Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

Autores
Hessell, Ann J.; Jaworski, Juan Pablo; Epson, Erin; Matsuda, Kenta; Pandey, Shilpi; Kahl, Christoph; Reed, Jason; Sutton, William F.; Hammond, Katherine B.; Cheever, Tracy A.; Barnette, Philip T.; Legasse, Alfred W.; Planer, Shannon; Stanton, Jeffrey J.; Pegu, Amarendra; Chen, Xuejun; Wang, Keyun; Siess, Don; Burke, David; Park, Byung S.; Axthelm, Michael K; Lewis, Anne; Hirsch, Vanessa M.; Graham, Barney S.; Mascola, John R.; Sacha, Jonah B.; Haigwood, Nancy L.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1–specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8+ T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs.
Fil: Hessell, Ann J.. Oregon Health and Science University; Estados Unidos
Fil: Jaworski, Juan Pablo. Oregon Health and Science University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Epson, Erin. Oregon Health and Science University; Estados Unidos
Fil: Matsuda, Kenta. National Institutes of Health; Estados Unidos
Fil: Pandey, Shilpi. Oregon Health and Science University; Estados Unidos
Fil: Kahl, Christoph. Oregon Health and Science University; Estados Unidos
Fil: Reed, Jason. Oregon Health and Science University; Estados Unidos
Fil: Sutton, William F.. Oregon Health and Science University; Estados Unidos
Fil: Hammond, Katherine B.. Oregon Health and Science University; Estados Unidos
Fil: Cheever, Tracy A.. Oregon Health and Science University; Estados Unidos
Fil: Barnette, Philip T.. Oregon Health and Science University; Estados Unidos
Fil: Legasse, Alfred W.. Oregon Health and Science University; Estados Unidos
Fil: Planer, Shannon. Oregon Health and Science University; Estados Unidos
Fil: Stanton, Jeffrey J.. Oregon Health and Science University; Estados Unidos
Fil: Pegu, Amarendra. National Institutes of Health; Estados Unidos
Fil: Chen, Xuejun. National Institutes of Health; Estados Unidos
Fil: Wang, Keyun. National Institutes of Health; Estados Unidos
Fil: Siess, Don. Oregon Health and Science University; Estados Unidos
Fil: Burke, David. Oregon Health and Science University; Estados Unidos
Fil: Park, Byung S.. Oregon Health and Science University; Estados Unidos
Fil: Axthelm, Michael K. Oregon Health and Science University; Estados Unidos
Fil: Lewis, Anne. Oregon Health and Science University; Estados Unidos
Fil: Hirsch, Vanessa M.. National Institutes of Health; Estados Unidos
Fil: Graham, Barney S.. National Institutes of Health; Estados Unidos
Fil: Mascola, John R.. National Institutes of Health; Estados Unidos
Fil: Sacha, Jonah B.. Oregon Health and Science University; Estados Unidos
Fil: Haigwood, Nancy L.. Oregon Health and Science University; Estados Unidos
Materia
Hiv
Anticuerpos Neutralizantes
Patogenia
Transmision Perinatal
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44381

id CONICETDig_bb17a9ab4182c2ab5983130a2324babb
oai_identifier_str oai:ri.conicet.gov.ar:11336/44381
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaquesHessell, Ann J.Jaworski, Juan PabloEpson, ErinMatsuda, KentaPandey, ShilpiKahl, ChristophReed, JasonSutton, William F.Hammond, Katherine B.Cheever, Tracy A.Barnette, Philip T.Legasse, Alfred W.Planer, ShannonStanton, Jeffrey J.Pegu, AmarendraChen, XuejunWang, KeyunSiess, DonBurke, DavidPark, Byung S.Axthelm, Michael KLewis, AnneHirsch, Vanessa M.Graham, Barney S.Mascola, John R.Sacha, Jonah B.Haigwood, Nancy L.HivAnticuerpos NeutralizantesPatogeniaTransmision Perinatalhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1–specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8+ T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs.Fil: Hessell, Ann J.. Oregon Health and Science University; Estados UnidosFil: Jaworski, Juan Pablo. Oregon Health and Science University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Epson, Erin. Oregon Health and Science University; Estados UnidosFil: Matsuda, Kenta. National Institutes of Health; Estados UnidosFil: Pandey, Shilpi. Oregon Health and Science University; Estados UnidosFil: Kahl, Christoph. Oregon Health and Science University; Estados UnidosFil: Reed, Jason. Oregon Health and Science University; Estados UnidosFil: Sutton, William F.. Oregon Health and Science University; Estados UnidosFil: Hammond, Katherine B.. Oregon Health and Science University; Estados UnidosFil: Cheever, Tracy A.. Oregon Health and Science University; Estados UnidosFil: Barnette, Philip T.. Oregon Health and Science University; Estados UnidosFil: Legasse, Alfred W.. Oregon Health and Science University; Estados UnidosFil: Planer, Shannon. Oregon Health and Science University; Estados UnidosFil: Stanton, Jeffrey J.. Oregon Health and Science University; Estados UnidosFil: Pegu, Amarendra. National Institutes of Health; Estados UnidosFil: Chen, Xuejun. National Institutes of Health; Estados UnidosFil: Wang, Keyun. National Institutes of Health; Estados UnidosFil: Siess, Don. Oregon Health and Science University; Estados UnidosFil: Burke, David. Oregon Health and Science University; Estados UnidosFil: Park, Byung S.. Oregon Health and Science University; Estados UnidosFil: Axthelm, Michael K. Oregon Health and Science University; Estados UnidosFil: Lewis, Anne. Oregon Health and Science University; Estados UnidosFil: Hirsch, Vanessa M.. National Institutes of Health; Estados UnidosFil: Graham, Barney S.. National Institutes of Health; Estados UnidosFil: Mascola, John R.. National Institutes of Health; Estados UnidosFil: Sacha, Jonah B.. Oregon Health and Science University; Estados UnidosFil: Haigwood, Nancy L.. Oregon Health and Science University; Estados UnidosNature Publishing Group2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44381Hessell, Ann J.; Jaworski, Juan Pablo; Epson, Erin; Matsuda, Kenta; Pandey, Shilpi; et al.; Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques; Nature Publishing Group; Nature Medicine; 22; 4; 3-2016; 362-3681078-8956CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/nm.4063info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nm.4063info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:21:27Zoai:ri.conicet.gov.ar:11336/44381instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:21:28.265CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques
title Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques
spellingShingle Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques
Hessell, Ann J.
Hiv
Anticuerpos Neutralizantes
Patogenia
Transmision Perinatal
title_short Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques
title_full Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques
title_fullStr Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques
title_full_unstemmed Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques
title_sort Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques
dc.creator.none.fl_str_mv Hessell, Ann J.
Jaworski, Juan Pablo
Epson, Erin
Matsuda, Kenta
Pandey, Shilpi
Kahl, Christoph
Reed, Jason
Sutton, William F.
Hammond, Katherine B.
Cheever, Tracy A.
Barnette, Philip T.
Legasse, Alfred W.
Planer, Shannon
Stanton, Jeffrey J.
Pegu, Amarendra
Chen, Xuejun
Wang, Keyun
Siess, Don
Burke, David
Park, Byung S.
Axthelm, Michael K
Lewis, Anne
Hirsch, Vanessa M.
Graham, Barney S.
Mascola, John R.
Sacha, Jonah B.
Haigwood, Nancy L.
author Hessell, Ann J.
author_facet Hessell, Ann J.
Jaworski, Juan Pablo
Epson, Erin
Matsuda, Kenta
Pandey, Shilpi
Kahl, Christoph
Reed, Jason
Sutton, William F.
Hammond, Katherine B.
Cheever, Tracy A.
Barnette, Philip T.
Legasse, Alfred W.
Planer, Shannon
Stanton, Jeffrey J.
Pegu, Amarendra
Chen, Xuejun
Wang, Keyun
Siess, Don
Burke, David
Park, Byung S.
Axthelm, Michael K
Lewis, Anne
Hirsch, Vanessa M.
Graham, Barney S.
Mascola, John R.
Sacha, Jonah B.
Haigwood, Nancy L.
author_role author
author2 Jaworski, Juan Pablo
Epson, Erin
Matsuda, Kenta
Pandey, Shilpi
Kahl, Christoph
Reed, Jason
Sutton, William F.
Hammond, Katherine B.
Cheever, Tracy A.
Barnette, Philip T.
Legasse, Alfred W.
Planer, Shannon
Stanton, Jeffrey J.
Pegu, Amarendra
Chen, Xuejun
Wang, Keyun
Siess, Don
Burke, David
Park, Byung S.
Axthelm, Michael K
Lewis, Anne
Hirsch, Vanessa M.
Graham, Barney S.
Mascola, John R.
Sacha, Jonah B.
Haigwood, Nancy L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hiv
Anticuerpos Neutralizantes
Patogenia
Transmision Perinatal
topic Hiv
Anticuerpos Neutralizantes
Patogenia
Transmision Perinatal
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1–specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8+ T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs.
Fil: Hessell, Ann J.. Oregon Health and Science University; Estados Unidos
Fil: Jaworski, Juan Pablo. Oregon Health and Science University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Epson, Erin. Oregon Health and Science University; Estados Unidos
Fil: Matsuda, Kenta. National Institutes of Health; Estados Unidos
Fil: Pandey, Shilpi. Oregon Health and Science University; Estados Unidos
Fil: Kahl, Christoph. Oregon Health and Science University; Estados Unidos
Fil: Reed, Jason. Oregon Health and Science University; Estados Unidos
Fil: Sutton, William F.. Oregon Health and Science University; Estados Unidos
Fil: Hammond, Katherine B.. Oregon Health and Science University; Estados Unidos
Fil: Cheever, Tracy A.. Oregon Health and Science University; Estados Unidos
Fil: Barnette, Philip T.. Oregon Health and Science University; Estados Unidos
Fil: Legasse, Alfred W.. Oregon Health and Science University; Estados Unidos
Fil: Planer, Shannon. Oregon Health and Science University; Estados Unidos
Fil: Stanton, Jeffrey J.. Oregon Health and Science University; Estados Unidos
Fil: Pegu, Amarendra. National Institutes of Health; Estados Unidos
Fil: Chen, Xuejun. National Institutes of Health; Estados Unidos
Fil: Wang, Keyun. National Institutes of Health; Estados Unidos
Fil: Siess, Don. Oregon Health and Science University; Estados Unidos
Fil: Burke, David. Oregon Health and Science University; Estados Unidos
Fil: Park, Byung S.. Oregon Health and Science University; Estados Unidos
Fil: Axthelm, Michael K. Oregon Health and Science University; Estados Unidos
Fil: Lewis, Anne. Oregon Health and Science University; Estados Unidos
Fil: Hirsch, Vanessa M.. National Institutes of Health; Estados Unidos
Fil: Graham, Barney S.. National Institutes of Health; Estados Unidos
Fil: Mascola, John R.. National Institutes of Health; Estados Unidos
Fil: Sacha, Jonah B.. Oregon Health and Science University; Estados Unidos
Fil: Haigwood, Nancy L.. Oregon Health and Science University; Estados Unidos
description Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1–specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8+ T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44381
Hessell, Ann J.; Jaworski, Juan Pablo; Epson, Erin; Matsuda, Kenta; Pandey, Shilpi; et al.; Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques; Nature Publishing Group; Nature Medicine; 22; 4; 3-2016; 362-368
1078-8956
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44381
identifier_str_mv Hessell, Ann J.; Jaworski, Juan Pablo; Epson, Erin; Matsuda, Kenta; Pandey, Shilpi; et al.; Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques; Nature Publishing Group; Nature Medicine; 22; 4; 3-2016; 362-368
1078-8956
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/nm.4063
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nm.4063
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082603379064832
score 13.22299