H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1
- Autores
- Ibañez, Irene Laura; Policastro, Lucia Laura; Tropper, Ivanna; Bracalente, María Candelaria; Palmieri, Mónica A.; Rojas, Paola Andrea; Molinari, Beatriz Lucia; Duran, Hebe Alicia
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The aim of the present study was to evaluate cell cycle regulation by scavenging H(2)O(2) in tumor cells. A significant arrest in the G1 phase of the cell cycle was demonstrated in CH72-T4 carcinoma cells exposed to catalase, associated with a decrease in cyclin D1 and an increase in the CDK inhibitory protein p27(KIP1). Moreover, we found a differential intracellular distribution of p27(KIP1), which remained in the nucleus after catalase treatment. In vivo experiments showed an increase in nuclear levels of p27(KIP1) associated with the inhibition of tumor growth by H(2)O(2) scavenging, confirming in vitro results. To conclude, H(2)O(2) scavenging may induce cell cycle arrest through the modulation of cyclin D1 and p27(KIP1) levels and nuclear localization of p27(KIP1). To our knowledge, this is the first report that demonstrates that the modulation of ROS alters the intracellular localization of a key regulatory protein of G1/S transition.
Fil: Ibañez, Irene Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Policastro, Lucia Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tropper, Ivanna. Universidad Nacional de San Martín; Argentina
Fil: Bracalente, María Candelaria. Comision Nacional de Energia Atomica; Argentina
Fil: Palmieri, Mónica A.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Fil: Molinari, Beatriz Lucia. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Duran, Hebe Alicia. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Desarrollo Tecnológico y Proyectos Especiales. Departamento de Micro y Nanotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Hydrogen Peroxide Drogen Peroxide
Cancer Cells
Proliferation
Cell Cycle
Cyclin D1
P27kip1 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/14697
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/14697 |
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3498 |
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CONICET Digital (CONICET) |
spelling |
H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1Ibañez, Irene LauraPolicastro, Lucia LauraTropper, IvannaBracalente, María CandelariaPalmieri, Mónica A.Rojas, Paola AndreaMolinari, Beatriz LuciaDuran, Hebe AliciaHydrogen Peroxide Drogen PeroxideCancer CellsProliferationCell CycleCyclin D1P27kip1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The aim of the present study was to evaluate cell cycle regulation by scavenging H(2)O(2) in tumor cells. A significant arrest in the G1 phase of the cell cycle was demonstrated in CH72-T4 carcinoma cells exposed to catalase, associated with a decrease in cyclin D1 and an increase in the CDK inhibitory protein p27(KIP1). Moreover, we found a differential intracellular distribution of p27(KIP1), which remained in the nucleus after catalase treatment. In vivo experiments showed an increase in nuclear levels of p27(KIP1) associated with the inhibition of tumor growth by H(2)O(2) scavenging, confirming in vitro results. To conclude, H(2)O(2) scavenging may induce cell cycle arrest through the modulation of cyclin D1 and p27(KIP1) levels and nuclear localization of p27(KIP1). To our knowledge, this is the first report that demonstrates that the modulation of ROS alters the intracellular localization of a key regulatory protein of G1/S transition.Fil: Ibañez, Irene Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Policastro, Lucia Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tropper, Ivanna. Universidad Nacional de San Martín; ArgentinaFil: Bracalente, María Candelaria. Comision Nacional de Energia Atomica; ArgentinaFil: Palmieri, Mónica A.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaFil: Molinari, Beatriz Lucia. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Duran, Hebe Alicia. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Desarrollo Tecnológico y Proyectos Especiales. Departamento de Micro y Nanotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Ireland2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14697Ibañez, Irene Laura; Policastro, Lucia Laura; Tropper, Ivanna; Bracalente, María Candelaria; Palmieri, Mónica A.; et al.; H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1; Elsevier Ireland; Cancer Letters; 305; 1; 1-6-2011; 58-680304-38351872-7980enginfo:eu-repo/semantics/altIdentifier/url/http://www.cancerletters.info/article/S0304-3835(11)00108-X/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2011.02.026info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S030438351100108Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:36Zoai:ri.conicet.gov.ar:11336/14697instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:36.704CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1 |
title |
H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1 |
spellingShingle |
H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1 Ibañez, Irene Laura Hydrogen Peroxide Drogen Peroxide Cancer Cells Proliferation Cell Cycle Cyclin D1 P27kip1 |
title_short |
H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1 |
title_full |
H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1 |
title_fullStr |
H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1 |
title_full_unstemmed |
H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1 |
title_sort |
H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1 |
dc.creator.none.fl_str_mv |
Ibañez, Irene Laura Policastro, Lucia Laura Tropper, Ivanna Bracalente, María Candelaria Palmieri, Mónica A. Rojas, Paola Andrea Molinari, Beatriz Lucia Duran, Hebe Alicia |
author |
Ibañez, Irene Laura |
author_facet |
Ibañez, Irene Laura Policastro, Lucia Laura Tropper, Ivanna Bracalente, María Candelaria Palmieri, Mónica A. Rojas, Paola Andrea Molinari, Beatriz Lucia Duran, Hebe Alicia |
author_role |
author |
author2 |
Policastro, Lucia Laura Tropper, Ivanna Bracalente, María Candelaria Palmieri, Mónica A. Rojas, Paola Andrea Molinari, Beatriz Lucia Duran, Hebe Alicia |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Hydrogen Peroxide Drogen Peroxide Cancer Cells Proliferation Cell Cycle Cyclin D1 P27kip1 |
topic |
Hydrogen Peroxide Drogen Peroxide Cancer Cells Proliferation Cell Cycle Cyclin D1 P27kip1 |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The aim of the present study was to evaluate cell cycle regulation by scavenging H(2)O(2) in tumor cells. A significant arrest in the G1 phase of the cell cycle was demonstrated in CH72-T4 carcinoma cells exposed to catalase, associated with a decrease in cyclin D1 and an increase in the CDK inhibitory protein p27(KIP1). Moreover, we found a differential intracellular distribution of p27(KIP1), which remained in the nucleus after catalase treatment. In vivo experiments showed an increase in nuclear levels of p27(KIP1) associated with the inhibition of tumor growth by H(2)O(2) scavenging, confirming in vitro results. To conclude, H(2)O(2) scavenging may induce cell cycle arrest through the modulation of cyclin D1 and p27(KIP1) levels and nuclear localization of p27(KIP1). To our knowledge, this is the first report that demonstrates that the modulation of ROS alters the intracellular localization of a key regulatory protein of G1/S transition. Fil: Ibañez, Irene Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Policastro, Lucia Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Tropper, Ivanna. Universidad Nacional de San Martín; Argentina Fil: Bracalente, María Candelaria. Comision Nacional de Energia Atomica; Argentina Fil: Palmieri, Mónica A.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina Fil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina Fil: Molinari, Beatriz Lucia. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Duran, Hebe Alicia. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Desarrollo Tecnológico y Proyectos Especiales. Departamento de Micro y Nanotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
The aim of the present study was to evaluate cell cycle regulation by scavenging H(2)O(2) in tumor cells. A significant arrest in the G1 phase of the cell cycle was demonstrated in CH72-T4 carcinoma cells exposed to catalase, associated with a decrease in cyclin D1 and an increase in the CDK inhibitory protein p27(KIP1). Moreover, we found a differential intracellular distribution of p27(KIP1), which remained in the nucleus after catalase treatment. In vivo experiments showed an increase in nuclear levels of p27(KIP1) associated with the inhibition of tumor growth by H(2)O(2) scavenging, confirming in vitro results. To conclude, H(2)O(2) scavenging may induce cell cycle arrest through the modulation of cyclin D1 and p27(KIP1) levels and nuclear localization of p27(KIP1). To our knowledge, this is the first report that demonstrates that the modulation of ROS alters the intracellular localization of a key regulatory protein of G1/S transition. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-06-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/14697 Ibañez, Irene Laura; Policastro, Lucia Laura; Tropper, Ivanna; Bracalente, María Candelaria; Palmieri, Mónica A.; et al.; H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1; Elsevier Ireland; Cancer Letters; 305; 1; 1-6-2011; 58-68 0304-3835 1872-7980 |
url |
http://hdl.handle.net/11336/14697 |
identifier_str_mv |
Ibañez, Irene Laura; Policastro, Lucia Laura; Tropper, Ivanna; Bracalente, María Candelaria; Palmieri, Mónica A.; et al.; H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1; Elsevier Ireland; Cancer Letters; 305; 1; 1-6-2011; 58-68 0304-3835 1872-7980 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.cancerletters.info/article/S0304-3835(11)00108-X/abstract info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2011.02.026 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S030438351100108X |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Ireland |
publisher.none.fl_str_mv |
Elsevier Ireland |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614112078725120 |
score |
13.070432 |