Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory

Autores
De Oliveira Alvares, Lucaa; Engelke, Douglas Senna; Diehl, Felipe; Scheffer-Teixeira, Robson; Haubrich, Josué; De Freitas Cassini, Lindsey; Molina, Víctor Alejandro; Quillfeldt, Jorge Alberto
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The modulation of memory processes is one of the several functions of the endocannabinoid system (ECS) in the brain, with CB1 receptors highly expressed in areas such as the dorsal hippocampus. Experimental evidence suggested an important role of the ECS in aversively motivated memories. Similarly, glucocorticoids released in response to stress exposure also modulates memory formation, and both stress and dexamethasone activate the ECS. Here, we investigate the interaction between the ECS and glucocorticoids in the hippocampus in the modulation of fear memory consolidation. Two protocols with different shock intensities were used in order to control the level of aversiveness. Local infusion of AM251 into the hippocampus immediately after training was amnestic in the strong, but not in the weak protocol. Moreover, AM251 was amnestic in animals stressed 0, but not 30-min prior to the weak protocol, reverting the stress-induced facilitatory effect. Finally, intrahippocampal AM251 infusion reduced memory in animals that received dexamethasone immediately, but not 30 min before training. These results are (1) consistent with the view that the dorsal hippocampus ECS is activated on demand, in a rapid and short-lived fashion in order to modulate the consolidation of an aversive memory, and (2) show that this recruitment seems to be mediated by glucocorticoids, either in the hippocampus or in other brain regions functionally associated with the hippocampus. © 2010 Cold Spring Harbor Laboratory Press.
Fil: De Oliveira Alvares, Lucaa. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Engelke, Douglas Senna. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Diehl, Felipe. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Scheffer-Teixeira, Robson. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Haubrich, Josué. Universidade Federal do Rio Grande do Sul; Brasil
Fil: De Freitas Cassini, Lindsey. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Molina, Víctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Quillfeldt, Jorge Alberto. Universidade Federal do Rio Grande do Sul; Brasil
Materia
STRESS
ENDOCANABINOID SYSTEM
FEAR MEMORY
HIPPOCAMPUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/132240
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/132240
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memoryDe Oliveira Alvares, LucaaEngelke, Douglas SennaDiehl, FelipeScheffer-Teixeira, RobsonHaubrich, JosuéDe Freitas Cassini, LindseyMolina, Víctor AlejandroQuillfeldt, Jorge AlbertoSTRESSENDOCANABINOID SYSTEMFEAR MEMORYHIPPOCAMPUShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The modulation of memory processes is one of the several functions of the endocannabinoid system (ECS) in the brain, with CB1 receptors highly expressed in areas such as the dorsal hippocampus. Experimental evidence suggested an important role of the ECS in aversively motivated memories. Similarly, glucocorticoids released in response to stress exposure also modulates memory formation, and both stress and dexamethasone activate the ECS. Here, we investigate the interaction between the ECS and glucocorticoids in the hippocampus in the modulation of fear memory consolidation. Two protocols with different shock intensities were used in order to control the level of aversiveness. Local infusion of AM251 into the hippocampus immediately after training was amnestic in the strong, but not in the weak protocol. Moreover, AM251 was amnestic in animals stressed 0, but not 30-min prior to the weak protocol, reverting the stress-induced facilitatory effect. Finally, intrahippocampal AM251 infusion reduced memory in animals that received dexamethasone immediately, but not 30 min before training. These results are (1) consistent with the view that the dorsal hippocampus ECS is activated on demand, in a rapid and short-lived fashion in order to modulate the consolidation of an aversive memory, and (2) show that this recruitment seems to be mediated by glucocorticoids, either in the hippocampus or in other brain regions functionally associated with the hippocampus. © 2010 Cold Spring Harbor Laboratory Press.Fil: De Oliveira Alvares, Lucaa. Universidade Federal do Rio Grande do Sul; BrasilFil: Engelke, Douglas Senna. Universidade Federal do Rio Grande do Sul; BrasilFil: Diehl, Felipe. Universidade Federal do Rio Grande do Sul; BrasilFil: Scheffer-Teixeira, Robson. Universidade Federal do Rio Grande do Sul; BrasilFil: Haubrich, Josué. Universidade Federal do Rio Grande do Sul; BrasilFil: De Freitas Cassini, Lindsey. Universidade Federal do Rio Grande do Sul; BrasilFil: Molina, Víctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Quillfeldt, Jorge Alberto. Universidade Federal do Rio Grande do Sul; BrasilCold Spring Harbor Laboratory Press2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/132240De Oliveira Alvares, Lucaa; Engelke, Douglas Senna; Diehl, Felipe; Scheffer-Teixeira, Robson; Haubrich, Josué; et al.; Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory; Cold Spring Harbor Laboratory Press; Learning & Memory (Cold Spring Harbor, N.Y.); 17; 4; 3-2010; 202-2091072-05021549-5485CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://learnmem.cshlp.org/content/17/4/202info:eu-repo/semantics/altIdentifier/doi/10.1101/lm.1721010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:18Zoai:ri.conicet.gov.ar:11336/132240instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:18.608CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory
title Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory
spellingShingle Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory
De Oliveira Alvares, Lucaa
STRESS
ENDOCANABINOID SYSTEM
FEAR MEMORY
HIPPOCAMPUS
title_short Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory
title_full Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory
title_fullStr Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory
title_full_unstemmed Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory
title_sort Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory
dc.creator.none.fl_str_mv De Oliveira Alvares, Lucaa
Engelke, Douglas Senna
Diehl, Felipe
Scheffer-Teixeira, Robson
Haubrich, Josué
De Freitas Cassini, Lindsey
Molina, Víctor Alejandro
Quillfeldt, Jorge Alberto
author De Oliveira Alvares, Lucaa
author_facet De Oliveira Alvares, Lucaa
Engelke, Douglas Senna
Diehl, Felipe
Scheffer-Teixeira, Robson
Haubrich, Josué
De Freitas Cassini, Lindsey
Molina, Víctor Alejandro
Quillfeldt, Jorge Alberto
author_role author
author2 Engelke, Douglas Senna
Diehl, Felipe
Scheffer-Teixeira, Robson
Haubrich, Josué
De Freitas Cassini, Lindsey
Molina, Víctor Alejandro
Quillfeldt, Jorge Alberto
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv STRESS
ENDOCANABINOID SYSTEM
FEAR MEMORY
HIPPOCAMPUS
topic STRESS
ENDOCANABINOID SYSTEM
FEAR MEMORY
HIPPOCAMPUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The modulation of memory processes is one of the several functions of the endocannabinoid system (ECS) in the brain, with CB1 receptors highly expressed in areas such as the dorsal hippocampus. Experimental evidence suggested an important role of the ECS in aversively motivated memories. Similarly, glucocorticoids released in response to stress exposure also modulates memory formation, and both stress and dexamethasone activate the ECS. Here, we investigate the interaction between the ECS and glucocorticoids in the hippocampus in the modulation of fear memory consolidation. Two protocols with different shock intensities were used in order to control the level of aversiveness. Local infusion of AM251 into the hippocampus immediately after training was amnestic in the strong, but not in the weak protocol. Moreover, AM251 was amnestic in animals stressed 0, but not 30-min prior to the weak protocol, reverting the stress-induced facilitatory effect. Finally, intrahippocampal AM251 infusion reduced memory in animals that received dexamethasone immediately, but not 30 min before training. These results are (1) consistent with the view that the dorsal hippocampus ECS is activated on demand, in a rapid and short-lived fashion in order to modulate the consolidation of an aversive memory, and (2) show that this recruitment seems to be mediated by glucocorticoids, either in the hippocampus or in other brain regions functionally associated with the hippocampus. © 2010 Cold Spring Harbor Laboratory Press.
Fil: De Oliveira Alvares, Lucaa. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Engelke, Douglas Senna. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Diehl, Felipe. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Scheffer-Teixeira, Robson. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Haubrich, Josué. Universidade Federal do Rio Grande do Sul; Brasil
Fil: De Freitas Cassini, Lindsey. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Molina, Víctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Quillfeldt, Jorge Alberto. Universidade Federal do Rio Grande do Sul; Brasil
description The modulation of memory processes is one of the several functions of the endocannabinoid system (ECS) in the brain, with CB1 receptors highly expressed in areas such as the dorsal hippocampus. Experimental evidence suggested an important role of the ECS in aversively motivated memories. Similarly, glucocorticoids released in response to stress exposure also modulates memory formation, and both stress and dexamethasone activate the ECS. Here, we investigate the interaction between the ECS and glucocorticoids in the hippocampus in the modulation of fear memory consolidation. Two protocols with different shock intensities were used in order to control the level of aversiveness. Local infusion of AM251 into the hippocampus immediately after training was amnestic in the strong, but not in the weak protocol. Moreover, AM251 was amnestic in animals stressed 0, but not 30-min prior to the weak protocol, reverting the stress-induced facilitatory effect. Finally, intrahippocampal AM251 infusion reduced memory in animals that received dexamethasone immediately, but not 30 min before training. These results are (1) consistent with the view that the dorsal hippocampus ECS is activated on demand, in a rapid and short-lived fashion in order to modulate the consolidation of an aversive memory, and (2) show that this recruitment seems to be mediated by glucocorticoids, either in the hippocampus or in other brain regions functionally associated with the hippocampus. © 2010 Cold Spring Harbor Laboratory Press.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/132240
De Oliveira Alvares, Lucaa; Engelke, Douglas Senna; Diehl, Felipe; Scheffer-Teixeira, Robson; Haubrich, Josué; et al.; Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory; Cold Spring Harbor Laboratory Press; Learning & Memory (Cold Spring Harbor, N.Y.); 17; 4; 3-2010; 202-209
1072-0502
1549-5485
CONICET Digital
CONICET
url http://hdl.handle.net/11336/132240
identifier_str_mv De Oliveira Alvares, Lucaa; Engelke, Douglas Senna; Diehl, Felipe; Scheffer-Teixeira, Robson; Haubrich, Josué; et al.; Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory; Cold Spring Harbor Laboratory Press; Learning & Memory (Cold Spring Harbor, N.Y.); 17; 4; 3-2010; 202-209
1072-0502
1549-5485
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://learnmem.cshlp.org/content/17/4/202
info:eu-repo/semantics/altIdentifier/doi/10.1101/lm.1721010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269573781389312
score 13.13397

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