Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model

Autores
Haro, Ana Cecilia; Zelaya, María Hortensia del Rosario; Lazarte, Sandra Stella; Alvarez, Gladis Susana; Aguero, Graciela
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lactobacilllus casei CRL 431 has the ability to modulate the local and systemic immune responses, which are significantly involved in liver injury caused by hepatotoxins. This work was conducted to determine whether L. casei has a preventive effect on the hepatic damage undergone during an acute liver injury (ALI). Methods: ALI was induced by an intraperitoneal injection of D-galactosamine (D-Gal). Different groups of mice received 1× 10 9 L. casei cells/day/mouse for 2 days before D-Gal injection. Blood and liver samples were obtained 0, 6, 12, and 24 h after D-Gal administration. Results: D-Gal induced increases in serum aminotransferases, reduced the number of blood leukocytes, enhanced neutrophil myeloperoxidase activity, increased dead cells, and altered prothrombin time and plasma fibrinogen levels. The preventive treatment with L. casei for 2 days modulated the innate immune response. This effect was shown by the earlier normalization of white blood cell counts, myeloperoxidase activity and aminotransferases levels. However, the haemostatic parameters were only partially recovered. The favourable effects obtained could be due to the capacity of L. casei to moderate the inflammatory response at the site of the injury with less damage to liver tissue.
Lactobacillus casei CRL 431 a la capacité de moduler les réponses immunes locale et systémique, lesquelles sont significativement impliquées dans le dommage au foie causé par les hépatotoxines. Ce travail a été réalisé pour déterminer si L. casei pouvait prévenir des dommages hépatiques subits lors d’une atteinteé hépatique aigue¨ (AHA). Méthode : l’AHA a été induite par une injection intrapéritonéale de D-galactosamine (D-Gal). Différents groupes d’animaux ont rec¸u 1 109 cellules/jour/souris (L. casei) pendant 2 jours avant l’injection de D-Gal. Des échantillons de sang et de foie ont été prélevés 0, 6, 12 et 24 h aprés l’administration de D-Gal. Résultats : La D-Gal a induit une augmentation de l’activité des aminotransférases sériques, une réduction du nombre de leucocytes sanguins et une augmentation de l’activité de la myéloperoxydase des neutrophiles. Un traitement préventif a` L. casei pendant 2 jours a contribé a` moduler la réponse immune innée. Cet effet a été mis en évidence par la normalisation précoce de globules blancs sanguins, de l’activité de la MPO ainsi que des niveaux d’aminotransférases. Cependant, les paramétres hémostatiques n’étaient que partiellement recouvrés. Les effets favorables obtenus pourraient ^etre dus a` la capacité de L. casei a` moduler la réponse inflammatoire au site atteint, résultant en un dommage moindre du tissu hépatique.
Fil: Haro, Ana Cecilia. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Zelaya, María Hortensia del Rosario. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Lazarte, Sandra Stella. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Alvarez, Gladis Susana. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Aguero, Graciela. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Materia
Acute Liver Injury
Blood Coagulation
Lactobacillus Casei
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/56031

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spelling Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury modelHaro, Ana CeciliaZelaya, María Hortensia del RosarioLazarte, Sandra StellaAlvarez, Gladis SusanaAguero, GracielaAcute Liver InjuryBlood CoagulationLactobacillus Caseihttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Lactobacilllus casei CRL 431 has the ability to modulate the local and systemic immune responses, which are significantly involved in liver injury caused by hepatotoxins. This work was conducted to determine whether L. casei has a preventive effect on the hepatic damage undergone during an acute liver injury (ALI). Methods: ALI was induced by an intraperitoneal injection of D-galactosamine (D-Gal). Different groups of mice received 1× 10 9 L. casei cells/day/mouse for 2 days before D-Gal injection. Blood and liver samples were obtained 0, 6, 12, and 24 h after D-Gal administration. Results: D-Gal induced increases in serum aminotransferases, reduced the number of blood leukocytes, enhanced neutrophil myeloperoxidase activity, increased dead cells, and altered prothrombin time and plasma fibrinogen levels. The preventive treatment with L. casei for 2 days modulated the innate immune response. This effect was shown by the earlier normalization of white blood cell counts, myeloperoxidase activity and aminotransferases levels. However, the haemostatic parameters were only partially recovered. The favourable effects obtained could be due to the capacity of L. casei to moderate the inflammatory response at the site of the injury with less damage to liver tissue.Lactobacillus casei CRL 431 a la capacité de moduler les réponses immunes locale et systémique, lesquelles sont significativement impliquées dans le dommage au foie causé par les hépatotoxines. Ce travail a été réalisé pour déterminer si L. casei pouvait prévenir des dommages hépatiques subits lors d’une atteinteé hépatique aigue¨ (AHA). Méthode : l’AHA a été induite par une injection intrapéritonéale de D-galactosamine (D-Gal). Différents groupes d’animaux ont rec¸u 1 109 cellules/jour/souris (L. casei) pendant 2 jours avant l’injection de D-Gal. Des échantillons de sang et de foie ont été prélevés 0, 6, 12 et 24 h aprés l’administration de D-Gal. Résultats : La D-Gal a induit une augmentation de l’activité des aminotransférases sériques, une réduction du nombre de leucocytes sanguins et une augmentation de l’activité de la myéloperoxydase des neutrophiles. Un traitement préventif a` L. casei pendant 2 jours a contribé a` moduler la réponse immune innée. Cet effet a été mis en évidence par la normalisation précoce de globules blancs sanguins, de l’activité de la MPO ainsi que des niveaux d’aminotransférases. Cependant, les paramétres hémostatiques n’étaient que partiellement recouvrés. Les effets favorables obtenus pourraient ^etre dus a` la capacité de L. casei a` moduler la réponse inflammatoire au site atteint, résultant en un dommage moindre du tissu hépatique.Fil: Haro, Ana Cecilia. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; ArgentinaFil: Zelaya, María Hortensia del Rosario. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; ArgentinaFil: Lazarte, Sandra Stella. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; ArgentinaFil: Alvarez, Gladis Susana. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Aguero, Graciela. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; ArgentinaNational Research Council Canada-NRC Research Press2009-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/56031Haro, Ana Cecilia; Zelaya, María Hortensia del Rosario; Lazarte, Sandra Stella; Alvarez, Gladis Susana; Aguero, Graciela; Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model; National Research Council Canada-NRC Research Press; Canadian Journal Of Microbiology; 55; 6; 6-2009; 648-6560008-41661480-3275CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1139/W09-022info:eu-repo/semantics/altIdentifier/url/http://www.nrcresearchpress.com/doi/10.1139/W09-022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:54Zoai:ri.conicet.gov.ar:11336/56031instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:55.211CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model
title Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model
spellingShingle Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model
Haro, Ana Cecilia
Acute Liver Injury
Blood Coagulation
Lactobacillus Casei
title_short Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model
title_full Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model
title_fullStr Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model
title_full_unstemmed Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model
title_sort Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model
dc.creator.none.fl_str_mv Haro, Ana Cecilia
Zelaya, María Hortensia del Rosario
Lazarte, Sandra Stella
Alvarez, Gladis Susana
Aguero, Graciela
author Haro, Ana Cecilia
author_facet Haro, Ana Cecilia
Zelaya, María Hortensia del Rosario
Lazarte, Sandra Stella
Alvarez, Gladis Susana
Aguero, Graciela
author_role author
author2 Zelaya, María Hortensia del Rosario
Lazarte, Sandra Stella
Alvarez, Gladis Susana
Aguero, Graciela
author2_role author
author
author
author
dc.subject.none.fl_str_mv Acute Liver Injury
Blood Coagulation
Lactobacillus Casei
topic Acute Liver Injury
Blood Coagulation
Lactobacillus Casei
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Lactobacilllus casei CRL 431 has the ability to modulate the local and systemic immune responses, which are significantly involved in liver injury caused by hepatotoxins. This work was conducted to determine whether L. casei has a preventive effect on the hepatic damage undergone during an acute liver injury (ALI). Methods: ALI was induced by an intraperitoneal injection of D-galactosamine (D-Gal). Different groups of mice received 1× 10 9 L. casei cells/day/mouse for 2 days before D-Gal injection. Blood and liver samples were obtained 0, 6, 12, and 24 h after D-Gal administration. Results: D-Gal induced increases in serum aminotransferases, reduced the number of blood leukocytes, enhanced neutrophil myeloperoxidase activity, increased dead cells, and altered prothrombin time and plasma fibrinogen levels. The preventive treatment with L. casei for 2 days modulated the innate immune response. This effect was shown by the earlier normalization of white blood cell counts, myeloperoxidase activity and aminotransferases levels. However, the haemostatic parameters were only partially recovered. The favourable effects obtained could be due to the capacity of L. casei to moderate the inflammatory response at the site of the injury with less damage to liver tissue.
Lactobacillus casei CRL 431 a la capacité de moduler les réponses immunes locale et systémique, lesquelles sont significativement impliquées dans le dommage au foie causé par les hépatotoxines. Ce travail a été réalisé pour déterminer si L. casei pouvait prévenir des dommages hépatiques subits lors d’une atteinteé hépatique aigue¨ (AHA). Méthode : l’AHA a été induite par une injection intrapéritonéale de D-galactosamine (D-Gal). Différents groupes d’animaux ont rec¸u 1 109 cellules/jour/souris (L. casei) pendant 2 jours avant l’injection de D-Gal. Des échantillons de sang et de foie ont été prélevés 0, 6, 12 et 24 h aprés l’administration de D-Gal. Résultats : La D-Gal a induit une augmentation de l’activité des aminotransférases sériques, une réduction du nombre de leucocytes sanguins et une augmentation de l’activité de la myéloperoxydase des neutrophiles. Un traitement préventif a` L. casei pendant 2 jours a contribé a` moduler la réponse immune innée. Cet effet a été mis en évidence par la normalisation précoce de globules blancs sanguins, de l’activité de la MPO ainsi que des niveaux d’aminotransférases. Cependant, les paramétres hémostatiques n’étaient que partiellement recouvrés. Les effets favorables obtenus pourraient ^etre dus a` la capacité de L. casei a` moduler la réponse inflammatoire au site atteint, résultant en un dommage moindre du tissu hépatique.
Fil: Haro, Ana Cecilia. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Zelaya, María Hortensia del Rosario. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Lazarte, Sandra Stella. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
Fil: Alvarez, Gladis Susana. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Aguero, Graciela. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Bioquímica Clinica Aplicada. Cátedra de Bioquímica Clinica I; Argentina
description Lactobacilllus casei CRL 431 has the ability to modulate the local and systemic immune responses, which are significantly involved in liver injury caused by hepatotoxins. This work was conducted to determine whether L. casei has a preventive effect on the hepatic damage undergone during an acute liver injury (ALI). Methods: ALI was induced by an intraperitoneal injection of D-galactosamine (D-Gal). Different groups of mice received 1× 10 9 L. casei cells/day/mouse for 2 days before D-Gal injection. Blood and liver samples were obtained 0, 6, 12, and 24 h after D-Gal administration. Results: D-Gal induced increases in serum aminotransferases, reduced the number of blood leukocytes, enhanced neutrophil myeloperoxidase activity, increased dead cells, and altered prothrombin time and plasma fibrinogen levels. The preventive treatment with L. casei for 2 days modulated the innate immune response. This effect was shown by the earlier normalization of white blood cell counts, myeloperoxidase activity and aminotransferases levels. However, the haemostatic parameters were only partially recovered. The favourable effects obtained could be due to the capacity of L. casei to moderate the inflammatory response at the site of the injury with less damage to liver tissue.
publishDate 2009
dc.date.none.fl_str_mv 2009-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/56031
Haro, Ana Cecilia; Zelaya, María Hortensia del Rosario; Lazarte, Sandra Stella; Alvarez, Gladis Susana; Aguero, Graciela; Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model; National Research Council Canada-NRC Research Press; Canadian Journal Of Microbiology; 55; 6; 6-2009; 648-656
0008-4166
1480-3275
CONICET Digital
CONICET
url http://hdl.handle.net/11336/56031
identifier_str_mv Haro, Ana Cecilia; Zelaya, María Hortensia del Rosario; Lazarte, Sandra Stella; Alvarez, Gladis Susana; Aguero, Graciela; Lactobacillus casei: Influence on the innate immune response and haemostatic alterations in a liver-injury model; National Research Council Canada-NRC Research Press; Canadian Journal Of Microbiology; 55; 6; 6-2009; 648-656
0008-4166
1480-3275
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/http://www.nrcresearchpress.com/doi/10.1139/W09-022
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
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dc.publisher.none.fl_str_mv National Research Council Canada-NRC Research Press
publisher.none.fl_str_mv National Research Council Canada-NRC Research Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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