Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model
- Autores
- Haro, Ana Cecilia; Zelaya, María Hortensia del Rosario; Lazarte, Sandra Stella; Alvarez, Gladis Susana; Aguero, Graciela
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Lactobacilllus casei CRL 431 has the ability to modulate the local and systemic immune responses, which are significantly involved in liver injury caused by hepatotoxins. This work was conducted to determine whether L. casei has a preventive effect on the hepatic damage undergone during an acute liver injury (ALI). Methods: ALI was induced by an intraperitoneal injection of D-galactosamine (D-Gal). Different groups of mice received 1× 10 9 L. casei cells/day/mouse for 2 days before D-Gal injection. Blood and liver samples were obtained 0, 6, 12, and 24 h after D-Gal administration. Results: D-Gal induced increases in serum aminotransferases, reduced the number of blood leukocytes, enhanced neutrophil myeloperoxidase activity, increased dead cells, and altered prothrombin time and plasma fibrinogen levels. The preventive treatment with L. casei for 2 days modulated the innate immune response. This effect was shown by the earlier normalization of white blood cell counts, myeloperoxidase activity and aminotransferases levels. However, the haemostatic parameters were only partially recovered. The favourable effects obtained could be due to the capacity of L. casei to moderate the inflammatory response at the site of the injury with less damage to liver tissue.
Lactobacillus casei CRL 431 a la capacité de moduler les réponses immunes locale et systémique, lesquelles sont significativement impliquées dans le dommage au foie causé par les hépatotoxines. Ce travail a été réalisé pour déterminer si L. casei pouvait prévenir des dommages hépatiques subits lors d’une atteinteé hépatique aigue¨ (AHA). Méthode : l’AHA a été induite par une injection intrapéritonéale de D-galactosamine (D-Gal). Différents groupes d’animaux ont rec¸u 1 109 cellules/jour/souris (L. casei) pendant 2 jours avant l’injection de D-Gal. Des échantillons de sang et de foie ont été prélevés 0, 6, 12 et 24 h aprés l’administration de D-Gal. Résultats : La D-Gal a induit une augmentation de l’activité des aminotransférases sériques, une réduction du nombre de leucocytes sanguins et une augmentation de l’activité de la myéloperoxydase des neutrophiles. Un traitement préventif a` L. casei pendant 2 jours a contribé a` moduler la réponse immune innée. Cet effet a été mis en évidence par la normalisation précoce de globules blancs sanguins, de l’activité de la MPO ainsi que des niveaux d’aminotransférases. Cependant, les paramétres hémostatiques n’étaient que partiellement recouvrés. Les effets favorables obtenus pourraient ^etre dus a` la capacité de L. casei a` moduler la réponse inflammatoire au site atteint, résultant en un dommage moindre du tissu hépatique.
Fil: Haro, Ana Cecilia. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Zelaya, María Hortensia del Rosario. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Lazarte, Sandra Stella. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Alvarez, Gladis Susana. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Aguero, Graciela. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina - Materia
-
Acute Liver Injury
Blood Coagulation
Lactobacillus Casei - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/56031
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Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury modelHaro, Ana CeciliaZelaya, María Hortensia del RosarioLazarte, Sandra StellaAlvarez, Gladis SusanaAguero, GracielaAcute Liver InjuryBlood CoagulationLactobacillus Caseihttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Lactobacilllus casei CRL 431 has the ability to modulate the local and systemic immune responses, which are significantly involved in liver injury caused by hepatotoxins. This work was conducted to determine whether L. casei has a preventive effect on the hepatic damage undergone during an acute liver injury (ALI). Methods: ALI was induced by an intraperitoneal injection of D-galactosamine (D-Gal). Different groups of mice received 1× 10 9 L. casei cells/day/mouse for 2 days before D-Gal injection. Blood and liver samples were obtained 0, 6, 12, and 24 h after D-Gal administration. Results: D-Gal induced increases in serum aminotransferases, reduced the number of blood leukocytes, enhanced neutrophil myeloperoxidase activity, increased dead cells, and altered prothrombin time and plasma fibrinogen levels. The preventive treatment with L. casei for 2 days modulated the innate immune response. This effect was shown by the earlier normalization of white blood cell counts, myeloperoxidase activity and aminotransferases levels. However, the haemostatic parameters were only partially recovered. The favourable effects obtained could be due to the capacity of L. casei to moderate the inflammatory response at the site of the injury with less damage to liver tissue.Lactobacillus casei CRL 431 a la capacité de moduler les réponses immunes locale et systémique, lesquelles sont significativement impliquées dans le dommage au foie causé par les hépatotoxines. Ce travail a été réalisé pour déterminer si L. casei pouvait prévenir des dommages hépatiques subits lors d’une atteinteé hépatique aigue¨ (AHA). Méthode : l’AHA a été induite par une injection intrapéritonéale de D-galactosamine (D-Gal). Différents groupes d’animaux ont rec¸u 1 109 cellules/jour/souris (L. casei) pendant 2 jours avant l’injection de D-Gal. Des échantillons de sang et de foie ont été prélevés 0, 6, 12 et 24 h aprés l’administration de D-Gal. Résultats : La D-Gal a induit une augmentation de l’activité des aminotransférases sériques, une réduction du nombre de leucocytes sanguins et une augmentation de l’activité de la myéloperoxydase des neutrophiles. Un traitement préventif a` L. casei pendant 2 jours a contribé a` moduler la réponse immune innée. Cet effet a été mis en évidence par la normalisation précoce de globules blancs sanguins, de l’activité de la MPO ainsi que des niveaux d’aminotransférases. Cependant, les paramétres hémostatiques n’étaient que partiellement recouvrés. Les effets favorables obtenus pourraient ^etre dus a` la capacité de L. casei a` moduler la réponse inflammatoire au site atteint, résultant en un dommage moindre du tissu hépatique.Fil: Haro, Ana Cecilia. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; ArgentinaFil: Zelaya, María Hortensia del Rosario. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; ArgentinaFil: Lazarte, Sandra Stella. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; ArgentinaFil: Alvarez, Gladis Susana. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Aguero, Graciela. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; ArgentinaNational Research Council Canada-NRC Research Press2009-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/56031Haro, Ana Cecilia; Zelaya, María Hortensia del Rosario; Lazarte, Sandra Stella; Alvarez, Gladis Susana; Aguero, Graciela; Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model; National Research Council Canada-NRC Research Press; Canadian Journal Of Microbiology; 55; 6; 6-2009; 648-6560008-41661480-3275CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1139/W09-022info:eu-repo/semantics/altIdentifier/url/http://www.nrcresearchpress.com/doi/10.1139/W09-022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:54Zoai:ri.conicet.gov.ar:11336/56031instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:55.211CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model |
title |
Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model |
spellingShingle |
Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model Haro, Ana Cecilia Acute Liver Injury Blood Coagulation Lactobacillus Casei |
title_short |
Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model |
title_full |
Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model |
title_fullStr |
Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model |
title_full_unstemmed |
Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model |
title_sort |
Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model |
dc.creator.none.fl_str_mv |
Haro, Ana Cecilia Zelaya, María Hortensia del Rosario Lazarte, Sandra Stella Alvarez, Gladis Susana Aguero, Graciela |
author |
Haro, Ana Cecilia |
author_facet |
Haro, Ana Cecilia Zelaya, María Hortensia del Rosario Lazarte, Sandra Stella Alvarez, Gladis Susana Aguero, Graciela |
author_role |
author |
author2 |
Zelaya, María Hortensia del Rosario Lazarte, Sandra Stella Alvarez, Gladis Susana Aguero, Graciela |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Acute Liver Injury Blood Coagulation Lactobacillus Casei |
topic |
Acute Liver Injury Blood Coagulation Lactobacillus Casei |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Lactobacilllus casei CRL 431 has the ability to modulate the local and systemic immune responses, which are significantly involved in liver injury caused by hepatotoxins. This work was conducted to determine whether L. casei has a preventive effect on the hepatic damage undergone during an acute liver injury (ALI). Methods: ALI was induced by an intraperitoneal injection of D-galactosamine (D-Gal). Different groups of mice received 1× 10 9 L. casei cells/day/mouse for 2 days before D-Gal injection. Blood and liver samples were obtained 0, 6, 12, and 24 h after D-Gal administration. Results: D-Gal induced increases in serum aminotransferases, reduced the number of blood leukocytes, enhanced neutrophil myeloperoxidase activity, increased dead cells, and altered prothrombin time and plasma fibrinogen levels. The preventive treatment with L. casei for 2 days modulated the innate immune response. This effect was shown by the earlier normalization of white blood cell counts, myeloperoxidase activity and aminotransferases levels. However, the haemostatic parameters were only partially recovered. The favourable effects obtained could be due to the capacity of L. casei to moderate the inflammatory response at the site of the injury with less damage to liver tissue. Lactobacillus casei CRL 431 a la capacité de moduler les réponses immunes locale et systémique, lesquelles sont significativement impliquées dans le dommage au foie causé par les hépatotoxines. Ce travail a été réalisé pour déterminer si L. casei pouvait prévenir des dommages hépatiques subits lors d’une atteinteé hépatique aigue¨ (AHA). Méthode : l’AHA a été induite par une injection intrapéritonéale de D-galactosamine (D-Gal). Différents groupes d’animaux ont rec¸u 1 109 cellules/jour/souris (L. casei) pendant 2 jours avant l’injection de D-Gal. Des échantillons de sang et de foie ont été prélevés 0, 6, 12 et 24 h aprés l’administration de D-Gal. Résultats : La D-Gal a induit une augmentation de l’activité des aminotransférases sériques, une réduction du nombre de leucocytes sanguins et une augmentation de l’activité de la myéloperoxydase des neutrophiles. Un traitement préventif a` L. casei pendant 2 jours a contribé a` moduler la réponse immune innée. Cet effet a été mis en évidence par la normalisation précoce de globules blancs sanguins, de l’activité de la MPO ainsi que des niveaux d’aminotransférases. Cependant, les paramétres hémostatiques n’étaient que partiellement recouvrés. Les effets favorables obtenus pourraient ^etre dus a` la capacité de L. casei a` moduler la réponse inflammatoire au site atteint, résultant en un dommage moindre du tissu hépatique. Fil: Haro, Ana Cecilia. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina Fil: Zelaya, María Hortensia del Rosario. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina Fil: Lazarte, Sandra Stella. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina Fil: Alvarez, Gladis Susana. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Aguero, Graciela. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina |
description |
Lactobacilllus casei CRL 431 has the ability to modulate the local and systemic immune responses, which are significantly involved in liver injury caused by hepatotoxins. This work was conducted to determine whether L. casei has a preventive effect on the hepatic damage undergone during an acute liver injury (ALI). Methods: ALI was induced by an intraperitoneal injection of D-galactosamine (D-Gal). Different groups of mice received 1× 10 9 L. casei cells/day/mouse for 2 days before D-Gal injection. Blood and liver samples were obtained 0, 6, 12, and 24 h after D-Gal administration. Results: D-Gal induced increases in serum aminotransferases, reduced the number of blood leukocytes, enhanced neutrophil myeloperoxidase activity, increased dead cells, and altered prothrombin time and plasma fibrinogen levels. The preventive treatment with L. casei for 2 days modulated the innate immune response. This effect was shown by the earlier normalization of white blood cell counts, myeloperoxidase activity and aminotransferases levels. However, the haemostatic parameters were only partially recovered. The favourable effects obtained could be due to the capacity of L. casei to moderate the inflammatory response at the site of the injury with less damage to liver tissue. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/56031 Haro, Ana Cecilia; Zelaya, María Hortensia del Rosario; Lazarte, Sandra Stella; Alvarez, Gladis Susana; Aguero, Graciela; Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model; National Research Council Canada-NRC Research Press; Canadian Journal Of Microbiology; 55; 6; 6-2009; 648-656 0008-4166 1480-3275 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/56031 |
identifier_str_mv |
Haro, Ana Cecilia; Zelaya, María Hortensia del Rosario; Lazarte, Sandra Stella; Alvarez, Gladis Susana; Aguero, Graciela; Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model; National Research Council Canada-NRC Research Press; Canadian Journal Of Microbiology; 55; 6; 6-2009; 648-656 0008-4166 1480-3275 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1139/W09-022 info:eu-repo/semantics/altIdentifier/url/http://www.nrcresearchpress.com/doi/10.1139/W09-022 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
National Research Council Canada-NRC Research Press |
publisher.none.fl_str_mv |
National Research Council Canada-NRC Research Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613007515058176 |
score |
13.070432 |