Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART

Autores
Zalar, Alberto; Figueroa, Maria Ines; Ruibal Ares, Beatriz; Baré, Patricia; Cahn, Pedro; de Bracco, Maria Marta de E.; Belmonte de Zalar, Liliana Elizabeth
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mucosal surfaces play a major role in human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis. Since the role of intestinal macrophages as viral reservoirs during chronic HIV-1 infection has not been elucidated, we investigated the effects of successful therapy on intestinal HIV-1 persistence. Intestinal macrophage infection was demonstrated by the expression of p24 antigen by flow cytometry and by the presence of proviral DNA, assessed by PCR. Proviral DNA was detected in duodenal mucosa of HIV-infected patients under treatment with undetectable plasma viral load. These findings confirm that intestinal macrophages can act as viral reservoirs and permit HIV-1 production even after viral suppression following antiretroviral therapy. © 2010 Elsevier B.V.
Fil: Zalar, Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Figueroa, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Ruibal Ares, Beatriz. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Cahn, Pedro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: de Bracco, Maria Marta de E.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Belmonte de Zalar, Liliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
Materia
Haart
Hiv-1
Intestinal Macrophages
Tissue Reservoirs
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52935
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/52935
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Macrophage HIV-1 infection in duodenal tissue of patients on long term HAARTZalar, AlbertoFigueroa, Maria InesRuibal Ares, BeatrizBaré, PatriciaCahn, Pedrode Bracco, Maria Marta de E.Belmonte de Zalar, Liliana ElizabethHaartHiv-1Intestinal MacrophagesTissue Reservoirshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Mucosal surfaces play a major role in human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis. Since the role of intestinal macrophages as viral reservoirs during chronic HIV-1 infection has not been elucidated, we investigated the effects of successful therapy on intestinal HIV-1 persistence. Intestinal macrophage infection was demonstrated by the expression of p24 antigen by flow cytometry and by the presence of proviral DNA, assessed by PCR. Proviral DNA was detected in duodenal mucosa of HIV-infected patients under treatment with undetectable plasma viral load. These findings confirm that intestinal macrophages can act as viral reservoirs and permit HIV-1 production even after viral suppression following antiretroviral therapy. © 2010 Elsevier B.V.Fil: Zalar, Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Figueroa, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Ruibal Ares, Beatriz. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Cahn, Pedro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: de Bracco, Maria Marta de E.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Belmonte de Zalar, Liliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; ArgentinaElsevier Science2010-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52935Zalar, Alberto; Figueroa, Maria Ines; Ruibal Ares, Beatriz; Baré, Patricia; Cahn, Pedro; et al.; Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART; Elsevier Science; Antiviral Research; 87; 2; 8-2010; 269-2710166-3542CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.antiviral.2010.05.005info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S016635421000608Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:16Zoai:ri.conicet.gov.ar:11336/52935instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:16.486CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART
title Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART
spellingShingle Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART
Zalar, Alberto
Haart
Hiv-1
Intestinal Macrophages
Tissue Reservoirs
title_short Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART
title_full Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART
title_fullStr Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART
title_full_unstemmed Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART
title_sort Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART
dc.creator.none.fl_str_mv Zalar, Alberto
Figueroa, Maria Ines
Ruibal Ares, Beatriz
Baré, Patricia
Cahn, Pedro
de Bracco, Maria Marta de E.
Belmonte de Zalar, Liliana Elizabeth
author Zalar, Alberto
author_facet Zalar, Alberto
Figueroa, Maria Ines
Ruibal Ares, Beatriz
Baré, Patricia
Cahn, Pedro
de Bracco, Maria Marta de E.
Belmonte de Zalar, Liliana Elizabeth
author_role author
author2 Figueroa, Maria Ines
Ruibal Ares, Beatriz
Baré, Patricia
Cahn, Pedro
de Bracco, Maria Marta de E.
Belmonte de Zalar, Liliana Elizabeth
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Haart
Hiv-1
Intestinal Macrophages
Tissue Reservoirs
topic Haart
Hiv-1
Intestinal Macrophages
Tissue Reservoirs
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mucosal surfaces play a major role in human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis. Since the role of intestinal macrophages as viral reservoirs during chronic HIV-1 infection has not been elucidated, we investigated the effects of successful therapy on intestinal HIV-1 persistence. Intestinal macrophage infection was demonstrated by the expression of p24 antigen by flow cytometry and by the presence of proviral DNA, assessed by PCR. Proviral DNA was detected in duodenal mucosa of HIV-infected patients under treatment with undetectable plasma viral load. These findings confirm that intestinal macrophages can act as viral reservoirs and permit HIV-1 production even after viral suppression following antiretroviral therapy. © 2010 Elsevier B.V.
Fil: Zalar, Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Figueroa, Maria Ines. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Ruibal Ares, Beatriz. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Baré, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Cahn, Pedro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: de Bracco, Maria Marta de E.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Belmonte de Zalar, Liliana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
description Mucosal surfaces play a major role in human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis. Since the role of intestinal macrophages as viral reservoirs during chronic HIV-1 infection has not been elucidated, we investigated the effects of successful therapy on intestinal HIV-1 persistence. Intestinal macrophage infection was demonstrated by the expression of p24 antigen by flow cytometry and by the presence of proviral DNA, assessed by PCR. Proviral DNA was detected in duodenal mucosa of HIV-infected patients under treatment with undetectable plasma viral load. These findings confirm that intestinal macrophages can act as viral reservoirs and permit HIV-1 production even after viral suppression following antiretroviral therapy. © 2010 Elsevier B.V.
publishDate 2010
dc.date.none.fl_str_mv 2010-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52935
Zalar, Alberto; Figueroa, Maria Ines; Ruibal Ares, Beatriz; Baré, Patricia; Cahn, Pedro; et al.; Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART; Elsevier Science; Antiviral Research; 87; 2; 8-2010; 269-271
0166-3542
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52935
identifier_str_mv Zalar, Alberto; Figueroa, Maria Ines; Ruibal Ares, Beatriz; Baré, Patricia; Cahn, Pedro; et al.; Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART; Elsevier Science; Antiviral Research; 87; 2; 8-2010; 269-271
0166-3542
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.antiviral.2010.05.005
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S016635421000608X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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