H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1

Autores
Ibañez, Irene Laura; Policastro, Lucia Laura; Tropper, Ivanna; Bracalente, María Candelaria; Palmieri, Mónica A.; Rojas, Paola Andrea; Molinari, Beatriz Lucia; Duran, Hebe Alicia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present study was to evaluate cell cycle regulation by scavenging H(2)O(2) in tumor cells. A significant arrest in the G1 phase of the cell cycle was demonstrated in CH72-T4 carcinoma cells exposed to catalase, associated with a decrease in cyclin D1 and an increase in the CDK inhibitory protein p27(KIP1). Moreover, we found a differential intracellular distribution of p27(KIP1), which remained in the nucleus after catalase treatment. In vivo experiments showed an increase in nuclear levels of p27(KIP1) associated with the inhibition of tumor growth by H(2)O(2) scavenging, confirming in vitro results. To conclude, H(2)O(2) scavenging may induce cell cycle arrest through the modulation of cyclin D1 and p27(KIP1) levels and nuclear localization of p27(KIP1). To our knowledge, this is the first report that demonstrates that the modulation of ROS alters the intracellular localization of a key regulatory protein of G1/S transition.
Fil: Ibañez, Irene Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Policastro, Lucia Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tropper, Ivanna. Universidad Nacional de San Martín; Argentina
Fil: Bracalente, María Candelaria. Comision Nacional de Energia Atomica; Argentina
Fil: Palmieri, Mónica A.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Fil: Molinari, Beatriz Lucia. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Duran, Hebe Alicia. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Desarrollo Tecnológico y Proyectos Especiales. Departamento de Micro y Nanotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Hydrogen Peroxide Drogen Peroxide
Cancer Cells
Proliferation
Cell Cycle
Cyclin D1
P27kip1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14697

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network_name_str CONICET Digital (CONICET)
spelling H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1Ibañez, Irene LauraPolicastro, Lucia LauraTropper, IvannaBracalente, María CandelariaPalmieri, Mónica A.Rojas, Paola AndreaMolinari, Beatriz LuciaDuran, Hebe AliciaHydrogen Peroxide Drogen PeroxideCancer CellsProliferationCell CycleCyclin D1P27kip1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The aim of the present study was to evaluate cell cycle regulation by scavenging H(2)O(2) in tumor cells. A significant arrest in the G1 phase of the cell cycle was demonstrated in CH72-T4 carcinoma cells exposed to catalase, associated with a decrease in cyclin D1 and an increase in the CDK inhibitory protein p27(KIP1). Moreover, we found a differential intracellular distribution of p27(KIP1), which remained in the nucleus after catalase treatment. In vivo experiments showed an increase in nuclear levels of p27(KIP1) associated with the inhibition of tumor growth by H(2)O(2) scavenging, confirming in vitro results. To conclude, H(2)O(2) scavenging may induce cell cycle arrest through the modulation of cyclin D1 and p27(KIP1) levels and nuclear localization of p27(KIP1). To our knowledge, this is the first report that demonstrates that the modulation of ROS alters the intracellular localization of a key regulatory protein of G1/S transition.Fil: Ibañez, Irene Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Policastro, Lucia Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tropper, Ivanna. Universidad Nacional de San Martín; ArgentinaFil: Bracalente, María Candelaria. Comision Nacional de Energia Atomica; ArgentinaFil: Palmieri, Mónica A.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaFil: Molinari, Beatriz Lucia. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Duran, Hebe Alicia. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Desarrollo Tecnológico y Proyectos Especiales. Departamento de Micro y Nanotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Ireland2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14697Ibañez, Irene Laura; Policastro, Lucia Laura; Tropper, Ivanna; Bracalente, María Candelaria; Palmieri, Mónica A.; et al.; H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1; Elsevier Ireland; Cancer Letters; 305; 1; 1-6-2011; 58-680304-38351872-7980enginfo:eu-repo/semantics/altIdentifier/url/http://www.cancerletters.info/article/S0304-3835(11)00108-X/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2011.02.026info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S030438351100108Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:36Zoai:ri.conicet.gov.ar:11336/14697instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:36.704CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1
title H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1
spellingShingle H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1
Ibañez, Irene Laura
Hydrogen Peroxide Drogen Peroxide
Cancer Cells
Proliferation
Cell Cycle
Cyclin D1
P27kip1
title_short H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1
title_full H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1
title_fullStr H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1
title_full_unstemmed H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1
title_sort H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1
dc.creator.none.fl_str_mv Ibañez, Irene Laura
Policastro, Lucia Laura
Tropper, Ivanna
Bracalente, María Candelaria
Palmieri, Mónica A.
Rojas, Paola Andrea
Molinari, Beatriz Lucia
Duran, Hebe Alicia
author Ibañez, Irene Laura
author_facet Ibañez, Irene Laura
Policastro, Lucia Laura
Tropper, Ivanna
Bracalente, María Candelaria
Palmieri, Mónica A.
Rojas, Paola Andrea
Molinari, Beatriz Lucia
Duran, Hebe Alicia
author_role author
author2 Policastro, Lucia Laura
Tropper, Ivanna
Bracalente, María Candelaria
Palmieri, Mónica A.
Rojas, Paola Andrea
Molinari, Beatriz Lucia
Duran, Hebe Alicia
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hydrogen Peroxide Drogen Peroxide
Cancer Cells
Proliferation
Cell Cycle
Cyclin D1
P27kip1
topic Hydrogen Peroxide Drogen Peroxide
Cancer Cells
Proliferation
Cell Cycle
Cyclin D1
P27kip1
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The aim of the present study was to evaluate cell cycle regulation by scavenging H(2)O(2) in tumor cells. A significant arrest in the G1 phase of the cell cycle was demonstrated in CH72-T4 carcinoma cells exposed to catalase, associated with a decrease in cyclin D1 and an increase in the CDK inhibitory protein p27(KIP1). Moreover, we found a differential intracellular distribution of p27(KIP1), which remained in the nucleus after catalase treatment. In vivo experiments showed an increase in nuclear levels of p27(KIP1) associated with the inhibition of tumor growth by H(2)O(2) scavenging, confirming in vitro results. To conclude, H(2)O(2) scavenging may induce cell cycle arrest through the modulation of cyclin D1 and p27(KIP1) levels and nuclear localization of p27(KIP1). To our knowledge, this is the first report that demonstrates that the modulation of ROS alters the intracellular localization of a key regulatory protein of G1/S transition.
Fil: Ibañez, Irene Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Policastro, Lucia Laura. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tropper, Ivanna. Universidad Nacional de San Martín; Argentina
Fil: Bracalente, María Candelaria. Comision Nacional de Energia Atomica; Argentina
Fil: Palmieri, Mónica A.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Rojas, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; Argentina
Fil: Molinari, Beatriz Lucia. Comision Nacional de Energia Atomica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Duran, Hebe Alicia. Comisión Nacional de Energía Atómica. Gerencia del Area de Investigación y Aplicaciones No Nucleares. Gerencia de Desarrollo Tecnológico y Proyectos Especiales. Departamento de Micro y Nanotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The aim of the present study was to evaluate cell cycle regulation by scavenging H(2)O(2) in tumor cells. A significant arrest in the G1 phase of the cell cycle was demonstrated in CH72-T4 carcinoma cells exposed to catalase, associated with a decrease in cyclin D1 and an increase in the CDK inhibitory protein p27(KIP1). Moreover, we found a differential intracellular distribution of p27(KIP1), which remained in the nucleus after catalase treatment. In vivo experiments showed an increase in nuclear levels of p27(KIP1) associated with the inhibition of tumor growth by H(2)O(2) scavenging, confirming in vitro results. To conclude, H(2)O(2) scavenging may induce cell cycle arrest through the modulation of cyclin D1 and p27(KIP1) levels and nuclear localization of p27(KIP1). To our knowledge, this is the first report that demonstrates that the modulation of ROS alters the intracellular localization of a key regulatory protein of G1/S transition.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14697
Ibañez, Irene Laura; Policastro, Lucia Laura; Tropper, Ivanna; Bracalente, María Candelaria; Palmieri, Mónica A.; et al.; H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1; Elsevier Ireland; Cancer Letters; 305; 1; 1-6-2011; 58-68
0304-3835
1872-7980
url http://hdl.handle.net/11336/14697
identifier_str_mv Ibañez, Irene Laura; Policastro, Lucia Laura; Tropper, Ivanna; Bracalente, María Candelaria; Palmieri, Mónica A.; et al.; H2O2 scavenging inhibits G1/S transition by increasing nuclear levels of p27KIP1; Elsevier Ireland; Cancer Letters; 305; 1; 1-6-2011; 58-68
0304-3835
1872-7980
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.cancerletters.info/article/S0304-3835(11)00108-X/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2011.02.026
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S030438351100108X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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