Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus

Autores
Cerqueira, Ana F.R.; Pérez, María Eugenia; Gsponer, Natalia Soledad; Neves, Maria Graça P. M. S.; Parola, A. Jorge; Durantini, Edgardo Néstor; Tomé, Augusto C.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The assessment of thiazolothiazoles (TzTz) as photosensitizers in photodynamic inactivation (PDI) experiments is reported for the first time. Mono and dicationic TzTz derivatives were synthesized, and their photosensitizing ability was assessed on Staphylococcus aureus cells, both in suspension or attached to a surface, and using white light. The biological results showed that the photodynamic efficiency of these derivatives is dependent on the TzTz structure and irradiation time. The best results were obtained with the monocationic derivative TPATzTzPyMeþthat allowed to reach a value over 7 log (99.9999 %) cell inactivation after white light irradiation for 30 min. Furthermore, TPATzTzPyMeþalso revealed to be effective on the inactivation of S. aureus adhered to surfaces, a good indication of its potential to prevent biofilm formation. TPATzTzPyMeþwas also effective against Escherichia coli, with a reduction in cell viability of 5.7 log after irradiation for 30 min.
Fil: Cerqueira, Ana F.R.. Universidade de Aveiro; Portugal
Fil: Pérez, María Eugenia. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Fil: Gsponer, Natalia Soledad. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Fil: Neves, Maria Graça P. M. S.. Universidade de Aveiro; Portugal
Fil: Parola, A. Jorge. Universidade de Aveiro; Portugal
Fil: Durantini, Edgardo Néstor. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Fil: Tomé, Augusto C.. Universidade de Aveiro; Portugal
Materia
THIAZOLOTHIAZOLE
PHOTODYNAMIC INACTIVATION
MICROORGANISM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/243163
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureusCerqueira, Ana F.R.Pérez, María EugeniaGsponer, Natalia SoledadNeves, Maria Graça P. M. S.Parola, A. JorgeDurantini, Edgardo NéstorTomé, Augusto C.THIAZOLOTHIAZOLEPHOTODYNAMIC INACTIVATIONMICROORGANISMhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The assessment of thiazolothiazoles (TzTz) as photosensitizers in photodynamic inactivation (PDI) experiments is reported for the first time. Mono and dicationic TzTz derivatives were synthesized, and their photosensitizing ability was assessed on Staphylococcus aureus cells, both in suspension or attached to a surface, and using white light. The biological results showed that the photodynamic efficiency of these derivatives is dependent on the TzTz structure and irradiation time. The best results were obtained with the monocationic derivative TPATzTzPyMeþthat allowed to reach a value over 7 log (99.9999 %) cell inactivation after white light irradiation for 30 min. Furthermore, TPATzTzPyMeþalso revealed to be effective on the inactivation of S. aureus adhered to surfaces, a good indication of its potential to prevent biofilm formation. TPATzTzPyMeþwas also effective against Escherichia coli, with a reduction in cell viability of 5.7 log after irradiation for 30 min.Fil: Cerqueira, Ana F.R.. Universidade de Aveiro; PortugalFil: Pérez, María Eugenia. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Gsponer, Natalia Soledad. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Neves, Maria Graça P. M. S.. Universidade de Aveiro; PortugalFil: Parola, A. Jorge. Universidade de Aveiro; PortugalFil: Durantini, Edgardo Néstor. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Tomé, Augusto C.. Universidade de Aveiro; PortugalElsevier Science SA2024-06-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/243163Cerqueira, Ana F.R.; Pérez, María Eugenia; Gsponer, Natalia Soledad; Neves, Maria Graça P. M. S.; Parola, A. Jorge; et al.; Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus; Elsevier Science SA; Journal of Photochemistry and Photobiology A: Chemistry; 456; 1158; 24-6-2024; 1-71010-6030CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1010603024003939info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotochem.2024.115849info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:45:52Zoai:ri.conicet.gov.ar:11336/243163instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:45:53.268CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus
title Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus
spellingShingle Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus
Cerqueira, Ana F.R.
THIAZOLOTHIAZOLE
PHOTODYNAMIC INACTIVATION
MICROORGANISM
title_short Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus
title_full Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus
title_fullStr Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus
title_full_unstemmed Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus
title_sort Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus
dc.creator.none.fl_str_mv Cerqueira, Ana F.R.
Pérez, María Eugenia
Gsponer, Natalia Soledad
Neves, Maria Graça P. M. S.
Parola, A. Jorge
Durantini, Edgardo Néstor
Tomé, Augusto C.
author Cerqueira, Ana F.R.
author_facet Cerqueira, Ana F.R.
Pérez, María Eugenia
Gsponer, Natalia Soledad
Neves, Maria Graça P. M. S.
Parola, A. Jorge
Durantini, Edgardo Néstor
Tomé, Augusto C.
author_role author
author2 Pérez, María Eugenia
Gsponer, Natalia Soledad
Neves, Maria Graça P. M. S.
Parola, A. Jorge
Durantini, Edgardo Néstor
Tomé, Augusto C.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv THIAZOLOTHIAZOLE
PHOTODYNAMIC INACTIVATION
MICROORGANISM
topic THIAZOLOTHIAZOLE
PHOTODYNAMIC INACTIVATION
MICROORGANISM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The assessment of thiazolothiazoles (TzTz) as photosensitizers in photodynamic inactivation (PDI) experiments is reported for the first time. Mono and dicationic TzTz derivatives were synthesized, and their photosensitizing ability was assessed on Staphylococcus aureus cells, both in suspension or attached to a surface, and using white light. The biological results showed that the photodynamic efficiency of these derivatives is dependent on the TzTz structure and irradiation time. The best results were obtained with the monocationic derivative TPATzTzPyMeþthat allowed to reach a value over 7 log (99.9999 %) cell inactivation after white light irradiation for 30 min. Furthermore, TPATzTzPyMeþalso revealed to be effective on the inactivation of S. aureus adhered to surfaces, a good indication of its potential to prevent biofilm formation. TPATzTzPyMeþwas also effective against Escherichia coli, with a reduction in cell viability of 5.7 log after irradiation for 30 min.
Fil: Cerqueira, Ana F.R.. Universidade de Aveiro; Portugal
Fil: Pérez, María Eugenia. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Fil: Gsponer, Natalia Soledad. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Fil: Neves, Maria Graça P. M. S.. Universidade de Aveiro; Portugal
Fil: Parola, A. Jorge. Universidade de Aveiro; Portugal
Fil: Durantini, Edgardo Néstor. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina
Fil: Tomé, Augusto C.. Universidade de Aveiro; Portugal
description The assessment of thiazolothiazoles (TzTz) as photosensitizers in photodynamic inactivation (PDI) experiments is reported for the first time. Mono and dicationic TzTz derivatives were synthesized, and their photosensitizing ability was assessed on Staphylococcus aureus cells, both in suspension or attached to a surface, and using white light. The biological results showed that the photodynamic efficiency of these derivatives is dependent on the TzTz structure and irradiation time. The best results were obtained with the monocationic derivative TPATzTzPyMeþthat allowed to reach a value over 7 log (99.9999 %) cell inactivation after white light irradiation for 30 min. Furthermore, TPATzTzPyMeþalso revealed to be effective on the inactivation of S. aureus adhered to surfaces, a good indication of its potential to prevent biofilm formation. TPATzTzPyMeþwas also effective against Escherichia coli, with a reduction in cell viability of 5.7 log after irradiation for 30 min.
publishDate 2024
dc.date.none.fl_str_mv 2024-06-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/243163
Cerqueira, Ana F.R.; Pérez, María Eugenia; Gsponer, Natalia Soledad; Neves, Maria Graça P. M. S.; Parola, A. Jorge; et al.; Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus; Elsevier Science SA; Journal of Photochemistry and Photobiology A: Chemistry; 456; 1158; 24-6-2024; 1-7
1010-6030
CONICET Digital
CONICET
url http://hdl.handle.net/11336/243163
identifier_str_mv Cerqueira, Ana F.R.; Pérez, María Eugenia; Gsponer, Natalia Soledad; Neves, Maria Graça P. M. S.; Parola, A. Jorge; et al.; Cationic thiazolothiazole derivatives – A new class of photosensitizing agents against Staphylococcus aureus; Elsevier Science SA; Journal of Photochemistry and Photobiology A: Chemistry; 456; 1158; 24-6-2024; 1-7
1010-6030
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1010603024003939
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotochem.2024.115849
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science SA
publisher.none.fl_str_mv Elsevier Science SA
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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