Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics

Autores
Martínez Abadías, Neus; Paschetta, Carolina Andrea; de Azevedo, Soledad; Esparza, Mireia; González José, Rolando
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neurocranial globularity is one of the few derived traits defining anatomically modern humans. Variations in this trait derive from multiple and complex interactions between portions of the brain and the size and shape of the cranial base, among other factors. Given their evolutionary and functional importance, neurocranial globularity is expected to present high genetic and developmental constraints on their phenotypic expression. Here we applied two independent approaches to investigate both types of constraints. First, we assessed if patterns of morphological integration are conserved or else disrupted on a series of artificially deformed skulls in comparison to nondeformed (ND) ones. Second, after the estimation of the genetic covariance matrix for human skull shape, we explored how neurocranial globularity would respond to putative selective events disrupting the normal morphological patterns. Simulations on these deviations were explicitly set to replicate the artificial deformation patterns in order to compare developmental and genetic constraints under the same biomechanical conditions. In general terms, our results indicate that putative developmental constraints help to preserve some aspects of normal morphological integration even in the deformed skulls. Moreover, we find that the response to selection in neurocranial globularity is pervasive. In other words, induced changes in the vault generate a global response, indicating that departures from normal patterns of neurocranial globularity are genetically constrained. In summary, our combined results suggest that neurocranial globularity behaves as a highly genetic and developmental constrained trait.
Fil: Martínez Abadías, Neus. Universidad de Barcelona; España
Fil: Paschetta, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Esparza, Mireia. Universidad de Barcelona; España
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Materia
ARTIFICIAL DEFORMATION
CONSTRAINTS
GEOMETRIC MORPHOMETRICS
MORPHOLOGICAL INTEGRATION
NEUROCRANIAL GLOBULARITY
QUANTITATIVE GENETICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/95384
Acceder
id CONICETDig_a2d76c661ed6a4a5497566ff50aa3f19
oai_identifier_str oai:ri.conicet.gov.ar:11336/95384
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative geneticsMartínez Abadías, NeusPaschetta, Carolina Andreade Azevedo, SoledadEsparza, MireiaGonzález José, RolandoARTIFICIAL DEFORMATIONCONSTRAINTSGEOMETRIC MORPHOMETRICSMORPHOLOGICAL INTEGRATIONNEUROCRANIAL GLOBULARITYQUANTITATIVE GENETICShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Neurocranial globularity is one of the few derived traits defining anatomically modern humans. Variations in this trait derive from multiple and complex interactions between portions of the brain and the size and shape of the cranial base, among other factors. Given their evolutionary and functional importance, neurocranial globularity is expected to present high genetic and developmental constraints on their phenotypic expression. Here we applied two independent approaches to investigate both types of constraints. First, we assessed if patterns of morphological integration are conserved or else disrupted on a series of artificially deformed skulls in comparison to nondeformed (ND) ones. Second, after the estimation of the genetic covariance matrix for human skull shape, we explored how neurocranial globularity would respond to putative selective events disrupting the normal morphological patterns. Simulations on these deviations were explicitly set to replicate the artificial deformation patterns in order to compare developmental and genetic constraints under the same biomechanical conditions. In general terms, our results indicate that putative developmental constraints help to preserve some aspects of normal morphological integration even in the deformed skulls. Moreover, we find that the response to selection in neurocranial globularity is pervasive. In other words, induced changes in the vault generate a global response, indicating that departures from normal patterns of neurocranial globularity are genetically constrained. In summary, our combined results suggest that neurocranial globularity behaves as a highly genetic and developmental constrained trait.Fil: Martínez Abadías, Neus. Universidad de Barcelona; EspañaFil: Paschetta, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Esparza, Mireia. Universidad de Barcelona; EspañaFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaSpringer2009-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/95384Martínez Abadías, Neus; Paschetta, Carolina Andrea; de Azevedo, Soledad; Esparza, Mireia; González José, Rolando; Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics; Springer; Evolutionary Biology; 36; 1; 3-2009; 37-560071-32601934-2845CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s11692-008-9045-4info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11692-008-9045-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:33:03Zoai:ri.conicet.gov.ar:11336/95384instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:33:03.539CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics
title Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics
spellingShingle Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics
Martínez Abadías, Neus
ARTIFICIAL DEFORMATION
CONSTRAINTS
GEOMETRIC MORPHOMETRICS
MORPHOLOGICAL INTEGRATION
NEUROCRANIAL GLOBULARITY
QUANTITATIVE GENETICS
title_short Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics
title_full Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics
title_fullStr Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics
title_full_unstemmed Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics
title_sort Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics
dc.creator.none.fl_str_mv Martínez Abadías, Neus
Paschetta, Carolina Andrea
de Azevedo, Soledad
Esparza, Mireia
González José, Rolando
author Martínez Abadías, Neus
author_facet Martínez Abadías, Neus
Paschetta, Carolina Andrea
de Azevedo, Soledad
Esparza, Mireia
González José, Rolando
author_role author
author2 Paschetta, Carolina Andrea
de Azevedo, Soledad
Esparza, Mireia
González José, Rolando
author2_role author
author
author
author
dc.subject.none.fl_str_mv ARTIFICIAL DEFORMATION
CONSTRAINTS
GEOMETRIC MORPHOMETRICS
MORPHOLOGICAL INTEGRATION
NEUROCRANIAL GLOBULARITY
QUANTITATIVE GENETICS
topic ARTIFICIAL DEFORMATION
CONSTRAINTS
GEOMETRIC MORPHOMETRICS
MORPHOLOGICAL INTEGRATION
NEUROCRANIAL GLOBULARITY
QUANTITATIVE GENETICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Neurocranial globularity is one of the few derived traits defining anatomically modern humans. Variations in this trait derive from multiple and complex interactions between portions of the brain and the size and shape of the cranial base, among other factors. Given their evolutionary and functional importance, neurocranial globularity is expected to present high genetic and developmental constraints on their phenotypic expression. Here we applied two independent approaches to investigate both types of constraints. First, we assessed if patterns of morphological integration are conserved or else disrupted on a series of artificially deformed skulls in comparison to nondeformed (ND) ones. Second, after the estimation of the genetic covariance matrix for human skull shape, we explored how neurocranial globularity would respond to putative selective events disrupting the normal morphological patterns. Simulations on these deviations were explicitly set to replicate the artificial deformation patterns in order to compare developmental and genetic constraints under the same biomechanical conditions. In general terms, our results indicate that putative developmental constraints help to preserve some aspects of normal morphological integration even in the deformed skulls. Moreover, we find that the response to selection in neurocranial globularity is pervasive. In other words, induced changes in the vault generate a global response, indicating that departures from normal patterns of neurocranial globularity are genetically constrained. In summary, our combined results suggest that neurocranial globularity behaves as a highly genetic and developmental constrained trait.
Fil: Martínez Abadías, Neus. Universidad de Barcelona; España
Fil: Paschetta, Carolina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Esparza, Mireia. Universidad de Barcelona; España
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
description Neurocranial globularity is one of the few derived traits defining anatomically modern humans. Variations in this trait derive from multiple and complex interactions between portions of the brain and the size and shape of the cranial base, among other factors. Given their evolutionary and functional importance, neurocranial globularity is expected to present high genetic and developmental constraints on their phenotypic expression. Here we applied two independent approaches to investigate both types of constraints. First, we assessed if patterns of morphological integration are conserved or else disrupted on a series of artificially deformed skulls in comparison to nondeformed (ND) ones. Second, after the estimation of the genetic covariance matrix for human skull shape, we explored how neurocranial globularity would respond to putative selective events disrupting the normal morphological patterns. Simulations on these deviations were explicitly set to replicate the artificial deformation patterns in order to compare developmental and genetic constraints under the same biomechanical conditions. In general terms, our results indicate that putative developmental constraints help to preserve some aspects of normal morphological integration even in the deformed skulls. Moreover, we find that the response to selection in neurocranial globularity is pervasive. In other words, induced changes in the vault generate a global response, indicating that departures from normal patterns of neurocranial globularity are genetically constrained. In summary, our combined results suggest that neurocranial globularity behaves as a highly genetic and developmental constrained trait.
publishDate 2009
dc.date.none.fl_str_mv 2009-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/95384
Martínez Abadías, Neus; Paschetta, Carolina Andrea; de Azevedo, Soledad; Esparza, Mireia; González José, Rolando; Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics; Springer; Evolutionary Biology; 36; 1; 3-2009; 37-56
0071-3260
1934-2845
CONICET Digital
CONICET
url http://hdl.handle.net/11336/95384
identifier_str_mv Martínez Abadías, Neus; Paschetta, Carolina Andrea; de Azevedo, Soledad; Esparza, Mireia; González José, Rolando; Developmental and genetic constraints on neurocranial globularity: Insights from analyses of deformed skulls and quantitative genetics; Springer; Evolutionary Biology; 36; 1; 3-2009; 37-56
0071-3260
1934-2845
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s11692-008-9045-4
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11692-008-9045-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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