Dendritic cell maturation and cross-presentation: timing matters!

Autores
Alloatti, Andrés; Kotsias, Fiorella; Magalhaes, Joao Gamelas; Amigorena, Sebastian
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
As a population, dendritic cells (DCs) appear to be the best cross-presenters of internalized antigens on major histocompatibility complex class I molecules in the mouse. To do this, DCs have developed a number of unique and dedicated means to control their endocytic and phagocytic pathways: among them, the capacity to limit acidification of their phagosomes, to prevent proteolytic degradation, to delay fusion of phagosomes to lysosomes, to recruit ER proteins to phagosomes, and to export phagocytosed antigens to the cytosol. The regulation of phagocytic functions, and thereby of antigen processing and presentation by innate signaling, represents a critical level of integration of adaptive and innate immune responses. Understanding how innate signals control antigen cross-presentation is critical to define effective vaccination strategies for CD8+ T-cell responses.
Fil: Alloatti, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Inserm; Francia
Fil: Kotsias, Fiorella. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Inserm; Francia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; Argentina
Fil: Magalhaes, Joao Gamelas. Inserm; Francia
Fil: Amigorena, Sebastian. Inserm; Francia
Materia
Cross-Presentation
Dendritic Cell
Dendritic Cells Maturation
Phagocytosis
Toll-Like Receptor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/51425
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Dendritic cell maturation and cross-presentation: timing matters!Alloatti, AndrésKotsias, FiorellaMagalhaes, Joao GamelasAmigorena, SebastianCross-PresentationDendritic CellDendritic Cells MaturationPhagocytosisToll-Like Receptorhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1As a population, dendritic cells (DCs) appear to be the best cross-presenters of internalized antigens on major histocompatibility complex class I molecules in the mouse. To do this, DCs have developed a number of unique and dedicated means to control their endocytic and phagocytic pathways: among them, the capacity to limit acidification of their phagosomes, to prevent proteolytic degradation, to delay fusion of phagosomes to lysosomes, to recruit ER proteins to phagosomes, and to export phagocytosed antigens to the cytosol. The regulation of phagocytic functions, and thereby of antigen processing and presentation by innate signaling, represents a critical level of integration of adaptive and innate immune responses. Understanding how innate signals control antigen cross-presentation is critical to define effective vaccination strategies for CD8+ T-cell responses.Fil: Alloatti, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Inserm; FranciaFil: Kotsias, Fiorella. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Inserm; Francia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; ArgentinaFil: Magalhaes, Joao Gamelas. Inserm; FranciaFil: Amigorena, Sebastian. Inserm; FranciaWiley Blackwell Publishing, Inc2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/51425Alloatti, Andrés; Kotsias, Fiorella; Magalhaes, Joao Gamelas; Amigorena, Sebastian; Dendritic cell maturation and cross-presentation: timing matters!; Wiley Blackwell Publishing, Inc; Immunological Reviews; 272; 1; 7-2016; 97-1080105-2896CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/imr.12432info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/imr.12432info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:41:20Zoai:ri.conicet.gov.ar:11336/51425instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:41:20.932CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dendritic cell maturation and cross-presentation: timing matters!
title Dendritic cell maturation and cross-presentation: timing matters!
spellingShingle Dendritic cell maturation and cross-presentation: timing matters!
Alloatti, Andrés
Cross-Presentation
Dendritic Cell
Dendritic Cells Maturation
Phagocytosis
Toll-Like Receptor
title_short Dendritic cell maturation and cross-presentation: timing matters!
title_full Dendritic cell maturation and cross-presentation: timing matters!
title_fullStr Dendritic cell maturation and cross-presentation: timing matters!
title_full_unstemmed Dendritic cell maturation and cross-presentation: timing matters!
title_sort Dendritic cell maturation and cross-presentation: timing matters!
dc.creator.none.fl_str_mv Alloatti, Andrés
Kotsias, Fiorella
Magalhaes, Joao Gamelas
Amigorena, Sebastian
author Alloatti, Andrés
author_facet Alloatti, Andrés
Kotsias, Fiorella
Magalhaes, Joao Gamelas
Amigorena, Sebastian
author_role author
author2 Kotsias, Fiorella
Magalhaes, Joao Gamelas
Amigorena, Sebastian
author2_role author
author
author
dc.subject.none.fl_str_mv Cross-Presentation
Dendritic Cell
Dendritic Cells Maturation
Phagocytosis
Toll-Like Receptor
topic Cross-Presentation
Dendritic Cell
Dendritic Cells Maturation
Phagocytosis
Toll-Like Receptor
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv As a population, dendritic cells (DCs) appear to be the best cross-presenters of internalized antigens on major histocompatibility complex class I molecules in the mouse. To do this, DCs have developed a number of unique and dedicated means to control their endocytic and phagocytic pathways: among them, the capacity to limit acidification of their phagosomes, to prevent proteolytic degradation, to delay fusion of phagosomes to lysosomes, to recruit ER proteins to phagosomes, and to export phagocytosed antigens to the cytosol. The regulation of phagocytic functions, and thereby of antigen processing and presentation by innate signaling, represents a critical level of integration of adaptive and innate immune responses. Understanding how innate signals control antigen cross-presentation is critical to define effective vaccination strategies for CD8+ T-cell responses.
Fil: Alloatti, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Inserm; Francia
Fil: Kotsias, Fiorella. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Inserm; Francia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; Argentina
Fil: Magalhaes, Joao Gamelas. Inserm; Francia
Fil: Amigorena, Sebastian. Inserm; Francia
description As a population, dendritic cells (DCs) appear to be the best cross-presenters of internalized antigens on major histocompatibility complex class I molecules in the mouse. To do this, DCs have developed a number of unique and dedicated means to control their endocytic and phagocytic pathways: among them, the capacity to limit acidification of their phagosomes, to prevent proteolytic degradation, to delay fusion of phagosomes to lysosomes, to recruit ER proteins to phagosomes, and to export phagocytosed antigens to the cytosol. The regulation of phagocytic functions, and thereby of antigen processing and presentation by innate signaling, represents a critical level of integration of adaptive and innate immune responses. Understanding how innate signals control antigen cross-presentation is critical to define effective vaccination strategies for CD8+ T-cell responses.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/51425
Alloatti, Andrés; Kotsias, Fiorella; Magalhaes, Joao Gamelas; Amigorena, Sebastian; Dendritic cell maturation and cross-presentation: timing matters!; Wiley Blackwell Publishing, Inc; Immunological Reviews; 272; 1; 7-2016; 97-108
0105-2896
CONICET Digital
CONICET
url http://hdl.handle.net/11336/51425
identifier_str_mv Alloatti, Andrés; Kotsias, Fiorella; Magalhaes, Joao Gamelas; Amigorena, Sebastian; Dendritic cell maturation and cross-presentation: timing matters!; Wiley Blackwell Publishing, Inc; Immunological Reviews; 272; 1; 7-2016; 97-108
0105-2896
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/imr.12432
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/imr.12432
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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