarren, Oscar Alberto; Pinto, José M.; Asenjo, Juan A.; The role of process variables in the design of multiproduct batch protein production plants; Planta Piloto de Ingeniería Química; Latin American Applied Research; 31; 5; 12-2001; 411-4170327-07931851-8796CONICET DigitalCONICETenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:13:11Zoai:ri.conicet.gov.ar:11336/189387instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:13:11.508CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of process variables in the design of multiproduct batch protein production plants
title The role of process variables in the design of multiproduct batch protein production plants
spellingShingle The role of process variables in the design of multiproduct batch protein production plants
Montagna, Jorge Marcelo
BATCH PROTEIN
PLANTS
title_short The role of process variables in the design of multiproduct batch protein production plants
title_full The role of process variables in the design of multiproduct batch protein production plants
title_fullStr The role of process variables in the design of multiproduct batch protein production plants
title_full_unstemmed The role of process variables in the design of multiproduct batch protein production plants
title_sort The role of process variables in the design of multiproduct batch protein production plants
dc.creator.none.fl_str_mv Montagna, Jorge Marcelo
Vecchietti, Aldo
Iribarren, Oscar Alberto
Pinto, José M.
Asenjo, Juan A.
author Montagna, Jorge Marcelo
author_facet Montagna, Jorge Marcelo
Vecchietti, Aldo
Iribarren, Oscar Alberto
Pinto, José M.
Asenjo, Juan A.
author_role author
author2 Vecchietti, Aldo
Iribarren, Oscar Alberto
Pinto, José M.
Asenjo, Juan A.
author2_role author
author
author
author
dc.subject.none.fl_str_mv BATCH PROTEIN
PLANTS
topic BATCH PROTEIN
PLANTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv This work reports findings about the role of process variables in the design of multiproduct batch plants. Unlike continuous processes, batch processes are subject to size and time constraints which depend on the structure of the plant: the number of units at each stage and the provision of intermediate storage. We used simple process performance models (yet involving all the process variables with significant economic impact) to get explicit expressions for these size and time factors. The traditional approach uses fixed size and time factors. So the addition of those expressions to the original fixed factors model, permitted to simultaneously optimize the plant structure and process variables, and study the role of the latter in the design. We found that if the plant structure constraints are disregarded (with a Free Unlimited Storage operating policy), process variables behave just alike in continuous processes. They trade off cost components with the Total Annual Cost being quite insensitive to them in the neighborhood of the optimal solution. As setting the process variables sets the size and time factors, this means that near the optimal set of process variables, cycle times and size factors can be accommodated to the plant structure, with little effect on the cost of equipment.
Fil: Montagna, Jorge Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentina
Fil: Vecchietti, Aldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentina
Fil: Iribarren, Oscar Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentina
Fil: Pinto, José M.. Universidade de Sao Paulo; Brasil
Fil: Asenjo, Juan A.. Universidad de Chile; Chile
description This work reports findings about the role of process variables in the design of multiproduct batch plants. Unlike continuous processes, batch processes are subject to size and time constraints which depend on the structure of the plant: the number of units at each stage and the provision of intermediate storage. We used simple process performance models (yet involving all the process variables with significant economic impact) to get explicit expressions for these size and time factors. The traditional approach uses fixed size and time factors. So the addition of those expressions to the original fixed factors model, permitted to simultaneously optimize the plant structure and process variables, and study the role of the latter in the design. We found that if the plant structure constraints are disregarded (with a Free Unlimited Storage operating policy), process variables behave just alike in continuous processes. They trade off cost components with the Total Annual Cost being quite insensitive to them in the neighborhood of the optimal solution. As setting the process variables sets the size and time factors, this means that near the optimal set of process variables, cycle times and size factors can be accommodated to the plant structure, with little effect on the cost of equipment.
publishDate 2001
dc.date.none.fl_str_mv 2001-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/189387
Montagna, Jorge Marcelo; Vecchietti, Aldo; Iribarren, Oscar Alberto; Pinto, José M.; Asenjo, Juan A.; The role of process variables in the design of multiproduct batch protein production plants; Planta Piloto de Ingeniería Química; Latin American Applied Research; 31; 5; 12-2001; 411-417
0327-0793
1851-8796
CONICET Digital
CONICET
url http://hdl.handle.net/11336/189387
identifier_str_mv Montagna, Jorge Marcelo; Vecchietti, Aldo; Iribarren, Oscar Alberto; Pinto, José M.; Asenjo, Juan A.; The role of process variables in the design of multiproduct batch protein production plants; Planta Piloto de Ingeniería Química; Latin American Applied Research; 31; 5; 12-2001; 411-417
0327-0793
1851-8796
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Planta Piloto de Ingeniería Química
publisher.none.fl_str_mv Planta Piloto de Ingeniería Química
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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