Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
- Autores
- Sekine, Takuya; Perez Potti, André; Rivera Ballesteros, Olga; Strålin, Kristoffer; Gorin, Jean Baptiste; Olsson, Annika; Llewellyn Lacey, Sian; Kamal, Habiba; Bogdanovic, Gordana; Muschiol, Sandra; Wullimann, David J.; Kammann, Tobias; Emgård, Johanna; Parrot, Tiphaine; Folkesson, Elin; Rooyackers, Olav; Eriksson, Lars I.; Henter, Jan Inge; Sönnerborg, Anders; Allander, Tobias; Albert, Jan; Nielsen, Morten; Klingstrom, Jonas; Gredmark Russ, Sara; Björkström, Niklas K.; Sandberg, Johan K.; Price, David A.; Ljunggren, Hans Gustaf; Aleman, Soo; Buggert, Marcus
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
Fil: Sekine, Takuya. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Perez Potti, André. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Rivera Ballesteros, Olga. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Strålin, Kristoffer. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Gorin, Jean Baptiste. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Olsson, Annika. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Llewellyn Lacey, Sian. University Hospital of Wales; Reino Unido
Fil: Kamal, Habiba. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Bogdanovic, Gordana. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Muschiol, Sandra. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Wullimann, David J.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Kammann, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Emgård, Johanna. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Parrot, Tiphaine. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Folkesson, Elin. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Rooyackers, Olav. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Karolinska University Hospital; Suecia
Fil: Eriksson, Lars I.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Henter, Jan Inge. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Sönnerborg, Anders. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Allander, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Albert, Jan. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Klingstrom, Jonas. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Gredmark Russ, Sara. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Björkström, Niklas K.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Sandberg, Johan K.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Price, David A.. Cardiff University School of Medicine; Reino Unido
Fil: Ljunggren, Hans Gustaf. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Aleman, Soo. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Buggert, Marcus. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia - Materia
-
T cell
Sars-Cov-2
Epitope
COVID-19 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/135121
Ver los metadatos del registro completo
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Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19Sekine, TakuyaPerez Potti, AndréRivera Ballesteros, OlgaStrålin, KristofferGorin, Jean BaptisteOlsson, AnnikaLlewellyn Lacey, SianKamal, HabibaBogdanovic, GordanaMuschiol, SandraWullimann, David J.Kammann, TobiasEmgård, JohannaParrot, TiphaineFolkesson, ElinRooyackers, OlavEriksson, Lars I.Henter, Jan IngeSönnerborg, AndersAllander, TobiasAlbert, JanNielsen, MortenKlingstrom, JonasGredmark Russ, SaraBjörkström, Niklas K.Sandberg, Johan K.Price, David A.Ljunggren, Hans GustafAleman, SooBuggert, MarcusT cellSars-Cov-2EpitopeCOVID-19https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.Fil: Sekine, Takuya. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Perez Potti, André. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Rivera Ballesteros, Olga. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Strålin, Kristoffer. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Gorin, Jean Baptiste. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Olsson, Annika. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Llewellyn Lacey, Sian. University Hospital of Wales; Reino UnidoFil: Kamal, Habiba. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Bogdanovic, Gordana. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Muschiol, Sandra. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Wullimann, David J.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Kammann, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Emgård, Johanna. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Parrot, Tiphaine. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Folkesson, Elin. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Rooyackers, Olav. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Karolinska University Hospital; SueciaFil: Eriksson, Lars I.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Henter, Jan Inge. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Sönnerborg, Anders. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Allander, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Albert, Jan. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Klingstrom, Jonas. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Gredmark Russ, Sara. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Björkström, Niklas K.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Sandberg, Johan K.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Price, David A.. Cardiff University School of Medicine; Reino UnidoFil: Ljunggren, Hans Gustaf. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Aleman, Soo. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Buggert, Marcus. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaCell Press2020-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/135121Sekine, Takuya; Perez Potti, André; Rivera Ballesteros, Olga; Strålin, Kristoffer; Gorin, Jean Baptiste; et al.; Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19; Cell Press; Cell; 183; 1; 1-10-2020; 158-1680092-8674CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2020.08.017info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420310084%3Fshowall%3Dtrueinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:20Zoai:ri.conicet.gov.ar:11336/135121instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:20.763CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 |
title |
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 |
spellingShingle |
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 Sekine, Takuya T cell Sars-Cov-2 Epitope COVID-19 |
title_short |
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 |
title_full |
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 |
title_fullStr |
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 |
title_full_unstemmed |
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 |
title_sort |
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 |
dc.creator.none.fl_str_mv |
Sekine, Takuya Perez Potti, André Rivera Ballesteros, Olga Strålin, Kristoffer Gorin, Jean Baptiste Olsson, Annika Llewellyn Lacey, Sian Kamal, Habiba Bogdanovic, Gordana Muschiol, Sandra Wullimann, David J. Kammann, Tobias Emgård, Johanna Parrot, Tiphaine Folkesson, Elin Rooyackers, Olav Eriksson, Lars I. Henter, Jan Inge Sönnerborg, Anders Allander, Tobias Albert, Jan Nielsen, Morten Klingstrom, Jonas Gredmark Russ, Sara Björkström, Niklas K. Sandberg, Johan K. Price, David A. Ljunggren, Hans Gustaf Aleman, Soo Buggert, Marcus |
author |
Sekine, Takuya |
author_facet |
Sekine, Takuya Perez Potti, André Rivera Ballesteros, Olga Strålin, Kristoffer Gorin, Jean Baptiste Olsson, Annika Llewellyn Lacey, Sian Kamal, Habiba Bogdanovic, Gordana Muschiol, Sandra Wullimann, David J. Kammann, Tobias Emgård, Johanna Parrot, Tiphaine Folkesson, Elin Rooyackers, Olav Eriksson, Lars I. Henter, Jan Inge Sönnerborg, Anders Allander, Tobias Albert, Jan Nielsen, Morten Klingstrom, Jonas Gredmark Russ, Sara Björkström, Niklas K. Sandberg, Johan K. Price, David A. Ljunggren, Hans Gustaf Aleman, Soo Buggert, Marcus |
author_role |
author |
author2 |
Perez Potti, André Rivera Ballesteros, Olga Strålin, Kristoffer Gorin, Jean Baptiste Olsson, Annika Llewellyn Lacey, Sian Kamal, Habiba Bogdanovic, Gordana Muschiol, Sandra Wullimann, David J. Kammann, Tobias Emgård, Johanna Parrot, Tiphaine Folkesson, Elin Rooyackers, Olav Eriksson, Lars I. Henter, Jan Inge Sönnerborg, Anders Allander, Tobias Albert, Jan Nielsen, Morten Klingstrom, Jonas Gredmark Russ, Sara Björkström, Niklas K. Sandberg, Johan K. Price, David A. Ljunggren, Hans Gustaf Aleman, Soo Buggert, Marcus |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
T cell Sars-Cov-2 Epitope COVID-19 |
topic |
T cell Sars-Cov-2 Epitope COVID-19 |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19. Fil: Sekine, Takuya. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Perez Potti, André. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Rivera Ballesteros, Olga. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Strålin, Kristoffer. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Gorin, Jean Baptiste. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Olsson, Annika. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Llewellyn Lacey, Sian. University Hospital of Wales; Reino Unido Fil: Kamal, Habiba. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Bogdanovic, Gordana. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Muschiol, Sandra. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Wullimann, David J.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Kammann, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Emgård, Johanna. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Parrot, Tiphaine. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Folkesson, Elin. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Rooyackers, Olav. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Karolinska University Hospital; Suecia Fil: Eriksson, Lars I.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Henter, Jan Inge. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Sönnerborg, Anders. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Allander, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Albert, Jan. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Klingstrom, Jonas. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Gredmark Russ, Sara. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Björkström, Niklas K.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Sandberg, Johan K.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Price, David A.. Cardiff University School of Medicine; Reino Unido Fil: Ljunggren, Hans Gustaf. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Aleman, Soo. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Buggert, Marcus. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia |
description |
SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/135121 Sekine, Takuya; Perez Potti, André; Rivera Ballesteros, Olga; Strålin, Kristoffer; Gorin, Jean Baptiste; et al.; Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19; Cell Press; Cell; 183; 1; 1-10-2020; 158-168 0092-8674 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/135121 |
identifier_str_mv |
Sekine, Takuya; Perez Potti, André; Rivera Ballesteros, Olga; Strålin, Kristoffer; Gorin, Jean Baptiste; et al.; Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19; Cell Press; Cell; 183; 1; 1-10-2020; 158-168 0092-8674 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2020.08.017 info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420310084%3Fshowall%3Dtrue |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Cell Press |
publisher.none.fl_str_mv |
Cell Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269906728386560 |
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13.13397 |