Delineating the Diversity of Spinal Interneurons in Locomotor Circuits

Autores
Gosgnach, Simon; Bikoff, Jay B.; Dougherty, Kimberly J.; El Manira, Abdeljabbar; Lanuza, Guillermo Marcos; Zhang, Ying
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Locomotion is common to all animals and is essential for survival. Neural circuits located in the spinal cord have been shown to be necessary and sufficient for the generation and control of the basic locomotor rhythm by activating muscles on either side of the body in a specific sequence. Activity in these neural circuits determines the speed, gait pattern, and direction of movement, so the specific locomotor pattern generated relies on the diversity of the neurons within spinal locomotor circuits. Here, we review findings demonstrating that developmental genetics can be used to identify populations of neurons that comprise these circuits and focus on recent work indicating that many of these populations can be further subdivided into distinct subtypes, with each likely to play complementary functions during locomotion. Finally, we discuss data describing the manner in which these populations interact with each other to produce efficient, task-dependent locomotion.
Fil: Gosgnach, Simon. University of Alberta; Canadá
Fil: Bikoff, Jay B.. Columbia University; Estados Unidos
Fil: Dougherty, Kimberly J.. Drexel University; Estados Unidos
Fil: El Manira, Abdeljabbar. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Zhang, Ying. Dalhousie University Halifax; Canadá
Materia
Interneurons
Locomotor
Developement
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38029
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Delineating the Diversity of Spinal Interneurons in Locomotor CircuitsGosgnach, SimonBikoff, Jay B.Dougherty, Kimberly J.El Manira, AbdeljabbarLanuza, Guillermo MarcosZhang, YingInterneuronsLocomotorDevelopementhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Locomotion is common to all animals and is essential for survival. Neural circuits located in the spinal cord have been shown to be necessary and sufficient for the generation and control of the basic locomotor rhythm by activating muscles on either side of the body in a specific sequence. Activity in these neural circuits determines the speed, gait pattern, and direction of movement, so the specific locomotor pattern generated relies on the diversity of the neurons within spinal locomotor circuits. Here, we review findings demonstrating that developmental genetics can be used to identify populations of neurons that comprise these circuits and focus on recent work indicating that many of these populations can be further subdivided into distinct subtypes, with each likely to play complementary functions during locomotion. Finally, we discuss data describing the manner in which these populations interact with each other to produce efficient, task-dependent locomotion.Fil: Gosgnach, Simon. University of Alberta; CanadáFil: Bikoff, Jay B.. Columbia University; Estados UnidosFil: Dougherty, Kimberly J.. Drexel University; Estados UnidosFil: El Manira, Abdeljabbar. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Zhang, Ying. Dalhousie University Halifax; CanadáSociety for Neuroscience2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38029Gosgnach, Simon; Bikoff, Jay B.; Dougherty, Kimberly J.; El Manira, Abdeljabbar; Lanuza, Guillermo Marcos; et al.; Delineating the Diversity of Spinal Interneurons in Locomotor Circuits; Society for Neuroscience; Journal of Neuroscience; 37; 45; 11-2017; 10831-108410270-64741529-2401CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.1829-17.2017info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/37/45/10835.longinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:38:04Zoai:ri.conicet.gov.ar:11336/38029instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:38:04.476CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
title Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
spellingShingle Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
Gosgnach, Simon
Interneurons
Locomotor
Developement
title_short Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
title_full Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
title_fullStr Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
title_full_unstemmed Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
title_sort Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
dc.creator.none.fl_str_mv Gosgnach, Simon
Bikoff, Jay B.
Dougherty, Kimberly J.
El Manira, Abdeljabbar
Lanuza, Guillermo Marcos
Zhang, Ying
author Gosgnach, Simon
author_facet Gosgnach, Simon
Bikoff, Jay B.
Dougherty, Kimberly J.
El Manira, Abdeljabbar
Lanuza, Guillermo Marcos
Zhang, Ying
author_role author
author2 Bikoff, Jay B.
Dougherty, Kimberly J.
El Manira, Abdeljabbar
Lanuza, Guillermo Marcos
Zhang, Ying
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Interneurons
Locomotor
Developement
topic Interneurons
Locomotor
Developement
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Locomotion is common to all animals and is essential for survival. Neural circuits located in the spinal cord have been shown to be necessary and sufficient for the generation and control of the basic locomotor rhythm by activating muscles on either side of the body in a specific sequence. Activity in these neural circuits determines the speed, gait pattern, and direction of movement, so the specific locomotor pattern generated relies on the diversity of the neurons within spinal locomotor circuits. Here, we review findings demonstrating that developmental genetics can be used to identify populations of neurons that comprise these circuits and focus on recent work indicating that many of these populations can be further subdivided into distinct subtypes, with each likely to play complementary functions during locomotion. Finally, we discuss data describing the manner in which these populations interact with each other to produce efficient, task-dependent locomotion.
Fil: Gosgnach, Simon. University of Alberta; Canadá
Fil: Bikoff, Jay B.. Columbia University; Estados Unidos
Fil: Dougherty, Kimberly J.. Drexel University; Estados Unidos
Fil: El Manira, Abdeljabbar. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Zhang, Ying. Dalhousie University Halifax; Canadá
description Locomotion is common to all animals and is essential for survival. Neural circuits located in the spinal cord have been shown to be necessary and sufficient for the generation and control of the basic locomotor rhythm by activating muscles on either side of the body in a specific sequence. Activity in these neural circuits determines the speed, gait pattern, and direction of movement, so the specific locomotor pattern generated relies on the diversity of the neurons within spinal locomotor circuits. Here, we review findings demonstrating that developmental genetics can be used to identify populations of neurons that comprise these circuits and focus on recent work indicating that many of these populations can be further subdivided into distinct subtypes, with each likely to play complementary functions during locomotion. Finally, we discuss data describing the manner in which these populations interact with each other to produce efficient, task-dependent locomotion.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38029
Gosgnach, Simon; Bikoff, Jay B.; Dougherty, Kimberly J.; El Manira, Abdeljabbar; Lanuza, Guillermo Marcos; et al.; Delineating the Diversity of Spinal Interneurons in Locomotor Circuits; Society for Neuroscience; Journal of Neuroscience; 37; 45; 11-2017; 10831-10841
0270-6474
1529-2401
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38029
identifier_str_mv Gosgnach, Simon; Bikoff, Jay B.; Dougherty, Kimberly J.; El Manira, Abdeljabbar; Lanuza, Guillermo Marcos; et al.; Delineating the Diversity of Spinal Interneurons in Locomotor Circuits; Society for Neuroscience; Journal of Neuroscience; 37; 45; 11-2017; 10831-10841
0270-6474
1529-2401
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.1829-17.2017
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/37/45/10835.long
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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