New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus

Autores
Talia, Juan Manuel; Debattista, Nora Beatriz; Pappano, Nora Beatriz
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Staphylococcus aureus, the most virulent Staphylococcus species, is also the prevalent pathogen isolated from hospitalized patients and the second most common from patients in outpatient settings. In general, bacteria have the genetic ability to transmit and acquire resistance to drugs, which are utilized as therapeutic agents. Related studies of antimicrobial activity indicate that crude extracts containing flavonoids, triterpenes and steroids have showed significative activity against several Staphylococcus aureus strains. Combination effects between flavonoids and antibiotics also have been reported. The aim of the present work was to investigate in vitro synergism between several chalcones substituted in combination with oxacillin, an antibiotic used conventionally against S. aureus ATCC 43 300 that is resistant to meticillin, using the kinetic turbidimetric method developed earlier. The results were satisfactory for all assayed combinations and in accordance with the mechanism of bacteriostatic inhibition previously proposed, except for 2´,4´-dihydroxy-3´-methoxychalcone - oxacillin. The best combination was 2´,3´-dihydroxychalcone - oxacillin (MIC: 11.2 μg/mL). Further investigations are needed to characterize the interaction mechanism with antibiotics. Thus, chalcones - oxacillin combination could lead to the development of new antibiotics against methicillin resistant S. aureus infection.
Fil: Talia, Juan Manuel. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis; Argentina
Fil: Debattista, Nora Beatriz. Universidad Nacional de San Luis; Argentina
Fil: Pappano, Nora Beatriz. Universidad Nacional de San Luis; Argentina
Materia
SUBSTITUTED CHALCONES
OXACILLIN
COMBINATIONS
ANTIMICROBIAL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13960
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/13960
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureusTalia, Juan ManuelDebattista, Nora BeatrizPappano, Nora BeatrizSUBSTITUTED CHALCONESOXACILLINCOMBINATIONSANTIMICROBIALhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Staphylococcus aureus, the most virulent Staphylococcus species, is also the prevalent pathogen isolated from hospitalized patients and the second most common from patients in outpatient settings. In general, bacteria have the genetic ability to transmit and acquire resistance to drugs, which are utilized as therapeutic agents. Related studies of antimicrobial activity indicate that crude extracts containing flavonoids, triterpenes and steroids have showed significative activity against several Staphylococcus aureus strains. Combination effects between flavonoids and antibiotics also have been reported. The aim of the present work was to investigate in vitro synergism between several chalcones substituted in combination with oxacillin, an antibiotic used conventionally against S. aureus ATCC 43 300 that is resistant to meticillin, using the kinetic turbidimetric method developed earlier. The results were satisfactory for all assayed combinations and in accordance with the mechanism of bacteriostatic inhibition previously proposed, except for 2´,4´-dihydroxy-3´-methoxychalcone - oxacillin. The best combination was 2´,3´-dihydroxychalcone - oxacillin (MIC: 11.2 μg/mL). Further investigations are needed to characterize the interaction mechanism with antibiotics. Thus, chalcones - oxacillin combination could lead to the development of new antibiotics against methicillin resistant S. aureus infection.Fil: Talia, Juan Manuel. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis; ArgentinaFil: Debattista, Nora Beatriz. Universidad Nacional de San Luis; ArgentinaFil: Pappano, Nora Beatriz. Universidad Nacional de San Luis; ArgentinaSociedade Brasileira de Microbiologia2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13960Talia, Juan Manuel; Debattista, Nora Beatriz; Pappano, Nora Beatriz; New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus; Sociedade Brasileira de Microbiologia; Brazilian Journal Of Microbiology; 42; 2; 6-2011; 470-4751517-83821678-4405enginfo:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/twd5yjinfo:eu-repo/semantics/altIdentifier/doi/10.1590/S1517-83822011000200010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:46:29Zoai:ri.conicet.gov.ar:11336/13960instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:46:29.533CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus
title New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus
spellingShingle New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus
Talia, Juan Manuel
SUBSTITUTED CHALCONES
OXACILLIN
COMBINATIONS
ANTIMICROBIAL
title_short New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus
title_full New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus
title_fullStr New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus
title_full_unstemmed New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus
title_sort New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus
dc.creator.none.fl_str_mv Talia, Juan Manuel
Debattista, Nora Beatriz
Pappano, Nora Beatriz
author Talia, Juan Manuel
author_facet Talia, Juan Manuel
Debattista, Nora Beatriz
Pappano, Nora Beatriz
author_role author
author2 Debattista, Nora Beatriz
Pappano, Nora Beatriz
author2_role author
author
dc.subject.none.fl_str_mv SUBSTITUTED CHALCONES
OXACILLIN
COMBINATIONS
ANTIMICROBIAL
topic SUBSTITUTED CHALCONES
OXACILLIN
COMBINATIONS
ANTIMICROBIAL
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Staphylococcus aureus, the most virulent Staphylococcus species, is also the prevalent pathogen isolated from hospitalized patients and the second most common from patients in outpatient settings. In general, bacteria have the genetic ability to transmit and acquire resistance to drugs, which are utilized as therapeutic agents. Related studies of antimicrobial activity indicate that crude extracts containing flavonoids, triterpenes and steroids have showed significative activity against several Staphylococcus aureus strains. Combination effects between flavonoids and antibiotics also have been reported. The aim of the present work was to investigate in vitro synergism between several chalcones substituted in combination with oxacillin, an antibiotic used conventionally against S. aureus ATCC 43 300 that is resistant to meticillin, using the kinetic turbidimetric method developed earlier. The results were satisfactory for all assayed combinations and in accordance with the mechanism of bacteriostatic inhibition previously proposed, except for 2´,4´-dihydroxy-3´-methoxychalcone - oxacillin. The best combination was 2´,3´-dihydroxychalcone - oxacillin (MIC: 11.2 μg/mL). Further investigations are needed to characterize the interaction mechanism with antibiotics. Thus, chalcones - oxacillin combination could lead to the development of new antibiotics against methicillin resistant S. aureus infection.
Fil: Talia, Juan Manuel. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis; Argentina
Fil: Debattista, Nora Beatriz. Universidad Nacional de San Luis; Argentina
Fil: Pappano, Nora Beatriz. Universidad Nacional de San Luis; Argentina
description Staphylococcus aureus, the most virulent Staphylococcus species, is also the prevalent pathogen isolated from hospitalized patients and the second most common from patients in outpatient settings. In general, bacteria have the genetic ability to transmit and acquire resistance to drugs, which are utilized as therapeutic agents. Related studies of antimicrobial activity indicate that crude extracts containing flavonoids, triterpenes and steroids have showed significative activity against several Staphylococcus aureus strains. Combination effects between flavonoids and antibiotics also have been reported. The aim of the present work was to investigate in vitro synergism between several chalcones substituted in combination with oxacillin, an antibiotic used conventionally against S. aureus ATCC 43 300 that is resistant to meticillin, using the kinetic turbidimetric method developed earlier. The results were satisfactory for all assayed combinations and in accordance with the mechanism of bacteriostatic inhibition previously proposed, except for 2´,4´-dihydroxy-3´-methoxychalcone - oxacillin. The best combination was 2´,3´-dihydroxychalcone - oxacillin (MIC: 11.2 μg/mL). Further investigations are needed to characterize the interaction mechanism with antibiotics. Thus, chalcones - oxacillin combination could lead to the development of new antibiotics against methicillin resistant S. aureus infection.
publishDate 2011
dc.date.none.fl_str_mv 2011-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13960
Talia, Juan Manuel; Debattista, Nora Beatriz; Pappano, Nora Beatriz; New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus; Sociedade Brasileira de Microbiologia; Brazilian Journal Of Microbiology; 42; 2; 6-2011; 470-475
1517-8382
1678-4405
url http://hdl.handle.net/11336/13960
identifier_str_mv Talia, Juan Manuel; Debattista, Nora Beatriz; Pappano, Nora Beatriz; New antimicrobial combinations: substituted chalcones- oxacillin against methicillin resistant Staphylococcus aureus; Sociedade Brasileira de Microbiologia; Brazilian Journal Of Microbiology; 42; 2; 6-2011; 470-475
1517-8382
1678-4405
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/twd5yj
info:eu-repo/semantics/altIdentifier/doi/10.1590/S1517-83822011000200010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
publisher.none.fl_str_mv Sociedade Brasileira de Microbiologia
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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