Delineating the Diversity of Spinal Interneurons in Locomotor Circuits
- Autores
- Gosgnach, Simon; Bikoff, Jay B.; Dougherty, Kimberly J.; El Manira, Abdeljabbar; Lanuza, Guillermo Marcos; Zhang, Ying
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Locomotion is common to all animals and is essential for survival. Neural circuits located in the spinal cord have been shown to be necessary and sufficient for the generation and control of the basic locomotor rhythm by activating muscles on either side of the body in a specific sequence. Activity in these neural circuits determines the speed, gait pattern, and direction of movement, so the specific locomotor pattern generated relies on the diversity of the neurons within spinal locomotor circuits. Here, we review findings demonstrating that developmental genetics can be used to identify populations of neurons that comprise these circuits and focus on recent work indicating that many of these populations can be further subdivided into distinct subtypes, with each likely to play complementary functions during locomotion. Finally, we discuss data describing the manner in which these populations interact with each other to produce efficient, task-dependent locomotion.
Fil: Gosgnach, Simon. University of Alberta; Canadá
Fil: Bikoff, Jay B.. Columbia University; Estados Unidos
Fil: Dougherty, Kimberly J.. Drexel University; Estados Unidos
Fil: El Manira, Abdeljabbar. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Zhang, Ying. Dalhousie University Halifax; Canadá - Materia
-
Interneurons
Locomotor
Developement - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/38029
Ver los metadatos del registro completo
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Delineating the Diversity of Spinal Interneurons in Locomotor CircuitsGosgnach, SimonBikoff, Jay B.Dougherty, Kimberly J.El Manira, AbdeljabbarLanuza, Guillermo MarcosZhang, YingInterneuronsLocomotorDevelopementhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Locomotion is common to all animals and is essential for survival. Neural circuits located in the spinal cord have been shown to be necessary and sufficient for the generation and control of the basic locomotor rhythm by activating muscles on either side of the body in a specific sequence. Activity in these neural circuits determines the speed, gait pattern, and direction of movement, so the specific locomotor pattern generated relies on the diversity of the neurons within spinal locomotor circuits. Here, we review findings demonstrating that developmental genetics can be used to identify populations of neurons that comprise these circuits and focus on recent work indicating that many of these populations can be further subdivided into distinct subtypes, with each likely to play complementary functions during locomotion. Finally, we discuss data describing the manner in which these populations interact with each other to produce efficient, task-dependent locomotion.Fil: Gosgnach, Simon. University of Alberta; CanadáFil: Bikoff, Jay B.. Columbia University; Estados UnidosFil: Dougherty, Kimberly J.. Drexel University; Estados UnidosFil: El Manira, Abdeljabbar. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Zhang, Ying. Dalhousie University Halifax; CanadáSociety for Neuroscience2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38029Gosgnach, Simon; Bikoff, Jay B.; Dougherty, Kimberly J.; El Manira, Abdeljabbar; Lanuza, Guillermo Marcos; et al.; Delineating the Diversity of Spinal Interneurons in Locomotor Circuits; Society for Neuroscience; Journal of Neuroscience; 37; 45; 11-2017; 10831-108410270-64741529-2401CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.1829-17.2017info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/37/45/10835.longinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:40Zoai:ri.conicet.gov.ar:11336/38029instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:41.25CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Delineating the Diversity of Spinal Interneurons in Locomotor Circuits |
title |
Delineating the Diversity of Spinal Interneurons in Locomotor Circuits |
spellingShingle |
Delineating the Diversity of Spinal Interneurons in Locomotor Circuits Gosgnach, Simon Interneurons Locomotor Developement |
title_short |
Delineating the Diversity of Spinal Interneurons in Locomotor Circuits |
title_full |
Delineating the Diversity of Spinal Interneurons in Locomotor Circuits |
title_fullStr |
Delineating the Diversity of Spinal Interneurons in Locomotor Circuits |
title_full_unstemmed |
Delineating the Diversity of Spinal Interneurons in Locomotor Circuits |
title_sort |
Delineating the Diversity of Spinal Interneurons in Locomotor Circuits |
dc.creator.none.fl_str_mv |
Gosgnach, Simon Bikoff, Jay B. Dougherty, Kimberly J. El Manira, Abdeljabbar Lanuza, Guillermo Marcos Zhang, Ying |
author |
Gosgnach, Simon |
author_facet |
Gosgnach, Simon Bikoff, Jay B. Dougherty, Kimberly J. El Manira, Abdeljabbar Lanuza, Guillermo Marcos Zhang, Ying |
author_role |
author |
author2 |
Bikoff, Jay B. Dougherty, Kimberly J. El Manira, Abdeljabbar Lanuza, Guillermo Marcos Zhang, Ying |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Interneurons Locomotor Developement |
topic |
Interneurons Locomotor Developement |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Locomotion is common to all animals and is essential for survival. Neural circuits located in the spinal cord have been shown to be necessary and sufficient for the generation and control of the basic locomotor rhythm by activating muscles on either side of the body in a specific sequence. Activity in these neural circuits determines the speed, gait pattern, and direction of movement, so the specific locomotor pattern generated relies on the diversity of the neurons within spinal locomotor circuits. Here, we review findings demonstrating that developmental genetics can be used to identify populations of neurons that comprise these circuits and focus on recent work indicating that many of these populations can be further subdivided into distinct subtypes, with each likely to play complementary functions during locomotion. Finally, we discuss data describing the manner in which these populations interact with each other to produce efficient, task-dependent locomotion. Fil: Gosgnach, Simon. University of Alberta; Canadá Fil: Bikoff, Jay B.. Columbia University; Estados Unidos Fil: Dougherty, Kimberly J.. Drexel University; Estados Unidos Fil: El Manira, Abdeljabbar. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Zhang, Ying. Dalhousie University Halifax; Canadá |
description |
Locomotion is common to all animals and is essential for survival. Neural circuits located in the spinal cord have been shown to be necessary and sufficient for the generation and control of the basic locomotor rhythm by activating muscles on either side of the body in a specific sequence. Activity in these neural circuits determines the speed, gait pattern, and direction of movement, so the specific locomotor pattern generated relies on the diversity of the neurons within spinal locomotor circuits. Here, we review findings demonstrating that developmental genetics can be used to identify populations of neurons that comprise these circuits and focus on recent work indicating that many of these populations can be further subdivided into distinct subtypes, with each likely to play complementary functions during locomotion. Finally, we discuss data describing the manner in which these populations interact with each other to produce efficient, task-dependent locomotion. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/38029 Gosgnach, Simon; Bikoff, Jay B.; Dougherty, Kimberly J.; El Manira, Abdeljabbar; Lanuza, Guillermo Marcos; et al.; Delineating the Diversity of Spinal Interneurons in Locomotor Circuits; Society for Neuroscience; Journal of Neuroscience; 37; 45; 11-2017; 10831-10841 0270-6474 1529-2401 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/38029 |
identifier_str_mv |
Gosgnach, Simon; Bikoff, Jay B.; Dougherty, Kimberly J.; El Manira, Abdeljabbar; Lanuza, Guillermo Marcos; et al.; Delineating the Diversity of Spinal Interneurons in Locomotor Circuits; Society for Neuroscience; Journal of Neuroscience; 37; 45; 11-2017; 10831-10841 0270-6474 1529-2401 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1523/JNEUROSCI.1829-17.2017 info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/37/45/10835.long |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Society for Neuroscience |
publisher.none.fl_str_mv |
Society for Neuroscience |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |