Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species

Autores
Ortiz, Javier Esteban; Piñeiro Gomez, Mauricio Daniel; Kaiser, Marcel; Mäser, Pascal; Bastida, Jaume; Feresin, Gabriela Egly
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Diseases caused by trypanosomatid parasites like human African trypanosomiasis (HAT), Chagas disease (CD), leishmaniasis, and malaria, are persistent health problems in developing countries that still demand for new drug development. The species of the Amaryllidoideae subfamily (Amaryllidaceae) represent a vast source of alkaloids with a wide range of bioactive properties, including antiparasitic effects. The aim of this study was to evaluate the antiparasitic activity of the alkaloids hamayne, 7-hydroxyclivonine, 4-O-methylnangustine, and candimine against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum parasites. The alkaloids were isolated from the leaves of Hippeastrum argentinum and H. escoipense using several chromatographic techniques then identified by GC-MS, UPLC-MS/MS, and NMR data. The compounds were assessed against different life cycle stages of these four parasites. Furthermore, the cytotoxic activity of the alkaloids against L6 rat skeletal myoblast cells, was tested. P. falciparum was very sensible to 7-hydroxyclivonine. Candimine showed significant antiparasitic activity against all the evaluated parasites, especially T. brucei rhodesiense. Candimine merits deeper research regarding its effect against trypanosomatid parasites as a lead compound for the development of alternative treatments for HAT, CD, and malaria.
Fil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Piñeiro Gomez, Mauricio Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Kaiser, Marcel. University Of Basel; Suiza
Fil: Mäser, Pascal. Universidad de Basilea; Suiza
Fil: Bastida, Jaume. Universidad de Barcelona; España
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Materia
AMARYLLIDACEAE
CANDIMINE
MALARIA
TRYPANOSOMA
TRYPANOSOMIASIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/279931
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/279931
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum SpeciesOrtiz, Javier EstebanPiñeiro Gomez, Mauricio DanielKaiser, MarcelMäser, PascalBastida, JaumeFeresin, Gabriela EglyAMARYLLIDACEAECANDIMINEMALARIATRYPANOSOMATRYPANOSOMIASIShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Diseases caused by trypanosomatid parasites like human African trypanosomiasis (HAT), Chagas disease (CD), leishmaniasis, and malaria, are persistent health problems in developing countries that still demand for new drug development. The species of the Amaryllidoideae subfamily (Amaryllidaceae) represent a vast source of alkaloids with a wide range of bioactive properties, including antiparasitic effects. The aim of this study was to evaluate the antiparasitic activity of the alkaloids hamayne, 7-hydroxyclivonine, 4-O-methylnangustine, and candimine against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum parasites. The alkaloids were isolated from the leaves of Hippeastrum argentinum and H. escoipense using several chromatographic techniques then identified by GC-MS, UPLC-MS/MS, and NMR data. The compounds were assessed against different life cycle stages of these four parasites. Furthermore, the cytotoxic activity of the alkaloids against L6 rat skeletal myoblast cells, was tested. P. falciparum was very sensible to 7-hydroxyclivonine. Candimine showed significant antiparasitic activity against all the evaluated parasites, especially T. brucei rhodesiense. Candimine merits deeper research regarding its effect against trypanosomatid parasites as a lead compound for the development of alternative treatments for HAT, CD, and malaria.Fil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Piñeiro Gomez, Mauricio Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Kaiser, Marcel. University Of Basel; SuizaFil: Mäser, Pascal. Universidad de Basilea; SuizaFil: Bastida, Jaume. Universidad de Barcelona; EspañaFil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaWiley VCH Verlag2025-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/279931Ortiz, Javier Esteban; Piñeiro Gomez, Mauricio Daniel; Kaiser, Marcel; Mäser, Pascal; Bastida, Jaume; et al.; Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species; Wiley VCH Verlag; Chemistry and Biodiversity; 22; 8; 3-2025; 1-181612-1872CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202500015info:eu-repo/semantics/altIdentifier/doi/10.1002/cbdv.202500015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:29:47Zoai:ri.conicet.gov.ar:11336/279931instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:29:48.183CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species
title Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species
spellingShingle Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species
Ortiz, Javier Esteban
AMARYLLIDACEAE
CANDIMINE
MALARIA
TRYPANOSOMA
TRYPANOSOMIASIS
title_short Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species
title_full Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species
title_fullStr Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species
title_full_unstemmed Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species
title_sort Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species
dc.creator.none.fl_str_mv Ortiz, Javier Esteban
Piñeiro Gomez, Mauricio Daniel
Kaiser, Marcel
Mäser, Pascal
Bastida, Jaume
Feresin, Gabriela Egly
author Ortiz, Javier Esteban
author_facet Ortiz, Javier Esteban
Piñeiro Gomez, Mauricio Daniel
Kaiser, Marcel
Mäser, Pascal
Bastida, Jaume
Feresin, Gabriela Egly
author_role author
author2 Piñeiro Gomez, Mauricio Daniel
Kaiser, Marcel
Mäser, Pascal
Bastida, Jaume
Feresin, Gabriela Egly
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv AMARYLLIDACEAE
CANDIMINE
MALARIA
TRYPANOSOMA
TRYPANOSOMIASIS
topic AMARYLLIDACEAE
CANDIMINE
MALARIA
TRYPANOSOMA
TRYPANOSOMIASIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Diseases caused by trypanosomatid parasites like human African trypanosomiasis (HAT), Chagas disease (CD), leishmaniasis, and malaria, are persistent health problems in developing countries that still demand for new drug development. The species of the Amaryllidoideae subfamily (Amaryllidaceae) represent a vast source of alkaloids with a wide range of bioactive properties, including antiparasitic effects. The aim of this study was to evaluate the antiparasitic activity of the alkaloids hamayne, 7-hydroxyclivonine, 4-O-methylnangustine, and candimine against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum parasites. The alkaloids were isolated from the leaves of Hippeastrum argentinum and H. escoipense using several chromatographic techniques then identified by GC-MS, UPLC-MS/MS, and NMR data. The compounds were assessed against different life cycle stages of these four parasites. Furthermore, the cytotoxic activity of the alkaloids against L6 rat skeletal myoblast cells, was tested. P. falciparum was very sensible to 7-hydroxyclivonine. Candimine showed significant antiparasitic activity against all the evaluated parasites, especially T. brucei rhodesiense. Candimine merits deeper research regarding its effect against trypanosomatid parasites as a lead compound for the development of alternative treatments for HAT, CD, and malaria.
Fil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Piñeiro Gomez, Mauricio Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Kaiser, Marcel. University Of Basel; Suiza
Fil: Mäser, Pascal. Universidad de Basilea; Suiza
Fil: Bastida, Jaume. Universidad de Barcelona; España
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
description Diseases caused by trypanosomatid parasites like human African trypanosomiasis (HAT), Chagas disease (CD), leishmaniasis, and malaria, are persistent health problems in developing countries that still demand for new drug development. The species of the Amaryllidoideae subfamily (Amaryllidaceae) represent a vast source of alkaloids with a wide range of bioactive properties, including antiparasitic effects. The aim of this study was to evaluate the antiparasitic activity of the alkaloids hamayne, 7-hydroxyclivonine, 4-O-methylnangustine, and candimine against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, and Plasmodium falciparum parasites. The alkaloids were isolated from the leaves of Hippeastrum argentinum and H. escoipense using several chromatographic techniques then identified by GC-MS, UPLC-MS/MS, and NMR data. The compounds were assessed against different life cycle stages of these four parasites. Furthermore, the cytotoxic activity of the alkaloids against L6 rat skeletal myoblast cells, was tested. P. falciparum was very sensible to 7-hydroxyclivonine. Candimine showed significant antiparasitic activity against all the evaluated parasites, especially T. brucei rhodesiense. Candimine merits deeper research regarding its effect against trypanosomatid parasites as a lead compound for the development of alternative treatments for HAT, CD, and malaria.
publishDate 2025
dc.date.none.fl_str_mv 2025-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/279931
Ortiz, Javier Esteban; Piñeiro Gomez, Mauricio Daniel; Kaiser, Marcel; Mäser, Pascal; Bastida, Jaume; et al.; Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species; Wiley VCH Verlag; Chemistry and Biodiversity; 22; 8; 3-2025; 1-18
1612-1872
CONICET Digital
CONICET
url http://hdl.handle.net/11336/279931
identifier_str_mv Ortiz, Javier Esteban; Piñeiro Gomez, Mauricio Daniel; Kaiser, Marcel; Mäser, Pascal; Bastida, Jaume; et al.; Anti‐Trypanosomatid and Antiplasmodial Activities of Alkaloids From Hippeastrum Species; Wiley VCH Verlag; Chemistry and Biodiversity; 22; 8; 3-2025; 1-18
1612-1872
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202500015
info:eu-repo/semantics/altIdentifier/doi/10.1002/cbdv.202500015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.665996

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