Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors

Autores
Gonzalez, Patricia Verónica; Schiöth, Helgi Birgir; Lasaga, Mercedes Isabel; Scimonelli, Teresa Nieves
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Interleukin-1beta (IL-1beta) significantly influences memory consolidation. Treatments that raise the level of IL-1beta in the brain, given after training, impair contextual fear conditioning. The melanocortin alpha-MSH exerts potent anti-inflammatory actions by physiologically antagonizing the effect of pro-inflammatory cytokines. Five subtypes of melanocortin receptors (MC1R-MC5R) have been identified, with MC3R and MC4R predominating in the central nervous system. The present experiments show that injection of IL-1beta (5ng/0.25mul) in dorsal hippocampus up to 15min after training decreased freezing during the contextual fear test. The treatment with IL-1beta (5ng/0.25mul) 12h after conditioning cause amnesia when animals were tested 7days post training. Thus, our results also demonstrated that IL-1beta can influence persistence of long-term memory. We determined that animals previously injected with IL-1beta can acquire a new contextual fear memory, demonstrating that the hippocampus was not damaged. Treatment with alpha-MSH (0.05mug/0.25mul) blocked the effect of IL-1beta on contextual fear memory. Administration of the MC4 receptor antagonist HS014 (0.5mug/0.25mul) reversed the effect of alpha-MSH. However, treatment with gamma-MSH (0.5mug/0.25mul), an MC3 agonist, did not affect IL-1beta-induced impairment of memory consolidation. These results suggest that alpha-MSH, through central MC4R can inhibit the effect of IL-1beta on memory consolidation.
Fil: Gonzalez, Patricia Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Schiöth, Helgi Birgir. Uppsala Universitet.; Suecia
Fil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina
Fil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Materia
INTERLEUKIN-1BETA
MELANOCORTINS
MELANOCORTINS RECEPTORS
FEAR CONDITIONING
MEMORY CONSOLIDATION
MEMORY PERSISTENCE
HIPPOCAMPUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/104814
Acceder
id CONICETDig_b9373752080ed49ac049de42d9ed082e
oai_identifier_str oai:ri.conicet.gov.ar:11336/104814
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptorsGonzalez, Patricia VerónicaSchiöth, Helgi BirgirLasaga, Mercedes IsabelScimonelli, Teresa NievesINTERLEUKIN-1BETAMELANOCORTINSMELANOCORTINS RECEPTORSFEAR CONDITIONINGMEMORY CONSOLIDATIONMEMORY PERSISTENCEHIPPOCAMPUShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Interleukin-1beta (IL-1beta) significantly influences memory consolidation. Treatments that raise the level of IL-1beta in the brain, given after training, impair contextual fear conditioning. The melanocortin alpha-MSH exerts potent anti-inflammatory actions by physiologically antagonizing the effect of pro-inflammatory cytokines. Five subtypes of melanocortin receptors (MC1R-MC5R) have been identified, with MC3R and MC4R predominating in the central nervous system. The present experiments show that injection of IL-1beta (5ng/0.25mul) in dorsal hippocampus up to 15min after training decreased freezing during the contextual fear test. The treatment with IL-1beta (5ng/0.25mul) 12h after conditioning cause amnesia when animals were tested 7days post training. Thus, our results also demonstrated that IL-1beta can influence persistence of long-term memory. We determined that animals previously injected with IL-1beta can acquire a new contextual fear memory, demonstrating that the hippocampus was not damaged. Treatment with alpha-MSH (0.05mug/0.25mul) blocked the effect of IL-1beta on contextual fear memory. Administration of the MC4 receptor antagonist HS014 (0.5mug/0.25mul) reversed the effect of alpha-MSH. However, treatment with gamma-MSH (0.5mug/0.25mul), an MC3 agonist, did not affect IL-1beta-induced impairment of memory consolidation. These results suggest that alpha-MSH, through central MC4R can inhibit the effect of IL-1beta on memory consolidation.Fil: Gonzalez, Patricia Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Schiöth, Helgi Birgir. Uppsala Universitet.; SueciaFil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; ArgentinaFil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaAcademic Press Inc Elsevier Science2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/104814Gonzalez, Patricia Verónica; Schiöth, Helgi Birgir; Lasaga, Mercedes Isabel; Scimonelli, Teresa Nieves; Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors; Academic Press Inc Elsevier Science; Brain Behavior And Immunity; 23; 12-2009; 617-6220889-1591CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbi.2009.03.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0889159109000695info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-29T12:43:36Zoai:ri.conicet.gov.ar:11336/104814instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-29 12:43:36.773CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
title Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
spellingShingle Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
Gonzalez, Patricia Verónica
INTERLEUKIN-1BETA
MELANOCORTINS
MELANOCORTINS RECEPTORS
FEAR CONDITIONING
MEMORY CONSOLIDATION
MEMORY PERSISTENCE
HIPPOCAMPUS
title_short Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
title_full Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
title_fullStr Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
title_full_unstemmed Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
title_sort Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
dc.creator.none.fl_str_mv Gonzalez, Patricia Verónica
Schiöth, Helgi Birgir
Lasaga, Mercedes Isabel
Scimonelli, Teresa Nieves
author Gonzalez, Patricia Verónica
author_facet Gonzalez, Patricia Verónica
Schiöth, Helgi Birgir
Lasaga, Mercedes Isabel
Scimonelli, Teresa Nieves
author_role author
author2 Schiöth, Helgi Birgir
Lasaga, Mercedes Isabel
Scimonelli, Teresa Nieves
author2_role author
author
author
dc.subject.none.fl_str_mv INTERLEUKIN-1BETA
MELANOCORTINS
MELANOCORTINS RECEPTORS
FEAR CONDITIONING
MEMORY CONSOLIDATION
MEMORY PERSISTENCE
HIPPOCAMPUS
topic INTERLEUKIN-1BETA
MELANOCORTINS
MELANOCORTINS RECEPTORS
FEAR CONDITIONING
MEMORY CONSOLIDATION
MEMORY PERSISTENCE
HIPPOCAMPUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Interleukin-1beta (IL-1beta) significantly influences memory consolidation. Treatments that raise the level of IL-1beta in the brain, given after training, impair contextual fear conditioning. The melanocortin alpha-MSH exerts potent anti-inflammatory actions by physiologically antagonizing the effect of pro-inflammatory cytokines. Five subtypes of melanocortin receptors (MC1R-MC5R) have been identified, with MC3R and MC4R predominating in the central nervous system. The present experiments show that injection of IL-1beta (5ng/0.25mul) in dorsal hippocampus up to 15min after training decreased freezing during the contextual fear test. The treatment with IL-1beta (5ng/0.25mul) 12h after conditioning cause amnesia when animals were tested 7days post training. Thus, our results also demonstrated that IL-1beta can influence persistence of long-term memory. We determined that animals previously injected with IL-1beta can acquire a new contextual fear memory, demonstrating that the hippocampus was not damaged. Treatment with alpha-MSH (0.05mug/0.25mul) blocked the effect of IL-1beta on contextual fear memory. Administration of the MC4 receptor antagonist HS014 (0.5mug/0.25mul) reversed the effect of alpha-MSH. However, treatment with gamma-MSH (0.5mug/0.25mul), an MC3 agonist, did not affect IL-1beta-induced impairment of memory consolidation. These results suggest that alpha-MSH, through central MC4R can inhibit the effect of IL-1beta on memory consolidation.
Fil: Gonzalez, Patricia Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Schiöth, Helgi Birgir. Uppsala Universitet.; Suecia
Fil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina
Fil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
description Interleukin-1beta (IL-1beta) significantly influences memory consolidation. Treatments that raise the level of IL-1beta in the brain, given after training, impair contextual fear conditioning. The melanocortin alpha-MSH exerts potent anti-inflammatory actions by physiologically antagonizing the effect of pro-inflammatory cytokines. Five subtypes of melanocortin receptors (MC1R-MC5R) have been identified, with MC3R and MC4R predominating in the central nervous system. The present experiments show that injection of IL-1beta (5ng/0.25mul) in dorsal hippocampus up to 15min after training decreased freezing during the contextual fear test. The treatment with IL-1beta (5ng/0.25mul) 12h after conditioning cause amnesia when animals were tested 7days post training. Thus, our results also demonstrated that IL-1beta can influence persistence of long-term memory. We determined that animals previously injected with IL-1beta can acquire a new contextual fear memory, demonstrating that the hippocampus was not damaged. Treatment with alpha-MSH (0.05mug/0.25mul) blocked the effect of IL-1beta on contextual fear memory. Administration of the MC4 receptor antagonist HS014 (0.5mug/0.25mul) reversed the effect of alpha-MSH. However, treatment with gamma-MSH (0.5mug/0.25mul), an MC3 agonist, did not affect IL-1beta-induced impairment of memory consolidation. These results suggest that alpha-MSH, through central MC4R can inhibit the effect of IL-1beta on memory consolidation.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/104814
Gonzalez, Patricia Verónica; Schiöth, Helgi Birgir; Lasaga, Mercedes Isabel; Scimonelli, Teresa Nieves; Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors; Academic Press Inc Elsevier Science; Brain Behavior And Immunity; 23; 12-2009; 617-622
0889-1591
CONICET Digital
CONICET
url http://hdl.handle.net/11336/104814
identifier_str_mv Gonzalez, Patricia Verónica; Schiöth, Helgi Birgir; Lasaga, Mercedes Isabel; Scimonelli, Teresa Nieves; Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors; Academic Press Inc Elsevier Science; Brain Behavior And Immunity; 23; 12-2009; 617-622
0889-1591
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbi.2009.03.001
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0889159109000695
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.10058

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