Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds

Autores
Solórzano, Eliana Rita; Vera, Nancy; Maldonado, Luis; Bedascarrasbure, Enrique Luciano; Ordóñez, Roxana Mabel; Isla, Maria Ines
Año de publicación
2011
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Pevious paper reported the antioxidant and antimicrobial activities of different NOA propolis extracts but very little has been reported about their chemistry. The aim of this study was the isolation and identification of bioactive compounds from ethanolic extracts of propolis from “Del Monte” phytogeographical region (Catamarca, Argentina) against Staphylococcus aureus resistant to methycillin (MRSA). Through high-resolution chromatographic techniques (HPLC), twelve flavonoids with different degrees of hydroxylation and methoxylation were isolated and their structures were elucidated by spectroscopic analysis. Isolation was bioguided by antibacterial activity against MRSA. The compounds 2´,4´- dihydroxychalcone, 2´,4´-dihydroxy-3-methoxychalcone, 2´,4´,4-trihydroxy- 6´-methoxychalcone, 5-hydroxy-4’,7-dimethoxyflavone, 4’,5-dihydroxy- 3,7,8- trimethoxyflavone and 7-hydroxy-5,8- dimethoxyflavone were the most active with values of minimal inhibitory concentration (MIC50) of 10 μg/ml. This is the first report of the isolation of metabolites with antibacterial activity of propolis from Catamarca, Argentina.
Fil: Solórzano, Eliana Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Vera, Nancy. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Tucuman-Santiago del Estero. Estación Experimental Agropecuaria Famaillá; Argentina
Fil: Maldonado, Luis. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Tucuman-Santiago del Estero. Estación Experimental Agropecuaria Famaillá; Argentina
Fil: Bedascarrasbure, Enrique Luciano. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Tucuman-Santiago del Estero. Estación Experimental Agropecuaria Famaillá; Argentina
Fil: Ordóñez, Roxana Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucuman. Facultad de Cs.naturales E Instituto Miguel Lillo. Cátedra de Química; Argentina
Fil: Isla, Maria Ines. Universidad Nacional de Tucuman. Facultad de Cs.naturales E Instituto Miguel Lillo. Cátedra de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
XXVII Jornadas Cientificas de la Asociación de Biologia de Tucuman
Tafí del Valle
Argentina
Asociación de Biología de Tucumán
Materia
ANTIBACTERIAL ACTIVITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/235372
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compoundsSolórzano, Eliana RitaVera, NancyMaldonado, LuisBedascarrasbure, Enrique LucianoOrdóñez, Roxana MabelIsla, Maria InesANTIBACTERIAL ACTIVITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Pevious paper reported the antioxidant and antimicrobial activities of different NOA propolis extracts but very little has been reported about their chemistry. The aim of this study was the isolation and identification of bioactive compounds from ethanolic extracts of propolis from “Del Monte” phytogeographical region (Catamarca, Argentina) against Staphylococcus aureus resistant to methycillin (MRSA). Through high-resolution chromatographic techniques (HPLC), twelve flavonoids with different degrees of hydroxylation and methoxylation were isolated and their structures were elucidated by spectroscopic analysis. Isolation was bioguided by antibacterial activity against MRSA. The compounds 2´,4´- dihydroxychalcone, 2´,4´-dihydroxy-3-methoxychalcone, 2´,4´,4-trihydroxy- 6´-methoxychalcone, 5-hydroxy-4’,7-dimethoxyflavone, 4’,5-dihydroxy- 3,7,8- trimethoxyflavone and 7-hydroxy-5,8- dimethoxyflavone were the most active with values of minimal inhibitory concentration (MIC50) of 10 μg/ml. This is the first report of the isolation of metabolites with antibacterial activity of propolis from Catamarca, Argentina.Fil: Solórzano, Eliana Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Vera, Nancy. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Tucuman-Santiago del Estero. Estación Experimental Agropecuaria Famaillá; ArgentinaFil: Maldonado, Luis. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Tucuman-Santiago del Estero. Estación Experimental Agropecuaria Famaillá; ArgentinaFil: Bedascarrasbure, Enrique Luciano. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Tucuman-Santiago del Estero. Estación Experimental Agropecuaria Famaillá; ArgentinaFil: Ordóñez, Roxana Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucuman. Facultad de Cs.naturales E Instituto Miguel Lillo. Cátedra de Química; ArgentinaFil: Isla, Maria Ines. Universidad Nacional de Tucuman. Facultad de Cs.naturales E Instituto Miguel Lillo. Cátedra de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaXXVII Jornadas Cientificas de la Asociación de Biologia de TucumanTafí del ValleArgentinaAsociación de Biología de TucumánAsociación de Biología de Tucumán2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectJornadaJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/235372Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds; XXVII Jornadas Cientificas de la Asociación de Biologia de Tucuman; Tafí del Valle; Argentina; 2011; 1-20327-9545CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://asobioltuc.com/uploads/archivos/1503953090_QmlvY2VsbCBYWFZJSSBKQyAyMDEwLnBkZg==.pdfNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:15:12Zoai:ri.conicet.gov.ar:11336/235372instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:15:12.894CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds
title Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds
spellingShingle Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds
Solórzano, Eliana Rita
ANTIBACTERIAL ACTIVITY
title_short Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds
title_full Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds
title_fullStr Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds
title_full_unstemmed Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds
title_sort Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds
dc.creator.none.fl_str_mv Solórzano, Eliana Rita
Vera, Nancy
Maldonado, Luis
Bedascarrasbure, Enrique Luciano
Ordóñez, Roxana Mabel
Isla, Maria Ines
author Solórzano, Eliana Rita
author_facet Solórzano, Eliana Rita
Vera, Nancy
Maldonado, Luis
Bedascarrasbure, Enrique Luciano
Ordóñez, Roxana Mabel
Isla, Maria Ines
author_role author
author2 Vera, Nancy
Maldonado, Luis
Bedascarrasbure, Enrique Luciano
Ordóñez, Roxana Mabel
Isla, Maria Ines
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANTIBACTERIAL ACTIVITY
topic ANTIBACTERIAL ACTIVITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Pevious paper reported the antioxidant and antimicrobial activities of different NOA propolis extracts but very little has been reported about their chemistry. The aim of this study was the isolation and identification of bioactive compounds from ethanolic extracts of propolis from “Del Monte” phytogeographical region (Catamarca, Argentina) against Staphylococcus aureus resistant to methycillin (MRSA). Through high-resolution chromatographic techniques (HPLC), twelve flavonoids with different degrees of hydroxylation and methoxylation were isolated and their structures were elucidated by spectroscopic analysis. Isolation was bioguided by antibacterial activity against MRSA. The compounds 2´,4´- dihydroxychalcone, 2´,4´-dihydroxy-3-methoxychalcone, 2´,4´,4-trihydroxy- 6´-methoxychalcone, 5-hydroxy-4’,7-dimethoxyflavone, 4’,5-dihydroxy- 3,7,8- trimethoxyflavone and 7-hydroxy-5,8- dimethoxyflavone were the most active with values of minimal inhibitory concentration (MIC50) of 10 μg/ml. This is the first report of the isolation of metabolites with antibacterial activity of propolis from Catamarca, Argentina.
Fil: Solórzano, Eliana Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Vera, Nancy. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Tucuman-Santiago del Estero. Estación Experimental Agropecuaria Famaillá; Argentina
Fil: Maldonado, Luis. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Tucuman-Santiago del Estero. Estación Experimental Agropecuaria Famaillá; Argentina
Fil: Bedascarrasbure, Enrique Luciano. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Tucuman-Santiago del Estero. Estación Experimental Agropecuaria Famaillá; Argentina
Fil: Ordóñez, Roxana Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina. Universidad Nacional de Tucuman. Facultad de Cs.naturales E Instituto Miguel Lillo. Cátedra de Química; Argentina
Fil: Isla, Maria Ines. Universidad Nacional de Tucuman. Facultad de Cs.naturales E Instituto Miguel Lillo. Cátedra de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
XXVII Jornadas Cientificas de la Asociación de Biologia de Tucuman
Tafí del Valle
Argentina
Asociación de Biología de Tucumán
description Pevious paper reported the antioxidant and antimicrobial activities of different NOA propolis extracts but very little has been reported about their chemistry. The aim of this study was the isolation and identification of bioactive compounds from ethanolic extracts of propolis from “Del Monte” phytogeographical region (Catamarca, Argentina) against Staphylococcus aureus resistant to methycillin (MRSA). Through high-resolution chromatographic techniques (HPLC), twelve flavonoids with different degrees of hydroxylation and methoxylation were isolated and their structures were elucidated by spectroscopic analysis. Isolation was bioguided by antibacterial activity against MRSA. The compounds 2´,4´- dihydroxychalcone, 2´,4´-dihydroxy-3-methoxychalcone, 2´,4´,4-trihydroxy- 6´-methoxychalcone, 5-hydroxy-4’,7-dimethoxyflavone, 4’,5-dihydroxy- 3,7,8- trimethoxyflavone and 7-hydroxy-5,8- dimethoxyflavone were the most active with values of minimal inhibitory concentration (MIC50) of 10 μg/ml. This is the first report of the isolation of metabolites with antibacterial activity of propolis from Catamarca, Argentina.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Jornada
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/235372
Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds; XXVII Jornadas Cientificas de la Asociación de Biologia de Tucuman; Tafí del Valle; Argentina; 2011; 1-2
0327-9545
CONICET Digital
CONICET
url http://hdl.handle.net/11336/235372
identifier_str_mv Antibacterial activity of propolis from rincón, catamarca, argentina. Isolation of bioactive compounds; XXVII Jornadas Cientificas de la Asociación de Biologia de Tucuman; Tafí del Valle; Argentina; 2011; 1-2
0327-9545
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://asobioltuc.com/uploads/archivos/1503953090_QmlvY2VsbCBYWFZJSSBKQyAyMDEwLnBkZg==.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Asociación de Biología de Tucumán
publisher.none.fl_str_mv Asociación de Biología de Tucumán
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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