The origin of human pathogenicity and biological interactions in Chaetothyriales
- Autores
- Quan, Yu; Deng, Shuwen; Prenafeta Boldủ, Francesc X.; Mayer, Veronika E.; Muggia, Lucia; Cometto, Agnese; Vicente, Vania A.; Silva, Nickolas Menezes da; Grisolia, Maria Eduarda; Song, Yinggai; Ahmed, Sarah A.; Niu, Xueke; Lima, Bruna Jacomel Favoreto de Souza; Feng, Peiying; Vitale, Roxana Gabriela; Teixeira, Marcus; Sudhadham, Montarop; Azevedo, Conceicao Pedrozo e Silva de; Bocca, Anamelia; Haase, Gerhard; Selbmann, Laura; Shi, Dongmei; Kang, Yingqian; de Hoog, Sybren
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fungi in the order Chaetothyriales are renowned for their ability to cause human infections. Nevertheless, they are not regarded as primary pathogens, but rather as opportunists with a natural habitat in the environment. Extremotolerance is a major trend in the order, but quite diferent from black yeasts in Capnodiales which focus on endurance, an important additional parameter is advancing toxin management. In the ancestral ecology of rock colonization, the association with metabolite-producing lichens is signifcant. Ant-association, dealing with pheromones and repellents, is another mainstay in the order. The phylogenetically derived family, Herpotrichiellaceae, shows dual ecology in monoaromatic hydrocarbon assimilation and the ability to cause disease in humans and cold-blooded vertebrates. In this study, data on ecology, phylogeny, and genomics were collected and analyzed in order to support this hypothesis on the evolutionary route of the species of Chaetothyriales. Comparing the ribosomal tree with that of enzymes involved in toluene degradation, a signifcant expansion of cytochromes is observed and the toluene catabolism is found to be complete in some of the Herpotrichiellaceae. This might enhance human systemic infection. However, since most species have to be traumatically inoculated in order to cause disease, their invasive potential is categorized as opportunism. Only in chromoblastomycosis, true pathogenicity might be surmised. The criterion would be the possible escape of agents of vertebrate disease from the host, enabling dispersal of adapted genotypes to subsequent generations.
Fil: Quan, Yu. Radboud University Medical Center; Países Bajos. Guizhou Medical University; China
Fil: Deng, Shuwen. People’s Hospital of Suzhou National New & Hi-Tech Industrial Development Zone; China
Fil: Prenafeta Boldủ, Francesc X.. Institute of Agrifood Research and Technology; España
Fil: Mayer, Veronika E.. University of Vienna; Austria
Fil: Muggia, Lucia. Università degli Studi di Trieste; Italia
Fil: Cometto, Agnese. Università degli Studi di Trieste; Italia
Fil: Vicente, Vania A.. Universidade Federal do Paraná; Brasil
Fil: Silva, Nickolas Menezes da. Universidade Federal do Paraná; Brasil
Fil: Grisolia, Maria Eduarda. Universidade Federal do Paraná; Brasil
Fil: Song, Yinggai. Peking University; China
Fil: Ahmed, Sarah A.. Radboud University Medical Center; Países Bajos
Fil: Niu, Xueke. Radboud University Medical Center; Países Bajos. Guizhou Medical University; China
Fil: Lima, Bruna Jacomel Favoreto de Souza. Universidade Federal do Paraná; Brasil
Fil: Feng, Peiying. Sun Yat-sen University; China
Fil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Teixeira, Marcus. Universidade do Brasília; Brasil
Fil: Sudhadham, Montarop. Suan Sunandha Rajabhat University; Tailandia
Fil: Azevedo, Conceicao Pedrozo e Silva de. Federal University of Maranhao; Brasil
Fil: Bocca, Anamelia. Universidade do Brasília; Brasil
Fil: Haase, Gerhard. RWTH Aachen University Hospital; Alemania
Fil: Selbmann, Laura. Università degli Studi della Tuscia; Italia
Fil: Shi, Dongmei. People’s Hospital; China
Fil: Kang, Yingqian. Guizhou Medical University; China
Fil: de Hoog, Sybren. Radboud University Medical Center; Países Bajos. Guizhou Medical University; China. People’s Hospital of Suzhou National New & Hi-Tech Industrial Development Zone; China. Universidade Federal do Paraná; Brasil. Peking University; China - Materia
-
HUMAN PATHOGENICITY
CHAETOTHYRIALES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/235485
Ver los metadatos del registro completo
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The origin of human pathogenicity and biological interactions in ChaetothyrialesQuan, YuDeng, ShuwenPrenafeta Boldủ, Francesc X.Mayer, Veronika E.Muggia, LuciaCometto, AgneseVicente, Vania A.Silva, Nickolas Menezes daGrisolia, Maria EduardaSong, YinggaiAhmed, Sarah A.Niu, XuekeLima, Bruna Jacomel Favoreto de SouzaFeng, PeiyingVitale, Roxana GabrielaTeixeira, MarcusSudhadham, MontaropAzevedo, Conceicao Pedrozo e Silva deBocca, AnameliaHaase, GerhardSelbmann, LauraShi, DongmeiKang, Yingqiande Hoog, SybrenHUMAN PATHOGENICITYCHAETOTHYRIALEShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Fungi in the order Chaetothyriales are renowned for their ability to cause human infections. Nevertheless, they are not regarded as primary pathogens, but rather as opportunists with a natural habitat in the environment. Extremotolerance is a major trend in the order, but quite diferent from black yeasts in Capnodiales which focus on endurance, an important additional parameter is advancing toxin management. In the ancestral ecology of rock colonization, the association with metabolite-producing lichens is signifcant. Ant-association, dealing with pheromones and repellents, is another mainstay in the order. The phylogenetically derived family, Herpotrichiellaceae, shows dual ecology in monoaromatic hydrocarbon assimilation and the ability to cause disease in humans and cold-blooded vertebrates. In this study, data on ecology, phylogeny, and genomics were collected and analyzed in order to support this hypothesis on the evolutionary route of the species of Chaetothyriales. Comparing the ribosomal tree with that of enzymes involved in toluene degradation, a signifcant expansion of cytochromes is observed and the toluene catabolism is found to be complete in some of the Herpotrichiellaceae. This might enhance human systemic infection. However, since most species have to be traumatically inoculated in order to cause disease, their invasive potential is categorized as opportunism. Only in chromoblastomycosis, true pathogenicity might be surmised. The criterion would be the possible escape of agents of vertebrate disease from the host, enabling dispersal of adapted genotypes to subsequent generations.Fil: Quan, Yu. Radboud University Medical Center; Países Bajos. Guizhou Medical University; ChinaFil: Deng, Shuwen. People’s Hospital of Suzhou National New & Hi-Tech Industrial Development Zone; ChinaFil: Prenafeta Boldủ, Francesc X.. Institute of Agrifood Research and Technology; EspañaFil: Mayer, Veronika E.. University of Vienna; AustriaFil: Muggia, Lucia. Università degli Studi di Trieste; ItaliaFil: Cometto, Agnese. Università degli Studi di Trieste; ItaliaFil: Vicente, Vania A.. Universidade Federal do Paraná; BrasilFil: Silva, Nickolas Menezes da. Universidade Federal do Paraná; BrasilFil: Grisolia, Maria Eduarda. Universidade Federal do Paraná; BrasilFil: Song, Yinggai. Peking University; ChinaFil: Ahmed, Sarah A.. Radboud University Medical Center; Países BajosFil: Niu, Xueke. Radboud University Medical Center; Países Bajos. Guizhou Medical University; ChinaFil: Lima, Bruna Jacomel Favoreto de Souza. Universidade Federal do Paraná; BrasilFil: Feng, Peiying. Sun Yat-sen University; ChinaFil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Teixeira, Marcus. Universidade do Brasília; BrasilFil: Sudhadham, Montarop. Suan Sunandha Rajabhat University; TailandiaFil: Azevedo, Conceicao Pedrozo e Silva de. Federal University of Maranhao; BrasilFil: Bocca, Anamelia. Universidade do Brasília; BrasilFil: Haase, Gerhard. RWTH Aachen University Hospital; AlemaniaFil: Selbmann, Laura. Università degli Studi della Tuscia; ItaliaFil: Shi, Dongmei. People’s Hospital; ChinaFil: Kang, Yingqian. Guizhou Medical University; ChinaFil: de Hoog, Sybren. Radboud University Medical Center; Países Bajos. Guizhou Medical University; China. People’s Hospital of Suzhou National New & Hi-Tech Industrial Development Zone; China. Universidade Federal do Paraná; Brasil. Peking University; ChinaKunming University of Science and Technology2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/235485Quan, Yu; Deng, Shuwen; Prenafeta Boldủ, Francesc X.; Mayer, Veronika E.; Muggia, Lucia; et al.; The origin of human pathogenicity and biological interactions in Chaetothyriales; Kunming University of Science and Technology; Fungal Diversity; 125; 3-2023; 99–1201560-2745CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s13225-023-00518-3info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s13225-023-00518-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:36:18Zoai:ri.conicet.gov.ar:11336/235485instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:36:18.929CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
The origin of human pathogenicity and biological interactions in Chaetothyriales |
| title |
The origin of human pathogenicity and biological interactions in Chaetothyriales |
| spellingShingle |
The origin of human pathogenicity and biological interactions in Chaetothyriales Quan, Yu HUMAN PATHOGENICITY CHAETOTHYRIALES |
| title_short |
The origin of human pathogenicity and biological interactions in Chaetothyriales |
| title_full |
The origin of human pathogenicity and biological interactions in Chaetothyriales |
| title_fullStr |
The origin of human pathogenicity and biological interactions in Chaetothyriales |
| title_full_unstemmed |
The origin of human pathogenicity and biological interactions in Chaetothyriales |
| title_sort |
The origin of human pathogenicity and biological interactions in Chaetothyriales |
| dc.creator.none.fl_str_mv |
Quan, Yu Deng, Shuwen Prenafeta Boldủ, Francesc X. Mayer, Veronika E. Muggia, Lucia Cometto, Agnese Vicente, Vania A. Silva, Nickolas Menezes da Grisolia, Maria Eduarda Song, Yinggai Ahmed, Sarah A. Niu, Xueke Lima, Bruna Jacomel Favoreto de Souza Feng, Peiying Vitale, Roxana Gabriela Teixeira, Marcus Sudhadham, Montarop Azevedo, Conceicao Pedrozo e Silva de Bocca, Anamelia Haase, Gerhard Selbmann, Laura Shi, Dongmei Kang, Yingqian de Hoog, Sybren |
| author |
Quan, Yu |
| author_facet |
Quan, Yu Deng, Shuwen Prenafeta Boldủ, Francesc X. Mayer, Veronika E. Muggia, Lucia Cometto, Agnese Vicente, Vania A. Silva, Nickolas Menezes da Grisolia, Maria Eduarda Song, Yinggai Ahmed, Sarah A. Niu, Xueke Lima, Bruna Jacomel Favoreto de Souza Feng, Peiying Vitale, Roxana Gabriela Teixeira, Marcus Sudhadham, Montarop Azevedo, Conceicao Pedrozo e Silva de Bocca, Anamelia Haase, Gerhard Selbmann, Laura Shi, Dongmei Kang, Yingqian de Hoog, Sybren |
| author_role |
author |
| author2 |
Deng, Shuwen Prenafeta Boldủ, Francesc X. Mayer, Veronika E. Muggia, Lucia Cometto, Agnese Vicente, Vania A. Silva, Nickolas Menezes da Grisolia, Maria Eduarda Song, Yinggai Ahmed, Sarah A. Niu, Xueke Lima, Bruna Jacomel Favoreto de Souza Feng, Peiying Vitale, Roxana Gabriela Teixeira, Marcus Sudhadham, Montarop Azevedo, Conceicao Pedrozo e Silva de Bocca, Anamelia Haase, Gerhard Selbmann, Laura Shi, Dongmei Kang, Yingqian de Hoog, Sybren |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
HUMAN PATHOGENICITY CHAETOTHYRIALES |
| topic |
HUMAN PATHOGENICITY CHAETOTHYRIALES |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Fungi in the order Chaetothyriales are renowned for their ability to cause human infections. Nevertheless, they are not regarded as primary pathogens, but rather as opportunists with a natural habitat in the environment. Extremotolerance is a major trend in the order, but quite diferent from black yeasts in Capnodiales which focus on endurance, an important additional parameter is advancing toxin management. In the ancestral ecology of rock colonization, the association with metabolite-producing lichens is signifcant. Ant-association, dealing with pheromones and repellents, is another mainstay in the order. The phylogenetically derived family, Herpotrichiellaceae, shows dual ecology in monoaromatic hydrocarbon assimilation and the ability to cause disease in humans and cold-blooded vertebrates. In this study, data on ecology, phylogeny, and genomics were collected and analyzed in order to support this hypothesis on the evolutionary route of the species of Chaetothyriales. Comparing the ribosomal tree with that of enzymes involved in toluene degradation, a signifcant expansion of cytochromes is observed and the toluene catabolism is found to be complete in some of the Herpotrichiellaceae. This might enhance human systemic infection. However, since most species have to be traumatically inoculated in order to cause disease, their invasive potential is categorized as opportunism. Only in chromoblastomycosis, true pathogenicity might be surmised. The criterion would be the possible escape of agents of vertebrate disease from the host, enabling dispersal of adapted genotypes to subsequent generations. Fil: Quan, Yu. Radboud University Medical Center; Países Bajos. Guizhou Medical University; China Fil: Deng, Shuwen. People’s Hospital of Suzhou National New & Hi-Tech Industrial Development Zone; China Fil: Prenafeta Boldủ, Francesc X.. Institute of Agrifood Research and Technology; España Fil: Mayer, Veronika E.. University of Vienna; Austria Fil: Muggia, Lucia. Università degli Studi di Trieste; Italia Fil: Cometto, Agnese. Università degli Studi di Trieste; Italia Fil: Vicente, Vania A.. Universidade Federal do Paraná; Brasil Fil: Silva, Nickolas Menezes da. Universidade Federal do Paraná; Brasil Fil: Grisolia, Maria Eduarda. Universidade Federal do Paraná; Brasil Fil: Song, Yinggai. Peking University; China Fil: Ahmed, Sarah A.. Radboud University Medical Center; Países Bajos Fil: Niu, Xueke. Radboud University Medical Center; Países Bajos. Guizhou Medical University; China Fil: Lima, Bruna Jacomel Favoreto de Souza. Universidade Federal do Paraná; Brasil Fil: Feng, Peiying. Sun Yat-sen University; China Fil: Vitale, Roxana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina Fil: Teixeira, Marcus. Universidade do Brasília; Brasil Fil: Sudhadham, Montarop. Suan Sunandha Rajabhat University; Tailandia Fil: Azevedo, Conceicao Pedrozo e Silva de. Federal University of Maranhao; Brasil Fil: Bocca, Anamelia. Universidade do Brasília; Brasil Fil: Haase, Gerhard. RWTH Aachen University Hospital; Alemania Fil: Selbmann, Laura. Università degli Studi della Tuscia; Italia Fil: Shi, Dongmei. People’s Hospital; China Fil: Kang, Yingqian. Guizhou Medical University; China Fil: de Hoog, Sybren. Radboud University Medical Center; Países Bajos. Guizhou Medical University; China. People’s Hospital of Suzhou National New & Hi-Tech Industrial Development Zone; China. Universidade Federal do Paraná; Brasil. Peking University; China |
| description |
Fungi in the order Chaetothyriales are renowned for their ability to cause human infections. Nevertheless, they are not regarded as primary pathogens, but rather as opportunists with a natural habitat in the environment. Extremotolerance is a major trend in the order, but quite diferent from black yeasts in Capnodiales which focus on endurance, an important additional parameter is advancing toxin management. In the ancestral ecology of rock colonization, the association with metabolite-producing lichens is signifcant. Ant-association, dealing with pheromones and repellents, is another mainstay in the order. The phylogenetically derived family, Herpotrichiellaceae, shows dual ecology in monoaromatic hydrocarbon assimilation and the ability to cause disease in humans and cold-blooded vertebrates. In this study, data on ecology, phylogeny, and genomics were collected and analyzed in order to support this hypothesis on the evolutionary route of the species of Chaetothyriales. Comparing the ribosomal tree with that of enzymes involved in toluene degradation, a signifcant expansion of cytochromes is observed and the toluene catabolism is found to be complete in some of the Herpotrichiellaceae. This might enhance human systemic infection. However, since most species have to be traumatically inoculated in order to cause disease, their invasive potential is categorized as opportunism. Only in chromoblastomycosis, true pathogenicity might be surmised. The criterion would be the possible escape of agents of vertebrate disease from the host, enabling dispersal of adapted genotypes to subsequent generations. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-03 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/235485 Quan, Yu; Deng, Shuwen; Prenafeta Boldủ, Francesc X.; Mayer, Veronika E.; Muggia, Lucia; et al.; The origin of human pathogenicity and biological interactions in Chaetothyriales; Kunming University of Science and Technology; Fungal Diversity; 125; 3-2023; 99–120 1560-2745 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/235485 |
| identifier_str_mv |
Quan, Yu; Deng, Shuwen; Prenafeta Boldủ, Francesc X.; Mayer, Veronika E.; Muggia, Lucia; et al.; The origin of human pathogenicity and biological interactions in Chaetothyriales; Kunming University of Science and Technology; Fungal Diversity; 125; 3-2023; 99–120 1560-2745 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/altIdentifier/doi/10.1007/s13225-023-00518-3 info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s13225-023-00518-3 |
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openAccess |
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application/pdf application/pdf |
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Kunming University of Science and Technology |
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Kunming University of Science and Technology |
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