Antibody-Antigen Binding Interface Analysis in the Big Data Era

Autores
Reis, Pedro B. P. S.; Barletta Roldan, Patricio German; Gagliardi, Lucas; Fortuna, Sara; Soler, Miguel A.; Rocchia, Walter
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Antibodies have become the Swiss Army tool for molecular biology and nanotechnology. Their outstanding ability to specifically recognise molecular antigens allows their use in many different applications from medicine to the industry. Moreover, the improvement of conventional structural biology techniques (e.g., X-ray, NMR) as well as the emergence of new ones (e.g., Cryo-EM), have permitted in the last years a notable increase of resolved antibody-antigen structures. This offers a unique opportunity to perform an exhaustive structural analysis of antibody-antigen interfaces by employing the large amount of data available nowadays. To leverage this factor, different geometric as well as chemical descriptors were evaluated to perform a comprehensive characterization.
Fil: Reis, Pedro B. P. S.. Istituto Italiano Di Technologie; Italia. Universidade Nova de Lisboa; Portugal
Fil: Barletta Roldan, Patricio German. The Abdus Salam; Italia. The Abdus Salam. International Centre for Theoretical Physics; Italia. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gagliardi, Lucas. Istituto Italiano Di Technologie; Italia
Fil: Fortuna, Sara. Istituto Italiano Di Technologie; Italia
Fil: Soler, Miguel A.. Istituto Italiano Di Technologie; Italia
Fil: Rocchia, Walter. Istituto Italiano Di Technologie; Italia
Materia
ANTIBODY-ANTIGEN COMPLEX
COMPLEMENTARITY-DETERMINING REGION (CDR)
EPITOPE ANALYSIS
PARATOPE ANALYSIS
STRUCTURE ANALYSIS AND CHARACTERIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/200993
Acceder
id CONICETDig_a3bd7ed9b0c0058c8c334b6b3bcf9927
oai_identifier_str oai:ri.conicet.gov.ar:11336/200993
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antibody-Antigen Binding Interface Analysis in the Big Data EraReis, Pedro B. P. S.Barletta Roldan, Patricio GermanGagliardi, LucasFortuna, SaraSoler, Miguel A.Rocchia, WalterANTIBODY-ANTIGEN COMPLEXCOMPLEMENTARITY-DETERMINING REGION (CDR)EPITOPE ANALYSISPARATOPE ANALYSISSTRUCTURE ANALYSIS AND CHARACTERIZATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Antibodies have become the Swiss Army tool for molecular biology and nanotechnology. Their outstanding ability to specifically recognise molecular antigens allows their use in many different applications from medicine to the industry. Moreover, the improvement of conventional structural biology techniques (e.g., X-ray, NMR) as well as the emergence of new ones (e.g., Cryo-EM), have permitted in the last years a notable increase of resolved antibody-antigen structures. This offers a unique opportunity to perform an exhaustive structural analysis of antibody-antigen interfaces by employing the large amount of data available nowadays. To leverage this factor, different geometric as well as chemical descriptors were evaluated to perform a comprehensive characterization.Fil: Reis, Pedro B. P. S.. Istituto Italiano Di Technologie; Italia. Universidade Nova de Lisboa; PortugalFil: Barletta Roldan, Patricio German. The Abdus Salam; Italia. The Abdus Salam. International Centre for Theoretical Physics; Italia. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gagliardi, Lucas. Istituto Italiano Di Technologie; ItaliaFil: Fortuna, Sara. Istituto Italiano Di Technologie; ItaliaFil: Soler, Miguel A.. Istituto Italiano Di Technologie; ItaliaFil: Rocchia, Walter. Istituto Italiano Di Technologie; ItaliaFrontiers Media2022-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/200993Reis, Pedro B. P. S.; Barletta Roldan, Patricio German; Gagliardi, Lucas; Fortuna, Sara; Soler, Miguel A.; et al.; Antibody-Antigen Binding Interface Analysis in the Big Data Era; Frontiers Media; Frontiers in Molecular Biosciences; 9; 7-2022; 1-172296-889XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmolb.2022.945808info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:46:47Zoai:ri.conicet.gov.ar:11336/200993instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:46:48.037CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antibody-Antigen Binding Interface Analysis in the Big Data Era
title Antibody-Antigen Binding Interface Analysis in the Big Data Era
spellingShingle Antibody-Antigen Binding Interface Analysis in the Big Data Era
Reis, Pedro B. P. S.
ANTIBODY-ANTIGEN COMPLEX
COMPLEMENTARITY-DETERMINING REGION (CDR)
EPITOPE ANALYSIS
PARATOPE ANALYSIS
STRUCTURE ANALYSIS AND CHARACTERIZATION
title_short Antibody-Antigen Binding Interface Analysis in the Big Data Era
title_full Antibody-Antigen Binding Interface Analysis in the Big Data Era
title_fullStr Antibody-Antigen Binding Interface Analysis in the Big Data Era
title_full_unstemmed Antibody-Antigen Binding Interface Analysis in the Big Data Era
title_sort Antibody-Antigen Binding Interface Analysis in the Big Data Era
dc.creator.none.fl_str_mv Reis, Pedro B. P. S.
Barletta Roldan, Patricio German
Gagliardi, Lucas
Fortuna, Sara
Soler, Miguel A.
Rocchia, Walter
author Reis, Pedro B. P. S.
author_facet Reis, Pedro B. P. S.
Barletta Roldan, Patricio German
Gagliardi, Lucas
Fortuna, Sara
Soler, Miguel A.
Rocchia, Walter
author_role author
author2 Barletta Roldan, Patricio German
Gagliardi, Lucas
Fortuna, Sara
Soler, Miguel A.
Rocchia, Walter
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANTIBODY-ANTIGEN COMPLEX
COMPLEMENTARITY-DETERMINING REGION (CDR)
EPITOPE ANALYSIS
PARATOPE ANALYSIS
STRUCTURE ANALYSIS AND CHARACTERIZATION
topic ANTIBODY-ANTIGEN COMPLEX
COMPLEMENTARITY-DETERMINING REGION (CDR)
EPITOPE ANALYSIS
PARATOPE ANALYSIS
STRUCTURE ANALYSIS AND CHARACTERIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Antibodies have become the Swiss Army tool for molecular biology and nanotechnology. Their outstanding ability to specifically recognise molecular antigens allows their use in many different applications from medicine to the industry. Moreover, the improvement of conventional structural biology techniques (e.g., X-ray, NMR) as well as the emergence of new ones (e.g., Cryo-EM), have permitted in the last years a notable increase of resolved antibody-antigen structures. This offers a unique opportunity to perform an exhaustive structural analysis of antibody-antigen interfaces by employing the large amount of data available nowadays. To leverage this factor, different geometric as well as chemical descriptors were evaluated to perform a comprehensive characterization.
Fil: Reis, Pedro B. P. S.. Istituto Italiano Di Technologie; Italia. Universidade Nova de Lisboa; Portugal
Fil: Barletta Roldan, Patricio German. The Abdus Salam; Italia. The Abdus Salam. International Centre for Theoretical Physics; Italia. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gagliardi, Lucas. Istituto Italiano Di Technologie; Italia
Fil: Fortuna, Sara. Istituto Italiano Di Technologie; Italia
Fil: Soler, Miguel A.. Istituto Italiano Di Technologie; Italia
Fil: Rocchia, Walter. Istituto Italiano Di Technologie; Italia
description Antibodies have become the Swiss Army tool for molecular biology and nanotechnology. Their outstanding ability to specifically recognise molecular antigens allows their use in many different applications from medicine to the industry. Moreover, the improvement of conventional structural biology techniques (e.g., X-ray, NMR) as well as the emergence of new ones (e.g., Cryo-EM), have permitted in the last years a notable increase of resolved antibody-antigen structures. This offers a unique opportunity to perform an exhaustive structural analysis of antibody-antigen interfaces by employing the large amount of data available nowadays. To leverage this factor, different geometric as well as chemical descriptors were evaluated to perform a comprehensive characterization.
publishDate 2022
dc.date.none.fl_str_mv 2022-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/200993
Reis, Pedro B. P. S.; Barletta Roldan, Patricio German; Gagliardi, Lucas; Fortuna, Sara; Soler, Miguel A.; et al.; Antibody-Antigen Binding Interface Analysis in the Big Data Era; Frontiers Media; Frontiers in Molecular Biosciences; 9; 7-2022; 1-17
2296-889X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/200993
identifier_str_mv Reis, Pedro B. P. S.; Barletta Roldan, Patricio German; Gagliardi, Lucas; Fortuna, Sara; Soler, Miguel A.; et al.; Antibody-Antigen Binding Interface Analysis in the Big Data Era; Frontiers Media; Frontiers in Molecular Biosciences; 9; 7-2022; 1-17
2296-889X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fmolb.2022.945808
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614510494613504
score 13.070432

Publicaciones similares