Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice

Autores
Molina, Veronica Carolina; Medici, Marta Graciela; Villena, Julio Cesar; Font, Graciela Maria; Taranto, Maria Pia
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ageing is associated with several anatomical and physiological changes of the organism and, the increase in global elderly population promotes the research to develop strategies to improve their quality of life. In this work, we characterized the immunological alterations naturally produced during aging in a mice model and, evaluated the effect of probiotic Lactobacillus (L.) rhamnosus CRL1505 administration on those immunological parameters. We demonstrated that L. rhamosus CRL1505 was able to improve peritoneal macrophages phagocytic activity and the number of intestinal IgA+ cells in aged mice, reaching values of those parameters similar to young adult mice. The results of this work indicate that is plausible that the immunobiotic CRL1505 strain may find applications as a beneficial immunomodulator in aging to reinforce the intestinal and systemic immunity. The immune modulation in aging induced by L. rhamnosus CRL1505 could lead to the development of new strategies for functional foods specifically tailored for the elderly.
Fil: Molina, Veronica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Medici, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Taranto, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Materia
AGING
INMUNOBIOTIC
INMUNOSENESCENCE
L. RHAMNOSUS CRL1505
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/59220
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged MiceMolina, Veronica CarolinaMedici, Marta GracielaVillena, Julio CesarFont, Graciela MariaTaranto, Maria PiaAGINGINMUNOBIOTICINMUNOSENESCENCEL. RHAMNOSUS CRL1505https://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Ageing is associated with several anatomical and physiological changes of the organism and, the increase in global elderly population promotes the research to develop strategies to improve their quality of life. In this work, we characterized the immunological alterations naturally produced during aging in a mice model and, evaluated the effect of probiotic Lactobacillus (L.) rhamnosus CRL1505 administration on those immunological parameters. We demonstrated that L. rhamosus CRL1505 was able to improve peritoneal macrophages phagocytic activity and the number of intestinal IgA+ cells in aged mice, reaching values of those parameters similar to young adult mice. The results of this work indicate that is plausible that the immunobiotic CRL1505 strain may find applications as a beneficial immunomodulator in aging to reinforce the intestinal and systemic immunity. The immune modulation in aging induced by L. rhamnosus CRL1505 could lead to the development of new strategies for functional foods specifically tailored for the elderly.Fil: Molina, Veronica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Medici, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Taranto, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaScientific Research Publishing2016-08-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/59220Molina, Veronica Carolina; Medici, Marta Graciela; Villena, Julio Cesar; Font, Graciela Maria; Taranto, Maria Pia; Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice; Scientific Research Publishing; Open Journal of Immunology; 6; 3; 5-8-2016; 73-78;69554-695542162-450X2162-4526CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4236/oji.2016.63008info:eu-repo/semantics/altIdentifier/url/http://file.scirp.org/Html/2-1410174_69554.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:54:43Zoai:ri.conicet.gov.ar:11336/59220instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:54:43.868CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice
title Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice
spellingShingle Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice
Molina, Veronica Carolina
AGING
INMUNOBIOTIC
INMUNOSENESCENCE
L. RHAMNOSUS CRL1505
title_short Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice
title_full Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice
title_fullStr Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice
title_full_unstemmed Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice
title_sort Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice
dc.creator.none.fl_str_mv Molina, Veronica Carolina
Medici, Marta Graciela
Villena, Julio Cesar
Font, Graciela Maria
Taranto, Maria Pia
author Molina, Veronica Carolina
author_facet Molina, Veronica Carolina
Medici, Marta Graciela
Villena, Julio Cesar
Font, Graciela Maria
Taranto, Maria Pia
author_role author
author2 Medici, Marta Graciela
Villena, Julio Cesar
Font, Graciela Maria
Taranto, Maria Pia
author2_role author
author
author
author
dc.subject.none.fl_str_mv AGING
INMUNOBIOTIC
INMUNOSENESCENCE
L. RHAMNOSUS CRL1505
topic AGING
INMUNOBIOTIC
INMUNOSENESCENCE
L. RHAMNOSUS CRL1505
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Ageing is associated with several anatomical and physiological changes of the organism and, the increase in global elderly population promotes the research to develop strategies to improve their quality of life. In this work, we characterized the immunological alterations naturally produced during aging in a mice model and, evaluated the effect of probiotic Lactobacillus (L.) rhamnosus CRL1505 administration on those immunological parameters. We demonstrated that L. rhamosus CRL1505 was able to improve peritoneal macrophages phagocytic activity and the number of intestinal IgA+ cells in aged mice, reaching values of those parameters similar to young adult mice. The results of this work indicate that is plausible that the immunobiotic CRL1505 strain may find applications as a beneficial immunomodulator in aging to reinforce the intestinal and systemic immunity. The immune modulation in aging induced by L. rhamnosus CRL1505 could lead to the development of new strategies for functional foods specifically tailored for the elderly.
Fil: Molina, Veronica Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Medici, Marta Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Font, Graciela Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Taranto, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
description Ageing is associated with several anatomical and physiological changes of the organism and, the increase in global elderly population promotes the research to develop strategies to improve their quality of life. In this work, we characterized the immunological alterations naturally produced during aging in a mice model and, evaluated the effect of probiotic Lactobacillus (L.) rhamnosus CRL1505 administration on those immunological parameters. We demonstrated that L. rhamosus CRL1505 was able to improve peritoneal macrophages phagocytic activity and the number of intestinal IgA+ cells in aged mice, reaching values of those parameters similar to young adult mice. The results of this work indicate that is plausible that the immunobiotic CRL1505 strain may find applications as a beneficial immunomodulator in aging to reinforce the intestinal and systemic immunity. The immune modulation in aging induced by L. rhamnosus CRL1505 could lead to the development of new strategies for functional foods specifically tailored for the elderly.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/59220
Molina, Veronica Carolina; Medici, Marta Graciela; Villena, Julio Cesar; Font, Graciela Maria; Taranto, Maria Pia; Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice; Scientific Research Publishing; Open Journal of Immunology; 6; 3; 5-8-2016; 73-78;69554-69554
2162-450X
2162-4526
CONICET Digital
CONICET
url http://hdl.handle.net/11336/59220
identifier_str_mv Molina, Veronica Carolina; Medici, Marta Graciela; Villena, Julio Cesar; Font, Graciela Maria; Taranto, Maria Pia; Dietary Supplementation with Probiotic Strain Improves Immune-Health in Aged Mice; Scientific Research Publishing; Open Journal of Immunology; 6; 3; 5-8-2016; 73-78;69554-69554
2162-450X
2162-4526
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4236/oji.2016.63008
info:eu-repo/semantics/altIdentifier/url/http://file.scirp.org/Html/2-1410174_69554.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Scientific Research Publishing
publisher.none.fl_str_mv Scientific Research Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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