Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cr...

Autores
Pech May, Angélica del Rosario; Mazariegos Hidalgo, Carlos Jesús; Izeta Alberdi Amaia; López Cancino, Sury Antonio; Tun Ku, Ezequiel; De la Cruz Félix, Keynes; Ibarra Cerdeña, Carlos; González Ittig, Raúl Enrique; Ramsey, Janine
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The population genetics of Triatoma dimidiata haplogroups was analyzed at landscape and sub-regional scales in Chiapas and regional level across the Mexican Neotropics, and phylogeography of the complex was re-analyzed across its complete geographic range. Two contiguous fragments of the ND4 gene were analyzed due to bias from differential haplogroup specificity using a previously designed sequence. At both landscape (anthropic modification gradient) and regional (demographic, fragmentation, biogeographic, climate) scales, lowest T. dimidiata genetic diversity occurs where there is greatest historical anthropic modification, and where T. cruzi infection prevalence is significantly highest. Trypanosoma cruzi prevalence was significantly higher than expected in haplogroups 1 and 3, while lower than expected in haplogroup 2. There was also a significant difference of DTUI and DTUVI infection frequencies in both haplogroups 1 and 3, while no difference of either in haplogroup 2. All haplogroups from the Mexican Neotropics had moderate to high haplotype diversity, while greatest genetic differentiation was between haplogroups 1 and 3 (above F ST = 0.868, p < 0.0001). Divergence of the complex from the MRCA was estimated between 0.97 MYA (95% HPD interval = 0.55-1.53 MYA) and 0.85 MYA (95% HPD interval = 0.42-1.5 MYA) for ND4A and both concatenated fragments, respectively, with primary divergence from the MRCA of haplogroups 2 and 3. Effective population size for Mexican haplogroups 1 and 2 increased between 0.02 and 0.03 MYA. This study supports previous ecological niche evidence for the complex´s origin surrounding the Tehuantepec Isthmus, and provides evidence for recent divergence of three primary dimidiata haplogroups, with differential T. cruzi infection frequency and DTU specificity, important components of vector capacity.
Fil: Pech May, Angélica del Rosario. Instituto Nacional de Salud Publica /centro Regional de; México
Fil: Mazariegos Hidalgo, Carlos Jesús. Instituto Nacional de Salud Publica; México
Fil: Izeta Alberdi Amaia. Instituto Nacional de Salud Publica; México
Fil: López Cancino, Sury Antonio. Instituto de Estudios Superiores de Chiapas; México. Universidad Anáhuac México; México
Fil: Tun Ku, Ezequiel. Instituto Nacional de Salud Publica; México
Fil: De la Cruz Félix, Keynes. Instituto Nacional de Salud Publica; México
Fil: Ibarra Cerdeña, Carlos. Instituto Politécnico Nacional. Centro de Investigación y de Estudios Avanzados; México
Fil: González Ittig, Raúl Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina
Fil: Ramsey, Janine. Instituto Nacional de Salud Publica; México
Materia
Triatoma dimidiata
Trypanosoma cruzi
Phylogeography
Population genetics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/125652
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/125652
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infectionsPech May, Angélica del RosarioMazariegos Hidalgo, Carlos JesúsIzeta Alberdi AmaiaLópez Cancino, Sury AntonioTun Ku, EzequielDe la Cruz Félix, KeynesIbarra Cerdeña, CarlosGonzález Ittig, Raúl EnriqueRamsey, JanineTriatoma dimidiataTrypanosoma cruziPhylogeographyPopulation geneticshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The population genetics of Triatoma dimidiata haplogroups was analyzed at landscape and sub-regional scales in Chiapas and regional level across the Mexican Neotropics, and phylogeography of the complex was re-analyzed across its complete geographic range. Two contiguous fragments of the ND4 gene were analyzed due to bias from differential haplogroup specificity using a previously designed sequence. At both landscape (anthropic modification gradient) and regional (demographic, fragmentation, biogeographic, climate) scales, lowest T. dimidiata genetic diversity occurs where there is greatest historical anthropic modification, and where T. cruzi infection prevalence is significantly highest. Trypanosoma cruzi prevalence was significantly higher than expected in haplogroups 1 and 3, while lower than expected in haplogroup 2. There was also a significant difference of DTUI and DTUVI infection frequencies in both haplogroups 1 and 3, while no difference of either in haplogroup 2. All haplogroups from the Mexican Neotropics had moderate to high haplotype diversity, while greatest genetic differentiation was between haplogroups 1 and 3 (above F ST = 0.868, p < 0.0001). Divergence of the complex from the MRCA was estimated between 0.97 MYA (95% HPD interval = 0.55-1.53 MYA) and 0.85 MYA (95% HPD interval = 0.42-1.5 MYA) for ND4A and both concatenated fragments, respectively, with primary divergence from the MRCA of haplogroups 2 and 3. Effective population size for Mexican haplogroups 1 and 2 increased between 0.02 and 0.03 MYA. This study supports previous ecological niche evidence for the complex´s origin surrounding the Tehuantepec Isthmus, and provides evidence for recent divergence of three primary dimidiata haplogroups, with differential T. cruzi infection frequency and DTU specificity, important components of vector capacity.Fil: Pech May, Angélica del Rosario. Instituto Nacional de Salud Publica /centro Regional de; MéxicoFil: Mazariegos Hidalgo, Carlos Jesús. Instituto Nacional de Salud Publica; MéxicoFil: Izeta Alberdi Amaia. Instituto Nacional de Salud Publica; MéxicoFil: López Cancino, Sury Antonio. Instituto de Estudios Superiores de Chiapas; México. Universidad Anáhuac México; MéxicoFil: Tun Ku, Ezequiel. Instituto Nacional de Salud Publica; MéxicoFil: De la Cruz Félix, Keynes. Instituto Nacional de Salud Publica; MéxicoFil: Ibarra Cerdeña, Carlos. Instituto Politécnico Nacional. Centro de Investigación y de Estudios Avanzados; MéxicoFil: González Ittig, Raúl Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; ArgentinaFil: Ramsey, Janine. Instituto Nacional de Salud Publica; MéxicoPublic Library of Science2019-01-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125652Pech May, Angélica del Rosario; Mazariegos Hidalgo, Carlos Jesús; Izeta Alberdi Amaia; López Cancino, Sury Antonio; Tun Ku, Ezequiel; et al.; Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections; Public Library of Science; PLoS Neglected Tropical Diseases; 13; 1; 28-1-2019; 1-311935-2735CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0007044info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007044info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:59:39Zoai:ri.conicet.gov.ar:11336/125652instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:59:39.56CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections
title Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections
spellingShingle Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections
Pech May, Angélica del Rosario
Triatoma dimidiata
Trypanosoma cruzi
Phylogeography
Population genetics
title_short Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections
title_full Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections
title_fullStr Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections
title_full_unstemmed Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections
title_sort Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections
dc.creator.none.fl_str_mv Pech May, Angélica del Rosario
Mazariegos Hidalgo, Carlos Jesús
Izeta Alberdi Amaia
López Cancino, Sury Antonio
Tun Ku, Ezequiel
De la Cruz Félix, Keynes
Ibarra Cerdeña, Carlos
González Ittig, Raúl Enrique
Ramsey, Janine
author Pech May, Angélica del Rosario
author_facet Pech May, Angélica del Rosario
Mazariegos Hidalgo, Carlos Jesús
Izeta Alberdi Amaia
López Cancino, Sury Antonio
Tun Ku, Ezequiel
De la Cruz Félix, Keynes
Ibarra Cerdeña, Carlos
González Ittig, Raúl Enrique
Ramsey, Janine
author_role author
author2 Mazariegos Hidalgo, Carlos Jesús
Izeta Alberdi Amaia
López Cancino, Sury Antonio
Tun Ku, Ezequiel
De la Cruz Félix, Keynes
Ibarra Cerdeña, Carlos
González Ittig, Raúl Enrique
Ramsey, Janine
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Triatoma dimidiata
Trypanosoma cruzi
Phylogeography
Population genetics
topic Triatoma dimidiata
Trypanosoma cruzi
Phylogeography
Population genetics
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The population genetics of Triatoma dimidiata haplogroups was analyzed at landscape and sub-regional scales in Chiapas and regional level across the Mexican Neotropics, and phylogeography of the complex was re-analyzed across its complete geographic range. Two contiguous fragments of the ND4 gene were analyzed due to bias from differential haplogroup specificity using a previously designed sequence. At both landscape (anthropic modification gradient) and regional (demographic, fragmentation, biogeographic, climate) scales, lowest T. dimidiata genetic diversity occurs where there is greatest historical anthropic modification, and where T. cruzi infection prevalence is significantly highest. Trypanosoma cruzi prevalence was significantly higher than expected in haplogroups 1 and 3, while lower than expected in haplogroup 2. There was also a significant difference of DTUI and DTUVI infection frequencies in both haplogroups 1 and 3, while no difference of either in haplogroup 2. All haplogroups from the Mexican Neotropics had moderate to high haplotype diversity, while greatest genetic differentiation was between haplogroups 1 and 3 (above F ST = 0.868, p < 0.0001). Divergence of the complex from the MRCA was estimated between 0.97 MYA (95% HPD interval = 0.55-1.53 MYA) and 0.85 MYA (95% HPD interval = 0.42-1.5 MYA) for ND4A and both concatenated fragments, respectively, with primary divergence from the MRCA of haplogroups 2 and 3. Effective population size for Mexican haplogroups 1 and 2 increased between 0.02 and 0.03 MYA. This study supports previous ecological niche evidence for the complex´s origin surrounding the Tehuantepec Isthmus, and provides evidence for recent divergence of three primary dimidiata haplogroups, with differential T. cruzi infection frequency and DTU specificity, important components of vector capacity.
Fil: Pech May, Angélica del Rosario. Instituto Nacional de Salud Publica /centro Regional de; México
Fil: Mazariegos Hidalgo, Carlos Jesús. Instituto Nacional de Salud Publica; México
Fil: Izeta Alberdi Amaia. Instituto Nacional de Salud Publica; México
Fil: López Cancino, Sury Antonio. Instituto de Estudios Superiores de Chiapas; México. Universidad Anáhuac México; México
Fil: Tun Ku, Ezequiel. Instituto Nacional de Salud Publica; México
Fil: De la Cruz Félix, Keynes. Instituto Nacional de Salud Publica; México
Fil: Ibarra Cerdeña, Carlos. Instituto Politécnico Nacional. Centro de Investigación y de Estudios Avanzados; México
Fil: González Ittig, Raúl Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina
Fil: Ramsey, Janine. Instituto Nacional de Salud Publica; México
description The population genetics of Triatoma dimidiata haplogroups was analyzed at landscape and sub-regional scales in Chiapas and regional level across the Mexican Neotropics, and phylogeography of the complex was re-analyzed across its complete geographic range. Two contiguous fragments of the ND4 gene were analyzed due to bias from differential haplogroup specificity using a previously designed sequence. At both landscape (anthropic modification gradient) and regional (demographic, fragmentation, biogeographic, climate) scales, lowest T. dimidiata genetic diversity occurs where there is greatest historical anthropic modification, and where T. cruzi infection prevalence is significantly highest. Trypanosoma cruzi prevalence was significantly higher than expected in haplogroups 1 and 3, while lower than expected in haplogroup 2. There was also a significant difference of DTUI and DTUVI infection frequencies in both haplogroups 1 and 3, while no difference of either in haplogroup 2. All haplogroups from the Mexican Neotropics had moderate to high haplotype diversity, while greatest genetic differentiation was between haplogroups 1 and 3 (above F ST = 0.868, p < 0.0001). Divergence of the complex from the MRCA was estimated between 0.97 MYA (95% HPD interval = 0.55-1.53 MYA) and 0.85 MYA (95% HPD interval = 0.42-1.5 MYA) for ND4A and both concatenated fragments, respectively, with primary divergence from the MRCA of haplogroups 2 and 3. Effective population size for Mexican haplogroups 1 and 2 increased between 0.02 and 0.03 MYA. This study supports previous ecological niche evidence for the complex´s origin surrounding the Tehuantepec Isthmus, and provides evidence for recent divergence of three primary dimidiata haplogroups, with differential T. cruzi infection frequency and DTU specificity, important components of vector capacity.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-28
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/125652
Pech May, Angélica del Rosario; Mazariegos Hidalgo, Carlos Jesús; Izeta Alberdi Amaia; López Cancino, Sury Antonio; Tun Ku, Ezequiel; et al.; Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections; Public Library of Science; PLoS Neglected Tropical Diseases; 13; 1; 28-1-2019; 1-31
1935-2735
CONICET Digital
CONICET
url http://hdl.handle.net/11336/125652
identifier_str_mv Pech May, Angélica del Rosario; Mazariegos Hidalgo, Carlos Jesús; Izeta Alberdi Amaia; López Cancino, Sury Antonio; Tun Ku, Ezequiel; et al.; Genetic variation and phylogeography of the Triatoma dimidiata complex evidence a potential center of origin and recent divergence of haplogroups having differential Trypanosoma cruzi and DTU infections; Public Library of Science; PLoS Neglected Tropical Diseases; 13; 1; 28-1-2019; 1-31
1935-2735
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0007044
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007044
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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