Identification of a novel Pfkfb1 mRNA variant in rat fetal liver

Autores
Cosin Roge, Jesús; Vernia, Santiago; Alvarez, María Soledad; Cucarella, Carme; Boscá, Lisardo; Martin Sanz, Paloma; Fernández Alvarez, Ana Julia; Casado, Marta
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a key metabolite in the glucose homeostasis. Four genes, Pfkfb1-4, have been characterized in mammals that code for several isoforms generated by alternative splicing through the control of several promoters and 5' non-coding exons. Here, we characterize in fetal rat liver new mRNA variants which are transcribed from a new Pfkfb1 gene promoter. The long variant codes to a new isoform (FL-PFK-2) that would be of relevant function to modulate the transition of fetal to adult liver metabolism.
Fil: Cosin Roge, Jesús. Consejo Superior de Investigaciones Cientificas; España
Fil: Vernia, Santiago. Consejo Superior de Investigaciones Cientificas; España
Fil: Alvarez, María Soledad. Consejo Superior de Investigaciones Cientificas; España
Fil: Cucarella, Carme. Consejo Superior de Investigaciones Cientificas; España
Fil: Boscá, Lisardo. Consejo Superior de Investigaciones Cientificas; España
Fil: Martin Sanz, Paloma. Consejo Superior de Investigaciones Cientificas; España
Fil: Fernández Alvarez, Ana Julia. Consejo Superior de Investigaciones Cientificas; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Casado, Marta. Consejo Superior de Investigaciones Cientificas; España
Materia
Pfk
Fetal Liver
Splicing
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/19538
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Identification of a novel Pfkfb1 mRNA variant in rat fetal liverCosin Roge, JesúsVernia, SantiagoAlvarez, María SoledadCucarella, CarmeBoscá, LisardoMartin Sanz, PalomaFernández Alvarez, Ana JuliaCasado, MartaPfkFetal LiverSplicinghttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a key metabolite in the glucose homeostasis. Four genes, Pfkfb1-4, have been characterized in mammals that code for several isoforms generated by alternative splicing through the control of several promoters and 5' non-coding exons. Here, we characterize in fetal rat liver new mRNA variants which are transcribed from a new Pfkfb1 gene promoter. The long variant codes to a new isoform (FL-PFK-2) that would be of relevant function to modulate the transition of fetal to adult liver metabolism.Fil: Cosin Roge, Jesús. Consejo Superior de Investigaciones Cientificas; EspañaFil: Vernia, Santiago. Consejo Superior de Investigaciones Cientificas; EspañaFil: Alvarez, María Soledad. Consejo Superior de Investigaciones Cientificas; EspañaFil: Cucarella, Carme. Consejo Superior de Investigaciones Cientificas; EspañaFil: Boscá, Lisardo. Consejo Superior de Investigaciones Cientificas; EspañaFil: Martin Sanz, Paloma. Consejo Superior de Investigaciones Cientificas; EspañaFil: Fernández Alvarez, Ana Julia. Consejo Superior de Investigaciones Cientificas; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Casado, Marta. Consejo Superior de Investigaciones Cientificas; EspañaElsevier2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/19538Cosin Roge, Jesús; Vernia, Santiago; Alvarez, María Soledad; Cucarella, Carme; Boscá, Lisardo; et al.; Identification of a novel Pfkfb1 mRNA variant in rat fetal liver; Elsevier; Biochemical And Biophysical Research Communications; 431; 1; 2-2013; 36-400006-291X1090-2104CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0006291X12024692info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbrc.2012.12.109info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:21Zoai:ri.conicet.gov.ar:11336/19538instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:22.145CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
title Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
spellingShingle Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
Cosin Roge, Jesús
Pfk
Fetal Liver
Splicing
title_short Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
title_full Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
title_fullStr Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
title_full_unstemmed Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
title_sort Identification of a novel Pfkfb1 mRNA variant in rat fetal liver
dc.creator.none.fl_str_mv Cosin Roge, Jesús
Vernia, Santiago
Alvarez, María Soledad
Cucarella, Carme
Boscá, Lisardo
Martin Sanz, Paloma
Fernández Alvarez, Ana Julia
Casado, Marta
author Cosin Roge, Jesús
author_facet Cosin Roge, Jesús
Vernia, Santiago
Alvarez, María Soledad
Cucarella, Carme
Boscá, Lisardo
Martin Sanz, Paloma
Fernández Alvarez, Ana Julia
Casado, Marta
author_role author
author2 Vernia, Santiago
Alvarez, María Soledad
Cucarella, Carme
Boscá, Lisardo
Martin Sanz, Paloma
Fernández Alvarez, Ana Julia
Casado, Marta
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pfk
Fetal Liver
Splicing
topic Pfk
Fetal Liver
Splicing
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a key metabolite in the glucose homeostasis. Four genes, Pfkfb1-4, have been characterized in mammals that code for several isoforms generated by alternative splicing through the control of several promoters and 5' non-coding exons. Here, we characterize in fetal rat liver new mRNA variants which are transcribed from a new Pfkfb1 gene promoter. The long variant codes to a new isoform (FL-PFK-2) that would be of relevant function to modulate the transition of fetal to adult liver metabolism.
Fil: Cosin Roge, Jesús. Consejo Superior de Investigaciones Cientificas; España
Fil: Vernia, Santiago. Consejo Superior de Investigaciones Cientificas; España
Fil: Alvarez, María Soledad. Consejo Superior de Investigaciones Cientificas; España
Fil: Cucarella, Carme. Consejo Superior de Investigaciones Cientificas; España
Fil: Boscá, Lisardo. Consejo Superior de Investigaciones Cientificas; España
Fil: Martin Sanz, Paloma. Consejo Superior de Investigaciones Cientificas; España
Fil: Fernández Alvarez, Ana Julia. Consejo Superior de Investigaciones Cientificas; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Casado, Marta. Consejo Superior de Investigaciones Cientificas; España
description The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a key metabolite in the glucose homeostasis. Four genes, Pfkfb1-4, have been characterized in mammals that code for several isoforms generated by alternative splicing through the control of several promoters and 5' non-coding exons. Here, we characterize in fetal rat liver new mRNA variants which are transcribed from a new Pfkfb1 gene promoter. The long variant codes to a new isoform (FL-PFK-2) that would be of relevant function to modulate the transition of fetal to adult liver metabolism.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/19538
Cosin Roge, Jesús; Vernia, Santiago; Alvarez, María Soledad; Cucarella, Carme; Boscá, Lisardo; et al.; Identification of a novel Pfkfb1 mRNA variant in rat fetal liver; Elsevier; Biochemical And Biophysical Research Communications; 431; 1; 2-2013; 36-40
0006-291X
1090-2104
CONICET Digital
CONICET
url http://hdl.handle.net/11336/19538
identifier_str_mv Cosin Roge, Jesús; Vernia, Santiago; Alvarez, María Soledad; Cucarella, Carme; Boscá, Lisardo; et al.; Identification of a novel Pfkfb1 mRNA variant in rat fetal liver; Elsevier; Biochemical And Biophysical Research Communications; 431; 1; 2-2013; 36-40
0006-291X
1090-2104
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0006291X12024692
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbrc.2012.12.109
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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