The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function

Autores
Lorenzo Martín, L. Francisco; Menacho Márquez, Mauricio Ariel; Fernández Parejo, Natalia; Rodríguez Fdez, Sonia; Pascual, Gloria; Abad, Antonio; Crespo, PIero; Dosil, Mercedes; Benitah, Salvador A.; Bustelo, Xosé R.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this issue, we have used here mouse models in which the activity of guanosine nucleotide exchange factors of the Vav subfamily has been manipulated using both gain- and loss-of-function strategies. These experiments indicate that Vav2 and Vav3 regulate the number, functional status, and responsiveness of hair follicle bulge stem cells. This is linked to gene expression programs related to the reinforcement of the identity and the quiescent state of normal SSCs. By contrast, in the case of cancer stem cells, they promote transcriptomal programs associated with the identity, activation state, and cytoskeletal remodeling. These results underscore the role of these Rho exchange factors in the regulation of normal and tumor epidermal stem cells.
Fil: Lorenzo Martín, L. Francisco. Consejo Superior de Investigaciones Científicas; España
Fil: Menacho Márquez, Mauricio Ariel. Consejo Superior de Investigaciones Científicas; España. Universidad de Salamanca; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Fernández Parejo, Natalia. Consejo Superior de Investigaciones Científicas; España
Fil: Rodríguez Fdez, Sonia. Consejo Superior de Investigaciones Científicas; España
Fil: Pascual, Gloria. Consejo Superior de Investigaciones Científicas; España
Fil: Abad, Antonio. No especifíca;
Fil: Crespo, PIero. Universidad de Cantabria; España
Fil: Dosil, Mercedes. Consejo Superior de Investigaciones Científicas; España
Fil: Benitah, Salvador A.. Consejo Superior de Investigaciones Científicas; España
Fil: Bustelo, Xosé R.. Consejo Superior de Investigaciones Científicas; España
Materia
stem cells
skin
Vav
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/214177
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/214177
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell functionLorenzo Martín, L. FranciscoMenacho Márquez, Mauricio ArielFernández Parejo, NataliaRodríguez Fdez, SoniaPascual, GloriaAbad, AntonioCrespo, PIeroDosil, MercedesBenitah, Salvador A.Bustelo, Xosé R.stem cellsskinVavhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this issue, we have used here mouse models in which the activity of guanosine nucleotide exchange factors of the Vav subfamily has been manipulated using both gain- and loss-of-function strategies. These experiments indicate that Vav2 and Vav3 regulate the number, functional status, and responsiveness of hair follicle bulge stem cells. This is linked to gene expression programs related to the reinforcement of the identity and the quiescent state of normal SSCs. By contrast, in the case of cancer stem cells, they promote transcriptomal programs associated with the identity, activation state, and cytoskeletal remodeling. These results underscore the role of these Rho exchange factors in the regulation of normal and tumor epidermal stem cells.Fil: Lorenzo Martín, L. Francisco. Consejo Superior de Investigaciones Científicas; EspañaFil: Menacho Márquez, Mauricio Ariel. Consejo Superior de Investigaciones Científicas; España. Universidad de Salamanca; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Fernández Parejo, Natalia. Consejo Superior de Investigaciones Científicas; EspañaFil: Rodríguez Fdez, Sonia. Consejo Superior de Investigaciones Científicas; EspañaFil: Pascual, Gloria. Consejo Superior de Investigaciones Científicas; EspañaFil: Abad, Antonio. No especifíca;Fil: Crespo, PIero. Universidad de Cantabria; EspañaFil: Dosil, Mercedes. Consejo Superior de Investigaciones Científicas; EspañaFil: Benitah, Salvador A.. Consejo Superior de Investigaciones Científicas; EspañaFil: Bustelo, Xosé R.. Consejo Superior de Investigaciones Científicas; EspañaNature Publishing Group2022-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214177Lorenzo Martín, L. Francisco; Menacho Márquez, Mauricio Ariel; Fernández Parejo, Natalia; Rodríguez Fdez, Sonia; Pascual, Gloria; et al.; The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function; Nature Publishing Group; Oncogene; 41; 24; 5-2022; 3341-33540950-9232CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41388-022-02341-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:04:34Zoai:ri.conicet.gov.ar:11336/214177instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:04:34.236CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
title The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
spellingShingle The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
Lorenzo Martín, L. Francisco
stem cells
skin
Vav
title_short The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
title_full The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
title_fullStr The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
title_full_unstemmed The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
title_sort The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
dc.creator.none.fl_str_mv Lorenzo Martín, L. Francisco
Menacho Márquez, Mauricio Ariel
Fernández Parejo, Natalia
Rodríguez Fdez, Sonia
Pascual, Gloria
Abad, Antonio
Crespo, PIero
Dosil, Mercedes
Benitah, Salvador A.
Bustelo, Xosé R.
author Lorenzo Martín, L. Francisco
author_facet Lorenzo Martín, L. Francisco
Menacho Márquez, Mauricio Ariel
Fernández Parejo, Natalia
Rodríguez Fdez, Sonia
Pascual, Gloria
Abad, Antonio
Crespo, PIero
Dosil, Mercedes
Benitah, Salvador A.
Bustelo, Xosé R.
author_role author
author2 Menacho Márquez, Mauricio Ariel
Fernández Parejo, Natalia
Rodríguez Fdez, Sonia
Pascual, Gloria
Abad, Antonio
Crespo, PIero
Dosil, Mercedes
Benitah, Salvador A.
Bustelo, Xosé R.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv stem cells
skin
Vav
topic stem cells
skin
Vav
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this issue, we have used here mouse models in which the activity of guanosine nucleotide exchange factors of the Vav subfamily has been manipulated using both gain- and loss-of-function strategies. These experiments indicate that Vav2 and Vav3 regulate the number, functional status, and responsiveness of hair follicle bulge stem cells. This is linked to gene expression programs related to the reinforcement of the identity and the quiescent state of normal SSCs. By contrast, in the case of cancer stem cells, they promote transcriptomal programs associated with the identity, activation state, and cytoskeletal remodeling. These results underscore the role of these Rho exchange factors in the regulation of normal and tumor epidermal stem cells.
Fil: Lorenzo Martín, L. Francisco. Consejo Superior de Investigaciones Científicas; España
Fil: Menacho Márquez, Mauricio Ariel. Consejo Superior de Investigaciones Científicas; España. Universidad de Salamanca; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Fernández Parejo, Natalia. Consejo Superior de Investigaciones Científicas; España
Fil: Rodríguez Fdez, Sonia. Consejo Superior de Investigaciones Científicas; España
Fil: Pascual, Gloria. Consejo Superior de Investigaciones Científicas; España
Fil: Abad, Antonio. No especifíca;
Fil: Crespo, PIero. Universidad de Cantabria; España
Fil: Dosil, Mercedes. Consejo Superior de Investigaciones Científicas; España
Fil: Benitah, Salvador A.. Consejo Superior de Investigaciones Científicas; España
Fil: Bustelo, Xosé R.. Consejo Superior de Investigaciones Científicas; España
description It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this issue, we have used here mouse models in which the activity of guanosine nucleotide exchange factors of the Vav subfamily has been manipulated using both gain- and loss-of-function strategies. These experiments indicate that Vav2 and Vav3 regulate the number, functional status, and responsiveness of hair follicle bulge stem cells. This is linked to gene expression programs related to the reinforcement of the identity and the quiescent state of normal SSCs. By contrast, in the case of cancer stem cells, they promote transcriptomal programs associated with the identity, activation state, and cytoskeletal remodeling. These results underscore the role of these Rho exchange factors in the regulation of normal and tumor epidermal stem cells.
publishDate 2022
dc.date.none.fl_str_mv 2022-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/214177
Lorenzo Martín, L. Francisco; Menacho Márquez, Mauricio Ariel; Fernández Parejo, Natalia; Rodríguez Fdez, Sonia; Pascual, Gloria; et al.; The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function; Nature Publishing Group; Oncogene; 41; 24; 5-2022; 3341-3354
0950-9232
CONICET Digital
CONICET
url http://hdl.handle.net/11336/214177
identifier_str_mv Lorenzo Martín, L. Francisco; Menacho Márquez, Mauricio Ariel; Fernández Parejo, Natalia; Rodríguez Fdez, Sonia; Pascual, Gloria; et al.; The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function; Nature Publishing Group; Oncogene; 41; 24; 5-2022; 3341-3354
0950-9232
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41388-022-02341-7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781305304383488
score 12.982451

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