Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Autores
Sekine, Takuya; Perez Potti, André; Rivera Ballesteros, Olga; Strålin, Kristoffer; Gorin, Jean Baptiste; Olsson, Annika; Llewellyn Lacey, Sian; Kamal, Habiba; Bogdanovic, Gordana; Muschiol, Sandra; Wullimann, David J.; Kammann, Tobias; Emgård, Johanna; Parrot, Tiphaine; Folkesson, Elin; Rooyackers, Olav; Eriksson, Lars I.; Henter, Jan Inge; Sönnerborg, Anders; Allander, Tobias; Albert, Jan; Nielsen, Morten; Klingstrom, Jonas; Gredmark Russ, Sara; Björkström, Niklas K.; Sandberg, Johan K.; Price, David A.; Ljunggren, Hans Gustaf; Aleman, Soo; Buggert, Marcus
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
Fil: Sekine, Takuya. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Perez Potti, André. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Rivera Ballesteros, Olga. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Strålin, Kristoffer. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Gorin, Jean Baptiste. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Olsson, Annika. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Llewellyn Lacey, Sian. University Hospital of Wales; Reino Unido
Fil: Kamal, Habiba. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Bogdanovic, Gordana. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Muschiol, Sandra. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Wullimann, David J.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Kammann, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Emgård, Johanna. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Parrot, Tiphaine. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Folkesson, Elin. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Rooyackers, Olav. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Karolinska University Hospital; Suecia
Fil: Eriksson, Lars I.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Henter, Jan Inge. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Sönnerborg, Anders. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Allander, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Albert, Jan. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Klingstrom, Jonas. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Gredmark Russ, Sara. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Björkström, Niklas K.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Sandberg, Johan K.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Price, David A.. Cardiff University School of Medicine; Reino Unido
Fil: Ljunggren, Hans Gustaf. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Aleman, Soo. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Buggert, Marcus. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Materia
T cell
Sars-Cov-2
Epitope
COVID-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/135121

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oai_identifier_str oai:ri.conicet.gov.ar:11336/135121
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19Sekine, TakuyaPerez Potti, AndréRivera Ballesteros, OlgaStrålin, KristofferGorin, Jean BaptisteOlsson, AnnikaLlewellyn Lacey, SianKamal, HabibaBogdanovic, GordanaMuschiol, SandraWullimann, David J.Kammann, TobiasEmgård, JohannaParrot, TiphaineFolkesson, ElinRooyackers, OlavEriksson, Lars I.Henter, Jan IngeSönnerborg, AndersAllander, TobiasAlbert, JanNielsen, MortenKlingstrom, JonasGredmark Russ, SaraBjörkström, Niklas K.Sandberg, Johan K.Price, David A.Ljunggren, Hans GustafAleman, SooBuggert, MarcusT cellSars-Cov-2EpitopeCOVID-19https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.Fil: Sekine, Takuya. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Perez Potti, André. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Rivera Ballesteros, Olga. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Strålin, Kristoffer. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Gorin, Jean Baptiste. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Olsson, Annika. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Llewellyn Lacey, Sian. University Hospital of Wales; Reino UnidoFil: Kamal, Habiba. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Bogdanovic, Gordana. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Muschiol, Sandra. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Wullimann, David J.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Kammann, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Emgård, Johanna. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Parrot, Tiphaine. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Folkesson, Elin. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Rooyackers, Olav. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Karolinska University Hospital; SueciaFil: Eriksson, Lars I.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Henter, Jan Inge. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Sönnerborg, Anders. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Allander, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Albert, Jan. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Klingstrom, Jonas. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Gredmark Russ, Sara. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Björkström, Niklas K.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Sandberg, Johan K.. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Price, David A.. Cardiff University School of Medicine; Reino UnidoFil: Ljunggren, Hans Gustaf. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Aleman, Soo. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Buggert, Marcus. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaCell Press2020-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/135121Sekine, Takuya; Perez Potti, André; Rivera Ballesteros, Olga; Strålin, Kristoffer; Gorin, Jean Baptiste; et al.; Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19; Cell Press; Cell; 183; 1; 1-10-2020; 158-1680092-8674CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2020.08.017info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420310084%3Fshowall%3Dtrueinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:20Zoai:ri.conicet.gov.ar:11336/135121instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:20.763CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
spellingShingle Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
Sekine, Takuya
T cell
Sars-Cov-2
Epitope
COVID-19
title_short Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title_full Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title_fullStr Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title_full_unstemmed Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
title_sort Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
dc.creator.none.fl_str_mv Sekine, Takuya
Perez Potti, André
Rivera Ballesteros, Olga
Strålin, Kristoffer
Gorin, Jean Baptiste
Olsson, Annika
Llewellyn Lacey, Sian
Kamal, Habiba
Bogdanovic, Gordana
Muschiol, Sandra
Wullimann, David J.
Kammann, Tobias
Emgård, Johanna
Parrot, Tiphaine
Folkesson, Elin
Rooyackers, Olav
Eriksson, Lars I.
Henter, Jan Inge
Sönnerborg, Anders
Allander, Tobias
Albert, Jan
Nielsen, Morten
Klingstrom, Jonas
Gredmark Russ, Sara
Björkström, Niklas K.
Sandberg, Johan K.
Price, David A.
Ljunggren, Hans Gustaf
Aleman, Soo
Buggert, Marcus
author Sekine, Takuya
author_facet Sekine, Takuya
Perez Potti, André
Rivera Ballesteros, Olga
Strålin, Kristoffer
Gorin, Jean Baptiste
Olsson, Annika
Llewellyn Lacey, Sian
Kamal, Habiba
Bogdanovic, Gordana
Muschiol, Sandra
Wullimann, David J.
Kammann, Tobias
Emgård, Johanna
Parrot, Tiphaine
Folkesson, Elin
Rooyackers, Olav
Eriksson, Lars I.
Henter, Jan Inge
Sönnerborg, Anders
Allander, Tobias
Albert, Jan
Nielsen, Morten
Klingstrom, Jonas
Gredmark Russ, Sara
Björkström, Niklas K.
Sandberg, Johan K.
Price, David A.
Ljunggren, Hans Gustaf
Aleman, Soo
Buggert, Marcus
author_role author
author2 Perez Potti, André
Rivera Ballesteros, Olga
Strålin, Kristoffer
Gorin, Jean Baptiste
Olsson, Annika
Llewellyn Lacey, Sian
Kamal, Habiba
Bogdanovic, Gordana
Muschiol, Sandra
Wullimann, David J.
Kammann, Tobias
Emgård, Johanna
Parrot, Tiphaine
Folkesson, Elin
Rooyackers, Olav
Eriksson, Lars I.
Henter, Jan Inge
Sönnerborg, Anders
Allander, Tobias
Albert, Jan
Nielsen, Morten
Klingstrom, Jonas
Gredmark Russ, Sara
Björkström, Niklas K.
Sandberg, Johan K.
Price, David A.
Ljunggren, Hans Gustaf
Aleman, Soo
Buggert, Marcus
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv T cell
Sars-Cov-2
Epitope
COVID-19
topic T cell
Sars-Cov-2
Epitope
COVID-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
Fil: Sekine, Takuya. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Perez Potti, André. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Rivera Ballesteros, Olga. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Strålin, Kristoffer. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Gorin, Jean Baptiste. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Olsson, Annika. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Llewellyn Lacey, Sian. University Hospital of Wales; Reino Unido
Fil: Kamal, Habiba. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Bogdanovic, Gordana. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Muschiol, Sandra. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Wullimann, David J.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Kammann, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Emgård, Johanna. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Parrot, Tiphaine. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Folkesson, Elin. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Rooyackers, Olav. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Karolinska University Hospital; Suecia
Fil: Eriksson, Lars I.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Henter, Jan Inge. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Sönnerborg, Anders. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Allander, Tobias. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Albert, Jan. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Klingstrom, Jonas. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Gredmark Russ, Sara. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Björkström, Niklas K.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Sandberg, Johan K.. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Price, David A.. Cardiff University School of Medicine; Reino Unido
Fil: Ljunggren, Hans Gustaf. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Aleman, Soo. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Buggert, Marcus. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
description SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
publishDate 2020
dc.date.none.fl_str_mv 2020-10-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/135121
Sekine, Takuya; Perez Potti, André; Rivera Ballesteros, Olga; Strålin, Kristoffer; Gorin, Jean Baptiste; et al.; Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19; Cell Press; Cell; 183; 1; 1-10-2020; 158-168
0092-8674
CONICET Digital
CONICET
url http://hdl.handle.net/11336/135121
identifier_str_mv Sekine, Takuya; Perez Potti, André; Rivera Ballesteros, Olga; Strålin, Kristoffer; Gorin, Jean Baptiste; et al.; Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19; Cell Press; Cell; 183; 1; 1-10-2020; 158-168
0092-8674
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2020.08.017
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell/fulltext/S0092-8674(20)31008-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420310084%3Fshowall%3Dtrue
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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