Trends in inpatient antiparkinson drug use in the USA, 2001-2012
- Autores
- Crispo, James; Fortin, Yannick; Thibault, Dylan P.; Emons, Matthew; Bjerre, Lise M.; Kohen, Dafna E.; Pérez Lloret, Santiago; Mattison, Donald; Willis, Allison W.; Krewski, Daniel
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Purpose: Although therapeutic options and clinical guidelines for Parkinson's disease (PD) have changed significantly in the past 15 years, prescribing trends in the USA remain unknown. The purpose of this population-based cohort study was to examine patterns of inpatient antiparkinson drug use between January 2001 and December 2012 in relation to clinical guideline publication, drug introduction/withdrawal, and emerging safety concerns. Methods: A total of 16,785 inpatients receiving pharmacological treatment for PD were identified in the Cerner Health Facts database. Our primary outcome was standardized (age, sex, race, and census region) annual prevalence of antiparkinson drug use. We also examined antiparkinson medication trends and polypharmacy by age and sex. Results: The most frequently prescribed antiparkinson drugs between 2001 and 2012 were levodopa (85 %) and dopamine agonists (28 %). Dopamine agonist use began declining in 2007, from 34 to 27 % in 2012. The decline followed publication of the American Academy of Neurology's practice parameter refuting levodopa toxicity, pergolide withdrawal, and pramipexole label revisions. Despite safety concerns for cognitive impairment and falls, individuals = 80 years of age demonstrated stable rates of dopamine agonist use from 2001 to 2012. Polypharmacy was most common in younger patients. Conclusions: Dopamine agonist use declined from 2007 to 2012, suggesting that increased awareness of safety issues and practice guidelines influenced prescribing. These events appear to have minimally influenced treatment provided to older PD patients. Antiparkinson prescribing trends indicate that safety and best practice information may be communicated effectively.
Fil: Crispo, James. University of Ottawa; Canadá. University of Pennsylvania; Estados Unidos
Fil: Fortin, Yannick. University of Ottawa; Canadá
Fil: Thibault, Dylan P.. University of Pennsylvania; Estados Unidos
Fil: Emons, Matthew. Cerner Corporation; Estados Unidos
Fil: Bjerre, Lise M.. University of Ottawa; Canadá. Bruyère Research Institute; Canadá
Fil: Kohen, Dafna E.. University of Ottawa; Canadá
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mattison, Donald. Risk Sciences International; Canadá. University of Ottawa; Canadá
Fil: Willis, Allison W.. University of Pennsylvania; Estados Unidos
Fil: Krewski, Daniel. University of Ottawa; Canadá - Materia
-
Cohort Study
Drug Utilization
Medical Records
Parkinson'S Disease
Pharmacoepidemiology - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/38806
Ver los metadatos del registro completo
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Trends in inpatient antiparkinson drug use in the USA, 2001-2012Crispo, JamesFortin, YannickThibault, Dylan P.Emons, MatthewBjerre, Lise M.Kohen, Dafna E.Pérez Lloret, SantiagoMattison, DonaldWillis, Allison W.Krewski, DanielCohort StudyDrug UtilizationMedical RecordsParkinson'S DiseasePharmacoepidemiologyhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose: Although therapeutic options and clinical guidelines for Parkinson's disease (PD) have changed significantly in the past 15 years, prescribing trends in the USA remain unknown. The purpose of this population-based cohort study was to examine patterns of inpatient antiparkinson drug use between January 2001 and December 2012 in relation to clinical guideline publication, drug introduction/withdrawal, and emerging safety concerns. Methods: A total of 16,785 inpatients receiving pharmacological treatment for PD were identified in the Cerner Health Facts database. Our primary outcome was standardized (age, sex, race, and census region) annual prevalence of antiparkinson drug use. We also examined antiparkinson medication trends and polypharmacy by age and sex. Results: The most frequently prescribed antiparkinson drugs between 2001 and 2012 were levodopa (85 %) and dopamine agonists (28 %). Dopamine agonist use began declining in 2007, from 34 to 27 % in 2012. The decline followed publication of the American Academy of Neurology's practice parameter refuting levodopa toxicity, pergolide withdrawal, and pramipexole label revisions. Despite safety concerns for cognitive impairment and falls, individuals = 80 years of age demonstrated stable rates of dopamine agonist use from 2001 to 2012. Polypharmacy was most common in younger patients. Conclusions: Dopamine agonist use declined from 2007 to 2012, suggesting that increased awareness of safety issues and practice guidelines influenced prescribing. These events appear to have minimally influenced treatment provided to older PD patients. Antiparkinson prescribing trends indicate that safety and best practice information may be communicated effectively.Fil: Crispo, James. University of Ottawa; Canadá. University of Pennsylvania; Estados UnidosFil: Fortin, Yannick. University of Ottawa; CanadáFil: Thibault, Dylan P.. University of Pennsylvania; Estados UnidosFil: Emons, Matthew. Cerner Corporation; Estados UnidosFil: Bjerre, Lise M.. University of Ottawa; Canadá. Bruyère Research Institute; CanadáFil: Kohen, Dafna E.. University of Ottawa; CanadáFil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mattison, Donald. Risk Sciences International; Canadá. University of Ottawa; CanadáFil: Willis, Allison W.. University of Pennsylvania; Estados UnidosFil: Krewski, Daniel. University of Ottawa; CanadáSpringer2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38806Crispo, James; Fortin, Yannick; Thibault, Dylan P.; Emons, Matthew; Bjerre, Lise M.; et al.; Trends in inpatient antiparkinson drug use in the USA, 2001-2012; Springer; European Journal Of Clinical Pharmacology; 71; 8; 8-2015; 1011-10190031-6970CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00228-015-1881-4info:eu-repo/semantics/altIdentifier/doi/10.1007/s00228-015-1881-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:18Zoai:ri.conicet.gov.ar:11336/38806instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:19.005CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Trends in inpatient antiparkinson drug use in the USA, 2001-2012 |
title |
Trends in inpatient antiparkinson drug use in the USA, 2001-2012 |
spellingShingle |
Trends in inpatient antiparkinson drug use in the USA, 2001-2012 Crispo, James Cohort Study Drug Utilization Medical Records Parkinson'S Disease Pharmacoepidemiology |
title_short |
Trends in inpatient antiparkinson drug use in the USA, 2001-2012 |
title_full |
Trends in inpatient antiparkinson drug use in the USA, 2001-2012 |
title_fullStr |
Trends in inpatient antiparkinson drug use in the USA, 2001-2012 |
title_full_unstemmed |
Trends in inpatient antiparkinson drug use in the USA, 2001-2012 |
title_sort |
Trends in inpatient antiparkinson drug use in the USA, 2001-2012 |
dc.creator.none.fl_str_mv |
Crispo, James Fortin, Yannick Thibault, Dylan P. Emons, Matthew Bjerre, Lise M. Kohen, Dafna E. Pérez Lloret, Santiago Mattison, Donald Willis, Allison W. Krewski, Daniel |
author |
Crispo, James |
author_facet |
Crispo, James Fortin, Yannick Thibault, Dylan P. Emons, Matthew Bjerre, Lise M. Kohen, Dafna E. Pérez Lloret, Santiago Mattison, Donald Willis, Allison W. Krewski, Daniel |
author_role |
author |
author2 |
Fortin, Yannick Thibault, Dylan P. Emons, Matthew Bjerre, Lise M. Kohen, Dafna E. Pérez Lloret, Santiago Mattison, Donald Willis, Allison W. Krewski, Daniel |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Cohort Study Drug Utilization Medical Records Parkinson'S Disease Pharmacoepidemiology |
topic |
Cohort Study Drug Utilization Medical Records Parkinson'S Disease Pharmacoepidemiology |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Purpose: Although therapeutic options and clinical guidelines for Parkinson's disease (PD) have changed significantly in the past 15 years, prescribing trends in the USA remain unknown. The purpose of this population-based cohort study was to examine patterns of inpatient antiparkinson drug use between January 2001 and December 2012 in relation to clinical guideline publication, drug introduction/withdrawal, and emerging safety concerns. Methods: A total of 16,785 inpatients receiving pharmacological treatment for PD were identified in the Cerner Health Facts database. Our primary outcome was standardized (age, sex, race, and census region) annual prevalence of antiparkinson drug use. We also examined antiparkinson medication trends and polypharmacy by age and sex. Results: The most frequently prescribed antiparkinson drugs between 2001 and 2012 were levodopa (85 %) and dopamine agonists (28 %). Dopamine agonist use began declining in 2007, from 34 to 27 % in 2012. The decline followed publication of the American Academy of Neurology's practice parameter refuting levodopa toxicity, pergolide withdrawal, and pramipexole label revisions. Despite safety concerns for cognitive impairment and falls, individuals = 80 years of age demonstrated stable rates of dopamine agonist use from 2001 to 2012. Polypharmacy was most common in younger patients. Conclusions: Dopamine agonist use declined from 2007 to 2012, suggesting that increased awareness of safety issues and practice guidelines influenced prescribing. These events appear to have minimally influenced treatment provided to older PD patients. Antiparkinson prescribing trends indicate that safety and best practice information may be communicated effectively. Fil: Crispo, James. University of Ottawa; Canadá. University of Pennsylvania; Estados Unidos Fil: Fortin, Yannick. University of Ottawa; Canadá Fil: Thibault, Dylan P.. University of Pennsylvania; Estados Unidos Fil: Emons, Matthew. Cerner Corporation; Estados Unidos Fil: Bjerre, Lise M.. University of Ottawa; Canadá. Bruyère Research Institute; Canadá Fil: Kohen, Dafna E.. University of Ottawa; Canadá Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Mattison, Donald. Risk Sciences International; Canadá. University of Ottawa; Canadá Fil: Willis, Allison W.. University of Pennsylvania; Estados Unidos Fil: Krewski, Daniel. University of Ottawa; Canadá |
description |
Purpose: Although therapeutic options and clinical guidelines for Parkinson's disease (PD) have changed significantly in the past 15 years, prescribing trends in the USA remain unknown. The purpose of this population-based cohort study was to examine patterns of inpatient antiparkinson drug use between January 2001 and December 2012 in relation to clinical guideline publication, drug introduction/withdrawal, and emerging safety concerns. Methods: A total of 16,785 inpatients receiving pharmacological treatment for PD were identified in the Cerner Health Facts database. Our primary outcome was standardized (age, sex, race, and census region) annual prevalence of antiparkinson drug use. We also examined antiparkinson medication trends and polypharmacy by age and sex. Results: The most frequently prescribed antiparkinson drugs between 2001 and 2012 were levodopa (85 %) and dopamine agonists (28 %). Dopamine agonist use began declining in 2007, from 34 to 27 % in 2012. The decline followed publication of the American Academy of Neurology's practice parameter refuting levodopa toxicity, pergolide withdrawal, and pramipexole label revisions. Despite safety concerns for cognitive impairment and falls, individuals = 80 years of age demonstrated stable rates of dopamine agonist use from 2001 to 2012. Polypharmacy was most common in younger patients. Conclusions: Dopamine agonist use declined from 2007 to 2012, suggesting that increased awareness of safety issues and practice guidelines influenced prescribing. These events appear to have minimally influenced treatment provided to older PD patients. Antiparkinson prescribing trends indicate that safety and best practice information may be communicated effectively. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/38806 Crispo, James; Fortin, Yannick; Thibault, Dylan P.; Emons, Matthew; Bjerre, Lise M.; et al.; Trends in inpatient antiparkinson drug use in the USA, 2001-2012; Springer; European Journal Of Clinical Pharmacology; 71; 8; 8-2015; 1011-1019 0031-6970 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/38806 |
identifier_str_mv |
Crispo, James; Fortin, Yannick; Thibault, Dylan P.; Emons, Matthew; Bjerre, Lise M.; et al.; Trends in inpatient antiparkinson drug use in the USA, 2001-2012; Springer; European Journal Of Clinical Pharmacology; 71; 8; 8-2015; 1011-1019 0031-6970 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00228-015-1881-4 info:eu-repo/semantics/altIdentifier/doi/10.1007/s00228-015-1881-4 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |