Antimicrobial properties of tetracycline and minocycline-montmorillonites

Autores
Parolo, Maria Eugenia; Avena, Marcelo Javier; Pettinari, Gisela Roxana; Zajonkovsky, I.; Valles, Jorge Manuel; Baschini, Miria Teresita
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The antimicrobial activity of adsorption complexes of antibiotics from the tetracycline family on sodium and calcium montmorillonite was evaluated for their use in human and veterinary medicine. Tetracycline (TC) and minocycline (MC) adsorption on Patagonian montmorillonite was studied as a function of pH using batch experiments, X-ray diffraction (XRD) and IR spectroscopy. The adsorption was high at low pH and decreased continuously as pH increased. Adsorption of MC was higher than adsorption of TC. TC and MC were intercalated into the interlayer space of montmorillonite as deduced from the increase of the basal spacing. IR spectroscopy suggested that NHR3+ and other polar groups were directly involved in the interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising field of application, in particular for the formulation of topical products.
Fil: Parolo, Maria Eugenia. Universidad Nacional del Comahue; Argentina
Fil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Pettinari, Gisela Roxana. Universidad Nacional del Comahue; Argentina
Fil: Zajonkovsky, I.. Universidad Nacional del Comahue; Argentina
Fil: Valles, Jorge Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Comahue; Argentina
Fil: Baschini, Miria Teresita. Universidad Nacional del Comahue; Argentina
Materia
ADSORPTION
ANTIMICROBIAL ACTIVITY
MONTMORILLONITE
TETRACYCLINES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117757
Acceder
id CONICETDig_af7af1bfd28b36a823a85fb2431fe26e
oai_identifier_str oai:ri.conicet.gov.ar:11336/117757
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antimicrobial properties of tetracycline and minocycline-montmorillonitesParolo, Maria EugeniaAvena, Marcelo JavierPettinari, Gisela RoxanaZajonkovsky, I.Valles, Jorge ManuelBaschini, Miria TeresitaADSORPTIONANTIMICROBIAL ACTIVITYMONTMORILLONITETETRACYCLINEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The antimicrobial activity of adsorption complexes of antibiotics from the tetracycline family on sodium and calcium montmorillonite was evaluated for their use in human and veterinary medicine. Tetracycline (TC) and minocycline (MC) adsorption on Patagonian montmorillonite was studied as a function of pH using batch experiments, X-ray diffraction (XRD) and IR spectroscopy. The adsorption was high at low pH and decreased continuously as pH increased. Adsorption of MC was higher than adsorption of TC. TC and MC were intercalated into the interlayer space of montmorillonite as deduced from the increase of the basal spacing. IR spectroscopy suggested that NHR3+ and other polar groups were directly involved in the interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising field of application, in particular for the formulation of topical products.Fil: Parolo, Maria Eugenia. Universidad Nacional del Comahue; ArgentinaFil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Pettinari, Gisela Roxana. Universidad Nacional del Comahue; ArgentinaFil: Zajonkovsky, I.. Universidad Nacional del Comahue; ArgentinaFil: Valles, Jorge Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Comahue; ArgentinaFil: Baschini, Miria Teresita. Universidad Nacional del Comahue; ArgentinaElsevier Science2010-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117757Parolo, Maria Eugenia; Avena, Marcelo Javier; Pettinari, Gisela Roxana; Zajonkovsky, I.; Valles, Jorge Manuel; et al.; Antimicrobial properties of tetracycline and minocycline-montmorillonites; Elsevier Science; Applied Clay Science; 49; 3; 7-2010; 194-1990169-1317CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.clay.2010.05.005info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0169131710001407info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:17:46Zoai:ri.conicet.gov.ar:11336/117757instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:17:46.367CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial properties of tetracycline and minocycline-montmorillonites
title Antimicrobial properties of tetracycline and minocycline-montmorillonites
spellingShingle Antimicrobial properties of tetracycline and minocycline-montmorillonites
Parolo, Maria Eugenia
ADSORPTION
ANTIMICROBIAL ACTIVITY
MONTMORILLONITE
TETRACYCLINES
title_short Antimicrobial properties of tetracycline and minocycline-montmorillonites
title_full Antimicrobial properties of tetracycline and minocycline-montmorillonites
title_fullStr Antimicrobial properties of tetracycline and minocycline-montmorillonites
title_full_unstemmed Antimicrobial properties of tetracycline and minocycline-montmorillonites
title_sort Antimicrobial properties of tetracycline and minocycline-montmorillonites
dc.creator.none.fl_str_mv Parolo, Maria Eugenia
Avena, Marcelo Javier
Pettinari, Gisela Roxana
Zajonkovsky, I.
Valles, Jorge Manuel
Baschini, Miria Teresita
author Parolo, Maria Eugenia
author_facet Parolo, Maria Eugenia
Avena, Marcelo Javier
Pettinari, Gisela Roxana
Zajonkovsky, I.
Valles, Jorge Manuel
Baschini, Miria Teresita
author_role author
author2 Avena, Marcelo Javier
Pettinari, Gisela Roxana
Zajonkovsky, I.
Valles, Jorge Manuel
Baschini, Miria Teresita
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ADSORPTION
ANTIMICROBIAL ACTIVITY
MONTMORILLONITE
TETRACYCLINES
topic ADSORPTION
ANTIMICROBIAL ACTIVITY
MONTMORILLONITE
TETRACYCLINES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The antimicrobial activity of adsorption complexes of antibiotics from the tetracycline family on sodium and calcium montmorillonite was evaluated for their use in human and veterinary medicine. Tetracycline (TC) and minocycline (MC) adsorption on Patagonian montmorillonite was studied as a function of pH using batch experiments, X-ray diffraction (XRD) and IR spectroscopy. The adsorption was high at low pH and decreased continuously as pH increased. Adsorption of MC was higher than adsorption of TC. TC and MC were intercalated into the interlayer space of montmorillonite as deduced from the increase of the basal spacing. IR spectroscopy suggested that NHR3+ and other polar groups were directly involved in the interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising field of application, in particular for the formulation of topical products.
Fil: Parolo, Maria Eugenia. Universidad Nacional del Comahue; Argentina
Fil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Pettinari, Gisela Roxana. Universidad Nacional del Comahue; Argentina
Fil: Zajonkovsky, I.. Universidad Nacional del Comahue; Argentina
Fil: Valles, Jorge Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Comahue; Argentina
Fil: Baschini, Miria Teresita. Universidad Nacional del Comahue; Argentina
description The antimicrobial activity of adsorption complexes of antibiotics from the tetracycline family on sodium and calcium montmorillonite was evaluated for their use in human and veterinary medicine. Tetracycline (TC) and minocycline (MC) adsorption on Patagonian montmorillonite was studied as a function of pH using batch experiments, X-ray diffraction (XRD) and IR spectroscopy. The adsorption was high at low pH and decreased continuously as pH increased. Adsorption of MC was higher than adsorption of TC. TC and MC were intercalated into the interlayer space of montmorillonite as deduced from the increase of the basal spacing. IR spectroscopy suggested that NHR3+ and other polar groups were directly involved in the interaction with montmorillonite. The antimicrobial activity, measured by inhibition tests, was maintained by the antibiotics after adsorption on montmorillonite, whereas unreacted montmorillonite did not show any antibacterial activity. The excellent activity shown by the TC and MC complexes provides a promising field of application, in particular for the formulation of topical products.
publishDate 2010
dc.date.none.fl_str_mv 2010-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117757
Parolo, Maria Eugenia; Avena, Marcelo Javier; Pettinari, Gisela Roxana; Zajonkovsky, I.; Valles, Jorge Manuel; et al.; Antimicrobial properties of tetracycline and minocycline-montmorillonites; Elsevier Science; Applied Clay Science; 49; 3; 7-2010; 194-199
0169-1317
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117757
identifier_str_mv Parolo, Maria Eugenia; Avena, Marcelo Javier; Pettinari, Gisela Roxana; Zajonkovsky, I.; Valles, Jorge Manuel; et al.; Antimicrobial properties of tetracycline and minocycline-montmorillonites; Elsevier Science; Applied Clay Science; 49; 3; 7-2010; 194-199
0169-1317
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clay.2010.05.005
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0169131710001407
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980970913857536
score 12.993085

Publicaciones similares