The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
- Autores
- Lorenzo Martín, L. Francisco; Menacho Márquez, Mauricio Ariel; Fernández Parejo, Natalia; Rodríguez Fdez, Sonia; Pascual, Gloria; Abad, Antonio; Crespo, PIero; Dosil, Mercedes; Benitah, Salvador A.; Bustelo, Xosé R.
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this issue, we have used here mouse models in which the activity of guanosine nucleotide exchange factors of the Vav subfamily has been manipulated using both gain- and loss-of-function strategies. These experiments indicate that Vav2 and Vav3 regulate the number, functional status, and responsiveness of hair follicle bulge stem cells. This is linked to gene expression programs related to the reinforcement of the identity and the quiescent state of normal SSCs. By contrast, in the case of cancer stem cells, they promote transcriptomal programs associated with the identity, activation state, and cytoskeletal remodeling. These results underscore the role of these Rho exchange factors in the regulation of normal and tumor epidermal stem cells.
Fil: Lorenzo Martín, L. Francisco. Consejo Superior de Investigaciones Científicas; España
Fil: Menacho Márquez, Mauricio Ariel. Consejo Superior de Investigaciones Científicas; España. Universidad de Salamanca; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Fernández Parejo, Natalia. Consejo Superior de Investigaciones Científicas; España
Fil: Rodríguez Fdez, Sonia. Consejo Superior de Investigaciones Científicas; España
Fil: Pascual, Gloria. Consejo Superior de Investigaciones Científicas; España
Fil: Abad, Antonio. No especifíca;
Fil: Crespo, PIero. Universidad de Cantabria; España
Fil: Dosil, Mercedes. Consejo Superior de Investigaciones Científicas; España
Fil: Benitah, Salvador A.. Consejo Superior de Investigaciones Científicas; España
Fil: Bustelo, Xosé R.. Consejo Superior de Investigaciones Científicas; España - Materia
-
stem cells
skin
Vav - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/214177
Ver los metadatos del registro completo
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The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell functionLorenzo Martín, L. FranciscoMenacho Márquez, Mauricio ArielFernández Parejo, NataliaRodríguez Fdez, SoniaPascual, GloriaAbad, AntonioCrespo, PIeroDosil, MercedesBenitah, Salvador A.Bustelo, Xosé R.stem cellsskinVavhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this issue, we have used here mouse models in which the activity of guanosine nucleotide exchange factors of the Vav subfamily has been manipulated using both gain- and loss-of-function strategies. These experiments indicate that Vav2 and Vav3 regulate the number, functional status, and responsiveness of hair follicle bulge stem cells. This is linked to gene expression programs related to the reinforcement of the identity and the quiescent state of normal SSCs. By contrast, in the case of cancer stem cells, they promote transcriptomal programs associated with the identity, activation state, and cytoskeletal remodeling. These results underscore the role of these Rho exchange factors in the regulation of normal and tumor epidermal stem cells.Fil: Lorenzo Martín, L. Francisco. Consejo Superior de Investigaciones Científicas; EspañaFil: Menacho Márquez, Mauricio Ariel. Consejo Superior de Investigaciones Científicas; España. Universidad de Salamanca; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Fernández Parejo, Natalia. Consejo Superior de Investigaciones Científicas; EspañaFil: Rodríguez Fdez, Sonia. Consejo Superior de Investigaciones Científicas; EspañaFil: Pascual, Gloria. Consejo Superior de Investigaciones Científicas; EspañaFil: Abad, Antonio. No especifíca;Fil: Crespo, PIero. Universidad de Cantabria; EspañaFil: Dosil, Mercedes. Consejo Superior de Investigaciones Científicas; EspañaFil: Benitah, Salvador A.. Consejo Superior de Investigaciones Científicas; EspañaFil: Bustelo, Xosé R.. Consejo Superior de Investigaciones Científicas; EspañaNature Publishing Group2022-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214177Lorenzo Martín, L. Francisco; Menacho Márquez, Mauricio Ariel; Fernández Parejo, Natalia; Rodríguez Fdez, Sonia; Pascual, Gloria; et al.; The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function; Nature Publishing Group; Oncogene; 41; 24; 5-2022; 3341-33540950-9232CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41388-022-02341-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:27Zoai:ri.conicet.gov.ar:11336/214177instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:27.999CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function |
title |
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function |
spellingShingle |
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function Lorenzo Martín, L. Francisco stem cells skin Vav |
title_short |
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function |
title_full |
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function |
title_fullStr |
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function |
title_full_unstemmed |
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function |
title_sort |
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function |
dc.creator.none.fl_str_mv |
Lorenzo Martín, L. Francisco Menacho Márquez, Mauricio Ariel Fernández Parejo, Natalia Rodríguez Fdez, Sonia Pascual, Gloria Abad, Antonio Crespo, PIero Dosil, Mercedes Benitah, Salvador A. Bustelo, Xosé R. |
author |
Lorenzo Martín, L. Francisco |
author_facet |
Lorenzo Martín, L. Francisco Menacho Márquez, Mauricio Ariel Fernández Parejo, Natalia Rodríguez Fdez, Sonia Pascual, Gloria Abad, Antonio Crespo, PIero Dosil, Mercedes Benitah, Salvador A. Bustelo, Xosé R. |
author_role |
author |
author2 |
Menacho Márquez, Mauricio Ariel Fernández Parejo, Natalia Rodríguez Fdez, Sonia Pascual, Gloria Abad, Antonio Crespo, PIero Dosil, Mercedes Benitah, Salvador A. Bustelo, Xosé R. |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
stem cells skin Vav |
topic |
stem cells skin Vav |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this issue, we have used here mouse models in which the activity of guanosine nucleotide exchange factors of the Vav subfamily has been manipulated using both gain- and loss-of-function strategies. These experiments indicate that Vav2 and Vav3 regulate the number, functional status, and responsiveness of hair follicle bulge stem cells. This is linked to gene expression programs related to the reinforcement of the identity and the quiescent state of normal SSCs. By contrast, in the case of cancer stem cells, they promote transcriptomal programs associated with the identity, activation state, and cytoskeletal remodeling. These results underscore the role of these Rho exchange factors in the regulation of normal and tumor epidermal stem cells. Fil: Lorenzo Martín, L. Francisco. Consejo Superior de Investigaciones Científicas; España Fil: Menacho Márquez, Mauricio Ariel. Consejo Superior de Investigaciones Científicas; España. Universidad de Salamanca; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina Fil: Fernández Parejo, Natalia. Consejo Superior de Investigaciones Científicas; España Fil: Rodríguez Fdez, Sonia. Consejo Superior de Investigaciones Científicas; España Fil: Pascual, Gloria. Consejo Superior de Investigaciones Científicas; España Fil: Abad, Antonio. No especifíca; Fil: Crespo, PIero. Universidad de Cantabria; España Fil: Dosil, Mercedes. Consejo Superior de Investigaciones Científicas; España Fil: Benitah, Salvador A.. Consejo Superior de Investigaciones Científicas; España Fil: Bustelo, Xosé R.. Consejo Superior de Investigaciones Científicas; España |
description |
It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this issue, we have used here mouse models in which the activity of guanosine nucleotide exchange factors of the Vav subfamily has been manipulated using both gain- and loss-of-function strategies. These experiments indicate that Vav2 and Vav3 regulate the number, functional status, and responsiveness of hair follicle bulge stem cells. This is linked to gene expression programs related to the reinforcement of the identity and the quiescent state of normal SSCs. By contrast, in the case of cancer stem cells, they promote transcriptomal programs associated with the identity, activation state, and cytoskeletal remodeling. These results underscore the role of these Rho exchange factors in the regulation of normal and tumor epidermal stem cells. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/214177 Lorenzo Martín, L. Francisco; Menacho Márquez, Mauricio Ariel; Fernández Parejo, Natalia; Rodríguez Fdez, Sonia; Pascual, Gloria; et al.; The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function; Nature Publishing Group; Oncogene; 41; 24; 5-2022; 3341-3354 0950-9232 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/214177 |
identifier_str_mv |
Lorenzo Martín, L. Francisco; Menacho Márquez, Mauricio Ariel; Fernández Parejo, Natalia; Rodríguez Fdez, Sonia; Pascual, Gloria; et al.; The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function; Nature Publishing Group; Oncogene; 41; 24; 5-2022; 3341-3354 0950-9232 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41388-022-02341-7 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613143662166016 |
score |
13.070432 |