Deleterious effect of chronic continuous hypoxia on oral health

Autores
Terrizzi, Antonela Romina; Fernández Solari, José Javier; Lee, Ching Ming; Conti, Maria Ines; Martinez, Maria del Pilar
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To evaluate the effect of chronic continuous hypoxia (CCH) in alveolar bone and its correlation with the inflammatory markers which play a key role in the development of periodontitis. Material and methods: Wistar rats were exposed to CCH (600 mbar, 3 months). Macroscopic and histological analyses of alveolar bone were performed, together with measurement of oxidative stress and inflammatory parameters in gums and submandibular glands (SMG). Results: HCC induced cortical alveolar bone loss, decreased interradicular bone volume and increased the periodontal ligament height compared to control rats (p < 0.05). CCH enhanced iNOS activity in gums (from 2735,04 ± 662,96 nmol/min/mg proteins to 4289,58 ± 915,63 p < 0.05) and in SMG (from 56,71 ± 12,05 nmol/min/mg proteins to 90,15 ± 21,78 p < 0.05). PGE2 did not change in gums or in SMG by means of CCH, while TNFα decreased in gums (p < 0.05). Regarding oxidative stress, thiobarbituric acid reactive species concentration in CCH animals was higher both in gums as in SMG, and catalase activity was decreased in SMG. Conclusion: Higher iNOS activity both in gums and SMG under CCH could be associated with the alveolar bone loss observed. The increase in oxidative stress occurring in SMG and gums, together with a lower antioxidant capacity might indicate a deleterious effect of HX in oral health.
Fil: Terrizzi, Antonela Romina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernández Solari, José Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Lee, Ching Ming. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Conti, Maria Ines. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Martinez, Maria del Pilar. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Materia
Alveolar Bone Loss
Environmental Hypoxia
Inflammation
Periodontitis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39375
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/39375
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Deleterious effect of chronic continuous hypoxia on oral healthTerrizzi, Antonela RominaFernández Solari, José JavierLee, Ching MingConti, Maria InesMartinez, Maria del PilarAlveolar Bone LossEnvironmental HypoxiaInflammationPeriodontitishttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: To evaluate the effect of chronic continuous hypoxia (CCH) in alveolar bone and its correlation with the inflammatory markers which play a key role in the development of periodontitis. Material and methods: Wistar rats were exposed to CCH (600 mbar, 3 months). Macroscopic and histological analyses of alveolar bone were performed, together with measurement of oxidative stress and inflammatory parameters in gums and submandibular glands (SMG). Results: HCC induced cortical alveolar bone loss, decreased interradicular bone volume and increased the periodontal ligament height compared to control rats (p < 0.05). CCH enhanced iNOS activity in gums (from 2735,04 ± 662,96 nmol/min/mg proteins to 4289,58 ± 915,63 p < 0.05) and in SMG (from 56,71 ± 12,05 nmol/min/mg proteins to 90,15 ± 21,78 p < 0.05). PGE2 did not change in gums or in SMG by means of CCH, while TNFα decreased in gums (p < 0.05). Regarding oxidative stress, thiobarbituric acid reactive species concentration in CCH animals was higher both in gums as in SMG, and catalase activity was decreased in SMG. Conclusion: Higher iNOS activity both in gums and SMG under CCH could be associated with the alveolar bone loss observed. The increase in oxidative stress occurring in SMG and gums, together with a lower antioxidant capacity might indicate a deleterious effect of HX in oral health.Fil: Terrizzi, Antonela Romina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fernández Solari, José Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: Lee, Ching Ming. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: Conti, Maria Ines. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaFil: Martinez, Maria del Pilar. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; ArgentinaPergamon-Elsevier Science Ltd2016-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39375Terrizzi, Antonela Romina; Fernández Solari, José Javier; Lee, Ching Ming; Conti, Maria Ines; Martinez, Maria del Pilar; Deleterious effect of chronic continuous hypoxia on oral health; Pergamon-Elsevier Science Ltd; Archives of Oral Biology; 72; 12-2016; 1-70003-9969CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0003996916301984info:eu-repo/semantics/altIdentifier/doi/10.1016/j.archoralbio.2016.08.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:20Zoai:ri.conicet.gov.ar:11336/39375instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:20.97CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Deleterious effect of chronic continuous hypoxia on oral health
title Deleterious effect of chronic continuous hypoxia on oral health
spellingShingle Deleterious effect of chronic continuous hypoxia on oral health
Terrizzi, Antonela Romina
Alveolar Bone Loss
Environmental Hypoxia
Inflammation
Periodontitis
title_short Deleterious effect of chronic continuous hypoxia on oral health
title_full Deleterious effect of chronic continuous hypoxia on oral health
title_fullStr Deleterious effect of chronic continuous hypoxia on oral health
title_full_unstemmed Deleterious effect of chronic continuous hypoxia on oral health
title_sort Deleterious effect of chronic continuous hypoxia on oral health
dc.creator.none.fl_str_mv Terrizzi, Antonela Romina
Fernández Solari, José Javier
Lee, Ching Ming
Conti, Maria Ines
Martinez, Maria del Pilar
author Terrizzi, Antonela Romina
author_facet Terrizzi, Antonela Romina
Fernández Solari, José Javier
Lee, Ching Ming
Conti, Maria Ines
Martinez, Maria del Pilar
author_role author
author2 Fernández Solari, José Javier
Lee, Ching Ming
Conti, Maria Ines
Martinez, Maria del Pilar
author2_role author
author
author
author
dc.subject.none.fl_str_mv Alveolar Bone Loss
Environmental Hypoxia
Inflammation
Periodontitis
topic Alveolar Bone Loss
Environmental Hypoxia
Inflammation
Periodontitis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To evaluate the effect of chronic continuous hypoxia (CCH) in alveolar bone and its correlation with the inflammatory markers which play a key role in the development of periodontitis. Material and methods: Wistar rats were exposed to CCH (600 mbar, 3 months). Macroscopic and histological analyses of alveolar bone were performed, together with measurement of oxidative stress and inflammatory parameters in gums and submandibular glands (SMG). Results: HCC induced cortical alveolar bone loss, decreased interradicular bone volume and increased the periodontal ligament height compared to control rats (p < 0.05). CCH enhanced iNOS activity in gums (from 2735,04 ± 662,96 nmol/min/mg proteins to 4289,58 ± 915,63 p < 0.05) and in SMG (from 56,71 ± 12,05 nmol/min/mg proteins to 90,15 ± 21,78 p < 0.05). PGE2 did not change in gums or in SMG by means of CCH, while TNFα decreased in gums (p < 0.05). Regarding oxidative stress, thiobarbituric acid reactive species concentration in CCH animals was higher both in gums as in SMG, and catalase activity was decreased in SMG. Conclusion: Higher iNOS activity both in gums and SMG under CCH could be associated with the alveolar bone loss observed. The increase in oxidative stress occurring in SMG and gums, together with a lower antioxidant capacity might indicate a deleterious effect of HX in oral health.
Fil: Terrizzi, Antonela Romina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernández Solari, José Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Lee, Ching Ming. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Conti, Maria Ines. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
Fil: Martinez, Maria del Pilar. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina
description Objective: To evaluate the effect of chronic continuous hypoxia (CCH) in alveolar bone and its correlation with the inflammatory markers which play a key role in the development of periodontitis. Material and methods: Wistar rats were exposed to CCH (600 mbar, 3 months). Macroscopic and histological analyses of alveolar bone were performed, together with measurement of oxidative stress and inflammatory parameters in gums and submandibular glands (SMG). Results: HCC induced cortical alveolar bone loss, decreased interradicular bone volume and increased the periodontal ligament height compared to control rats (p < 0.05). CCH enhanced iNOS activity in gums (from 2735,04 ± 662,96 nmol/min/mg proteins to 4289,58 ± 915,63 p < 0.05) and in SMG (from 56,71 ± 12,05 nmol/min/mg proteins to 90,15 ± 21,78 p < 0.05). PGE2 did not change in gums or in SMG by means of CCH, while TNFα decreased in gums (p < 0.05). Regarding oxidative stress, thiobarbituric acid reactive species concentration in CCH animals was higher both in gums as in SMG, and catalase activity was decreased in SMG. Conclusion: Higher iNOS activity both in gums and SMG under CCH could be associated with the alveolar bone loss observed. The increase in oxidative stress occurring in SMG and gums, together with a lower antioxidant capacity might indicate a deleterious effect of HX in oral health.
publishDate 2016
dc.date.none.fl_str_mv 2016-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39375
Terrizzi, Antonela Romina; Fernández Solari, José Javier; Lee, Ching Ming; Conti, Maria Ines; Martinez, Maria del Pilar; Deleterious effect of chronic continuous hypoxia on oral health; Pergamon-Elsevier Science Ltd; Archives of Oral Biology; 72; 12-2016; 1-7
0003-9969
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39375
identifier_str_mv Terrizzi, Antonela Romina; Fernández Solari, José Javier; Lee, Ching Ming; Conti, Maria Ines; Martinez, Maria del Pilar; Deleterious effect of chronic continuous hypoxia on oral health; Pergamon-Elsevier Science Ltd; Archives of Oral Biology; 72; 12-2016; 1-7
0003-9969
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0003996916301984
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.archoralbio.2016.08.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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