"Protein" no longer means what it used to

Autores
Parisi, Gustavo Daniel; Palopoli, Nicolás; Tosatto, Silvio C. E.; Fornasari, Maria Silvina; Tompa, Peter
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Every biologist knows that the word protein describes a group of macromolecules essential to sustain life on Earth. As biologists, we are invariably trained under a protein paradigm established since the early twentieth century. However, in recent years, the term protein unveiled itself as an euphemism to describe the overwhelming heterogeneity of these compounds. Most of our current studies are targeted on carefully selected subsets of proteins, but we tend to think and write about these as representative of the whole population. Here we discuss how seeking for universal definitions and general rules in any arbitrarily segmented study would be misleading about the conclusions. Of course, it is not our purpose to discourage the use of the word protein. Instead, we suggest to embrace the extended universe of proteins to reach a deeper understanding of their full potential, realizing that the term encompasses a group of molecules very heterogeneous in terms of size, shape, chemistry and functions, i.e. the term protein no longer means what it used to.
Fil: Parisi, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Palopoli, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Tosatto, Silvio C. E.. Università di Padova; Italia
Fil: Fornasari, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Tompa, Peter. Vrije Unviversiteit Brussel; Bélgica. Research Centre for Natural Sciences. Institute of Enzymology; Hungría
Materia
PROTEIN TYPES
NATIVE STATE
HETEROGENEITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/157732
Acceder
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spelling "Protein" no longer means what it used toParisi, Gustavo DanielPalopoli, NicolásTosatto, Silvio C. E.Fornasari, Maria SilvinaTompa, PeterPROTEIN TYPESNATIVE STATEHETEROGENEITYhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Every biologist knows that the word protein describes a group of macromolecules essential to sustain life on Earth. As biologists, we are invariably trained under a protein paradigm established since the early twentieth century. However, in recent years, the term protein unveiled itself as an euphemism to describe the overwhelming heterogeneity of these compounds. Most of our current studies are targeted on carefully selected subsets of proteins, but we tend to think and write about these as representative of the whole population. Here we discuss how seeking for universal definitions and general rules in any arbitrarily segmented study would be misleading about the conclusions. Of course, it is not our purpose to discourage the use of the word protein. Instead, we suggest to embrace the extended universe of proteins to reach a deeper understanding of their full potential, realizing that the term encompasses a group of molecules very heterogeneous in terms of size, shape, chemistry and functions, i.e. the term protein no longer means what it used to.Fil: Parisi, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Palopoli, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Tosatto, Silvio C. E.. Università di Padova; ItaliaFil: Fornasari, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Tompa, Peter. Vrije Unviversiteit Brussel; Bélgica. Research Centre for Natural Sciences. Institute of Enzymology; HungríaElsevier2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/157732Parisi, Gustavo Daniel; Palopoli, Nicolás; Tosatto, Silvio C. E.; Fornasari, Maria Silvina; Tompa, Peter; "Protein" no longer means what it used to; Elsevier; Current Research in Structural Biology; 3; 6-2021; 146-1522665-928XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2665928X2100012Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.crstbi.2021.06.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:54:06Zoai:ri.conicet.gov.ar:11336/157732instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:54:06.24CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv "Protein" no longer means what it used to
title "Protein" no longer means what it used to
spellingShingle "Protein" no longer means what it used to
Parisi, Gustavo Daniel
PROTEIN TYPES
NATIVE STATE
HETEROGENEITY
title_short "Protein" no longer means what it used to
title_full "Protein" no longer means what it used to
title_fullStr "Protein" no longer means what it used to
title_full_unstemmed "Protein" no longer means what it used to
title_sort "Protein" no longer means what it used to
dc.creator.none.fl_str_mv Parisi, Gustavo Daniel
Palopoli, Nicolás
Tosatto, Silvio C. E.
Fornasari, Maria Silvina
Tompa, Peter
author Parisi, Gustavo Daniel
author_facet Parisi, Gustavo Daniel
Palopoli, Nicolás
Tosatto, Silvio C. E.
Fornasari, Maria Silvina
Tompa, Peter
author_role author
author2 Palopoli, Nicolás
Tosatto, Silvio C. E.
Fornasari, Maria Silvina
Tompa, Peter
author2_role author
author
author
author
dc.subject.none.fl_str_mv PROTEIN TYPES
NATIVE STATE
HETEROGENEITY
topic PROTEIN TYPES
NATIVE STATE
HETEROGENEITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Every biologist knows that the word protein describes a group of macromolecules essential to sustain life on Earth. As biologists, we are invariably trained under a protein paradigm established since the early twentieth century. However, in recent years, the term protein unveiled itself as an euphemism to describe the overwhelming heterogeneity of these compounds. Most of our current studies are targeted on carefully selected subsets of proteins, but we tend to think and write about these as representative of the whole population. Here we discuss how seeking for universal definitions and general rules in any arbitrarily segmented study would be misleading about the conclusions. Of course, it is not our purpose to discourage the use of the word protein. Instead, we suggest to embrace the extended universe of proteins to reach a deeper understanding of their full potential, realizing that the term encompasses a group of molecules very heterogeneous in terms of size, shape, chemistry and functions, i.e. the term protein no longer means what it used to.
Fil: Parisi, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Palopoli, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Tosatto, Silvio C. E.. Università di Padova; Italia
Fil: Fornasari, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Tompa, Peter. Vrije Unviversiteit Brussel; Bélgica. Research Centre for Natural Sciences. Institute of Enzymology; Hungría
description Every biologist knows that the word protein describes a group of macromolecules essential to sustain life on Earth. As biologists, we are invariably trained under a protein paradigm established since the early twentieth century. However, in recent years, the term protein unveiled itself as an euphemism to describe the overwhelming heterogeneity of these compounds. Most of our current studies are targeted on carefully selected subsets of proteins, but we tend to think and write about these as representative of the whole population. Here we discuss how seeking for universal definitions and general rules in any arbitrarily segmented study would be misleading about the conclusions. Of course, it is not our purpose to discourage the use of the word protein. Instead, we suggest to embrace the extended universe of proteins to reach a deeper understanding of their full potential, realizing that the term encompasses a group of molecules very heterogeneous in terms of size, shape, chemistry and functions, i.e. the term protein no longer means what it used to.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/157732
Parisi, Gustavo Daniel; Palopoli, Nicolás; Tosatto, Silvio C. E.; Fornasari, Maria Silvina; Tompa, Peter; "Protein" no longer means what it used to; Elsevier; Current Research in Structural Biology; 3; 6-2021; 146-152
2665-928X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/157732
identifier_str_mv Parisi, Gustavo Daniel; Palopoli, Nicolás; Tosatto, Silvio C. E.; Fornasari, Maria Silvina; Tompa, Peter; "Protein" no longer means what it used to; Elsevier; Current Research in Structural Biology; 3; 6-2021; 146-152
2665-928X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2665928X2100012X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.crstbi.2021.06.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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