A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line

Autores
Martino, Renzo Fabricio; Sülsen, Valeria; Alonso, Rosario; Anesini, Claudia Alejandra
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Leukemia and lymphoma are a group of heterogeneous neoplastic disorder of white blood cells charac-terized by the uncontrolled proliferation and block in differentiation of hematopoietic cells. Nowadays,there is an interest in therapy with drugs of plant origin because conventional medicine can be inefficientor also results in side effects. Larrea divaricata Cav., is a plant widely distributed in Argentina that possessantiproliferative and antioxidant activities reported. Nordihydroguaiaretic acid (NDGA) was previouslyfound in the plant and related to both antiproliferative and pro-proliferative actions on a lymphoma cellline. In order to demonstrate whether the presence of NDGA may be beneficial or not in the antiprolifera-tive action of the aqueous extract, the extract of L. divaricata was submitted to a fractionation and fractionswith and without NDGA were studied in a murine lymphocitic leukemia cell line (EL-4) proliferation. Theeffect of the most active fraction was studied in relation to H2O2modulation and the synergistic actionbetween compounds, found in fractions, was analyzed. The presence of NDGA was not a detonator forpro-proliferative action and its presence could be beneficial in low concentrations allowing a synergistantiproliferative action with other compounds.
Fil: Martino, Renzo Fabricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
Fil: Sülsen, Valeria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
Fil: Alonso, Rosario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
Fil: Anesini, Claudia Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
Materia
Larrea Divaricata
El4 Lymphoma
Ndga
Quercetin-3-Methyl Ether
Oxidative Stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12545
Acceder
id CONICETDig_a9508bac2a8cc696f234e3e61c1a9482
oai_identifier_str oai:ri.conicet.gov.ar:11336/12545
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell lineMartino, Renzo FabricioSülsen, ValeriaAlonso, RosarioAnesini, Claudia AlejandraLarrea DivaricataEl4 LymphomaNdgaQuercetin-3-Methyl EtherOxidative Stresshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Leukemia and lymphoma are a group of heterogeneous neoplastic disorder of white blood cells charac-terized by the uncontrolled proliferation and block in differentiation of hematopoietic cells. Nowadays,there is an interest in therapy with drugs of plant origin because conventional medicine can be inefficientor also results in side effects. Larrea divaricata Cav., is a plant widely distributed in Argentina that possessantiproliferative and antioxidant activities reported. Nordihydroguaiaretic acid (NDGA) was previouslyfound in the plant and related to both antiproliferative and pro-proliferative actions on a lymphoma cellline. In order to demonstrate whether the presence of NDGA may be beneficial or not in the antiprolifera-tive action of the aqueous extract, the extract of L. divaricata was submitted to a fractionation and fractionswith and without NDGA were studied in a murine lymphocitic leukemia cell line (EL-4) proliferation. Theeffect of the most active fraction was studied in relation to H2O2modulation and the synergistic actionbetween compounds, found in fractions, was analyzed. The presence of NDGA was not a detonator forpro-proliferative action and its presence could be beneficial in low concentrations allowing a synergistantiproliferative action with other compounds.Fil: Martino, Renzo Fabricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; ArgentinaFil: Sülsen, Valeria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; ArgentinaFil: Alonso, Rosario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; ArgentinaFil: Anesini, Claudia Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; ArgentinaElsevier2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12545Martino, Renzo Fabricio; Sülsen, Valeria; Alonso, Rosario; Anesini, Claudia Alejandra; A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line; Elsevier; Leukemia Research; 37; 9; 6-2013; 1137-11430145-2126enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.leukres.2013.06.004info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0145212613001902info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:16:07Zoai:ri.conicet.gov.ar:11336/12545instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:16:07.572CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line
title A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line
spellingShingle A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line
Martino, Renzo Fabricio
Larrea Divaricata
El4 Lymphoma
Ndga
Quercetin-3-Methyl Ether
Oxidative Stress
title_short A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line
title_full A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line
title_fullStr A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line
title_full_unstemmed A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line
title_sort A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line
dc.creator.none.fl_str_mv Martino, Renzo Fabricio
Sülsen, Valeria
Alonso, Rosario
Anesini, Claudia Alejandra
author Martino, Renzo Fabricio
author_facet Martino, Renzo Fabricio
Sülsen, Valeria
Alonso, Rosario
Anesini, Claudia Alejandra
author_role author
author2 Sülsen, Valeria
Alonso, Rosario
Anesini, Claudia Alejandra
author2_role author
author
author
dc.subject.none.fl_str_mv Larrea Divaricata
El4 Lymphoma
Ndga
Quercetin-3-Methyl Ether
Oxidative Stress
topic Larrea Divaricata
El4 Lymphoma
Ndga
Quercetin-3-Methyl Ether
Oxidative Stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Leukemia and lymphoma are a group of heterogeneous neoplastic disorder of white blood cells charac-terized by the uncontrolled proliferation and block in differentiation of hematopoietic cells. Nowadays,there is an interest in therapy with drugs of plant origin because conventional medicine can be inefficientor also results in side effects. Larrea divaricata Cav., is a plant widely distributed in Argentina that possessantiproliferative and antioxidant activities reported. Nordihydroguaiaretic acid (NDGA) was previouslyfound in the plant and related to both antiproliferative and pro-proliferative actions on a lymphoma cellline. In order to demonstrate whether the presence of NDGA may be beneficial or not in the antiprolifera-tive action of the aqueous extract, the extract of L. divaricata was submitted to a fractionation and fractionswith and without NDGA were studied in a murine lymphocitic leukemia cell line (EL-4) proliferation. Theeffect of the most active fraction was studied in relation to H2O2modulation and the synergistic actionbetween compounds, found in fractions, was analyzed. The presence of NDGA was not a detonator forpro-proliferative action and its presence could be beneficial in low concentrations allowing a synergistantiproliferative action with other compounds.
Fil: Martino, Renzo Fabricio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
Fil: Sülsen, Valeria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
Fil: Alonso, Rosario. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
Fil: Anesini, Claudia Alejandra. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina. Universidad de Buenos Aires; Argentina
description Leukemia and lymphoma are a group of heterogeneous neoplastic disorder of white blood cells charac-terized by the uncontrolled proliferation and block in differentiation of hematopoietic cells. Nowadays,there is an interest in therapy with drugs of plant origin because conventional medicine can be inefficientor also results in side effects. Larrea divaricata Cav., is a plant widely distributed in Argentina that possessantiproliferative and antioxidant activities reported. Nordihydroguaiaretic acid (NDGA) was previouslyfound in the plant and related to both antiproliferative and pro-proliferative actions on a lymphoma cellline. In order to demonstrate whether the presence of NDGA may be beneficial or not in the antiprolifera-tive action of the aqueous extract, the extract of L. divaricata was submitted to a fractionation and fractionswith and without NDGA were studied in a murine lymphocitic leukemia cell line (EL-4) proliferation. Theeffect of the most active fraction was studied in relation to H2O2modulation and the synergistic actionbetween compounds, found in fractions, was analyzed. The presence of NDGA was not a detonator forpro-proliferative action and its presence could be beneficial in low concentrations allowing a synergistantiproliferative action with other compounds.
publishDate 2013
dc.date.none.fl_str_mv 2013-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12545
Martino, Renzo Fabricio; Sülsen, Valeria; Alonso, Rosario; Anesini, Claudia Alejandra; A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line; Elsevier; Leukemia Research; 37; 9; 6-2013; 1137-1143
0145-2126
url http://hdl.handle.net/11336/12545
identifier_str_mv Martino, Renzo Fabricio; Sülsen, Valeria; Alonso, Rosario; Anesini, Claudia Alejandra; A fraction rich in phenyl propanoids from L. divaricata aqueous extract is capable of inducing apoptosis, in relation to H2O2 modulation, on a murine lymphoma cell line; Elsevier; Leukemia Research; 37; 9; 6-2013; 1137-1143
0145-2126
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.leukres.2013.06.004
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0145212613001902
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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