Random inbreeding, isonymy, and population isolates in Argentina

Autores
Dipierri, Jose Edgardo; Rodriguez Larralde, Alvaro; Barrai, Italo; López Camelo, Jorge Santiago; Gutierrez Redomero, Esperanza; Alonso Rodriguez, Concepcion; Ramallo, Virginia; Bronberg, Ruben; Alfaro Gómez, Emma Laura
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Population isolates are an important tool in identi-fying and mapping genes of Mendelian diseases and complextraits. The geographical identification of isolates represents apriority from a genetic and health care standpoint. The pur-pose of this study is to analyze the spatial distribution ofconsanguinity by random isonymy (FST)inArgentinaanditsrelationship with the isolates previously identified in thecountry.FSTwas estimated from the surname distribution of22.6 million electors registered for the year 2001 in the 24provinces, 5 geographical regions, and 510 departments of thecountry. Statistically significant spatial clustering ofFSTwasdetermined using the SaTScan V5.1 software.FSTexhibited amarked regional and departamental variation, showing thehighest values towards the North and West of Argentina.The clusters of high consanguinity by random isonymyfollowed the same distribution. Recognized Argentinean ge-netic isolates are mainly localized at the north of the country,in clusters of high inbreeding. Given the availability of listingsof surnames in high-capacity storage devices for differentcountries, estimatingFSTfrom them can provide informationon inbreeding for all levels of administrative subdivisions, tobe used as a demographic variable for the identification ofisolates within the country for public health purposes.
Fil: Dipierri, Jose Edgardo. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina
Fil: Rodriguez Larralde, Alvaro. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Barrai, Italo. Universita Di Ferrara; Italia
Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gutierrez Redomero, Esperanza. Universidad de Alcalá; España
Fil: Alonso Rodriguez, Concepcion. Universidad de Alcalá; España
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bronberg, Ruben. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Alfaro Gómez, Emma Laura. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Surnames
Random Isonymy
Consanguinity
Clusters
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32309
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/32309
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Random inbreeding, isonymy, and population isolates in ArgentinaDipierri, Jose EdgardoRodriguez Larralde, AlvaroBarrai, ItaloLópez Camelo, Jorge SantiagoGutierrez Redomero, EsperanzaAlonso Rodriguez, ConcepcionRamallo, VirginiaBronberg, RubenAlfaro Gómez, Emma LauraSurnamesRandom IsonymyConsanguinityClustershttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Population isolates are an important tool in identi-fying and mapping genes of Mendelian diseases and complextraits. The geographical identification of isolates represents apriority from a genetic and health care standpoint. The pur-pose of this study is to analyze the spatial distribution ofconsanguinity by random isonymy (FST)inArgentinaanditsrelationship with the isolates previously identified in thecountry.FSTwas estimated from the surname distribution of22.6 million electors registered for the year 2001 in the 24provinces, 5 geographical regions, and 510 departments of thecountry. Statistically significant spatial clustering ofFSTwasdetermined using the SaTScan V5.1 software.FSTexhibited amarked regional and departamental variation, showing thehighest values towards the North and West of Argentina.The clusters of high consanguinity by random isonymyfollowed the same distribution. Recognized Argentinean ge-netic isolates are mainly localized at the north of the country,in clusters of high inbreeding. Given the availability of listingsof surnames in high-capacity storage devices for differentcountries, estimatingFSTfrom them can provide informationon inbreeding for all levels of administrative subdivisions, tobe used as a demographic variable for the identification ofisolates within the country for public health purposes.Fil: Dipierri, Jose Edgardo. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; ArgentinaFil: Rodriguez Larralde, Alvaro. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: Barrai, Italo. Universita Di Ferrara; ItaliaFil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gutierrez Redomero, Esperanza. Universidad de Alcalá; EspañaFil: Alonso Rodriguez, Concepcion. Universidad de Alcalá; EspañaFil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bronberg, Ruben. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Alfaro Gómez, Emma Laura. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSpringer Verlag Berlín2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32309Alfaro Gómez, Emma Laura; Bronberg, Ruben; Ramallo, Virginia; Alonso Rodriguez, Concepcion; Gutierrez Redomero, Esperanza; López Camelo, Jorge Santiago; et al.; Random inbreeding, isonymy, and population isolates in Argentina; Springer Verlag Berlín; Journal of Community Genetics; 5; 3; 2-2014; 241-2481868-310XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s12687-013-0181-xinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12687-013-0181-xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:45:45Zoai:ri.conicet.gov.ar:11336/32309instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:45:45.419CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Random inbreeding, isonymy, and population isolates in Argentina
title Random inbreeding, isonymy, and population isolates in Argentina
spellingShingle Random inbreeding, isonymy, and population isolates in Argentina
Dipierri, Jose Edgardo
Surnames
Random Isonymy
Consanguinity
Clusters
title_short Random inbreeding, isonymy, and population isolates in Argentina
title_full Random inbreeding, isonymy, and population isolates in Argentina
title_fullStr Random inbreeding, isonymy, and population isolates in Argentina
title_full_unstemmed Random inbreeding, isonymy, and population isolates in Argentina
title_sort Random inbreeding, isonymy, and population isolates in Argentina
dc.creator.none.fl_str_mv Dipierri, Jose Edgardo
Rodriguez Larralde, Alvaro
Barrai, Italo
López Camelo, Jorge Santiago
Gutierrez Redomero, Esperanza
Alonso Rodriguez, Concepcion
Ramallo, Virginia
Bronberg, Ruben
Alfaro Gómez, Emma Laura
author Dipierri, Jose Edgardo
author_facet Dipierri, Jose Edgardo
Rodriguez Larralde, Alvaro
Barrai, Italo
López Camelo, Jorge Santiago
Gutierrez Redomero, Esperanza
Alonso Rodriguez, Concepcion
Ramallo, Virginia
Bronberg, Ruben
Alfaro Gómez, Emma Laura
author_role author
author2 Rodriguez Larralde, Alvaro
Barrai, Italo
López Camelo, Jorge Santiago
Gutierrez Redomero, Esperanza
Alonso Rodriguez, Concepcion
Ramallo, Virginia
Bronberg, Ruben
Alfaro Gómez, Emma Laura
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Surnames
Random Isonymy
Consanguinity
Clusters
topic Surnames
Random Isonymy
Consanguinity
Clusters
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Population isolates are an important tool in identi-fying and mapping genes of Mendelian diseases and complextraits. The geographical identification of isolates represents apriority from a genetic and health care standpoint. The pur-pose of this study is to analyze the spatial distribution ofconsanguinity by random isonymy (FST)inArgentinaanditsrelationship with the isolates previously identified in thecountry.FSTwas estimated from the surname distribution of22.6 million electors registered for the year 2001 in the 24provinces, 5 geographical regions, and 510 departments of thecountry. Statistically significant spatial clustering ofFSTwasdetermined using the SaTScan V5.1 software.FSTexhibited amarked regional and departamental variation, showing thehighest values towards the North and West of Argentina.The clusters of high consanguinity by random isonymyfollowed the same distribution. Recognized Argentinean ge-netic isolates are mainly localized at the north of the country,in clusters of high inbreeding. Given the availability of listingsof surnames in high-capacity storage devices for differentcountries, estimatingFSTfrom them can provide informationon inbreeding for all levels of administrative subdivisions, tobe used as a demographic variable for the identification ofisolates within the country for public health purposes.
Fil: Dipierri, Jose Edgardo. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina
Fil: Rodriguez Larralde, Alvaro. Instituto Venezolano de Investigaciones Científicas; Venezuela
Fil: Barrai, Italo. Universita Di Ferrara; Italia
Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gutierrez Redomero, Esperanza. Universidad de Alcalá; España
Fil: Alonso Rodriguez, Concepcion. Universidad de Alcalá; España
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bronberg, Ruben. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Alfaro Gómez, Emma Laura. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Population isolates are an important tool in identi-fying and mapping genes of Mendelian diseases and complextraits. The geographical identification of isolates represents apriority from a genetic and health care standpoint. The pur-pose of this study is to analyze the spatial distribution ofconsanguinity by random isonymy (FST)inArgentinaanditsrelationship with the isolates previously identified in thecountry.FSTwas estimated from the surname distribution of22.6 million electors registered for the year 2001 in the 24provinces, 5 geographical regions, and 510 departments of thecountry. Statistically significant spatial clustering ofFSTwasdetermined using the SaTScan V5.1 software.FSTexhibited amarked regional and departamental variation, showing thehighest values towards the North and West of Argentina.The clusters of high consanguinity by random isonymyfollowed the same distribution. Recognized Argentinean ge-netic isolates are mainly localized at the north of the country,in clusters of high inbreeding. Given the availability of listingsof surnames in high-capacity storage devices for differentcountries, estimatingFSTfrom them can provide informationon inbreeding for all levels of administrative subdivisions, tobe used as a demographic variable for the identification ofisolates within the country for public health purposes.
publishDate 2014
dc.date.none.fl_str_mv 2014-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32309
Alfaro Gómez, Emma Laura; Bronberg, Ruben; Ramallo, Virginia; Alonso Rodriguez, Concepcion; Gutierrez Redomero, Esperanza; López Camelo, Jorge Santiago; et al.; Random inbreeding, isonymy, and population isolates in Argentina; Springer Verlag Berlín; Journal of Community Genetics; 5; 3; 2-2014; 241-248
1868-310X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32309
identifier_str_mv Alfaro Gómez, Emma Laura; Bronberg, Ruben; Ramallo, Virginia; Alonso Rodriguez, Concepcion; Gutierrez Redomero, Esperanza; López Camelo, Jorge Santiago; et al.; Random inbreeding, isonymy, and population isolates in Argentina; Springer Verlag Berlín; Journal of Community Genetics; 5; 3; 2-2014; 241-248
1868-310X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s12687-013-0181-x
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12687-013-0181-x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag Berlín
publisher.none.fl_str_mv Springer Verlag Berlín
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1848597846028189696
score 12.976206

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