Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques
- Autores
- Hessell, Ann J.; Jaworski, Juan Pablo; Epson, Erin; Matsuda, Kenta; Pandey, Shilpi; Kahl, Christoph; Reed, Jason; Sutton, William F.; Hammond, Katherine B.; Cheever, Tracy A.; Barnette, Philip T.; Legasse, Alfred W.; Planer, Shannon; Stanton, Jeffrey J.; Pegu, Amarendra; Chen, Xuejun; Wang, Keyun; Siess, Don; Burke, David; Park, Byung S.; Axthelm, Michael K; Lewis, Anne; Hirsch, Vanessa M.; Graham, Barney S.; Mascola, John R.; Sacha, Jonah B.; Haigwood, Nancy L.
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1–specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8+ T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs.
Fil: Hessell, Ann J.. Oregon Health and Science University; Estados Unidos
Fil: Jaworski, Juan Pablo. Oregon Health and Science University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Epson, Erin. Oregon Health and Science University; Estados Unidos
Fil: Matsuda, Kenta. National Institutes of Health; Estados Unidos
Fil: Pandey, Shilpi. Oregon Health and Science University; Estados Unidos
Fil: Kahl, Christoph. Oregon Health and Science University; Estados Unidos
Fil: Reed, Jason. Oregon Health and Science University; Estados Unidos
Fil: Sutton, William F.. Oregon Health and Science University; Estados Unidos
Fil: Hammond, Katherine B.. Oregon Health and Science University; Estados Unidos
Fil: Cheever, Tracy A.. Oregon Health and Science University; Estados Unidos
Fil: Barnette, Philip T.. Oregon Health and Science University; Estados Unidos
Fil: Legasse, Alfred W.. Oregon Health and Science University; Estados Unidos
Fil: Planer, Shannon. Oregon Health and Science University; Estados Unidos
Fil: Stanton, Jeffrey J.. Oregon Health and Science University; Estados Unidos
Fil: Pegu, Amarendra. National Institutes of Health; Estados Unidos
Fil: Chen, Xuejun. National Institutes of Health; Estados Unidos
Fil: Wang, Keyun. National Institutes of Health; Estados Unidos
Fil: Siess, Don. Oregon Health and Science University; Estados Unidos
Fil: Burke, David. Oregon Health and Science University; Estados Unidos
Fil: Park, Byung S.. Oregon Health and Science University; Estados Unidos
Fil: Axthelm, Michael K. Oregon Health and Science University; Estados Unidos
Fil: Lewis, Anne. Oregon Health and Science University; Estados Unidos
Fil: Hirsch, Vanessa M.. National Institutes of Health; Estados Unidos
Fil: Graham, Barney S.. National Institutes of Health; Estados Unidos
Fil: Mascola, John R.. National Institutes of Health; Estados Unidos
Fil: Sacha, Jonah B.. Oregon Health and Science University; Estados Unidos
Fil: Haigwood, Nancy L.. Oregon Health and Science University; Estados Unidos - Materia
-
Hiv
Anticuerpos Neutralizantes
Patogenia
Transmision Perinatal - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/44381
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/44381 |
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3498 |
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CONICET Digital (CONICET) |
spelling |
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaquesHessell, Ann J.Jaworski, Juan PabloEpson, ErinMatsuda, KentaPandey, ShilpiKahl, ChristophReed, JasonSutton, William F.Hammond, Katherine B.Cheever, Tracy A.Barnette, Philip T.Legasse, Alfred W.Planer, ShannonStanton, Jeffrey J.Pegu, AmarendraChen, XuejunWang, KeyunSiess, DonBurke, DavidPark, Byung S.Axthelm, Michael KLewis, AnneHirsch, Vanessa M.Graham, Barney S.Mascola, John R.Sacha, Jonah B.Haigwood, Nancy L.HivAnticuerpos NeutralizantesPatogeniaTransmision Perinatalhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1–specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8+ T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs.Fil: Hessell, Ann J.. Oregon Health and Science University; Estados UnidosFil: Jaworski, Juan Pablo. Oregon Health and Science University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Epson, Erin. Oregon Health and Science University; Estados UnidosFil: Matsuda, Kenta. National Institutes of Health; Estados UnidosFil: Pandey, Shilpi. Oregon Health and Science University; Estados UnidosFil: Kahl, Christoph. Oregon Health and Science University; Estados UnidosFil: Reed, Jason. Oregon Health and Science University; Estados UnidosFil: Sutton, William F.. Oregon Health and Science University; Estados UnidosFil: Hammond, Katherine B.. Oregon Health and Science University; Estados UnidosFil: Cheever, Tracy A.. Oregon Health and Science University; Estados UnidosFil: Barnette, Philip T.. Oregon Health and Science University; Estados UnidosFil: Legasse, Alfred W.. Oregon Health and Science University; Estados UnidosFil: Planer, Shannon. Oregon Health and Science University; Estados UnidosFil: Stanton, Jeffrey J.. Oregon Health and Science University; Estados UnidosFil: Pegu, Amarendra. National Institutes of Health; Estados UnidosFil: Chen, Xuejun. National Institutes of Health; Estados UnidosFil: Wang, Keyun. National Institutes of Health; Estados UnidosFil: Siess, Don. Oregon Health and Science University; Estados UnidosFil: Burke, David. Oregon Health and Science University; Estados UnidosFil: Park, Byung S.. Oregon Health and Science University; Estados UnidosFil: Axthelm, Michael K. Oregon Health and Science University; Estados UnidosFil: Lewis, Anne. Oregon Health and Science University; Estados UnidosFil: Hirsch, Vanessa M.. National Institutes of Health; Estados UnidosFil: Graham, Barney S.. National Institutes of Health; Estados UnidosFil: Mascola, John R.. National Institutes of Health; Estados UnidosFil: Sacha, Jonah B.. Oregon Health and Science University; Estados UnidosFil: Haigwood, Nancy L.. Oregon Health and Science University; Estados UnidosNature Publishing Group2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44381Hessell, Ann J.; Jaworski, Juan Pablo; Epson, Erin; Matsuda, Kenta; Pandey, Shilpi; et al.; Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques; Nature Publishing Group; Nature Medicine; 22; 4; 3-2016; 362-3681078-8956CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/nm.4063info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nm.4063info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:01:26Zoai:ri.conicet.gov.ar:11336/44381instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:01:26.886CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques |
title |
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques |
spellingShingle |
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques Hessell, Ann J. Hiv Anticuerpos Neutralizantes Patogenia Transmision Perinatal |
title_short |
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques |
title_full |
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques |
title_fullStr |
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques |
title_full_unstemmed |
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques |
title_sort |
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques |
dc.creator.none.fl_str_mv |
Hessell, Ann J. Jaworski, Juan Pablo Epson, Erin Matsuda, Kenta Pandey, Shilpi Kahl, Christoph Reed, Jason Sutton, William F. Hammond, Katherine B. Cheever, Tracy A. Barnette, Philip T. Legasse, Alfred W. Planer, Shannon Stanton, Jeffrey J. Pegu, Amarendra Chen, Xuejun Wang, Keyun Siess, Don Burke, David Park, Byung S. Axthelm, Michael K Lewis, Anne Hirsch, Vanessa M. Graham, Barney S. Mascola, John R. Sacha, Jonah B. Haigwood, Nancy L. |
author |
Hessell, Ann J. |
author_facet |
Hessell, Ann J. Jaworski, Juan Pablo Epson, Erin Matsuda, Kenta Pandey, Shilpi Kahl, Christoph Reed, Jason Sutton, William F. Hammond, Katherine B. Cheever, Tracy A. Barnette, Philip T. Legasse, Alfred W. Planer, Shannon Stanton, Jeffrey J. Pegu, Amarendra Chen, Xuejun Wang, Keyun Siess, Don Burke, David Park, Byung S. Axthelm, Michael K Lewis, Anne Hirsch, Vanessa M. Graham, Barney S. Mascola, John R. Sacha, Jonah B. Haigwood, Nancy L. |
author_role |
author |
author2 |
Jaworski, Juan Pablo Epson, Erin Matsuda, Kenta Pandey, Shilpi Kahl, Christoph Reed, Jason Sutton, William F. Hammond, Katherine B. Cheever, Tracy A. Barnette, Philip T. Legasse, Alfred W. Planer, Shannon Stanton, Jeffrey J. Pegu, Amarendra Chen, Xuejun Wang, Keyun Siess, Don Burke, David Park, Byung S. Axthelm, Michael K Lewis, Anne Hirsch, Vanessa M. Graham, Barney S. Mascola, John R. Sacha, Jonah B. Haigwood, Nancy L. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Hiv Anticuerpos Neutralizantes Patogenia Transmision Perinatal |
topic |
Hiv Anticuerpos Neutralizantes Patogenia Transmision Perinatal |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1–specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8+ T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs. Fil: Hessell, Ann J.. Oregon Health and Science University; Estados Unidos Fil: Jaworski, Juan Pablo. Oregon Health and Science University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Epson, Erin. Oregon Health and Science University; Estados Unidos Fil: Matsuda, Kenta. National Institutes of Health; Estados Unidos Fil: Pandey, Shilpi. Oregon Health and Science University; Estados Unidos Fil: Kahl, Christoph. Oregon Health and Science University; Estados Unidos Fil: Reed, Jason. Oregon Health and Science University; Estados Unidos Fil: Sutton, William F.. Oregon Health and Science University; Estados Unidos Fil: Hammond, Katherine B.. Oregon Health and Science University; Estados Unidos Fil: Cheever, Tracy A.. Oregon Health and Science University; Estados Unidos Fil: Barnette, Philip T.. Oregon Health and Science University; Estados Unidos Fil: Legasse, Alfred W.. Oregon Health and Science University; Estados Unidos Fil: Planer, Shannon. Oregon Health and Science University; Estados Unidos Fil: Stanton, Jeffrey J.. Oregon Health and Science University; Estados Unidos Fil: Pegu, Amarendra. National Institutes of Health; Estados Unidos Fil: Chen, Xuejun. National Institutes of Health; Estados Unidos Fil: Wang, Keyun. National Institutes of Health; Estados Unidos Fil: Siess, Don. Oregon Health and Science University; Estados Unidos Fil: Burke, David. Oregon Health and Science University; Estados Unidos Fil: Park, Byung S.. Oregon Health and Science University; Estados Unidos Fil: Axthelm, Michael K. Oregon Health and Science University; Estados Unidos Fil: Lewis, Anne. Oregon Health and Science University; Estados Unidos Fil: Hirsch, Vanessa M.. National Institutes of Health; Estados Unidos Fil: Graham, Barney S.. National Institutes of Health; Estados Unidos Fil: Mascola, John R.. National Institutes of Health; Estados Unidos Fil: Sacha, Jonah B.. Oregon Health and Science University; Estados Unidos Fil: Haigwood, Nancy L.. Oregon Health and Science University; Estados Unidos |
description |
Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1–specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8+ T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/44381 Hessell, Ann J.; Jaworski, Juan Pablo; Epson, Erin; Matsuda, Kenta; Pandey, Shilpi; et al.; Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques; Nature Publishing Group; Nature Medicine; 22; 4; 3-2016; 362-368 1078-8956 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/44381 |
identifier_str_mv |
Hessell, Ann J.; Jaworski, Juan Pablo; Epson, Erin; Matsuda, Kenta; Pandey, Shilpi; et al.; Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques; Nature Publishing Group; Nature Medicine; 22; 4; 3-2016; 362-368 1078-8956 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/nm.4063 info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nm.4063 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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