Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta

Autores
Fortuna, Antonio Mario; Juárez, Zaida N.; Bach, Horacio; Nematallah, Anouf; Av Gay, Yossef; Sánchez Arreola, Eugenio; Catalan, Cesar Atilio Nazareno; Turbay, S.; Hernández, Luis R.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Six compounds from the aerial parts of the Argentinean plant Hymenoxys robusta (Rusby) Parker were isolated and their structures elucidated using extensive spectroscopic analyses. These compounds comprise two inositol derivatives and four 3,4-seco-pseudoguaianolides, including vermeerin. Bioactivity assays of these compounds against bacterial and fungal pathogens showed that only vermeerin possessed antimicrobial activity specific against Staphylococcus aureus, and showed no toxicity when exposed to human-derived macrophages.
Fil: Fortuna, Antonio Mario. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina
Fil: Juárez, Zaida N.. Universidad de las Américas Puebla; México. Universidad Popular Autónoma del Estado de Puebla; México
Fil: Bach, Horacio. University of British Columbia; Canadá
Fil: Nematallah, Anouf. University of British Columbia; Canadá
Fil: Av Gay, Yossef. University of British Columbia; Canadá
Fil: Sánchez Arreola, Eugenio. Universidad de las Américas Puebla; México
Fil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Turbay, S.. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina
Fil: Hernández, Luis R.. Universidad de las Américas Puebla; México
Materia
Asteraceae
Bioactivity
Helenieae
Hymenoxys Robusta
Inositol Derivatives
Sesquiterpene Lactones
Tetraneurinae
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52097
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robustaFortuna, Antonio MarioJuárez, Zaida N.Bach, HoracioNematallah, AnoufAv Gay, YossefSánchez Arreola, EugenioCatalan, Cesar Atilio NazarenoTurbay, S.Hernández, Luis R.AsteraceaeBioactivityHelenieaeHymenoxys RobustaInositol DerivativesSesquiterpene LactonesTetraneurinaehttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Six compounds from the aerial parts of the Argentinean plant Hymenoxys robusta (Rusby) Parker were isolated and their structures elucidated using extensive spectroscopic analyses. These compounds comprise two inositol derivatives and four 3,4-seco-pseudoguaianolides, including vermeerin. Bioactivity assays of these compounds against bacterial and fungal pathogens showed that only vermeerin possessed antimicrobial activity specific against Staphylococcus aureus, and showed no toxicity when exposed to human-derived macrophages.Fil: Fortuna, Antonio Mario. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Juárez, Zaida N.. Universidad de las Américas Puebla; México. Universidad Popular Autónoma del Estado de Puebla; MéxicoFil: Bach, Horacio. University of British Columbia; CanadáFil: Nematallah, Anouf. University of British Columbia; CanadáFil: Av Gay, Yossef. University of British Columbia; CanadáFil: Sánchez Arreola, Eugenio. Universidad de las Américas Puebla; MéxicoFil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Turbay, S.. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Hernández, Luis R.. Universidad de las Américas Puebla; MéxicoPergamon-Elsevier Science Ltd2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52097Fortuna, Antonio Mario; Juárez, Zaida N.; Bach, Horacio; Nematallah, Anouf; Av Gay, Yossef; et al.; Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta; Pergamon-Elsevier Science Ltd; Phytochemistry; 72; 18; 12-2011; 2413-24180031-9422CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.phytochem.2011.09.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0031942211004134info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:01Zoai:ri.conicet.gov.ar:11336/52097instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:02.292CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta
title Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta
spellingShingle Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta
Fortuna, Antonio Mario
Asteraceae
Bioactivity
Helenieae
Hymenoxys Robusta
Inositol Derivatives
Sesquiterpene Lactones
Tetraneurinae
title_short Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta
title_full Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta
title_fullStr Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta
title_full_unstemmed Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta
title_sort Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta
dc.creator.none.fl_str_mv Fortuna, Antonio Mario
Juárez, Zaida N.
Bach, Horacio
Nematallah, Anouf
Av Gay, Yossef
Sánchez Arreola, Eugenio
Catalan, Cesar Atilio Nazareno
Turbay, S.
Hernández, Luis R.
author Fortuna, Antonio Mario
author_facet Fortuna, Antonio Mario
Juárez, Zaida N.
Bach, Horacio
Nematallah, Anouf
Av Gay, Yossef
Sánchez Arreola, Eugenio
Catalan, Cesar Atilio Nazareno
Turbay, S.
Hernández, Luis R.
author_role author
author2 Juárez, Zaida N.
Bach, Horacio
Nematallah, Anouf
Av Gay, Yossef
Sánchez Arreola, Eugenio
Catalan, Cesar Atilio Nazareno
Turbay, S.
Hernández, Luis R.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Asteraceae
Bioactivity
Helenieae
Hymenoxys Robusta
Inositol Derivatives
Sesquiterpene Lactones
Tetraneurinae
topic Asteraceae
Bioactivity
Helenieae
Hymenoxys Robusta
Inositol Derivatives
Sesquiterpene Lactones
Tetraneurinae
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Six compounds from the aerial parts of the Argentinean plant Hymenoxys robusta (Rusby) Parker were isolated and their structures elucidated using extensive spectroscopic analyses. These compounds comprise two inositol derivatives and four 3,4-seco-pseudoguaianolides, including vermeerin. Bioactivity assays of these compounds against bacterial and fungal pathogens showed that only vermeerin possessed antimicrobial activity specific against Staphylococcus aureus, and showed no toxicity when exposed to human-derived macrophages.
Fil: Fortuna, Antonio Mario. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina
Fil: Juárez, Zaida N.. Universidad de las Américas Puebla; México. Universidad Popular Autónoma del Estado de Puebla; México
Fil: Bach, Horacio. University of British Columbia; Canadá
Fil: Nematallah, Anouf. University of British Columbia; Canadá
Fil: Av Gay, Yossef. University of British Columbia; Canadá
Fil: Sánchez Arreola, Eugenio. Universidad de las Américas Puebla; México
Fil: Catalan, Cesar Atilio Nazareno. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Turbay, S.. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina
Fil: Hernández, Luis R.. Universidad de las Américas Puebla; México
description Six compounds from the aerial parts of the Argentinean plant Hymenoxys robusta (Rusby) Parker were isolated and their structures elucidated using extensive spectroscopic analyses. These compounds comprise two inositol derivatives and four 3,4-seco-pseudoguaianolides, including vermeerin. Bioactivity assays of these compounds against bacterial and fungal pathogens showed that only vermeerin possessed antimicrobial activity specific against Staphylococcus aureus, and showed no toxicity when exposed to human-derived macrophages.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52097
Fortuna, Antonio Mario; Juárez, Zaida N.; Bach, Horacio; Nematallah, Anouf; Av Gay, Yossef; et al.; Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta; Pergamon-Elsevier Science Ltd; Phytochemistry; 72; 18; 12-2011; 2413-2418
0031-9422
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52097
identifier_str_mv Fortuna, Antonio Mario; Juárez, Zaida N.; Bach, Horacio; Nematallah, Anouf; Av Gay, Yossef; et al.; Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta; Pergamon-Elsevier Science Ltd; Phytochemistry; 72; 18; 12-2011; 2413-2418
0031-9422
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phytochem.2011.09.001
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0031942211004134
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269131430166529
score 13.13397

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