Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission

Autores
Rojas de Arias, Antonieta; Monroy, Carlota; Guhl, Felipe; Sosa-Estani, Sergio Alejandro; Santos, Walter Souza; Abad Franch, Fernando
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chagas disease (CD) still imposes a heavy burden on most Latin American countries. Vector-borne and mother-to-child transmission cause several thousand new infections per year, and at least 5 million people carry Trypanosoma cruzi. Access to diagnosis and medical care, however, is far from universal. Starting in the 1990s, CD-endemic countries and the Pan American Health Organization-World Health Organization (PAHO-WHO) launched a series of multinational initiatives for CD control-surveillance. An overview of the initiatives’ aims, achievements, and challenges reveals some key common themes that we discuss here in the context of the WHO 2030 goals for CD. Transmission of T. cruzi via blood transfusion and organ transplantation is effectively under control. T. cruzi, however, is a zoonotic pathogen with 100+ vector species widely spread across the Americas; interrupting vector-borne transmission seems therefore unfeasible. Stronger surveillance systems are, and will continue to be, needed to monitor and control CD. Prevention of vertical transmission demands boosting current efforts to screen pregnant and childbearing-aged women. Finally, integral patient care is a critical unmet need in most countries. The decades-long experience of the initiatives, in sum, hints at the practical impossibility of interrupting vector-borne T. cruzi transmission in the Americas. The concept of disease control seems to provide a more realistic description of what can in effect be achieved by 2030.
Fil: Rojas de Arias, Antonieta. Centro para el Desarrollo de la Investigación Científica; Paraguay
Fil: Monroy, Carlota. Universidad de San Carlos de Guatemala (univ. de San C. de Guatemala);
Fil: Guhl, Felipe. Universidad de los Andes; Colombia
Fil: Sosa-Estani, Sergio Alejandro. Drugs For Neglected Diseases Initiative; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Santos, Walter Souza. Ministério da Saúde; Brasil
Fil: Abad Franch, Fernando. Universidade do Brasília; Brasil
Materia
CHAGAS DISEASE
CONTROL
INTERRUPTION OF TRANSMISSION
MULTINATIONAL INITIATIVES
SURVEILLANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/214523
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmissionRojas de Arias, AntonietaMonroy, CarlotaGuhl, FelipeSosa-Estani, Sergio AlejandroSantos, Walter SouzaAbad Franch, FernandoCHAGAS DISEASECONTROLINTERRUPTION OF TRANSMISSIONMULTINATIONAL INITIATIVESSURVEILLANCEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Chagas disease (CD) still imposes a heavy burden on most Latin American countries. Vector-borne and mother-to-child transmission cause several thousand new infections per year, and at least 5 million people carry Trypanosoma cruzi. Access to diagnosis and medical care, however, is far from universal. Starting in the 1990s, CD-endemic countries and the Pan American Health Organization-World Health Organization (PAHO-WHO) launched a series of multinational initiatives for CD control-surveillance. An overview of the initiatives’ aims, achievements, and challenges reveals some key common themes that we discuss here in the context of the WHO 2030 goals for CD. Transmission of T. cruzi via blood transfusion and organ transplantation is effectively under control. T. cruzi, however, is a zoonotic pathogen with 100+ vector species widely spread across the Americas; interrupting vector-borne transmission seems therefore unfeasible. Stronger surveillance systems are, and will continue to be, needed to monitor and control CD. Prevention of vertical transmission demands boosting current efforts to screen pregnant and childbearing-aged women. Finally, integral patient care is a critical unmet need in most countries. The decades-long experience of the initiatives, in sum, hints at the practical impossibility of interrupting vector-borne T. cruzi transmission in the Americas. The concept of disease control seems to provide a more realistic description of what can in effect be achieved by 2030.Fil: Rojas de Arias, Antonieta. Centro para el Desarrollo de la Investigación Científica; ParaguayFil: Monroy, Carlota. Universidad de San Carlos de Guatemala (univ. de San C. de Guatemala);Fil: Guhl, Felipe. Universidad de los Andes; ColombiaFil: Sosa-Estani, Sergio Alejandro. Drugs For Neglected Diseases Initiative; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Santos, Walter Souza. Ministério da Saúde; BrasilFil: Abad Franch, Fernando. Universidade do Brasília; BrasilFundação Oswaldo Cruz2022-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214523Rojas de Arias, Antonieta; Monroy, Carlota; Guhl, Felipe; Sosa-Estani, Sergio Alejandro; Santos, Walter Souza; et al.; Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 116; 1; 7-2022; 1-150074-02761678-8060CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1590/0074-02760210130info:eu-repo/semantics/altIdentifier/url/https://www.scielo.br/j/mioc/a/FhyNZKMGxpf5TCSGgLcvCXh/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:13:55Zoai:ri.conicet.gov.ar:11336/214523instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:13:56.159CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission
title Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission
spellingShingle Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission
Rojas de Arias, Antonieta
CHAGAS DISEASE
CONTROL
INTERRUPTION OF TRANSMISSION
MULTINATIONAL INITIATIVES
SURVEILLANCE
title_short Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission
title_full Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission
title_fullStr Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission
title_full_unstemmed Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission
title_sort Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission
dc.creator.none.fl_str_mv Rojas de Arias, Antonieta
Monroy, Carlota
Guhl, Felipe
Sosa-Estani, Sergio Alejandro
Santos, Walter Souza
Abad Franch, Fernando
author Rojas de Arias, Antonieta
author_facet Rojas de Arias, Antonieta
Monroy, Carlota
Guhl, Felipe
Sosa-Estani, Sergio Alejandro
Santos, Walter Souza
Abad Franch, Fernando
author_role author
author2 Monroy, Carlota
Guhl, Felipe
Sosa-Estani, Sergio Alejandro
Santos, Walter Souza
Abad Franch, Fernando
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CHAGAS DISEASE
CONTROL
INTERRUPTION OF TRANSMISSION
MULTINATIONAL INITIATIVES
SURVEILLANCE
topic CHAGAS DISEASE
CONTROL
INTERRUPTION OF TRANSMISSION
MULTINATIONAL INITIATIVES
SURVEILLANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chagas disease (CD) still imposes a heavy burden on most Latin American countries. Vector-borne and mother-to-child transmission cause several thousand new infections per year, and at least 5 million people carry Trypanosoma cruzi. Access to diagnosis and medical care, however, is far from universal. Starting in the 1990s, CD-endemic countries and the Pan American Health Organization-World Health Organization (PAHO-WHO) launched a series of multinational initiatives for CD control-surveillance. An overview of the initiatives’ aims, achievements, and challenges reveals some key common themes that we discuss here in the context of the WHO 2030 goals for CD. Transmission of T. cruzi via blood transfusion and organ transplantation is effectively under control. T. cruzi, however, is a zoonotic pathogen with 100+ vector species widely spread across the Americas; interrupting vector-borne transmission seems therefore unfeasible. Stronger surveillance systems are, and will continue to be, needed to monitor and control CD. Prevention of vertical transmission demands boosting current efforts to screen pregnant and childbearing-aged women. Finally, integral patient care is a critical unmet need in most countries. The decades-long experience of the initiatives, in sum, hints at the practical impossibility of interrupting vector-borne T. cruzi transmission in the Americas. The concept of disease control seems to provide a more realistic description of what can in effect be achieved by 2030.
Fil: Rojas de Arias, Antonieta. Centro para el Desarrollo de la Investigación Científica; Paraguay
Fil: Monroy, Carlota. Universidad de San Carlos de Guatemala (univ. de San C. de Guatemala);
Fil: Guhl, Felipe. Universidad de los Andes; Colombia
Fil: Sosa-Estani, Sergio Alejandro. Drugs For Neglected Diseases Initiative; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Santos, Walter Souza. Ministério da Saúde; Brasil
Fil: Abad Franch, Fernando. Universidade do Brasília; Brasil
description Chagas disease (CD) still imposes a heavy burden on most Latin American countries. Vector-borne and mother-to-child transmission cause several thousand new infections per year, and at least 5 million people carry Trypanosoma cruzi. Access to diagnosis and medical care, however, is far from universal. Starting in the 1990s, CD-endemic countries and the Pan American Health Organization-World Health Organization (PAHO-WHO) launched a series of multinational initiatives for CD control-surveillance. An overview of the initiatives’ aims, achievements, and challenges reveals some key common themes that we discuss here in the context of the WHO 2030 goals for CD. Transmission of T. cruzi via blood transfusion and organ transplantation is effectively under control. T. cruzi, however, is a zoonotic pathogen with 100+ vector species widely spread across the Americas; interrupting vector-borne transmission seems therefore unfeasible. Stronger surveillance systems are, and will continue to be, needed to monitor and control CD. Prevention of vertical transmission demands boosting current efforts to screen pregnant and childbearing-aged women. Finally, integral patient care is a critical unmet need in most countries. The decades-long experience of the initiatives, in sum, hints at the practical impossibility of interrupting vector-borne T. cruzi transmission in the Americas. The concept of disease control seems to provide a more realistic description of what can in effect be achieved by 2030.
publishDate 2022
dc.date.none.fl_str_mv 2022-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/214523
Rojas de Arias, Antonieta; Monroy, Carlota; Guhl, Felipe; Sosa-Estani, Sergio Alejandro; Santos, Walter Souza; et al.; Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 116; 1; 7-2022; 1-15
0074-0276
1678-8060
CONICET Digital
CONICET
url http://hdl.handle.net/11336/214523
identifier_str_mv Rojas de Arias, Antonieta; Monroy, Carlota; Guhl, Felipe; Sosa-Estani, Sergio Alejandro; Santos, Walter Souza; et al.; Chagas disease control-surveillance in the americas: The multinational initiatives and the practical impossibility of interrupting vector-borne trypanosoma cruzi transmission; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 116; 1; 7-2022; 1-15
0074-0276
1678-8060
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1590/0074-02760210130
info:eu-repo/semantics/altIdentifier/url/https://www.scielo.br/j/mioc/a/FhyNZKMGxpf5TCSGgLcvCXh/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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