Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease

Autores
Anastasia Gonzalez, Agustin; de Erausquin, Gabriel Alejandro; Wojnacki Fonseca, José Ignacio; Masco, Daniel Hugo
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity. © 2007 The Authors.
Fil: Anastasia Gonzalez, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
Fil: de Erausquin, Gabriel Alejandro. The George Washington University; Estados Unidos
Fil: Wojnacki Fonseca, José Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
Fil: Masco, Daniel Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
Materia
6-Hydroxydopamine
Electroconvulsive Shock
Glial Cell-Line Derived Neurotrophic Factor
Neuroprotection
Parkinson
Substantia Nigra
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/61638
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's diseaseAnastasia Gonzalez, Agustinde Erausquin, Gabriel AlejandroWojnacki Fonseca, José IgnacioMasco, Daniel Hugo6-HydroxydopamineElectroconvulsive ShockGlial Cell-Line Derived Neurotrophic FactorNeuroprotectionParkinsonSubstantia Nigrahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity. © 2007 The Authors.Fil: Anastasia Gonzalez, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; ArgentinaFil: de Erausquin, Gabriel Alejandro. The George Washington University; Estados UnidosFil: Wojnacki Fonseca, José Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; ArgentinaFil: Masco, Daniel Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; ArgentinaWiley Blackwell Publishing, Inc2007-11-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/61638Anastasia Gonzalez, Agustin; de Erausquin, Gabriel Alejandro; Wojnacki Fonseca, José Ignacio; Masco, Daniel Hugo; Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 103; 4; 26-11-2007; 1542-15520022-30421471-4159CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1471-4159.2007.04856.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2007.04856.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:59Zoai:ri.conicet.gov.ar:11336/61638instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:59.606CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease
title Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease
spellingShingle Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease
Anastasia Gonzalez, Agustin
6-Hydroxydopamine
Electroconvulsive Shock
Glial Cell-Line Derived Neurotrophic Factor
Neuroprotection
Parkinson
Substantia Nigra
title_short Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease
title_full Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease
title_fullStr Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease
title_full_unstemmed Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease
title_sort Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease
dc.creator.none.fl_str_mv Anastasia Gonzalez, Agustin
de Erausquin, Gabriel Alejandro
Wojnacki Fonseca, José Ignacio
Masco, Daniel Hugo
author Anastasia Gonzalez, Agustin
author_facet Anastasia Gonzalez, Agustin
de Erausquin, Gabriel Alejandro
Wojnacki Fonseca, José Ignacio
Masco, Daniel Hugo
author_role author
author2 de Erausquin, Gabriel Alejandro
Wojnacki Fonseca, José Ignacio
Masco, Daniel Hugo
author2_role author
author
author
dc.subject.none.fl_str_mv 6-Hydroxydopamine
Electroconvulsive Shock
Glial Cell-Line Derived Neurotrophic Factor
Neuroprotection
Parkinson
Substantia Nigra
topic 6-Hydroxydopamine
Electroconvulsive Shock
Glial Cell-Line Derived Neurotrophic Factor
Neuroprotection
Parkinson
Substantia Nigra
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity. © 2007 The Authors.
Fil: Anastasia Gonzalez, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
Fil: de Erausquin, Gabriel Alejandro. The George Washington University; Estados Unidos
Fil: Wojnacki Fonseca, José Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
Fil: Masco, Daniel Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Biología Celular y Molecular; Argentina
description Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity. © 2007 The Authors.
publishDate 2007
dc.date.none.fl_str_mv 2007-11-26
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/61638
Anastasia Gonzalez, Agustin; de Erausquin, Gabriel Alejandro; Wojnacki Fonseca, José Ignacio; Masco, Daniel Hugo; Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 103; 4; 26-11-2007; 1542-1552
0022-3042
1471-4159
CONICET Digital
CONICET
url http://hdl.handle.net/11336/61638
identifier_str_mv Anastasia Gonzalez, Agustin; de Erausquin, Gabriel Alejandro; Wojnacki Fonseca, José Ignacio; Masco, Daniel Hugo; Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 103; 4; 26-11-2007; 1542-1552
0022-3042
1471-4159
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1471-4159.2007.04856.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2007.04856.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269066110173184
score 13.13397

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