Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol

Autores
Luengo, Carina Vanesa; Crescitelli, Maria Carla; Lopez, Nicolas Alfredo; Avena, Marcelo Javier
Año de publicación
2022
Idioma
inglés
Tipo de recurso
conjunto de datos
Estado
Descripción
This work examines the effect of drug structure and ionization degree on the formation and properties of biocompatible layered double hydroxides (LDH) intercalated with ibuprofen and paracetamol. Ibuprofen (pKa 1⁄4 5.3) is in its anionic form, whereas paracetamol (pKa 9.4) is only partially ionized at the synthesis pH (9.0), and thus intercalation is expected to be different in the two cases. Chemical analyses, X-ray diffraction, electron microscopy, infrared spectroscopy and thermal analyses were applied to characterize the materials. Dissolution kinetics and drug release kinetics were also investigated, in an ample range of pH (3.0e9.0) in NaCl solutions, and in physiological buffers (1.2, 4.5 and 6.8). All characterization tech- niques showed that an efficient intercalation of ibuprofen took place, resulting in a material with 30% of its weight corresponding to the drug. On the contrary, all techniques revealed a very poor intercalation of paracetamol (1.2%). The dissolution kinetics of LDHs was highly pH-dependent, being higher as pH decreased. The drug release kinetics, conversely, increased as pH increased. In physiological buffers the release rate depended not only on the pH but also on the type of buffer. This last behavior is useful to control the release in different parts of the digestive system.
Fil: Luengo, Carina Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Crescitelli, Maria Carla. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Lopez, Nicolas Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Datos sujetos al derecho de propiedad intelectual o industrial
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
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oai:ri.conicet.gov.ar:11336/160543
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spelling Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of ParacetamolLuengo, Carina VanesaCrescitelli, Maria CarlaLopez, Nicolas AlfredoAvena, Marcelo Javierhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This work examines the effect of drug structure and ionization degree on the formation and properties of biocompatible layered double hydroxides (LDH) intercalated with ibuprofen and paracetamol. Ibuprofen (pKa 1⁄4 5.3) is in its anionic form, whereas paracetamol (pKa 9.4) is only partially ionized at the synthesis pH (9.0), and thus intercalation is expected to be different in the two cases. Chemical analyses, X-ray diffraction, electron microscopy, infrared spectroscopy and thermal analyses were applied to characterize the materials. Dissolution kinetics and drug release kinetics were also investigated, in an ample range of pH (3.0e9.0) in NaCl solutions, and in physiological buffers (1.2, 4.5 and 6.8). All characterization tech- niques showed that an efficient intercalation of ibuprofen took place, resulting in a material with 30% of its weight corresponding to the drug. On the contrary, all techniques revealed a very poor intercalation of paracetamol (1.2%). The dissolution kinetics of LDHs was highly pH-dependent, being higher as pH decreased. The drug release kinetics, conversely, increased as pH increased. In physiological buffers the release rate depended not only on the pH but also on the type of buffer. This last behavior is useful to control the release in different parts of the digestive system.Fil: Luengo, Carina Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Crescitelli, Maria Carla. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Lopez, Nicolas Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina2022info:ar-repo/semantics/conjuntoDeDatosv1.0info:eu-repo/semantics/dataSetimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffhttp://hdl.handle.net/11336/160543Luengo, Carina Vanesa; Crescitelli, Maria Carla; Lopez, Nicolas Alfredo; Avena, Marcelo Javier; (2022): Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/160543CONICET DigitalCONICETenginfo:eu-repo/grantAgreement/Ministerio de Ciencia. Tecnología e Innovación Productiva. Agencia Nacional de Promoción Científica y Tecnológica/PICT-2018-03592info:eu-repo/grantAgreement/Universidad Nacional del Sur/PICT-2018-03592info:eu-repo/semantics/restrictedAccessDatos sujetos al derecho de propiedad intelectual o industrialreponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:22Zoai:ri.conicet.gov.ar:11336/160543instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:22.514CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol
title Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol
spellingShingle Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol
Luengo, Carina Vanesa
title_short Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol
title_full Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol
title_fullStr Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol
title_full_unstemmed Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol
title_sort Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol
dc.creator.none.fl_str_mv Luengo, Carina Vanesa
Crescitelli, Maria Carla
Lopez, Nicolas Alfredo
Avena, Marcelo Javier
author Luengo, Carina Vanesa
author_facet Luengo, Carina Vanesa
Crescitelli, Maria Carla
Lopez, Nicolas Alfredo
Avena, Marcelo Javier
author_role author
author2 Crescitelli, Maria Carla
Lopez, Nicolas Alfredo
Avena, Marcelo Javier
author2_role author
author
author
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This work examines the effect of drug structure and ionization degree on the formation and properties of biocompatible layered double hydroxides (LDH) intercalated with ibuprofen and paracetamol. Ibuprofen (pKa 1⁄4 5.3) is in its anionic form, whereas paracetamol (pKa 9.4) is only partially ionized at the synthesis pH (9.0), and thus intercalation is expected to be different in the two cases. Chemical analyses, X-ray diffraction, electron microscopy, infrared spectroscopy and thermal analyses were applied to characterize the materials. Dissolution kinetics and drug release kinetics were also investigated, in an ample range of pH (3.0e9.0) in NaCl solutions, and in physiological buffers (1.2, 4.5 and 6.8). All characterization tech- niques showed that an efficient intercalation of ibuprofen took place, resulting in a material with 30% of its weight corresponding to the drug. On the contrary, all techniques revealed a very poor intercalation of paracetamol (1.2%). The dissolution kinetics of LDHs was highly pH-dependent, being higher as pH decreased. The drug release kinetics, conversely, increased as pH increased. In physiological buffers the release rate depended not only on the pH but also on the type of buffer. This last behavior is useful to control the release in different parts of the digestive system.
Fil: Luengo, Carina Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Crescitelli, Maria Carla. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Lopez, Nicolas Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description This work examines the effect of drug structure and ionization degree on the formation and properties of biocompatible layered double hydroxides (LDH) intercalated with ibuprofen and paracetamol. Ibuprofen (pKa 1⁄4 5.3) is in its anionic form, whereas paracetamol (pKa 9.4) is only partially ionized at the synthesis pH (9.0), and thus intercalation is expected to be different in the two cases. Chemical analyses, X-ray diffraction, electron microscopy, infrared spectroscopy and thermal analyses were applied to characterize the materials. Dissolution kinetics and drug release kinetics were also investigated, in an ample range of pH (3.0e9.0) in NaCl solutions, and in physiological buffers (1.2, 4.5 and 6.8). All characterization tech- niques showed that an efficient intercalation of ibuprofen took place, resulting in a material with 30% of its weight corresponding to the drug. On the contrary, all techniques revealed a very poor intercalation of paracetamol (1.2%). The dissolution kinetics of LDHs was highly pH-dependent, being higher as pH decreased. The drug release kinetics, conversely, increased as pH increased. In physiological buffers the release rate depended not only on the pH but also on the type of buffer. This last behavior is useful to control the release in different parts of the digestive system.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:ar-repo/semantics/conjuntoDeDatos
v1.0
info:eu-repo/semantics/dataSet
format dataSet
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/160543
Luengo, Carina Vanesa; Crescitelli, Maria Carla; Lopez, Nicolas Alfredo; Avena, Marcelo Javier; (2022): Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/160543
CONICET Digital
CONICET
url http://hdl.handle.net/11336/160543
identifier_str_mv Luengo, Carina Vanesa; Crescitelli, Maria Carla; Lopez, Nicolas Alfredo; Avena, Marcelo Javier; (2022): Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/160543
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/grantAgreement/Universidad Nacional del Sur/PICT-2018-03592
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