Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes

Autores
Soto Espinoza, Silvia Lorena; Rezzano, Irene Noemí; Sobral, Santiago Andres; Carballo, Romina Raquel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A highly hydrophobic porphyrin: di-octadecyl-amide deuteroporphyrin (D-ODA) was synthesized and incorporated into liposomes (Lipo-D-ODA) through self-assembling of the aliphatic chains. From the fluorescence spectra, it was concluded that the long alkyl carboxylate chains accommodate the sensitizer into the lipid bilayer, is less exposed to quenching induced by aggregation. The light excited liposome Lipo-D*-ODA activated the ground state molecular oxygen to produce oxygen singlet or superoxide anion. The electrochemical responses of two structurally different redox-active analytes were studied. Quercetin oxidation at 200 mV was only observed after irradiation on the Lipo-D-ODA/Quercetin, indicating that it is embedded in the liposome and requires membrane rupture. On the contrary, the signal of Ferrocene-ODA was independent of irradiation because the redox polar moieties (Ferrocene) were oriented in aqueous space.
Fil: Soto Espinoza, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Rezzano, Irene Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Sobral, Santiago Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Carballo, Romina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Materia
BIOMIMETIC
LIPOSOMES
OPTICAL MATERIALS AND PROPERTIES
PHOTO-RESPONSE
PORPHYRINS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93099
Acceder
id CONICETDig_b4f3c079e705339e4a9d96175181cb33
oai_identifier_str oai:ri.conicet.gov.ar:11336/93099
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomesSoto Espinoza, Silvia LorenaRezzano, Irene NoemíSobral, Santiago AndresCarballo, Romina RaquelBIOMIMETICLIPOSOMESOPTICAL MATERIALS AND PROPERTIESPHOTO-RESPONSEPORPHYRINShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A highly hydrophobic porphyrin: di-octadecyl-amide deuteroporphyrin (D-ODA) was synthesized and incorporated into liposomes (Lipo-D-ODA) through self-assembling of the aliphatic chains. From the fluorescence spectra, it was concluded that the long alkyl carboxylate chains accommodate the sensitizer into the lipid bilayer, is less exposed to quenching induced by aggregation. The light excited liposome Lipo-D*-ODA activated the ground state molecular oxygen to produce oxygen singlet or superoxide anion. The electrochemical responses of two structurally different redox-active analytes were studied. Quercetin oxidation at 200 mV was only observed after irradiation on the Lipo-D-ODA/Quercetin, indicating that it is embedded in the liposome and requires membrane rupture. On the contrary, the signal of Ferrocene-ODA was independent of irradiation because the redox polar moieties (Ferrocene) were oriented in aqueous space.Fil: Soto Espinoza, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Rezzano, Irene Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Sobral, Santiago Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Carballo, Romina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaElsevier Science Sa2018-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93099Soto Espinoza, Silvia Lorena; Rezzano, Irene Noemí; Sobral, Santiago Andres; Carballo, Romina Raquel; Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes; Elsevier Science Sa; Journal of Photochemistry and Photobiology A: Chemistry; 364; 1-9-2018; 140-1441010-6030CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S1010603018302223info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotochem.2018.06.010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T08:39:58Zoai:ri.conicet.gov.ar:11336/93099instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 08:39:58.496CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes
title Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes
spellingShingle Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes
Soto Espinoza, Silvia Lorena
BIOMIMETIC
LIPOSOMES
OPTICAL MATERIALS AND PROPERTIES
PHOTO-RESPONSE
PORPHYRINS
title_short Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes
title_full Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes
title_fullStr Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes
title_full_unstemmed Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes
title_sort Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes
dc.creator.none.fl_str_mv Soto Espinoza, Silvia Lorena
Rezzano, Irene Noemí
Sobral, Santiago Andres
Carballo, Romina Raquel
author Soto Espinoza, Silvia Lorena
author_facet Soto Espinoza, Silvia Lorena
Rezzano, Irene Noemí
Sobral, Santiago Andres
Carballo, Romina Raquel
author_role author
author2 Rezzano, Irene Noemí
Sobral, Santiago Andres
Carballo, Romina Raquel
author2_role author
author
author
dc.subject.none.fl_str_mv BIOMIMETIC
LIPOSOMES
OPTICAL MATERIALS AND PROPERTIES
PHOTO-RESPONSE
PORPHYRINS
topic BIOMIMETIC
LIPOSOMES
OPTICAL MATERIALS AND PROPERTIES
PHOTO-RESPONSE
PORPHYRINS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A highly hydrophobic porphyrin: di-octadecyl-amide deuteroporphyrin (D-ODA) was synthesized and incorporated into liposomes (Lipo-D-ODA) through self-assembling of the aliphatic chains. From the fluorescence spectra, it was concluded that the long alkyl carboxylate chains accommodate the sensitizer into the lipid bilayer, is less exposed to quenching induced by aggregation. The light excited liposome Lipo-D*-ODA activated the ground state molecular oxygen to produce oxygen singlet or superoxide anion. The electrochemical responses of two structurally different redox-active analytes were studied. Quercetin oxidation at 200 mV was only observed after irradiation on the Lipo-D-ODA/Quercetin, indicating that it is embedded in the liposome and requires membrane rupture. On the contrary, the signal of Ferrocene-ODA was independent of irradiation because the redox polar moieties (Ferrocene) were oriented in aqueous space.
Fil: Soto Espinoza, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Rezzano, Irene Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Sobral, Santiago Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Carballo, Romina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
description A highly hydrophobic porphyrin: di-octadecyl-amide deuteroporphyrin (D-ODA) was synthesized and incorporated into liposomes (Lipo-D-ODA) through self-assembling of the aliphatic chains. From the fluorescence spectra, it was concluded that the long alkyl carboxylate chains accommodate the sensitizer into the lipid bilayer, is less exposed to quenching induced by aggregation. The light excited liposome Lipo-D*-ODA activated the ground state molecular oxygen to produce oxygen singlet or superoxide anion. The electrochemical responses of two structurally different redox-active analytes were studied. Quercetin oxidation at 200 mV was only observed after irradiation on the Lipo-D-ODA/Quercetin, indicating that it is embedded in the liposome and requires membrane rupture. On the contrary, the signal of Ferrocene-ODA was independent of irradiation because the redox polar moieties (Ferrocene) were oriented in aqueous space.
publishDate 2018
dc.date.none.fl_str_mv 2018-09-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93099
Soto Espinoza, Silvia Lorena; Rezzano, Irene Noemí; Sobral, Santiago Andres; Carballo, Romina Raquel; Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes; Elsevier Science Sa; Journal of Photochemistry and Photobiology A: Chemistry; 364; 1-9-2018; 140-144
1010-6030
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93099
identifier_str_mv Soto Espinoza, Silvia Lorena; Rezzano, Irene Noemí; Sobral, Santiago Andres; Carballo, Romina Raquel; Approach for the electrochemical analysis of hydrophobic compounds included in photo-responsive liposomes; Elsevier Science Sa; Journal of Photochemistry and Photobiology A: Chemistry; 364; 1-9-2018; 140-144
1010-6030
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S1010603018302223
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotochem.2018.06.010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Sa
publisher.none.fl_str_mv Elsevier Science Sa
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1849872376279334912
score 13.011256

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