p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer

Autores
Lodillinsky, Catalina; Infante, E.; Guichard, A.; Chaligné, R.; Fuhrmann, L.; Cyrta, J.; Irondelle, Marie; Lagoutte, Emilie; Vacher, Sophie; Bonsang-Kitzis, H.; Glukhova, M.; Reyal, F.; Bièche, I.; Vincent Salomon, Anne; Chavrier, Philippe
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The transition of ductal carcinoma in situ (DCIS) to invasive breast carcinoma requires tumor cells to cross the basement membrane (BM). However, mechanisms underlying BM transmigration are poorly understood. Here, we report that expression of membrane-type 1 (MT1)-matrix metalloproteinase (MMP), a key component of the BM invasion program, increases during breast cancer progression at the in situ to invasive breast carcinoma transition. In the intraductal xenograft model, MT1-MMP is required for BM transmigration of MCF10DCIS.com breast adenocarcinoma cells and is overexpressed in cell clusters overlying focal BM disruptions and at the invasive tumor front. Mirrored upregulation of p63 and MT1-MMP is observed at the edge of MCF10DCIS.com xenograft tumors and p63 is required for induction of MT1-MMP-dependent invasive program in response to microenvironmental signals. Immunohistochemistry and analysis of public database reveal that p63 and MT1-MMP are upregulated in human basal-like breast tumors suggesting that p63/MT1-MMP axis contributes to progression of basal-like breast cancers with elevated p63 and MT1-MMP levels.
Fil: Lodillinsky, Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centre National de la Recherche Scientifique; Francia
Fil: Infante, E.. Centre National de la Recherche Scientifique; Francia
Fil: Guichard, A.. Centre National de la Recherche Scientifique; Francia
Fil: Chaligné, R.. Génétique Et Biologie Du Développement; Francia
Fil: Fuhrmann, L.. Centre National de la Recherche Scientifique; Francia
Fil: Cyrta, J.. Centre National de la Recherche Scientifique; Francia
Fil: Irondelle, Marie. Centre National de la Recherche Scientifique; Francia
Fil: Lagoutte, Emilie. Centre National de la Recherche Scientifique; Francia
Fil: Vacher, Sophie. Institut Curie; Francia
Fil: Bonsang-Kitzis, H.. Institut Curie; Francia
Fil: Glukhova, M.. Centre National de la Recherche Scientifique; Francia
Fil: Reyal, F.. Institut Curie; Francia
Fil: Bièche, I.. Institut Curie; Francia
Fil: Vincent Salomon, Anne. Institut Curie; Francia. Génétique Et Biologie Du Développement; Francia
Fil: Chavrier, Philippe. Centre National de la Recherche Scientifique; Francia
Materia
cancer de mama
p63
MT1-MMP
basal-like breast cancer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96179
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96179
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancerLodillinsky, CatalinaInfante, E.Guichard, A.Chaligné, R.Fuhrmann, L.Cyrta, J.Irondelle, MarieLagoutte, EmilieVacher, SophieBonsang-Kitzis, H.Glukhova, M.Reyal, F.Bièche, I.Vincent Salomon, AnneChavrier, Philippecancer de mamap63MT1-MMPbasal-like breast cancerhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The transition of ductal carcinoma in situ (DCIS) to invasive breast carcinoma requires tumor cells to cross the basement membrane (BM). However, mechanisms underlying BM transmigration are poorly understood. Here, we report that expression of membrane-type 1 (MT1)-matrix metalloproteinase (MMP), a key component of the BM invasion program, increases during breast cancer progression at the in situ to invasive breast carcinoma transition. In the intraductal xenograft model, MT1-MMP is required for BM transmigration of MCF10DCIS.com breast adenocarcinoma cells and is overexpressed in cell clusters overlying focal BM disruptions and at the invasive tumor front. Mirrored upregulation of p63 and MT1-MMP is observed at the edge of MCF10DCIS.com xenograft tumors and p63 is required for induction of MT1-MMP-dependent invasive program in response to microenvironmental signals. Immunohistochemistry and analysis of public database reveal that p63 and MT1-MMP are upregulated in human basal-like breast tumors suggesting that p63/MT1-MMP axis contributes to progression of basal-like breast cancers with elevated p63 and MT1-MMP levels.Fil: Lodillinsky, Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centre National de la Recherche Scientifique; FranciaFil: Infante, E.. Centre National de la Recherche Scientifique; FranciaFil: Guichard, A.. Centre National de la Recherche Scientifique; FranciaFil: Chaligné, R.. Génétique Et Biologie Du Développement; FranciaFil: Fuhrmann, L.. Centre National de la Recherche Scientifique; FranciaFil: Cyrta, J.. Centre National de la Recherche Scientifique; FranciaFil: Irondelle, Marie. Centre National de la Recherche Scientifique; FranciaFil: Lagoutte, Emilie. Centre National de la Recherche Scientifique; FranciaFil: Vacher, Sophie. Institut Curie; FranciaFil: Bonsang-Kitzis, H.. Institut Curie; FranciaFil: Glukhova, M.. Centre National de la Recherche Scientifique; FranciaFil: Reyal, F.. Institut Curie; FranciaFil: Bièche, I.. Institut Curie; FranciaFil: Vincent Salomon, Anne. Institut Curie; Francia. Génétique Et Biologie Du Développement; FranciaFil: Chavrier, Philippe. Centre National de la Recherche Scientifique; FranciaNature Publishing Group2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96179Lodillinsky, Catalina; Infante, E.; Guichard, A.; Chaligné, R.; Fuhrmann, L.; et al.; p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer; Nature Publishing Group; Oncogene; 35; 3; 1-2016; 344-3570950-9232CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/onc201587info:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2015.87info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:42Zoai:ri.conicet.gov.ar:11336/96179instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:42.674CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
title p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
spellingShingle p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
Lodillinsky, Catalina
cancer de mama
p63
MT1-MMP
basal-like breast cancer
title_short p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
title_full p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
title_fullStr p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
title_full_unstemmed p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
title_sort p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
dc.creator.none.fl_str_mv Lodillinsky, Catalina
Infante, E.
Guichard, A.
Chaligné, R.
Fuhrmann, L.
Cyrta, J.
Irondelle, Marie
Lagoutte, Emilie
Vacher, Sophie
Bonsang-Kitzis, H.
Glukhova, M.
Reyal, F.
Bièche, I.
Vincent Salomon, Anne
Chavrier, Philippe
author Lodillinsky, Catalina
author_facet Lodillinsky, Catalina
Infante, E.
Guichard, A.
Chaligné, R.
Fuhrmann, L.
Cyrta, J.
Irondelle, Marie
Lagoutte, Emilie
Vacher, Sophie
Bonsang-Kitzis, H.
Glukhova, M.
Reyal, F.
Bièche, I.
Vincent Salomon, Anne
Chavrier, Philippe
author_role author
author2 Infante, E.
Guichard, A.
Chaligné, R.
Fuhrmann, L.
Cyrta, J.
Irondelle, Marie
Lagoutte, Emilie
Vacher, Sophie
Bonsang-Kitzis, H.
Glukhova, M.
Reyal, F.
Bièche, I.
Vincent Salomon, Anne
Chavrier, Philippe
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv cancer de mama
p63
MT1-MMP
basal-like breast cancer
topic cancer de mama
p63
MT1-MMP
basal-like breast cancer
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The transition of ductal carcinoma in situ (DCIS) to invasive breast carcinoma requires tumor cells to cross the basement membrane (BM). However, mechanisms underlying BM transmigration are poorly understood. Here, we report that expression of membrane-type 1 (MT1)-matrix metalloproteinase (MMP), a key component of the BM invasion program, increases during breast cancer progression at the in situ to invasive breast carcinoma transition. In the intraductal xenograft model, MT1-MMP is required for BM transmigration of MCF10DCIS.com breast adenocarcinoma cells and is overexpressed in cell clusters overlying focal BM disruptions and at the invasive tumor front. Mirrored upregulation of p63 and MT1-MMP is observed at the edge of MCF10DCIS.com xenograft tumors and p63 is required for induction of MT1-MMP-dependent invasive program in response to microenvironmental signals. Immunohistochemistry and analysis of public database reveal that p63 and MT1-MMP are upregulated in human basal-like breast tumors suggesting that p63/MT1-MMP axis contributes to progression of basal-like breast cancers with elevated p63 and MT1-MMP levels.
Fil: Lodillinsky, Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centre National de la Recherche Scientifique; Francia
Fil: Infante, E.. Centre National de la Recherche Scientifique; Francia
Fil: Guichard, A.. Centre National de la Recherche Scientifique; Francia
Fil: Chaligné, R.. Génétique Et Biologie Du Développement; Francia
Fil: Fuhrmann, L.. Centre National de la Recherche Scientifique; Francia
Fil: Cyrta, J.. Centre National de la Recherche Scientifique; Francia
Fil: Irondelle, Marie. Centre National de la Recherche Scientifique; Francia
Fil: Lagoutte, Emilie. Centre National de la Recherche Scientifique; Francia
Fil: Vacher, Sophie. Institut Curie; Francia
Fil: Bonsang-Kitzis, H.. Institut Curie; Francia
Fil: Glukhova, M.. Centre National de la Recherche Scientifique; Francia
Fil: Reyal, F.. Institut Curie; Francia
Fil: Bièche, I.. Institut Curie; Francia
Fil: Vincent Salomon, Anne. Institut Curie; Francia. Génétique Et Biologie Du Développement; Francia
Fil: Chavrier, Philippe. Centre National de la Recherche Scientifique; Francia
description The transition of ductal carcinoma in situ (DCIS) to invasive breast carcinoma requires tumor cells to cross the basement membrane (BM). However, mechanisms underlying BM transmigration are poorly understood. Here, we report that expression of membrane-type 1 (MT1)-matrix metalloproteinase (MMP), a key component of the BM invasion program, increases during breast cancer progression at the in situ to invasive breast carcinoma transition. In the intraductal xenograft model, MT1-MMP is required for BM transmigration of MCF10DCIS.com breast adenocarcinoma cells and is overexpressed in cell clusters overlying focal BM disruptions and at the invasive tumor front. Mirrored upregulation of p63 and MT1-MMP is observed at the edge of MCF10DCIS.com xenograft tumors and p63 is required for induction of MT1-MMP-dependent invasive program in response to microenvironmental signals. Immunohistochemistry and analysis of public database reveal that p63 and MT1-MMP are upregulated in human basal-like breast tumors suggesting that p63/MT1-MMP axis contributes to progression of basal-like breast cancers with elevated p63 and MT1-MMP levels.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96179
Lodillinsky, Catalina; Infante, E.; Guichard, A.; Chaligné, R.; Fuhrmann, L.; et al.; p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer; Nature Publishing Group; Oncogene; 35; 3; 1-2016; 344-357
0950-9232
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96179
identifier_str_mv Lodillinsky, Catalina; Infante, E.; Guichard, A.; Chaligné, R.; Fuhrmann, L.; et al.; p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer; Nature Publishing Group; Oncogene; 35; 3; 1-2016; 344-357
0950-9232
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/onc201587
info:eu-repo/semantics/altIdentifier/doi/10.1038/onc.2015.87
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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