Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise

Autores
Gagliardi, Juan A.; Maciel, Neiva; Castellano, José L.; Masoli, Osvaldo; Miksztowicz, Verónica Julieta; Berg, Gabriela Alicia; Bermejo, Emilse; Lazzari, María Ángela; Gelpi, Ricardo Jorge
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The aim of our study was to evaluate the effect of programmed physical activity and a single exercise test on the number of CD309+ circulating endothelial progenitor cell (EPC) and their relation to the variation in plasma levels of VEGF in chronic coronary patients. Methods: 21 patients < 75 years with chronic stable coronary artery disease were included. All patients underwent exercise myocardial perfusion SPECT. Then, participants were divided into two groups: one group (11 patients) underwent cardiac rehabilitation program and the other (10 patients) continued with the standard treatment. Blood samples were obtained at baseline, 30 min after exercise ended and at one and three months during follow-up. Results: VEGF values decreased significantly after exercise SPECT test. After one month, there was a significant increase in VEGF levels compared to those measured immediately after exercise. All patients showed a decrease in the values of EPC at 1 and 3-month follow-up. There was an inverse and statistically significant relation between change of EPC and VEGF between the baseline and 1 month. Conclusions: The increase of VEGF at 1-month, with respect to baseline values correlated with decreased levels of EPC. This association was independent of the onset of ischemia in the perfusion study.
Fil: Gagliardi, Juan A.. Gobierno de la Ciudad de Buenos Aires. Ministerio de Salud; Argentina
Fil: Maciel, Neiva. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dr. Cosme Argerich"; Argentina
Fil: Castellano, José L.. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dr. Cosme Argerich"; Argentina
Fil: Masoli, Osvaldo. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dr. Cosme Argerich"; Argentina
Fil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bermejo, Emilse. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Lazzari, María Ángela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gelpi, Ricardo Jorge. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Vegf
Excercise
Progenitor Cell
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38917
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/38917
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exerciseGagliardi, Juan A.Maciel, NeivaCastellano, José L.Masoli, OsvaldoMiksztowicz, Verónica JulietaBerg, Gabriela AliciaBermejo, EmilseLazzari, María ÁngelaGelpi, Ricardo JorgeVegfExcerciseProgenitor Cellhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: The aim of our study was to evaluate the effect of programmed physical activity and a single exercise test on the number of CD309+ circulating endothelial progenitor cell (EPC) and their relation to the variation in plasma levels of VEGF in chronic coronary patients. Methods: 21 patients < 75 years with chronic stable coronary artery disease were included. All patients underwent exercise myocardial perfusion SPECT. Then, participants were divided into two groups: one group (11 patients) underwent cardiac rehabilitation program and the other (10 patients) continued with the standard treatment. Blood samples were obtained at baseline, 30 min after exercise ended and at one and three months during follow-up. Results: VEGF values decreased significantly after exercise SPECT test. After one month, there was a significant increase in VEGF levels compared to those measured immediately after exercise. All patients showed a decrease in the values of EPC at 1 and 3-month follow-up. There was an inverse and statistically significant relation between change of EPC and VEGF between the baseline and 1 month. Conclusions: The increase of VEGF at 1-month, with respect to baseline values correlated with decreased levels of EPC. This association was independent of the onset of ischemia in the perfusion study.Fil: Gagliardi, Juan A.. Gobierno de la Ciudad de Buenos Aires. Ministerio de Salud; ArgentinaFil: Maciel, Neiva. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dr. Cosme Argerich"; ArgentinaFil: Castellano, José L.. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dr. Cosme Argerich"; ArgentinaFil: Masoli, Osvaldo. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dr. Cosme Argerich"; ArgentinaFil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bermejo, Emilse. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Lazzari, María Ángela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gelpi, Ricardo Jorge. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPergamon-Elsevier Science Ltd2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38917Gagliardi, Juan A.; Maciel, Neiva; Castellano, José L.; Masoli, Osvaldo; Miksztowicz, Verónica Julieta; et al.; Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise; Pergamon-Elsevier Science Ltd; Thrombosis Research; 137; 1-2016; 92-960049-3848CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.thromres.2015.11.012info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0049384815301882info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:00Zoai:ri.conicet.gov.ar:11336/38917instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:00.374CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise
title Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise
spellingShingle Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise
Gagliardi, Juan A.
Vegf
Excercise
Progenitor Cell
title_short Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise
title_full Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise
title_fullStr Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise
title_full_unstemmed Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise
title_sort Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise
dc.creator.none.fl_str_mv Gagliardi, Juan A.
Maciel, Neiva
Castellano, José L.
Masoli, Osvaldo
Miksztowicz, Verónica Julieta
Berg, Gabriela Alicia
Bermejo, Emilse
Lazzari, María Ángela
Gelpi, Ricardo Jorge
author Gagliardi, Juan A.
author_facet Gagliardi, Juan A.
Maciel, Neiva
Castellano, José L.
Masoli, Osvaldo
Miksztowicz, Verónica Julieta
Berg, Gabriela Alicia
Bermejo, Emilse
Lazzari, María Ángela
Gelpi, Ricardo Jorge
author_role author
author2 Maciel, Neiva
Castellano, José L.
Masoli, Osvaldo
Miksztowicz, Verónica Julieta
Berg, Gabriela Alicia
Bermejo, Emilse
Lazzari, María Ángela
Gelpi, Ricardo Jorge
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Vegf
Excercise
Progenitor Cell
topic Vegf
Excercise
Progenitor Cell
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The aim of our study was to evaluate the effect of programmed physical activity and a single exercise test on the number of CD309+ circulating endothelial progenitor cell (EPC) and their relation to the variation in plasma levels of VEGF in chronic coronary patients. Methods: 21 patients < 75 years with chronic stable coronary artery disease were included. All patients underwent exercise myocardial perfusion SPECT. Then, participants were divided into two groups: one group (11 patients) underwent cardiac rehabilitation program and the other (10 patients) continued with the standard treatment. Blood samples were obtained at baseline, 30 min after exercise ended and at one and three months during follow-up. Results: VEGF values decreased significantly after exercise SPECT test. After one month, there was a significant increase in VEGF levels compared to those measured immediately after exercise. All patients showed a decrease in the values of EPC at 1 and 3-month follow-up. There was an inverse and statistically significant relation between change of EPC and VEGF between the baseline and 1 month. Conclusions: The increase of VEGF at 1-month, with respect to baseline values correlated with decreased levels of EPC. This association was independent of the onset of ischemia in the perfusion study.
Fil: Gagliardi, Juan A.. Gobierno de la Ciudad de Buenos Aires. Ministerio de Salud; Argentina
Fil: Maciel, Neiva. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dr. Cosme Argerich"; Argentina
Fil: Castellano, José L.. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dr. Cosme Argerich"; Argentina
Fil: Masoli, Osvaldo. Ciudad Autónoma de Buenos Aires. Hospital General de Agudos "Dr. Cosme Argerich"; Argentina
Fil: Miksztowicz, Verónica Julieta. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bermejo, Emilse. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Lazzari, María Ángela. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gelpi, Ricardo Jorge. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiopatología Cardiovascular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: The aim of our study was to evaluate the effect of programmed physical activity and a single exercise test on the number of CD309+ circulating endothelial progenitor cell (EPC) and their relation to the variation in plasma levels of VEGF in chronic coronary patients. Methods: 21 patients < 75 years with chronic stable coronary artery disease were included. All patients underwent exercise myocardial perfusion SPECT. Then, participants were divided into two groups: one group (11 patients) underwent cardiac rehabilitation program and the other (10 patients) continued with the standard treatment. Blood samples were obtained at baseline, 30 min after exercise ended and at one and three months during follow-up. Results: VEGF values decreased significantly after exercise SPECT test. After one month, there was a significant increase in VEGF levels compared to those measured immediately after exercise. All patients showed a decrease in the values of EPC at 1 and 3-month follow-up. There was an inverse and statistically significant relation between change of EPC and VEGF between the baseline and 1 month. Conclusions: The increase of VEGF at 1-month, with respect to baseline values correlated with decreased levels of EPC. This association was independent of the onset of ischemia in the perfusion study.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38917
Gagliardi, Juan A.; Maciel, Neiva; Castellano, José L.; Masoli, Osvaldo; Miksztowicz, Verónica Julieta; et al.; Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise; Pergamon-Elsevier Science Ltd; Thrombosis Research; 137; 1-2016; 92-96
0049-3848
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38917
identifier_str_mv Gagliardi, Juan A.; Maciel, Neiva; Castellano, José L.; Masoli, Osvaldo; Miksztowicz, Verónica Julieta; et al.; Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise; Pergamon-Elsevier Science Ltd; Thrombosis Research; 137; 1-2016; 92-96
0049-3848
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.thromres.2015.11.012
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0049384815301882
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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